{ "uniprot_canonical_ac": "P27768-1", "uniprot_ac": "P27768", "uniprot_id": "TNNI2_RAT", "mass": { "chemical_mass": 21328.0, "monoisotopic_mass": 21328.0 }, "refseq": { "ac": "NP_058881", "name": "troponin I, fast skeletal muscle", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881" }, "gene_names": [ { "name": "Tnni2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P27768", "id": "P27768" }, { "name": "Tnni2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881", "id": "NP_058881" }, { "name": "Trp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P27768", "id": "P27768" } ], "protein_names": [ { "name": "Troponin I, fast skeletal muscle", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P27768" }, { "name": "Troponin I, fast-twitch isoform", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P27768" }, { "name": "troponin I, fast skeletal muscle", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881", "id": "NP_058881" }, { "name": "troponin I, skeletal, fast 2; troponin 1, type 2; troponin I type 2 (skeletal, fast)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881", "id": "NP_058881" } ], "function": [ { "annotation": "Release of fast sTnI consistent with load-induced injury of fast glycolytic fibres of inspiratory muscles, probably diaphragm. May provide insights into molecular basis of respiratory muscle dysfunction. Marker of respiratory muscle fatigue.", "evidence": [ { "database": "RefSeq", "id": "NP_058881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881" }, { "database": "PubMed", "id": "14673191", "url": "https://glygen.org/publication/PubMed/14673191" } ] }, { "annotation": "The effects of reactive oxygen species on tryptophan residues in alpha skeletal actin and troponin I, was investigated.", "evidence": [ { "database": "RefSeq", "id": "NP_058881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881" }, { "database": "PubMed", "id": "20455213", "url": "https://glygen.org/publication/PubMed/20455213" } ] }, { "annotation": "Troponin I interaction with calcium and Troponin C in cardiac muscle", "evidence": [ { "database": "RefSeq", "id": "NP_058881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881" }, { "database": "PubMed", "id": "28864299", "url": "https://glygen.org/publication/PubMed/28864299" } ] }, { "annotation": "Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "P27768", "url": "https://www.uniprot.org/uniprot/P27768#function" } ] } ], "disease": [ { "disease_id": "DOID:0050646", "recommended_name": { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "distal arthrogryposis", "description": "A muscle tissue disease characterized by congenital joint contractures of hand and feet." }, "synonyms": [ { "id": "DOID:0050646", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050646", "name": "Arthrogryposis Multiplex Congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "AMC", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "DA1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1A", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis multiplex congenita, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 1", "description": "" }, { "id": "MONDO:0007157", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007157", "name": "arthrogryposis, distal, type 2B4", "description": "" }, { "id": "MIM:108120", "resource": "MIM", "url": "https://www.omim.org/entry/108120", "name": "Arthrogryposis, distal, 1A", "description": "Arthrogryposis, distal, 1A" } ], "evidence": [ { "id": "0050646", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050646" } ] }, { "disease_id": "DOID:0050700", "recommended_name": { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle." }, "synonyms": [ { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "Cardiomyopathies", "description": "" } ], "evidence": [ { "id": "0050700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ] }, { "disease_id": "DOID:0080954", "recommended_name": { "id": "DOID:0080954", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080954", "name": "arthrogryposis multiplex congenita", "description": "A nervous system disease that is characterized by development of multiple joint contractures affecting two or more areas of the body prior to birth." }, "synonyms": [ { "id": "MONDO:0060486", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0060486", "name": "arthrogryposis multiplex congenita 1, neurogenic, with myelin defect", "description": "" }, { "id": "MONDO:0060486", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0060486", "name": "arthrogryposis multiplex congenita, neurogenic, with myelin defect", "description": "" }, { "id": "MONDO:0060486", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0060486", "name": "AMCNMY", "description": "" }, { "id": "MIM:617468", "resource": "MIM", "url": "https://www.omim.org/entry/617468", "name": "Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect", "description": "Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect" } ], "evidence": [ { "id": "0080954", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080954" } ] }, { "disease_id": "DOID:0111600", "recommended_name": { "id": "DOID:0111600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111600", "name": "distal arthrogryposis type 2B1", "description": "A distal arthrogryposis type 2B that has_material_basis_in heterozygous mutation in the TNNI2 gene on chromosome 11p15.5." }, "synonyms": [ { "id": "DOID:0111600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111600", "name": "DA2B1", "description": "" }, { "id": "MONDO:0020820", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020820", "name": "distal arthrogryposis type 2B1", "description": "" }, { "id": "MONDO:0020820", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020820", "name": "DA2B1", "description": "" }, { "id": "MONDO:0020820", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020820", "name": "arthrogryposis, distal, type 2B1", "description": "" }, { "id": "MIM:601680", "resource": "MIM", "url": "https://www.omim.org/entry/601680", "name": "Arthrogryposis, distal, 2B1", "description": "Arthrogryposis, distal, 2B1" } ], "evidence": [ { "id": "0111600", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111600" } ] }, { "disease_id": "DOID:114", "recommended_name": { "id": "DOID:114", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:114", "name": "heart disease", "description": "A cardiovascular system disease that involves the heart." }, "synonyms": [], "evidence": [ { "id": "114", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:114" } ] }, { "disease_id": "DOID:12930", "recommended_name": { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently." }, "synonyms": [ { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "primary dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation is a rare familial dilated cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase." }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "CDCD1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "LMNA familial isolated dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy dilated with conduction defect type 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial isolated dilated cardiomyopathy caused by mutation in LMNA", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, congestive", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, familial idiopathic", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, idiopathic dilated", "description": "" }, { "id": "MIM:115200", "resource": "MIM", "url": "https://www.omim.org/entry/115200", "name": "Cardiomyopathy, dilated, 1A", "description": "Cardiomyopathy, dilated, 1A" } ], "evidence": [ { "id": "12930", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ] }, { "disease_id": "DOID:299", "recommended_name": { "id": "DOID:299", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:299", "name": "adenocarcinoma", "description": "A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue." }, "synonyms": [], "evidence": [ { "id": "299", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:299" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P27768", "url": "https://www.uniprot.org/uniprot/P27768" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tnni2", "url": "https://www.uniprot.org/uniprot/P27768", "locus": { "chromosome": "1", "start_pos": 197597560, "end_pos": 197594813, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020276", "url": "https://www.ensembl.org/id/ENSRNOG00000020276" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020276", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020276", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "29389", "url": "https://www.ncbi.nlm.nih.gov/gene/29389", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:29389", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29389", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KRHRAIT", "url": "https://omabrowser.org/oma/group/KRHRAIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2882372at2759", "url": "http://www.orthodb.org/?query=2882372at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13738:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13738:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00992", "url": "http://pfam.xfam.org/family/PF00992", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P27768", "url": "http://purl.obolibrary.org/obo/PR_P27768", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-390522", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390522", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_058881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "62050", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=62050", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8L2QZW1", "url": "https://www.uniprot.org/uniprot/A0A8L2QZW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QZW1-1", "url": "https://www.uniprot.org/uniprot/A0A8L2QZW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WG17", "url": "https://www.uniprot.org/uniprot/F8WG17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WG17-1", "url": "https://www.uniprot.org/uniprot/F8WG17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P27768", "url": "https://www.uniprot.org/uniprot/P27768", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P27768-1", "url": "https://www.uniprot.org/uniprot/P27768-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRRESEKQNYLSEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVKVQKSSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES", "length": 182, "header": "sp|P27768-1|TNNI2_RAT Isoform 1 of Troponin I, fast skeletal muscle OS=Rattus norvegicus OX=10116 GN=Tnni2 PE=1 SV=2 CANONICAL=P27768-1" }, "isoforms": [ { "isoform_ac": "A0A8L2QZW1-1", "url": "", "sequence": { "sequence": "LQKRNRAITARRQHLKSVMLQIAATELEKEESRRESEKQNYLSEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVKVQKSSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES", "length": 179, "header": "tr|A0A8L2QZW1-1|A0A8L2QZW1_RAT Computationally mapped isoform of Troponin I2, fast skeletal type OS=Rattus norvegicus OX=10116 GN=Tnni2 PE=1 SV=1 CANONICAL=P27768-1" }, "locus": { "chromosome": "1", "start_pos": 197597454, "end_pos": 197596330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076187.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076187.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068190.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068190.2" } ] } }, { "isoform_ac": "F8WG17-1", "url": "", "sequence": { "sequence": "MGDLQKRNRAITARRQHLKSVMLQIAATELEKEESRRESEKQNYLSEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVKVQKSSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES", "length": 182, "header": "tr|F8WG17-1|F8WG17_RAT Computationally mapped isoform of Troponin I, fast skeletal muscle OS=Rattus norvegicus OX=10116 GN=Tnni2 PE=1 SV=3 CANONICAL=P27768-1" }, "locus": { "chromosome": "1", "start_pos": 197597454, "end_pos": 197595657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000027487", "url": "https://www.ensembl.org/id/ENSRNOT00000027487" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000027487", "url": "https://www.ensembl.org/id/ENSRNOP00000027487" } ] } }, { "isoform_ac": "P27768-1", "url": "", "sequence": { "sequence": "MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRRESEKQNYLSEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVKVQKSSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES", "length": 182, "header": "sp|P27768-1|TNNI2_RAT Isoform 1 of Troponin I, fast skeletal muscle OS=Rattus norvegicus OX=10116 GN=Tnni2 PE=1 SV=2 CANONICAL=P27768-1" }, "locus": { "chromosome": "1", "start_pos": 197597454, "end_pos": 197595657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000027487", "url": "https://www.ensembl.org/id/ENSRNOT00000027487" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000027487", "url": "https://www.ensembl.org/id/ENSRNOP00000027487" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 118, "end_pos": 118, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P27768", "url": 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"https://glygen.org/publication/PubMed/14673191" } ] }, { "title": "Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress.", "journal": "Proteomics", "date": "2010", "authors": "Fedorova M, Todorovsky T, Kuleva N, Hoffmann R", "evidence": [ { "database": "RefSeq", "id": "NP_058881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058881" } ], "reference": [ { "type": "PubMed", "id": "20455213", "url": "https://glygen.org/publication/PubMed/20455213" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P27768", "url": "https://www.uniprot.org/uniprot/P27768" }, { "database": "UniProtKB", "id": "F8WG17", "url": "https://www.uniprot.org/uniprot/F8WG17" }, { 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