{ "uniprot_canonical_ac": "P23255-1", "uniprot_ac": "P23255", "uniprot_id": "TAF2_YEAST", "mass": { "chemical_mass": 161471.0, "monoisotopic_mass": 161471.0 }, "refseq": { "ac": "NP_009971", "name": "Taf2p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009971" }, "gene_names": [ { "name": "TAF2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P23255", "id": "P23255" }, { "name": "TAF150; TSM1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009971", "id": "NP_009971" }, { "name": "TAF150", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23255", "id": "P23255" }, { "name": "TAF2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009971", "id": "NP_009971" }, { "name": "TSM1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23255", "id": "P23255" }, { "name": "YCR42C", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23255", "id": "P23255" }, { "name": "YCR724", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23255", "id": "P23255" } ], "protein_names": [ { "name": "Transcription initiation factor TFIID subunit 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P23255" }, { "name": "TAFII-150", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23255" }, { "name": "TBP-associated factor 150 kDa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23255" }, { "name": "TBP-associated factor 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23255" }, { "name": "TSM-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23255" }, { "name": "Taf2p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009971", "id": "NP_009971" } ], "function": [ { "annotation": "Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255#function" }, { "database": "PubMed", "id": "10788514", "url": "https://glygen.org/publication/PubMed/10788514" }, { "database": "PubMed", "id": "12516863", "url": "https://glygen.org/publication/PubMed/12516863" }, { "database": "PubMed", "id": "12138208", "url": "https://glygen.org/publication/PubMed/12138208" } ] } ], "disease": [ { "disease_id": "DOID:0081205", "recommended_name": { "id": "DOID:0081205", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081205", "name": "autosomal recessive intellectual developmental disorder 40", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the TAF2 gene on chromosome 8q24." }, "synonyms": [ { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "microcephaly-thin corpus callosum-intellectual disability syndrome", "description": "Microcephaly-thin corpus callosum-intellectual disability syndrome is a rare, genetic, syndromic intellectual disability disease characterized by progressive postnatal microcephaly and global developmental delay, as well as moderate to profound intellectual disability, difficulty or inability to walk, pyramidal signs (including spasticity, hyperreflexia and extensor plantar response) and thin corpus callosum revealed by brain imaging. Ophthalmologic signs (including nystagmus, strabismus and abnormal retinal pigmentation), foot deformity and genital anomalies may also be associated." }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "intellectual developmental disorder, autosomal recessive 40", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "intellectual disability, autosomal recessive type 40", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "mental retardation, autosomal recessive type 40", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "microcephaly-thin corpus callosum-intellectual disability syndrome", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "MRT40", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "intellectual disability, autosomal recessive 40", "description": "" }, { "id": "MONDO:0014273", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014273", "name": "mental retardation, autosomal recessive 40", "description": "" }, { "id": "MIM:615599", "resource": "MIM", "url": "https://www.omim.org/entry/615599", "name": "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity", "description": "Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity" } ], "evidence": [ { "id": "0081205", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081205" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "common_name": "Yeast" } ], "gene": [ { "name": "TAF2", "url": "https://www.uniprot.org/uniprot/P23255", "locus": { "chromosome": "III", "start_pos": 201174, "end_pos": 205397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YCR042C", "url": "https://www.ensembl.org/id/YCR042C" } ] } } ], "crossref": [ { "id": "cd09839", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09839", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "850409", "url": "https://www.ncbi.nlm.nih.gov/gene/850409", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P23255", "url": "https://www.ebi.ac.uk/intact/interactors/id:P23255*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR027268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YCR042C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YCR042C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TDLFMKK", "url": "https://omabrowser.org/oma/group/TDLFMKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1342632at2759", "url": "http://www.orthodb.org/?query=1342632at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15137:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15137:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7UHE", "url": "https://www.rcsb.org/structure/7UHE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PR_P23255", "url": "http://purl.obolibrary.org/obo/PR_P23255", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009971", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000638", "url": "https://www.yeastgenome.org/locus/S000000638", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P23255-1", "url": "https://www.uniprot.org/uniprot/P23255-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { 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"length": 1407, "header": "sp|P23255-1|TAF2_YEAST Isoform 1 of Transcription initiation factor TFIID subunit 2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=TAF2 PE=1 SV=3 CANONICAL=P23255-1" }, "isoforms": [ { "isoform_ac": "P23255-1", "url": "", "sequence": { "sequence": 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"length": 1407, "header": "sp|P23255-1|TAF2_YEAST Isoform 1 of Transcription initiation factor TFIID subunit 2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=TAF2 PE=1 SV=3 CANONICAL=P23255-1" }, "locus": { "chromosome": "III", "start_pos": 205397, "end_pos": 201177, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YCR042C_mRNA", "url": "https://www.ensembl.org/id/YCR042C_mRNA" }, { "database": "Ensembl Peptide", "id": "YCR042C", "url": "https://www.ensembl.org/id/YCR042C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ], "site_lbl": "Thr158" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser15" }, { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" } ], "site_lbl": "Thr161" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" } ], "site_lbl": "Ser163" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ], "site_lbl": "Thr166" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser18" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" } ], "site_lbl": "Thr19" }, { "start_pos": 268, "end_pos": 268, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ], "site_lbl": "Thr268" }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P23255", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23255" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P23255", "url": "https://www.yeastgenome.org/locus/P23255" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser318" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Sanders S.L., Weil P.A.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "10788514", "url": "https://glygen.org/publication/PubMed/10788514" } ] }, { "title": "Mapping histone fold TAFs within yeast TFIID.", "journal": "EMBO J.", "date": "2002", "authors": "Tora L., Kirschner D.B., Schultz P., Ruhlmann C., Sanders S.L., Weil P.A., Leurent C., Mallouh V.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "12093743", "url": "https://glygen.org/publication/PubMed/12093743" } ] }, { "title": "Molecular characterization of Saccharomyces cerevisiae TFIID.", "journal": "Mol. Cell. Biol.", "date": "2002", "authors": "Sanders S.L., Weil P.A., Garbett K.A.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "12138208", "url": "https://glygen.org/publication/PubMed/12138208" } ] }, { "title": "Multi-protein complexes in eukaryotic gene transcription.", "journal": "Plant Mol. Biol.", "date": "2002", "authors": "Martinez E.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "12516863", "url": "https://glygen.org/publication/PubMed/12516863" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The complete DNA sequence of yeast chromosome III.", "journal": "Nature", "date": "1992", "authors": "Duesterhoeft A., Mewes H.-W., Schweitzer B., Wang H., Brown A., Lanfranchi G., Rodriguez F., Valle G., Wilson C., Kelly A., Xu G., Huse K., Jia Y., Planta R.J., Vreken 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Bolotin-Fukuhara M., Chanet R., Fabre F., Fairhead C., Frontali L., Purnelle B., Ramezani Rad M., Skala J., Tzermia M., Urrestarazu L.A., Voet M., Agostoni-Carbone M.L., Aigle M., Bergantino E., Biteau N., Bolle P.-A., Carcano C., Defoor E., Demolder J., Doira C., Erdmann D., Francingues-Gaillard M.-C., Franco L., Fuller L.J., Galland P., Gent M.E., Grisanti P., Indge K.J., Kleinhans U., Kreisl P., Lutzenkirchen K., Maat M.J., Maurer C.T.C., McConnell D., McKee R.A., Montague M.A., Navas L., Noone D., Panzeri L., Poetsch B., Pohl F.M., Rasmussen S.W., Raynal A., Richterich P., Sgouros J.G., Soustelle C., Spiegelberg R., Stateva L.I., Thireos G., Warmington J.R., Wicksteed B.L., de Haan M., van Vliet-Reedijk J.C., van der Aart Q.J.M., van der Linden C.G., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P23255", "url": "https://www.uniprot.org/uniprot/P23255" } ], "reference": [ { "type": "PubMed", "id": "1574125", "url": "https://glygen.org/publication/PubMed/1574125" 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