{ "uniprot_canonical_ac": "P24276-1", "uniprot_ac": "P24276", "uniprot_id": "SSD1_YEAST", "mass": { "chemical_mass": 139954.0, "monoisotopic_mass": 139954.0 }, "refseq": { "ac": "NP_010579", "name": "mRNA-binding translational repressor SSD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010579" }, "gene_names": [ { "name": "SSD1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P24276", "id": "P24276" }, { "name": "CLA1; MCS1; RLT1; SRK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010579", "id": "NP_010579" }, { "name": "CLA1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P24276", "id": "P24276" }, { "name": "D9819.4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P24276", "id": "P24276" }, { "name": "RLD1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P24276", "id": "P24276" }, { "name": "SRK1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P24276", "id": "P24276" }, { "name": "SSD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010579", "id": "NP_010579" } ], "protein_names": [ { "name": "Protein SSD1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P24276" }, { "name": "Protein SRK1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P24276" }, { "name": "mRNA-binding translational repressor SSD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010579", "id": "NP_010579" } ], "function": [ { "annotation": "Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.", "evidence": [ { "database": "UniProtKB", "id": "P24276", "url": "https://www.uniprot.org/uniprot/P24276#function" } ] } ], "disease": [ { "disease_id": "DOID:0060476", "recommended_name": { "id": "DOID:0060476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060476", "name": "Perlman syndrome", "description": "A syndrome characterized by polyhydramnios with neonatal macrosomia, nephromegaly, distinctive facial appearance, renal dysplasia, nephroblastomatosis, and predisposition to Wilms tumor. It shows similarities to Beckwith-Wiedemann syndrome." }, "synonyms": [ { "id": "DOID:0060476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060476", "name": "nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor", "description": "" }, { "id": "DOID:0060476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060476", "name": "renal hamartomas, nephroblastomatosis and fetal gigantism", "description": "" }, { "id": "DOID:0060476", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060476", "name": "nephroblastomatosis - fetal ascites - macrosomia - Wilms tumor", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "Perlman syndrome", "description": "Perlman syndrome is characterized principally by polyhydramnios, neonatal macrosomia, bilateral renal tumors (hamartomas with or without nephroblastomatosis), hypertrophy of the islets of Langerhans and facial dysmorphism." }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "Perlman syndrome", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis - fetal ascites - macrosomia - Wilms tumor", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis - foetal ascites - macrosomia - Wilms tumour", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis, foetal ascites, macrosomia and Wilms tumour", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis-fetal ascites-macrosomia-Wilms tumor syndrome", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis-fetal ascites-macrosomia-Wilms tumour syndrome", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "renal hamartomas, nephroblastomatosis and fetal gigantism", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "renal hamartomas, nephroblastomatosis and foetal gigantism", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "PRLMNS", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis fetal ascites macrosomia and Wilms tumor", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis foetal ascites macrosomia and Wilms tumour", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis, fetal ascites, macrosomia, and Wilms tumor", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "nephroblastomatosis, foetal ascites, macrosomia, and Wilms tumour", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "renal hamartomas, nephroblastomatosis, and fetal gigantism", "description": "" }, { "id": "MONDO:0009965", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009965", "name": "renal hamartomas, nephroblastomatosis, and foetal gigantism", "description": "" }, { "id": "MIM:267000", "resource": "MIM", "url": "https://www.omim.org/entry/267000", "name": "Perlman syndrome", "description": "Perlman syndrome" } ], "evidence": [ { "id": "0060476", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060476" } ] }, { "disease_id": "DOID:2154", "recommended_name": { "id": "DOID:2154", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2154", "name": "nephroblastoma", "description": "A kidney cancer that affects the kidneys and typically located_in children." }, "synonyms": [ { "id": "DOID:2154", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2154", "name": "adult nephroblastoma", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor 1", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms' tumor", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms' tumour", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "renal Wilms tumor", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "renal Wilms tumour", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor 1", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor type 1", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor, somatic", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumor, type 1, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "Wilms tumour type 1", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "WT1", "description": "" }, { "id": "MONDO:0008679", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008679", "name": "nephroblastoma", "description": "" }, { "id": "MIM:194070", "resource": "MIM", "url": "https://www.omim.org/entry/194070", "name": "Wilms tumor 1", "description": "Wilms tumor 1" } ], "evidence": [ { "id": "2154", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2154" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P24276", "url": "https://www.uniprot.org/uniprot/P24276" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SSD1", "url": "https://www.uniprot.org/uniprot/P24276", "locus": { "chromosome": "IV", "start_pos": 1045640, "end_pos": 1049392, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YDR293C", "url": "https://www.ensembl.org/id/YDR293C" } ] } } ], "crossref": [ { "id": "851887", "url": "https://www.ncbi.nlm.nih.gov/gene/851887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P24276", "url": "https://www.ebi.ac.uk/intact/interactors/id:P24276*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YDR293C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR293C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPRAKYF", "url": "https://omabrowser.org/oma/group/MPRAKYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "945235at2759", "url": "http://www.orthodb.org/?query=945235at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23355:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23355:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5NCL", "url": "https://www.rcsb.org/structure/5NCL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7AM1", "url": "https://www.rcsb.org/structure/7AM1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00773", "url": "http://pfam.xfam.org/family/PF00773", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17849", "url": "http://pfam.xfam.org/family/PF17849", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17877", "url": "http://pfam.xfam.org/family/PF17877", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P24276", "url": "http://purl.obolibrary.org/obo/PR_P24276", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_010579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000002701", "url": "https://www.yeastgenome.org/locus/S000002701", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P24276", "url": "https://www.uniprot.org/uniprot/P24276", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P24276-1", "url": "https://www.uniprot.org/uniprot/P24276-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKNSNVNNNRSQEPNNMFVQTTGGGKNAPKQIHVAHRRSQSELTNLMIEQFTLQKQLEQVQAQQQQLMAQQQQLAQQTGQYLSGNSGSNNHFTPQPPHPHYNSNGNSPGMSAGGSRSRTHSRNNSGYYHNSYDNNNNSNNPGSNSHRKTSSQSSIYGHSRRHSLGLNEAKKAAAEEQAKRISGGEAGVTVKIDSVQADSGSNSTTEQSDFKFPPPPNAHQGHRRATSNLSPPSFKFPPNSHGDNDDEFIATSSTHRRSKTRNNEYSPGINSNWRNQSQQPQQQLSPFRHRGSNSRDYNSFNTLEPPAIFQQGHKHRASNSSVHSFSSQGNNNGGGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRSDAWVSTDGALDADIYICGSKDRNRALEGDLVAVELLVVDDVWESKKEKEEKKRRKDASMQHDLIPLNSSDDYHNDASVTAATSNNFLSSPSSSDSLSKDDLSVRRKRSSTINNDSDSLSSPTKSGVRRRSSLKQRPTQKKNDDVEVEGQSLLLVEEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRPSQQANSDNNKPPQSPKIAWFKPTDKKVPLIAIPTELAPKDFVENADKYSEKLFVASIKRWPITSLHPFGILVSELGDIHDPDTEIDSILRDNNFLSNEYLDQKNPQKEKPSFQPLPLTAESLEYRRNFTDTNEYNIFAISELGWVSEFALHVRNNGNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAVFMPQKLVNLLPQSFNDELSLAPGKESATLSVVYTLDSSTLRIKSTWVGESTISPSNILSLEQLDEKLSTGSPTSYLSTVQEIARSFYARRINDPEATLLPTLSLLESLDDEKVKVDLNILDRTLGFVVINEIKRKVNSTVAEKIYTKLGDLALLRRQMQPIATKMASFRKKIQNFGYNFDTNTADELIKGVLKIKDDDVRVGIEILLFKTMPRARYFIAGKVDPDQYGHYALNLPIYTHFTAPMRRYADHVVHRQLKAVIHDTPYTEDMEALKITSEYCNFKKDCAYQAQEQAIHLLLCKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIEKRVHGDQLPLIKAEFDGTNRVLELHWQPGVDSATFIPADEKNPKSYRNSIKNKFRSTAAEIANIELDKEAESEPLISDPLSKELSDLHLTVPNLRLPSASDNKQNALEKFISTTETRIENDNYIQEIHELQKIPILLRAEVGMALPCLTVRALNPFMKRV", 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"length": 1250, "header": "sp|P24276-1|SSD1_YEAST Isoform 1 of Protein SSD1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SSD1 PE=1 SV=1 CANONICAL=P24276-1" }, "locus": { "chromosome": "IV", "start_pos": 1049392, "end_pos": 1045643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YDR293C_mRNA", "url": "https://www.ensembl.org/id/YDR293C_mRNA" }, { "database": "Ensembl Peptide", "id": "YDR293C", "url": "https://www.ensembl.org/id/YDR293C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1175, "end_pos": 1175, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P24276", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P24276" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P24276", "url": "https://www.yeastgenome.org/locus/P24276" } ], "site_lbl": "Ser1175" }, { "start_pos": 1188, "end_pos": 1188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P24276", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P24276" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P24276", "url": "https://www.yeastgenome.org/locus/P24276" } ], "site_lbl": "Ser1188" }, { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P24276", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P24276" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19779198", "url": 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