{ "uniprot_canonical_ac": "P23180-1", "uniprot_ac": "P23180", "uniprot_id": "AIM17_YEAST", "mass": { "chemical_mass": 53135.0, "monoisotopic_mass": 53135.0 }, "refseq": { "ac": "NP_011842", "name": "Aim17p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011842" }, "gene_names": [ { "name": "AIM17", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P23180", "id": "P23180" }, { "name": "AIM17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011842", "id": "NP_011842" }, { "name": "FMP12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011842", "id": "NP_011842" }, { "name": "FMP12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23180", "id": "P23180" } ], "protein_names": [ { "name": "Probable oxidoreductase AIM17", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P23180" }, { "name": "1.14.11.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23180" }, { "name": "Aim17p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011842", "id": "NP_011842" }, { "name": "Altered inheritance of mitochondria protein 17, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23180" }, { "name": "Found in mitochondrial proteome protein 12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23180" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "common_name": "Yeast" } ], "gene": [ { "name": "AIM17", "url": "https://www.uniprot.org/uniprot/P23180", "locus": { "chromosome": "VIII", "start_pos": 64462, "end_pos": 65859, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YHL021C", "url": "https://www.ensembl.org/id/YHL021C" } ] } } ], "crossref": [ { "id": "cd00250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "856365", "url": "https://www.ncbi.nlm.nih.gov/gene/856365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P23180", "url": "https://www.ebi.ac.uk/intact/interactors/id:P23180*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YHL021C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YHL021C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AFHIADR", "url": "https://omabrowser.org/oma/group/AFHIADR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5485575at2759", "url": "http://www.orthodb.org/?query=5485575at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10696", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10696", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10696:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10696:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02668", "url": "http://pfam.xfam.org/family/PF02668", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P23180", "url": "http://purl.obolibrary.org/obo/PR_P23180", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_011842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011842", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000001013", "url": "https://www.yeastgenome.org/locus/S000001013", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P23180-1", "url": "https://www.uniprot.org/uniprot/P23180-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSNLCRGSRILARLTTTPRTYTSAATAAAANRGHIIKTYFNRDSTTITFSMEESSKPVSVCFNNVFLRDASHSAKLVTTGELYHNEKLTAPQDIQISEDGKSLVVKWKDGGHHQFPLQFFIDYKGSSFVSPATRKQESRYRPQLWNKRILKDNVKDLLSVSYNEFIDPKDDSKLFQTLVNLQKFGIAFISGTPSSSSEGLTIQKICERIGPIRSTVHGEGTFDVNASQATSVNAHYANKDLPLHTDLPFLENVPGFQILQSLPATEGEDPNTRPMNYFVDAFYATRNVRESDFEAYEALQIVPVNYIYENGDKRYYQSKPLIEHHDINEDNTLLGNYEALIKCINYSPPYQAPFTFGIYDKPSDLNNNLDLNLITTPAKLTERFLFKSFIRGLNLFESHINDFNNQFRLQLPENCCVIFNNRRILHANSLTSSNQQWLKGCYFDSDTFKSKLKFLEEKFPHDK", "length": 465, "header": "sp|P23180-1|AIM17_YEAST Isoform 1 of Probable oxidoreductase AIM17 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AIM17 PE=1 SV=2 CANONICAL=P23180-1" }, "isoforms": [ { "isoform_ac": "P23180-1", "url": "", "sequence": { "sequence": "MLRSNLCRGSRILARLTTTPRTYTSAATAAAANRGHIIKTYFNRDSTTITFSMEESSKPVSVCFNNVFLRDASHSAKLVTTGELYHNEKLTAPQDIQISEDGKSLVVKWKDGGHHQFPLQFFIDYKGSSFVSPATRKQESRYRPQLWNKRILKDNVKDLLSVSYNEFIDPKDDSKLFQTLVNLQKFGIAFISGTPSSSSEGLTIQKICERIGPIRSTVHGEGTFDVNASQATSVNAHYANKDLPLHTDLPFLENVPGFQILQSLPATEGEDPNTRPMNYFVDAFYATRNVRESDFEAYEALQIVPVNYIYENGDKRYYQSKPLIEHHDINEDNTLLGNYEALIKCINYSPPYQAPFTFGIYDKPSDLNNNLDLNLITTPAKLTERFLFKSFIRGLNLFESHINDFNNQFRLQLPENCCVIFNNRRILHANSLTSSNQQWLKGCYFDSDTFKSKLKFLEEKFPHDK", "length": 465, "header": "sp|P23180-1|AIM17_YEAST Isoform 1 of Probable oxidoreductase AIM17 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AIM17 PE=1 SV=2 CANONICAL=P23180-1" }, "locus": { "chromosome": "VIII", "start_pos": 65859, "end_pos": 64465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YHL021C_mRNA", "url": "https://www.ensembl.org/id/YHL021C_mRNA" }, { "database": "Ensembl Peptide", "id": "YHL021C", "url": "https://www.ensembl.org/id/YHL021C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.", "journal": "PLoS Genet.", "date": "2009", "authors": "Costanzo M., Nislow C., Caudy A.A., Giaever G., Huttenhower C., Troyanskaya O.G., Clore J.J., Hayes A.P., Hess D.C., Hibbs M.A., Luis B.S., Mendoza R.M., Myers C.L., Paw J.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "19300474", "url": "https://glygen.org/publication/PubMed/19300474" } ] }, { "title": "Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Roepstorff P., Bayot A., Bulteau A.L., Friguet B., Gareil M., Rogowska-Wrzesinska A.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "20150421", "url": "https://glygen.org/publication/PubMed/20150421" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination gene.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Elder R.T., Esposito R.E., Atcheson C.L., Didomenico B., Frackman S.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "3317399", "url": "https://glygen.org/publication/PubMed/3317399" } ] }, { "title": "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.", "journal": "Science", "date": "1994", "authors": "Andrews S., Du Z., Fulton L., Hillier L.W., Latreille P., Mardis E., Vaudin M., Waterston R., Wilson R., Favello A., Kucaba T., Rifkin L., Trevaskis E., Wohldman P., Ding H., Cooper J., Vaughan K., Macri C., Louis E.J., Johnston L., Nhan M., Menezes S., Johnston M., Dover J., Wilcox L., Brinkman R., Gattung S., Geisel C., Jier M., Kirsten J., Langston Y., Mouser L., Riles L., St Peter H., Vignati D.", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "reference": [ { "type": "PubMed", "id": "8091229", "url": "https://glygen.org/publication/PubMed/8091229" } ] } ], "pathway": [ { "id": "sce:YHL021C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YHL021C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "pmid": "" }, { "name": "dioxygenase activity", "id": "GO:0051213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051213", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carnitine biosynthetic process", "id": "GO:0045329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045329", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "P23180", "url": "https://www.uniprot.org/uniprot/P23180" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-SCE-71261", "name": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-31369" ], "output_participant_list": [ "R-ALL-30235", "R-ALL-29434" ], "enzyme_list": [ "P23180-1" ], "evidence": [ { "id": "R-SCE-71261", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-71261" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29434", "participant_name": "SUCCA [cytosol]", "crossref": [ { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-30235", "participant_name": "CAR [cytosol]", "crossref": [ { "id": "C00487", "database": "COMPOUND", "url": "" }, { "id": "17126", "database": "ChEBI", "url": "" }, { "id": "8145619", "database": "PubChem Substance", "url": "" }, { "id": "000000154729", "database": "ZINC", "url": "" }, { "id": "000003079340", "database": "ZINC", "url": "" }, { "id": "C00487", "database": "COMPOUND", "url": "" }, { "id": "17126", "database": "ChEBI", "url": "" }, { "id": "8145619", "database": "PubChem Substance", "url": "" }, { "id": "000000154729", "database": "ZINC", "url": "" }, { "id": "000003079340", "database": "ZINC", "url": "" }, { "id": "C00487", "database": "COMPOUND", "url": "" }, { "id": "17126", "database": "ChEBI", "url": "" }, { "id": "8145619", "database": "PubChem Substance", "url": "" }, { "id": "000000154729", "database": "ZINC", "url": "" }, { "id": "000003079340", "database": "ZINC", "url": "" }, { "id": "17126", "database": "ChEBI", "url": "" }, { "id": "000000154729", "database": "ZINC", "url": "" }, { "id": "C00487", "database": "COMPOUND", "url": "" }, { "id": "000003079340", "database": "ZINC", "url": "" }, { "id": "8145619", "database": "PubChem Substance", "url": "" }, { "id": "C00487", "database": "COMPOUND", "url": "" }, { "id": "17126", "database": "ChEBI", "url": "" }, { "id": "8145619", "database": "PubChem Substance", "url": "" }, { "id": "000000154729", "database": "ZINC", "url": "" }, { "id": "000003079340", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-31369", "participant_name": "TEABT [cytosol]", "crossref": [ { "id": "8144690", "database": "PubChem Substance", "url": "" }, { "id": "6605", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C01181", "database": "COMPOUND", "url": "" }, { "id": "000000395560", "database": "ZINC", "url": "" }, { "id": "HMDB0001161", "database": "HMDB Metabolite", "url": "" }, { "id": "16244", "database": "ChEBI", "url": "" }, { "id": "16244", "database": "ChEBI", "url": "" }, { "id": "000000395560", "database": "ZINC", "url": "" }, { "id": "HMDB0001161", "database": "HMDB Metabolite", "url": "" }, { "id": "8144690", "database": "PubChem Substance", "url": "" }, { "id": "C01181", "database": "COMPOUND", "url": "" }, { "id": "6605", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C01181", "database": "COMPOUND", "url": "" }, { "id": "16244", "database": "ChEBI", "url": "" }, { "id": "8144690", "database": "PubChem Substance", "url": "" }, { "id": "000000395560", "database": "ZINC", "url": "" }, { "id": "6605", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0001161", "database": "HMDB Metabolite", "url": "" }, { "id": "C01181", "database": "COMPOUND", "url": "" }, { "id": "16244", "database": "ChEBI", "url": "" }, { "id": "8144690", "database": "PubChem Substance", "url": "" }, { "id": "000000395560", "database": "ZINC", "url": "" }, { "id": "6605", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0001161", "database": "HMDB Metabolite", "url": "" }, { "id": "C01181", "database": "COMPOUND", "url": "" }, { "id": "16244", "database": "ChEBI", "url": "" }, { "id": "8144690", "database": "PubChem Substance", "url": "" }, { "id": "000000395560", "database": "ZINC", "url": "" }, { "id": "6605", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0001161", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P23180", "gene_name": "AIM17", "activity": [ { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "P23180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23180" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }