{ "uniprot_canonical_ac": "P27600-1", "uniprot_ac": "P27600", "uniprot_id": "GNA12_MOUSE", "mass": { "chemical_mass": 44095.0, "monoisotopic_mass": 44095.0 }, "refseq": { "ac": "NP_034432", "name": "guanine nucleotide-binding protein subunit alpha-12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432" }, "gene_names": [ { "name": "Gna12", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P27600", "id": "P27600" }, { "name": "Galpha12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "id": "NP_034432" }, { "name": "Gna-12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P27600", "id": "P27600" }, { "name": "Gna12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "id": "NP_034432" } ], "protein_names": [ { "name": "Guanine nucleotide-binding protein subunit alpha-12", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P27600" }, { "name": "G alpha-12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P27600" }, { "name": "G-protein subunit alpha-12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P27600" }, { "name": "g alpha-12; G-protein subunit alpha-12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "id": "NP_034432" }, { "name": "guanine nucleotide-binding protein subunit alpha-12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "id": "NP_034432" } ], "function": [ { "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:19151758, PubMed:21212405, PubMed:22609986). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600#function" }, { "database": "UniProtKB", "id": "Q03113", "url": "https://www.uniprot.org/uniprot/Q03113#function" }, { "database": "PubMed", "id": "19151758", "url": "https://glygen.org/publication/PubMed/19151758" }, { "database": "PubMed", "id": "22609986", "url": "https://glygen.org/publication/PubMed/22609986" }, { "database": "PubMed", "id": "21212405", "url": "https://glygen.org/publication/PubMed/21212405" } ] }, { "annotation": "Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432" }, { "database": "PubMed", "id": "31549965", "url": "https://glygen.org/publication/PubMed/31549965" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 11, "end_pos": 11, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes palmitoylation and transformation activity.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" }, { "database": "PubMed", "id": "9485474", "url": "https://glygen.org/publication/PubMed/9485474" } ] }, { "start_pos": 2, "end_pos": 2, "sequence_org": "S", "sequence_mut": "G", "comment": "Results in myristoylation of G-2, which restores the transformation activity; when associated with S-6.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" }, { "database": "PubMed", "id": "9485474", "url": "https://glygen.org/publication/PubMed/9485474" } ] }, { "start_pos": 6, "end_pos": 6, "sequence_org": "R", "sequence_mut": "S", "comment": "Results in myristoylation of G-2, which restores the transformation activity; when associated with G-2.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" }, { "database": "PubMed", "id": "9485474", "url": "https://glygen.org/publication/PubMed/9485474" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Gna12", "url": "https://www.uniprot.org/uniprot/P27600", "locus": { "chromosome": "5", "start_pos": 140744163, "end_pos": 140816186, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000000149", "url": "https://www.ensembl.org/id/ENSMUSG00000000149" } ] } } ], "crossref": [ { "id": "ENSMUSG00000000149", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000000149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "14673", "url": "https://www.ncbi.nlm.nih.gov/gene/14673", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P27600", "url": "https://www.ebi.ac.uk/intact/interactors/id:P27600*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:14673", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14673", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "95767", "url": "http://www.informatics.jax.org/marker/MGI:95767", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P27600", "url": "https://oglcnac.org/atlas/detail/P27600", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P27600", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P27600", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "LMEDRCT", "url": "https://omabrowser.org/oma/group/LMEDRCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2897309at2759", "url": "http://www.orthodb.org/?query=2897309at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10218:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10218:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1ZCA", "url": "https://www.rcsb.org/structure/1ZCA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00503", "url": "http://pfam.xfam.org/family/PF00503", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P27600", "url": "http://purl.obolibrary.org/obo/PR_P27600", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-456926", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-456926", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_034432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0G2JG40", "url": "https://www.uniprot.org/uniprot/A0A0G2JG40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JG40-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JG40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P27600-1", "url": "https://www.uniprot.org/uniprot/P27600-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ", "length": 379, "header": "sp|P27600-1|GNA12_MOUSE Isoform 1 of Guanine nucleotide-binding protein subunit alpha-12 OS=Mus musculus OX=10090 GN=Gna12 PE=1 SV=3 CANONICAL=P27600-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JG40-1", "url": "", "sequence": { "sequence": "XERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ", "length": 316, "header": "tr|A0A0G2JG40-1|GNA12_MOUSE Computationally mapped isoform of Guanine nucleotide-binding protein subunit alpha-12 OS=Mus musculus OX=10090 GN=Gna12 PE=1 SV=1 CANONICAL=P27600-1" }, "locus": { "chromosome": "5", "start_pos": 140815912, "end_pos": 140746306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000198447.2", "url": "https://www.ensembl.org/id/ENSMUST00000198447.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143414.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143414.2" } ] } }, { "isoform_ac": "P27600-1", "url": "", "sequence": { "sequence": "MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ", "length": 379, "header": "sp|P27600-1|GNA12_MOUSE Isoform 1 of Guanine nucleotide-binding protein subunit alpha-12 OS=Mus musculus OX=10090 GN=Gna12 PE=1 SV=3 CANONICAL=P27600-1" }, "locus": { "chromosome": "5", "start_pos": 140816051, "end_pos": 140746307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000000153", "url": "https://www.ensembl.org/id/ENSMUST00000000153" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000000153", "url": "https://www.ensembl.org/id/ENSMUSP00000000153" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 66, "start_aa": "Ser", "end_pos": 66, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser66", "evidence": [ { "id": "P27600", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P27600" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P27600", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P27600" }, { "id": "37225434", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37225434" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "phosphorylation": [ { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "site_lbl": "Thr206" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A role for Galpha12/Galpha13 in p120ctn regulation.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Aragay A.M., Ardawatia V.V., Krakstad B.F.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "15240885", "url": "https://glygen.org/publication/PubMed/15240885" } ] }, { "title": "A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.", "journal": "Biochemistry", "date": "2006", "authors": "Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "16388592", "url": "https://glygen.org/publication/PubMed/16388592" } ] }, { "title": "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1991", "authors": "Simon M.I., Strathmann M.P.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "1905812", "url": "https://glygen.org/publication/PubMed/1905812" } ] }, { "title": "The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene.", "journal": "Oncogene", "date": "2009", "authors": "Lee C.H., Lee S.J., Kim S.G., Yang J.W., Cho I.J., Cho M.K., Kim W.D.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "19151758", "url": "https://glygen.org/publication/PubMed/19151758" } ] }, { "title": "G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.", "journal": "Arterioscler. Thromb. Vasc. Biol.", "date": "2011", "authors": "Lim S.C., Lee C.H., Han C.Y., Kim Y.M., Lee M.Y., Kim S.G., Kwon H.M., Cho I.J., Ki S.H., Kay H.Y.", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "21212405", "url": "https://glygen.org/publication/PubMed/21212405" } ] }, { "title": "PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.", "journal": "Nat. Cell Biol.", "date": "2012", "authors": "Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "22609986", "url": "https://glygen.org/publication/PubMed/22609986" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "P27600", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P27600" }, { "database": "O-GlcNAc Atlas", "id": "P27600", "url": "https://oglcnac.org/atlas/detail/P27600" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1989", "authors": "Strathmann M, Wilkie TM, Simon MI", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "2508088", "url": "https://glygen.org/publication/PubMed/2508088" } ] }, { "title": "Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance.", "journal": "eLife", "date": "2019", "authors": "Chennupati R, Wirth A, Favre J, Li R, Bonnavion R, Jin YJ, Wietelmann A, Schweda F, Wettschureck N, Henrion D, Offermanns S", "evidence": [ { "database": "RefSeq", "id": "NP_034432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034432" } ], "reference": [ { "type": "PubMed", "id": "31549965", "url": "https://glygen.org/publication/PubMed/31549965" } ] }, { "title": "Ogt Deficiency Induces Abnormal Cerebellar Function and Behavioral Deficits of Adult Mice through Modulating RhoA/ROCK Signaling.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2023-06-21", "authors": "Zhang Jinyu, Wei Kaiyan, Qu Wenzheng, Wang Mengxuan, Zhu Qiang, Dong Xiaoxue, Huang Xiaoli, Yi Wen, Xu Shunliang, Li Xuekun", "evidence": [ { "database": "O-GlcNAc Database", "id": "P27600", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P27600" } ], "reference": [ { "type": "PubMed", "id": "37225434", "url": "https://glygen.org/publication/PubMed/37225434" } ] }, { "title": "Galpha12 requires acylation for its transforming activity.", "journal": "Biochemistry", "date": "1998", "authors": "Jones TL, Gutkind JS", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "reference": [ { "type": "PubMed", "id": "9485474", "url": "https://glygen.org/publication/PubMed/9485474" } ] } ], "pathway": [ { "id": "mmu:14673", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14673", "resource": "KEGG Pathway" }, { "id": "R-MMU-416482", "name": "G alpha (12/13) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-MMU-456926", "name": "Thrombin signalling through proteinase activated receptors (PARs)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-456926", "resource": "Reactome", "description": "Thrombin signalling through proteinase activated receptors (PARs)" } ], "orthologs": [ { "uniprot_canonical_ac": "Q03113-1", "protein_name": "Guanine nucleotide-binding protein subunit alpha-12", "gene_name": "GNA12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVRFVFHAVKDTILQENLKDIMLQ", "length": 381 }, "evidence": [ { "id": "45226944", "url": "http://www.informatics.jax.org/homology/45226944", "database": "MGI" }, { "id": "P27600", "url": "https://omabrowser.org/oma/group/P27600/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q63210-1", "protein_name": "Guanine nucleotide-binding protein subunit alpha-12", "gene_name": "Gna12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ", "length": 379 }, "evidence": [ { "id": "45226944", "url": "http://www.informatics.jax.org/homology/45226944", "database": "MGI" }, { "id": "P27600", "url": "https://omabrowser.org/oma/group/P27600/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "regulation of fibroblast migration", "id": "GO:0010762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010762", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "in utero 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"pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "embryonic digit morphogenesis", "id": "GO:0042733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042733", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "regulation of TOR signaling", "id": "GO:0032006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032434", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904706", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell migration", "id": "GO:1904753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904753", "evidence": [ { "database": "UniProtKB", "id": "P27600", "url": "https://www.uniprot.org/uniprot/P27600" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "D5 dopamine receptor binding", "id": "GO:0031752", "url": 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