{ "uniprot_canonical_ac": "P23501-1", "uniprot_ac": "P23501", "uniprot_id": "DS1P2_YEAST", "mass": { "chemical_mass": 46488.0, "monoisotopic_mass": 46488.0 }, "refseq": { "ac": "NP_012979", "name": "sphinganine kinase YSR3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012979" }, "gene_names": [ { "name": "YSR3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P23501", "id": "P23501" }, { "name": "LBP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012979", "id": "NP_012979" }, { "name": "LBP2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23501", "id": "P23501" }, { "name": "YSR3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012979", "id": "NP_012979" } ], "protein_names": [ { "name": "Dihydrosphingosine 1-phosphate phosphatase YSR3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P23501" }, { "name": "3.1.3.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23501" }, { "name": "Long-chain base protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23501" }, { "name": "Sphingolipid resistance protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23501" }, { "name": "sphinganine kinase YSR3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012979", "id": "NP_012979" } ], "function": [ { "annotation": "Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:9353337, PubMed:9419344). Involved in endocytosis and calcium-mediated signaling (PubMed:10856228).", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501#function" }, { "database": "PubMed", "id": "10856228", "url": "https://glygen.org/publication/PubMed/10856228" }, { "database": "PubMed", "id": "10563329", "url": "https://glygen.org/publication/PubMed/10563329" }, { "database": "PubMed", "id": "9419344", "url": "https://glygen.org/publication/PubMed/9419344" }, { "database": "PubMed", "id": "9353337", "url": "https://glygen.org/publication/PubMed/9353337" }, { "database": "PubMed", "id": "10477278", "url": "https://glygen.org/publication/PubMed/10477278" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "common_name": "Yeast" } ], "gene": [ { "name": "YSR3", "url": "https://www.uniprot.org/uniprot/P23501", "locus": { "chromosome": "XI", "start_pos": 534067, "end_pos": 535281, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YKR053C", "url": "https://www.ensembl.org/id/YKR053C" } ] } } ], "crossref": [ { "id": "cd03388", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03388", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "853927", "url": "https://www.ncbi.nlm.nih.gov/gene/853927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P23501", "url": "https://www.ebi.ac.uk/intact/interactors/id:P23501*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YKR053C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YKR053C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YWVNEQL", "url": "https://omabrowser.org/oma/group/YWVNEQL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2958177at2759", "url": "http://www.orthodb.org/?query=2958177at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14969:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14969:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01569", "url": "http://pfam.xfam.org/family/PF01569", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P23501", "url": "http://purl.obolibrary.org/obo/PR_P23501", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_012979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012979", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000001761", "url": "https://www.yeastgenome.org/locus/S000001761", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P23501-1", "url": "https://www.uniprot.org/uniprot/P23501-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR", "length": 404, "header": "sp|P23501-1|DS1P2_YEAST Isoform 1 of Dihydrosphingosine 1-phosphate phosphatase YSR3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=YSR3 PE=1 SV=2 CANONICAL=P23501-1" }, "isoforms": [ { "isoform_ac": "P23501-1", "url": "", "sequence": { "sequence": "MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR", "length": 404, "header": "sp|P23501-1|DS1P2_YEAST Isoform 1 of Dihydrosphingosine 1-phosphate phosphatase YSR3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=YSR3 PE=1 SV=2 CANONICAL=P23501-1" }, "locus": { "chromosome": "XI", "start_pos": 535281, "end_pos": 534070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YKR053C_mRNA", "url": "https://www.ensembl.org/id/YKR053C_mRNA" }, { "database": "Ensembl Peptide", "id": "YKR053C", "url": "https://www.ensembl.org/id/YKR053C" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 62, "start_aa": "Asn", "end_pos": 62, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn62", "evidence": [ { "id": "P23501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23501#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.", "journal": "Biochem. J.", "date": "1999", "authors": "Mao C., Obeid L.M., Saba J.D.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "10477278", "url": "https://glygen.org/publication/PubMed/10477278" } ] }, { "title": "Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging.", "journal": "Methods Enzymol.", "date": "2000", "authors": "Mao C., Obeid L.M.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "10563329", "url": "https://glygen.org/publication/PubMed/10563329" } ] }, { "title": "Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae.", "journal": "EMBO J.", "date": "2000", "authors": "Stevenson B.J., Funato K., Riezman H., Suetterlin C., Friant S., Zanolari B.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "10856228", "url": "https://glygen.org/publication/PubMed/10856228" } ] }, { "title": "MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.", "journal": "J. Mol. Biol.", "date": "1991", "authors": "Schweyen R.J., Wiesenberger G., Link T.A., Waldherr M., von Ahsen U.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "1703236", "url": "https://glygen.org/publication/PubMed/1703236" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids.", "journal": "Nat. Commun.", "date": "2014", "authors": "Kondo N., Seki N., Kihara A., Kitamura T., Naganuma T., Ohno Y., Obara T., Yamagata M.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "25345524", "url": "https://glygen.org/publication/PubMed/25345524" } ] }, { "title": "Complete DNA sequence of yeast chromosome XI.", "journal": "Nature", "date": "1994", "authors": "Ansorge W., Duesterhoeft A., Mewes H.-W., Obermaier B., Wiemann S., Legrain P., Zimmermann J., Xu G., Rose M., Planta R.J., Colleaux L., Rieger M., Fukuhara H., Portetelle D., Mueller S., Becker I., Feldmann H., Kleine K., Gonzalez A., Hewitt N., Schwager C., Voss H., Jimenez A., Erfle H., Jauniaux J.-C., Jacquier A., Dion C., Maia e Silva A., Pallier C., Stegemann J., Andre B., Cheret G., Sor F., Haasemann M., Koetter P., Entian K.-D., Baladron V., Vilela C., Thierry A., Louis E.J., Hollenberg C.P., Marck C., Santos M.A., Soares H., Philippsen P., Poehlmann R., Vandenbol M., Domdey H., Garcia-Ramirez J.J., Pohl T.M., James C.M., Pfeiffer F., Ghazvini M., Ballesta J.P.G., Bossier P., Daignan-Fornier B., Dujon B., Esteban P.F., Fernandes L., Goffeau A., Hegemann J.H., Hilger F., Oliver S.G., Remacha M.A., Revuelta J.L., Rodrigues-Pousada C., Vissers S., del Rey F., van Dyck L., Alexandraki D., Bolotin-Fukuhara M., Duesterhus S., Guerreiro P., Kirchrath L., Purnelle B., Ramezani Rad M., Skala J., Tzermia M., Urrestarazu L.A., Banrevi A., Bolle P.-A., Bou G., Boyer J., Buitrago M.J., Fobo G.M., Fritz C., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Gent M.E., Grothues D., Horaitis O., Indge K.J., Keuchel H., Liebl S., Moestl D., Monnier A.-L., Pascolo S., Pohl F.M., Puzos V., Rasmussen S.W., Richard G.-F., Rupp T., Sensen C., Tettelin H., Valens M., van Vliet-Reedijk J.C., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "8196765", "url": "https://glygen.org/publication/PubMed/8196765" } ] }, { "title": "Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase.", "journal": "J. Biol. Chem.", "date": "1997", "authors": "Mao C., Obeid L.M., Hannun Y.A., Jenkins G.M., Wadleigh M.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "9353337", "url": "https://glygen.org/publication/PubMed/9353337" } ] }, { "title": "Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1998", "authors": "Spiegel S., Nickels J., Tu Z., Menzeleev R., Mandala S.M., Thornton R., Kurtz M.B., Broach J.", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "reference": [ { "type": "PubMed", "id": "9419344", "url": "https://glygen.org/publication/PubMed/9419344" } ] } ], "pathway": [ { "id": "sce:YKR053C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YKR053C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dihydrosphingosine-1-phosphate phosphatase activity", "id": "GO:0070780", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070780", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" }, { "name": "sphingosine-1-phosphate phosphatase activity", "id": "GO:0042392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042392", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sphingolipid biosynthetic process", "id": "GO:0030148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030148", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" }, { "name": "phospholipid dephosphorylation", "id": "GO:0046839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046839", "evidence": [ { "database": "UniProtKB", "id": "P23501", "url": "https://www.uniprot.org/uniprot/P23501" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "27514", "name": "", "equation": "H2O + sphinganine 1-phosphate = phosphate + sphinganine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99P55-1", "Q8IWX5-1", "Q9BX95-1", "Q810K3-1", "Q9JI99-1", "P23501-1", "P47013-1" ], "evidence": [ { "id": "27514", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27514" } ] }, { "id": "R-SCE-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-428694" ], "enzyme_list": [ "P23501-1", "P47013-1" ], "evidence": [ { "id": "R-SCE-428664", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-428664" } ] }, { "id": "R-SCE-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P23501-1", "P47013-1" ], "evidence": [ { "id": "R-SCE-428701", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-428701" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-428694", "participant_name": "SPA [cytosol]", "crossref": [ { "id": "16566", "database": "ChEBI", "url": "" }, { "id": "HMDB0000269", "database": "HMDB Metabolite", "url": "" }, { "id": "000008036012", "database": "ZINC", "url": "" }, { "id": "2453", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00836", "database": "COMPOUND", "url": "" }, { "id": "16566", "database": "ChEBI", "url": "" }, { "id": "HMDB0000269", "database": "HMDB Metabolite", "url": "" }, { "id": "000008036012", "database": "ZINC", "url": "" }, { "id": "2453", "database": 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