{ "uniprot_canonical_ac": "P28564-1", "uniprot_ac": "P28564", "uniprot_id": "5HT1B_RAT", "mass": { "chemical_mass": 43163.0, "monoisotopic_mass": 43163.0 }, "refseq": { "ac": "NP_071561", "name": "5-hydroxytryptamine receptor 1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561" }, "gene_names": [ { "name": "Htr1b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P28564", "id": "P28564" }, { "name": "5ht1b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P28564", "id": "P28564" }, { "name": "Htr1b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561", "id": "NP_071561" } ], "protein_names": [ { "name": "5-hydroxytryptamine receptor 1B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P28564" }, { "name": "5-HT-1B; serotonin receptor 1B; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561", "id": "NP_071561" }, { "name": "5-HT-1B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P28564" }, { "name": "5-HT1B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P28564" }, { "name": "5-hydroxytryptamine receptor 1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561", "id": "NP_071561" }, { "name": "Serotonin receptor 1B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P28564" } ], "function": [ { "annotation": "Findings indicate that stimulation of the 5-HT1B receptor can enhance methylphenidate-induced gene regulation.", "evidence": [ { "database": "RefSeq", "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561" }, { "database": "PubMed", "id": "28720013", "url": "https://glygen.org/publication/PubMed/28720013" } ] }, { "annotation": "G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.", "evidence": [ { "database": "UniProtKB", "id": "P28564", "url": "https://www.uniprot.org/uniprot/P28564#function" }, { "database": "UniProtKB", "id": "SIP3245B6196361B28C", "url": "https://www.uniprot.org/uniprot/SIP3245B6196361B28C#function" }, { "database": "PubMed", "id": "1836757", "url": "https://glygen.org/publication/PubMed/1836757" } ] }, { "annotation": "Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561" }, { "database": "PubMed", "id": "32574671", "url": "https://glygen.org/publication/PubMed/32574671" } ] }, { "annotation": "Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias.", "evidence": [ { "database": "RefSeq", "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561" }, { "database": "PubMed", "id": "31468338", "url": "https://glygen.org/publication/PubMed/31468338" } ] }, { "annotation": "The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561" }, { "database": "PubMed", "id": "34061415", "url": "https://glygen.org/publication/PubMed/34061415" } ] } ], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:1094", "recommended_name": { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit hyperactivity disorder", "description": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age." }, "synonyms": 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type 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "ADHD2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": 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"url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "ADHD4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0100518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100518", "name": "hereditary attention deficit-hyperactivity disorder", "description": "An instance of attention deficit-hyperactivity disorder that is caused by an inherited genomic modification in an individual." }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, 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"Protein Classification" ] }, { "id": "rno:25075", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25075", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LIRFRCC", "url": "https://omabrowser.org/oma/group/LIRFRCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2999405at2759", "url": "http://www.orthodb.org/?query=2999405at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P28564", "url": "http://purl.obolibrary.org/obo/PR_P28564", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-390666", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390666", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2846", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2846", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "P28564", "url": "https://www.uniprot.org/uniprot/P28564", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P28564-1", "url": "https://www.uniprot.org/uniprot/P28564-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG", "length": 386, "header": "sp|P28564-1|5HT1B_RAT Isoform 1 of 5-hydroxytryptamine receptor 1B OS=Rattus norvegicus OX=10116 GN=Htr1b PE=2 SV=1 CANONICAL=P28564-1" }, "isoforms": [ { "isoform_ac": "P28564-1", "url": "", "sequence": { "sequence": 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