{
    "uniprot_canonical_ac": "P29457-1",
    "uniprot_ac": "P29457",
    "uniprot_id": "SERPH_RAT",
    "mass": {
        "chemical_mass": 46518.0,
        "monoisotopic_mass": 46518.0
    },
    "refseq": {
        "ac": "NP_058869",
        "name": "serpin H1 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869"
    },
    "gene_names": [
        {
            "name": "Serpinh1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P29457",
            "id": "P29457"
        },
        {
            "name": "Cbp1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P29457",
            "id": "P29457"
        },
        {
            "name": "Cbp2; Serpinh2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869",
            "id": "NP_058869"
        },
        {
            "name": "Hsp47",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P29457",
            "id": "P29457"
        },
        {
            "name": "Serpinh1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869",
            "id": "NP_058869"
        }
    ],
    "protein_names": [
        {
            "name": "Serpin H1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P29457"
        },
        {
            "name": "47 kDa heat shock protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P29457"
        },
        {
            "name": "Collagen-binding protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P29457"
        },
        {
            "name": "Colligin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P29457"
        },
        {
            "name": "GP46",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P29457"
        },
        {
            "name": "serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine proteinase inhibitor, clade H (heat shock protein 47), member 1; serpin H1; GP46; colligin; collagen-binding protein; 47 kDa heat shock protein; serine (or cysteine) proteinase inhibitor, clade H, member 1; serine (or cysteine) peptidase inhibitor, clade H, member 1; serpin peptidase inhibitor, clade H, member 1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); collagen binding protein 2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869",
            "id": "NP_058869"
        },
        {
            "name": "serpin H1 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869",
            "id": "NP_058869"
        }
    ],
    "function": [
        {
            "annotation": "Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6I6G9",
                    "url": "https://www.uniprot.org/uniprot/A6I6G9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00025405",
                    "url": "https://www.uniprot.org/uniprot/ARBA00025405#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "P29457",
                    "url": "https://www.uniprot.org/uniprot/P29457#function"
                }
            ]
        },
        {
            "annotation": "It could be concluded that LF is a promising antifibrotic drug and could be considered as one of the HSP47 inhibitors but SM is still more potent",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869"
                },
                {
                    "database": "PubMed",
                    "id": "30092114",
                    "url": "https://glygen.org/publication/PubMed/30092114"
                }
            ]
        },
        {
            "annotation": "The results suggest that Hsp47 turnover may increase during heat stress or that Hsp47 consumption exceeds its production. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869"
                },
                {
                    "database": "PubMed",
                    "id": "25526199",
                    "url": "https://glygen.org/publication/PubMed/25526199"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0110346",
            "recommended_name": {
                "id": "DOID:0110346",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110346",
                "name": "osteogenesis imperfecta type 10",
                "description": "An osteogenesis imperfecta that has_material_basis_in mutation in the SERPINH gene on chromosome 11q13."
            },
            "synonyms": [
                {
                    "id": "DOID:0110346",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110346",
                    "name": "OI10",
                    "description": ""
                },
                {
                    "id": "DOID:0110346",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110346",
                    "name": "osteogenesis imperfecta type X",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "osteogenesis imperfecta type 10",
                    "description": "Any osteogenesis imperfecta in which the cause of the disease is a mutation in the SERPINH1 gene."
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "OI10",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "SERPINH1 osteogenesis imperfecta",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "osteogenesis imperfecta caused by mutation in SERPINH1",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "osteogenesis imperfecta type X",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "OI type 10",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "OI type X",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "OI, type 10",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "osteogenesis imperfecta, type 10",
                    "description": ""
                },
                {
                    "id": "MONDO:0013459",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013459",
                    "name": "osteogenesis imperfecta, type X",
                    "description": ""
                },
                {
                    "id": "MIM:613848",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613848",
                    "name": "Osteogenesis imperfecta 10",
                    "description": "Osteogenesis imperfecta 10"
                }
            ],
            "evidence": [
                {
                    "id": "0110346",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110346"
                }
            ]
        },
        {
            "disease_id": "DOID:0111144",
            "recommended_name": {
                "id": "DOID:0111144",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111144",
                "name": "preterm premature rupture of the membranes",
                "description": "A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation."
            },
            "synonyms": [
                {
                    "id": "DOID:0111144",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111144",
                    "name": "PPROM",
                    "description": ""
                },
                {
                    "id": "MONDO:0012511",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012511",
                    "name": "preterm premature rupture of the membranes",
                    "description": "A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation."
                },
                {
                    "id": "MONDO:0012511",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012511",
                    "name": "PPROM",
                    "description": ""
                },
                {
                    "id": "MONDO:0012511",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012511",
                    "name": "preterm premature rupture of the membranes",
                    "description": ""
                },
                {
                    "id": "MONDO:0012511",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012511",
                    "name": "preterm premature rupture of the membranes, susceptibility to",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0111144",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111144"
                }
            ]
        },
        {
            "disease_id": "DOID:5082",
            "recommended_name": {
                "id": "DOID:5082",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:5082",
                "name": "liver cirrhosis",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:5082",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5082",
                    "name": "Cirrhosis",
                    "description": ""
                },
                {
                    "id": "DOID:5082",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5082",
                    "name": "cirrhosis of liver",
                    "description": ""
                },
                {
                    "id": "MONDO:0005155",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005155",
                    "name": "cirrhosis of liver",
                    "description": "A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy."
                },
                {
                    "id": "MONDO:0005155",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005155",
                    "name": "cirrhosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0005155",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005155",
                    "name": "cirrhosis of liver",
                    "description": ""
                },
                {
                    "id": "MONDO:0005155",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0005155",
                    "name": "liver cirrhosis",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "5082",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:5082"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P29457",
                    "url": "https://www.uniprot.org/uniprot/P29457"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Serpinh1",
            "url": "https://www.uniprot.org/uniprot/P29457",
            "locus": {
                "chromosome": "1",
                "start_pos": 153643510,
                "end_pos": 153650801,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000016831",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000016831"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000016831",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016831",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd02046",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02046",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "29345",
            "url": "https://www.ncbi.nlm.nih.gov/gene/29345",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P29457",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P29457*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000215",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023795",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023796",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR033830",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033830",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036186",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042178",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042185",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:29345",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29345",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "WDEKFHE",
            "url": "https://omabrowser.org/oma/group/WDEKFHE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3218836at2759",
            "url": "http://www.orthodb.org/?query=3218836at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11461",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11461:SF27",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF27",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00079",
            "url": "http://pfam.xfam.org/family/PF00079",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P29457",
            "url": "http://purl.obolibrary.org/obo/PR_P29457",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-1650814",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1650814",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_058869",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "69302",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=69302",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A6I6G9",
            "url": "https://www.uniprot.org/uniprot/A6I6G9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A6I6G9-1",
            "url": "https://www.uniprot.org/uniprot/A6I6G9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P29457",
            "url": "https://www.uniprot.org/uniprot/P29457",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P29457-1",
            "url": "https://www.uniprot.org/uniprot/P29457-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MRSLLLGTLCLLAVALAAEVKKPVEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELVRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL",
        "length": 417,
        "header": "sp|P29457-1|SERPH_RAT Isoform 1 of Serpin H1  OS=Rattus norvegicus OX=10116 GN=Serpinh1 PE=1 SV=1 CANONICAL=P29457-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A6I6G9-1",
            "url": "",
            "sequence": {
                "sequence": "MRSLLLGTLCLLAVALAAEVKKPVEATAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL",
                "length": 417,
                "header": "tr|A6I6G9-1|A6I6G9_RAT Computationally mapped isoform of Serpin H1  OS=Rattus norvegicus OX=10116 GN=Serpinh1 PE=2 SV=1 CANONICAL=P29457-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 153647165,
                "end_pos": 153644195,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000086091.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086091.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000070279.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070279.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P29457-1",
            "url": "",
            "sequence": {
                "sequence": "MRSLLLGTLCLLAVALAAEVKKPVEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELVRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQLVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL",
                "length": 417,
                "header": "sp|P29457-1|SERPH_RAT Isoform 1 of Serpin H1  OS=Rattus norvegicus OX=10116 GN=Serpinh1 PE=1 SV=1 CANONICAL=P29457-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 119,
            "start_aa": "Asn",
            "end_pos": 119,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn119",
            "evidence": [
                {
                    "id": "P29457",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P29457#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 124,
            "start_aa": "Asn",
            "end_pos": 124,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn124",
            "evidence": [
                {
                    "id": "P29457",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P29457#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 394,
            "start_aa": "Asn",
            "end_pos": 394,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn394",
            "evidence": [
                {
                    "id": "P29457",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P29457#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 140,
            "end_pos": 140,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
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                {
                    "database": "UniProtKB",
                    "id": "P29457",
                    "url": "https://www.uniprot.org/uniprot/P29457"
                }
            ],
            "site_lbl": "Ser140"
        }
    ],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors.",
            "journal": "J. Biol. Chem.",
            "date": "1991",
            "authors": "Ball E.H., Cates G.A., Clarke E.P., Sanwal B.D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P29457",
                    "url": "https://www.uniprot.org/uniprot/P29457"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1654327",
                    "url": "https://glygen.org/publication/PubMed/1654327"
                }
            ]
        },
        {
            "title": "Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts.",
            "journal": "Arch. Biochem. Biophys.",
            "date": "1990",
            "authors": "Nandan D, Cates GA, Ball EH, Sanwal BD",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P29457",
                    "url": "https://www.uniprot.org/uniprot/P29457"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2158279",
                    "url": "https://glygen.org/publication/PubMed/2158279"
                }
            ]
        },
        {
            "title": "Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo.",
            "journal": "Genetics and molecular research : GMR",
            "date": "2014",
            "authors": "Abdelnasir A, Sun JR, Cheng YF, Chen HB, Tang S, Kemper N, Hartung J, Bao ED",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25526199",
                    "url": "https://glygen.org/publication/PubMed/25526199"
                }
            ]
        },
        {
            "title": "Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin.",
            "journal": "IUBMB life",
            "date": "2018",
            "authors": "Rizk FH, Sarhan NI, Soliman NA, Ibrahim MAA, Abd-Elsalam M, Abd-Elsalam S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058869",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30092114",
                    "url": "https://glygen.org/publication/PubMed/30092114"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:29345",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29345",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1650814",
            "name": "Collagen biosynthesis and modifying enzymes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1650814",
            "resource": "Reactome",
            "description": "Collagen biosynthesis and modifying enzymes"
        }
    ],
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        {
            "uniprot_canonical_ac": "P19324-1",
            "protein_name": "Serpin H1",
            "gene_name": "Serpinh1",
            "tax_id": 10090,
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            "sequence": {
                "sequence": "MRSLLLGTLCLLAVALAAEVKKPLEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL",
                "length": 417
            },
            "evidence": [
                {
                    "id": "45224532",
                    "url": "http://www.informatics.jax.org/homology/45224532",
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                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P50454-1",
            "protein_name": "Serpin H1",
            "gene_name": "SERPINH1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL",
                "length": 418
            },
            "evidence": [
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                    "id": "45224532",
                    "url": "http://www.informatics.jax.org/homology/45224532",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
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                "name": "Molecular Function",
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                    {
                        "name": "serine-type endopeptidase inhibitor activity",
                        "id": "GO:0004867",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867",
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                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
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                                "id": "P29457",
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                            }
                        ],
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                    },
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                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 6,
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                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
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                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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                            {
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                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum lumen",
                        "id": "GO:0005788",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane raft",
                        "id": "GO:0045121",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum-Golgi intermediate compartment",
                        "id": "GO:0005793",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "response to organic cyclic compound",
                        "id": "GO:0014070",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen fibril organization",
                        "id": "GO:0030199",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of endopeptidase activity",
                        "id": "GO:0010951",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010951",
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                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to vitamin D",
                        "id": "GO:0033280",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033280",
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                            {
                                "database": "UniProtKB",
                                "id": "P29457",
                                "url": "https://www.uniprot.org/uniprot/P29457"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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                            {
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                                "id": "P29457",
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                            }
                        ],
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                    },
                    {
                        "name": "collagen biosynthetic process",
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                            }
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                    {
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                                "database": "UniProtKB",
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                            }
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            "end_pos": 121,
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    "ptm_annotation": [],
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    "biomarkers": [],
    "synthesized_glycans": [],
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        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
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