{ "uniprot_canonical_ac": "P25574-1", "uniprot_ac": "P25574", "uniprot_id": "EMC1_YEAST", "mass": { "chemical_mass": 87181.0, "monoisotopic_mass": 87181.0 }, "refseq": { "ac": "NP_009884", "name": "Emc1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009884" }, "gene_names": [ { "name": "EMC1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P25574", "id": "P25574" }, { "name": "EMC1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009884", "id": "NP_009884" }, { "name": "YCL315", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P25574", "id": "P25574" }, { "name": "YCL45C", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P25574", "id": "P25574" } ], "protein_names": [ { "name": "ER membrane protein complex subunit 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P25574" }, { "name": "Emc1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009884", "id": "NP_009884" } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574#function" }, { "database": "PubMed", "id": "29809151", "url": "https://glygen.org/publication/PubMed/29809151" }, { "database": "UniProtKB", "id": "Q8N766", "url": "https://www.uniprot.org/uniprot/Q8N766#function" } ] } ], "disease": [ { "disease_id": "DOID:0081276", "recommended_name": { "id": "DOID:0081276", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081276", "name": "cerebellar atrophy, visual impairment, and psychomotor retardation", "description": "A syndrome that is characterized by cerebellar atrophy, visual impairment and psychomotor retardation and that has_material_basis_in homozygous mutation in the EMC1 gene on chromosome 1p36." }, "synonyms": [ { "id": "DOID:0081276", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081276", "name": "CAVIPMR", "description": "" }, { "id": "MONDO:0014811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014811", "name": "cerebellar atrophy, visual impairment, and psychomotor retardation;", "description": "" }, { "id": "MONDO:0014811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014811", "name": "CAVIPMR", "description": "" }, { "id": "MONDO:0014811", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014811", "name": "cerebellar atrophy, visual impairment, and psychomotor retardation", "description": "" }, { "id": "MIM:616875", "resource": "MIM", "url": "https://www.omim.org/entry/616875", "name": "Cerebellar atrophy, visual impairment, and psychomotor retardation", "description": "Cerebellar atrophy, visual impairment, and psychomotor retardation" } ], "evidence": [ { "id": "0081276", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081276" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "common_name": "Yeast" } ], "gene": [ { "name": "EMC1", "url": "https://www.uniprot.org/uniprot/P25574", "locus": {} } ], "crossref": [ { "id": "850312", "url": "https://www.ncbi.nlm.nih.gov/gene/850312", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P25574", "url": "https://www.ebi.ac.uk/intact/interactors/id:P25574*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YCL045C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YCL045C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIPEQKL", "url": "https://omabrowser.org/oma/group/PIPEQKL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "37872at2759", "url": "http://www.orthodb.org/?query=37872at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21573", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21573", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21573:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21573:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6WB9", "url": "https://www.rcsb.org/structure/6WB9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KRA", "url": "https://www.rcsb.org/structure/7KRA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KTX", "url": "https://www.rcsb.org/structure/7KTX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07774", "url": "http://pfam.xfam.org/family/PF07774", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P25574", "url": "http://purl.obolibrary.org/obo/PR_P25574", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009884", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000550", "url": "https://www.yeastgenome.org/locus/S000000550", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P25574-1", "url": "https://www.uniprot.org/uniprot/P25574-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKITCTDLVYVFILLFLNTSCVQAVFSDDAFITDWQLANLGPWEKVIPDSRDRNRVLILSNPTETSCLVSSFNVSSGQILFRNVLPFTIDEIQLDSNDHNAMVCVNSSSNHWQKYDLHDWFLLEEGVDNAPSTTILPQSSYLNDQVSIKNNELHILDEQSKLAEWKLELPQGFNKVEYFHREDPLALVLNVNDTQYMGFSANGTELIPVWQRDEWLTNVVDYAVLDVFDSRDVELNKDMKAELDSNSLWNAYWLRLTTNWNRLINLLKENQFSPGRVFTKLLALDAKDTTVSDLKFGFAKILIVLTHDGFIGGLDMVNKGQLIWKLDLEIDQGVKMFWTDKNHDELVVFSHDGHYLTIEVTKDQPIIKSRSPLSERKTVDSVIRLNEHDHQYLIKFEDKDHLLFKLNPGKNTDVPIVANNHSSSHIFVTEHDTNGIYGYIIENDTVKQTWKKAVNSKEKMVAYSKRETTNLNTLGITLGDKSVLYKYLYPNLAAYLIANEEHHTITFNLIDTITGEILITQEHKDSPDFRFPMDIVFGEYWVVYSYFSSEPVPEQKLVVVELYESLTPDERLSNSSDNFSYDPLTGHINKPQFQTKQFIFPEIIKTMSISKTTDDITTKAIVMELENGQITYIPKLLLNARGKPAEEMAKDKKKEFMATPYTPVIPINDNFIITHFRNLLPGSDSQLISIPTNLESTSIICDLGLDVFCTRITPSGQFDLMSPTFEKGKLLITIFVLLVITYFIRPSVSNKKLKSQWLIK", "length": 760, "header": "sp|P25574-1|EMC1_YEAST Isoform 1 of ER membrane protein complex subunit 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=EMC1 PE=1 SV=1 CANONICAL=P25574-1" }, "isoforms": [ { "isoform_ac": "P25574-1", "url": "", "sequence": { "sequence": "MKITCTDLVYVFILLFLNTSCVQAVFSDDAFITDWQLANLGPWEKVIPDSRDRNRVLILSNPTETSCLVSSFNVSSGQILFRNVLPFTIDEIQLDSNDHNAMVCVNSSSNHWQKYDLHDWFLLEEGVDNAPSTTILPQSSYLNDQVSIKNNELHILDEQSKLAEWKLELPQGFNKVEYFHREDPLALVLNVNDTQYMGFSANGTELIPVWQRDEWLTNVVDYAVLDVFDSRDVELNKDMKAELDSNSLWNAYWLRLTTNWNRLINLLKENQFSPGRVFTKLLALDAKDTTVSDLKFGFAKILIVLTHDGFIGGLDMVNKGQLIWKLDLEIDQGVKMFWTDKNHDELVVFSHDGHYLTIEVTKDQPIIKSRSPLSERKTVDSVIRLNEHDHQYLIKFEDKDHLLFKLNPGKNTDVPIVANNHSSSHIFVTEHDTNGIYGYIIENDTVKQTWKKAVNSKEKMVAYSKRETTNLNTLGITLGDKSVLYKYLYPNLAAYLIANEEHHTITFNLIDTITGEILITQEHKDSPDFRFPMDIVFGEYWVVYSYFSSEPVPEQKLVVVELYESLTPDERLSNSSDNFSYDPLTGHINKPQFQTKQFIFPEIIKTMSISKTTDDITTKAIVMELENGQITYIPKLLLNARGKPAEEMAKDKKKEFMATPYTPVIPINDNFIITHFRNLLPGSDSQLISIPTNLESTSIICDLGLDVFCTRITPSGQFDLMSPTFEKGKLLITIFVLLVITYFIRPSVSNKKLKSQWLIK", "length": 760, "header": "sp|P25574-1|EMC1_YEAST Isoform 1 of ER membrane protein complex subunit 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=EMC1 PE=1 SV=1 CANONICAL=P25574-1" }, "locus": { "chromosome": "III", "start_pos": 46905, "end_pos": 44626, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YCL045C_mRNA", "url": "https://www.ensembl.org/id/YCL045C_mRNA" }, { "database": "Ensembl Peptide", "id": "YCL045C", "url": "https://www.ensembl.org/id/YCL045C" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 106, "start_aa": "Asn", "end_pos": 106, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn106", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 192, "start_aa": "Asn", "end_pos": 192, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn192", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 202, "start_aa": "Asn", "end_pos": 202, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn202", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 420, "start_aa": "Asn", "end_pos": 420, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn420", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 443, "start_aa": "Asn", "end_pos": 443, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 574, "start_aa": "Asn", "end_pos": 574, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn574", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 578, "start_aa": "Asn", "end_pos": 578, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn578", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 73, "start_aa": "Asn", "end_pos": 73, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn73", "evidence": [ { "id": "P25574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25574#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The complete sequence of a 9,543 bp segment on the left arm of chromosome III reveals five open reading frames including glucokinase and the protein disulfide isomerase.", "journal": "Yeast", "date": "1992", "authors": "Dubois E., Gigot D., Messenguy F., Scherens B.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "1523890", "url": "https://glygen.org/publication/PubMed/1523890" } ] }, { "title": "The complete DNA sequence of yeast chromosome III.", "journal": "Nature", "date": "1992", "authors": "Duesterhoeft A., Mewes H.-W., Schweitzer B., Wang H., Brown A., Lanfranchi G., Rodriguez F., Valle G., Wilson C., Kelly A., Xu G., Huse K., Jia Y., Planta R.J., Vreken P., Benit P., Jacquet M., Plevani P., Hohmann S., Antoine G., Roberts A.B., Fukuhara H., Lewis C., Molemans F., Shu Y., Esteban M., Feldmann H., Delgado M.D., Isono K., Fiers W., Mallet L., Jimenez A., Jauniaux J.-C., Dubois E., Pallier C., Volckaert G., Lucchini G., Newlon C.S., Sor F., Faye G., Anwar R., Haasemann M., Iborra F., Slonimski P.P., Hoenicka J., Vetter I., Thierry A., Yoshikawa A., Hollenberg C.P., Contreras R., Philippsen P., Martegani E., Gigot D., Alberghina L., Hatat D., Brown A.J.P., James C.M., Pearson B.M., Mathieu A., Sanz E., Steiner S., Ballesta J.P.G., Buhler J.-M., Carignani G., Cederberg H., Crouzet M., Daignan-Fornier B., Dujon B., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grivell L.A., Hegemann J.H., Herbert C.J., Hilger F., Jacq C., Mannhaupt G., Messenguy F., Muzi Falconi M., Oliver S.G., Perea J., Pierard A., Remacha M.A., Schaaff-Gerstenschlaeger I., Scherens B., Steensma H.Y., Wurst H., Zimmermann F.K., Alexandraki D., Berben G., Bolotin-Fukuhara M., Chanet R., Fabre F., Fairhead C., Frontali L., Purnelle B., Ramezani Rad M., Skala J., Tzermia M., Urrestarazu L.A., Voet M., Agostoni-Carbone M.L., Aigle M., Bergantino E., Biteau N., Bolle P.-A., Carcano C., Defoor E., Demolder J., Doira C., Erdmann D., Francingues-Gaillard M.-C., Franco L., Fuller L.J., Galland P., Gent M.E., Grisanti P., Indge K.J., Kleinhans U., Kreisl P., Lutzenkirchen K., Maat M.J., Maurer C.T.C., McConnell D., McKee R.A., Montague M.A., Navas L., Noone D., Panzeri L., Poetsch B., Pohl F.M., Rasmussen S.W., Raynal A., Richterich P., Sgouros J.G., Soustelle C., Spiegelberg R., Stateva L.I., Thireos G., Warmington J.R., Wicksteed B.L., de Haan M., van Vliet-Reedijk J.C., van der Aart Q.J.M., van der Linden C.G., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "1574125", "url": "https://glygen.org/publication/PubMed/1574125" } ] }, { "title": "A global topology map of the Saccharomyces cerevisiae membrane proteome.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "journal": "Science", "date": "2009", "authors": "Schwappach B., Oh E., Schuldiner M., Walter P., Weissman J.S., Collins S.R., Denic V., Schmid V., Jonikas M.C., Quan E.M., Weibezahn J.", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "19325107", "url": "https://glygen.org/publication/PubMed/19325107" } ] }, { "title": "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.", "journal": "Mol. Syst. Biol.", "date": "2009", "authors": "Kung Li A, Tao Sheng-Ce, Qian Jiang, Smith Michael G, Snyder Michael, Zhu Heng", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "19756047", "url": "https://glygen.org/publication/PubMed/19756047" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P25574", "url": "https://www.uniprot.org/uniprot/P25574" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] } ], "pathway": [ { 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