{
    "uniprot_canonical_ac": "P28742-1",
    "uniprot_ac": "P28742",
    "uniprot_id": "KIP1_YEAST",
    "mass": {
        "chemical_mass": 125795.0,
        "monoisotopic_mass": 125795.0
    },
    "refseq": {
        "ac": "NP_009490",
        "name": "Kip1p",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490"
    },
    "gene_names": [
        {
            "name": "KIP1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "id": "P28742"
        },
        {
            "name": "CIN9",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490",
            "id": "NP_009490"
        },
        {
            "name": "CIN9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "id": "P28742"
        },
        {
            "name": "KIP1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490",
            "id": "NP_009490"
        },
        {
            "name": "YBL0504",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "id": "P28742"
        },
        {
            "name": "YBL0521",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "id": "P28742"
        }
    ],
    "protein_names": [
        {
            "name": "Kinesin-like protein KIP1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P28742"
        },
        {
            "name": "Chromosome instability protein 9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P28742"
        },
        {
            "name": "Kip1p",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490",
            "id": "NP_009490"
        }
    ],
    "function": [
        {
            "annotation": "Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28742",
                    "url": "https://www.uniprot.org/uniprot/P28742#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060349",
            "recommended_name": {
                "id": "DOID:0060349",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060349",
                "name": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation",
                "description": "A syndrome characterized byvariable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability."
            },
            "synonyms": [
                {
                    "id": "DOID:0060349",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060349",
                    "name": "lymphedema, microcephaly and chorioretinopathy syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0060349",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060349",
                    "name": "lymphedema and retinal folds with ficrocephaly and microphthalmos",
                    "description": ""
                },
                {
                    "id": "DOID:0060349",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060349",
                    "name": "microcephaly lymphedema chorioretinal dysplasia",
                    "description": ""
                },
                {
                    "id": "DOID:0060349",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060349",
                    "name": "chorioretinal dysplasia-microcephaly-mental retardation syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0060349",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060349",
                    "name": "microcephaly, lymphedema, chorioretinal dysplasia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability",
                    "description": "Microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) is a rare autosomal dominant condition characterized by variable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability."
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "MLCRD",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "chorioretinal dysplasia-microcephaly-intellectual disability syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "chorioretinal dysplasia-microcephaly-mental retardation syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "lymphedema and retinal folds with ficrocephaly and microphthalmos",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "lymphedema, microcephaly and chorioretinopathy syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly lymphedema chorioretinal dysplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly, lymphedema, chorioretinal dysplasia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "Cdmmr syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "MCLMR",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "Mlcrd syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "lymphedema and retinal Folds with microcephaly and microphthalmos",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "lymphedema, microcephaly, chorioretinopathy syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly and chorioretinopathy with or without intellectual disability, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly and chorioretinopathy with or without mental retardation, autosomal dominant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007918",
                    "name": "microcephaly-lymphedema-chorioretinopathy syndrome",
                    "description": ""
                },
                {
                    "id": "MIM:152950",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/152950",
                    "name": "Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development",
                    "description": "Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development"
                }
            ],
            "evidence": [
                {
                    "id": "0060349",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060349"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28742",
                    "url": "https://www.uniprot.org/uniprot/P28742"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "KIP1",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "locus": {
                "chromosome": "II",
                "start_pos": 105221,
                "end_pos": 101886,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "YBL063W",
                        "url": "https://www.ensembl.org/id/YBL063W"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "cd01364",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01364",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "852216",
            "url": "https://www.ncbi.nlm.nih.gov/gene/852216",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P28742",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P28742*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019821",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036961",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047149",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047149",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047241",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047241",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YBL063W",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBL063W",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "536293at2759",
            "url": "http://www.orthodb.org/?query=536293at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47970",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47970",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47970:SF19",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47970:SF19",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00225",
            "url": "http://pfam.xfam.org/family/PF00225",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P28742",
            "url": "http://purl.obolibrary.org/obo/PR_P28742",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_009490",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000000159",
            "url": "https://www.yeastgenome.org/locus/S000000159",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P28742",
            "url": "https://www.uniprot.org/uniprot/P28742",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P28742-1",
            "url": "https://www.uniprot.org/uniprot/P28742-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ",
        "length": 1111,
        "header": "sp|P28742-1|KIP1_YEAST Isoform 1 of Kinesin-like protein KIP1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=KIP1 PE=1 SV=1 CANONICAL=P28742-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P28742-1",
            "url": "",
            "sequence": {
                "sequence": "MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ",
                "length": 1111,
                "header": "sp|P28742-1|KIP1_YEAST Isoform 1 of Kinesin-like protein KIP1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=KIP1 PE=1 SV=1 CANONICAL=P28742-1"
            },
            "locus": {
                "chromosome": "II",
                "start_pos": 105218,
                "end_pos": 101886,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YBL063W_mRNA",
                        "url": "https://www.ensembl.org/id/YBL063W_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YBL063W",
                        "url": "https://www.ensembl.org/id/YBL063W"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 1037,
            "end_pos": 1037,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P28742",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P28742"
                },
                {
                    "database": "PubMed",
                    "id": "20463882",
                    "url": "https://glygen.org/publication/PubMed/20463882"
                },
                {
                    "database": "SGD",
                    "id": "P28742",
                    "url": "https://www.yeastgenome.org/locus/P28742"
                }
            ],
            "site_lbl": "Ser1037"
        },
        {
            "start_pos": 1040,
            "end_pos": 1040,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P28742",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P28742"
                },
                {
                    "database": "PubMed",
                    "id": "20463882",
                    "url": "https://glygen.org/publication/PubMed/20463882"
                },
                {
                    "database": "SGD",
                    "id": "P28742",
                    "url": "https://www.yeastgenome.org/locus/P28742"
                }
            ],
            "site_lbl": "Thr1040"
        },
        {
            "start_pos": 1060,
            "end_pos": 1060,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P28742",
                    "url": "https://www.yeastgenome.org/locus/P28742"
                },
                {
                    "database": "iPTMnet",
                    "id": "P28742",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P28742"
                },
                {
                    "database": "PubMed",
                    "id": "20463882",
                    "url": "https://glygen.org/publication/PubMed/20463882"
                }
            ],
            "site_lbl": "Ser1060"
        },
        {
            "start_pos": 1068,
            "end_pos": 1068,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P28742",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P28742"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "SGD",
                    "id": "P28742",
                    "url": "https://www.yeastgenome.org/locus/P28742"
                },
                {
                    "database": "PubMed",
                    "id": "20463882",
                    "url": "https://glygen.org/publication/PubMed/20463882"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Thr1068"
        },
        {
            "start_pos": 1088,
            "end_pos": 1088,
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