{ "uniprot_canonical_ac": "P23116-1", "uniprot_ac": "P23116", "uniprot_id": "EIF3A_MOUSE", "mass": { "chemical_mass": 161936.0, "monoisotopic_mass": 161936.0 }, "refseq": { "ac": "NP_034253", "name": "eukaryotic translation initiation factor 3 subunit A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" }, "gene_names": [ { "name": "Eif3a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P23116", "id": "P23116" }, { "name": "A830012B05Rik; Csma; Eif3; Eif3s10; mKIAA0139", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253", "id": "NP_034253" }, { "name": "Csma", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23116", "id": "P23116" }, { "name": "Eif3a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253", "id": "NP_034253" }, { "name": "Eif3s10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23116", "id": "P23116" }, { "name": "Eif3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P23116", "id": "P23116" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 3 subunit A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P23116" }, { "name": "Centrosomin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "Eukaryotic translation initiation factor 3 subunit 10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eIF-3-theta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eIF3 p167", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eIF3 p180", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eIF3 p185", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eIF3a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" }, { "name": "eukaryotic translation initiation factor 3 subunit A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253", "id": "NP_034253" }, { "name": "eukaryotic translation initiation factor 3, subunit 10 (theta); p162; eIF3 p167; eIF3 p180; eIF3 p185; centrosomin; eIF-3-theta; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253", "id": "NP_034253" }, { "name": "p162", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P23116" } ], "function": [ { "annotation": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116#function" }, { "database": "UniProtKB", "id": "MF_03000", "url": "https://www.uniprot.org/uniprot/MF_03000#function" }, { "database": "PubMed", "id": "17581632", "url": "https://glygen.org/publication/PubMed/17581632" } ] }, { "annotation": "Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" }, { "database": "PubMed", "id": "11904180", "url": "https://glygen.org/publication/PubMed/11904180" } ] }, { "annotation": "The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations.", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" }, { "database": "PubMed", "id": "21292980", "url": "https://glygen.org/publication/PubMed/21292980" } ] }, { "annotation": "[IL-33 up-regulates eIF3a expression by activating NF-kappaB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" }, { "database": "PubMed", "id": "37515335", "url": "https://glygen.org/publication/PubMed/37515335" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Eif3a", "url": "https://www.uniprot.org/uniprot/P23116", "locus": { "chromosome": "19", "start_pos": 60749555, "end_pos": 60779096, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000024991", "url": "https://www.ensembl.org/id/ENSMUSG00000024991" } ] } } ], "crossref": [ { "id": "ENSMUSG00000024991", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024991", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "13669", "url": "https://www.ncbi.nlm.nih.gov/gene/13669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P23116", "url": "https://www.ebi.ac.uk/intact/interactors/id:P23116*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027512", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027512", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:13669", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13669", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "95301", "url": "http://www.informatics.jax.org/marker/MGI:95301", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P23116", "url": "https://oglcnac.org/atlas/detail/P23116", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "HQAFQFC", "url": "https://omabrowser.org/oma/group/HQAFQFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "10990at2759", "url": "http://www.orthodb.org/?query=10990at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14005:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14005:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "http://pfam.xfam.org/family/PF01399", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P23116", "url": "http://purl.obolibrary.org/obo/PR_P23116", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72649", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72689", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72706", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A494B9I0", "url": "https://www.uniprot.org/uniprot/A0A494B9I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9I0-1", "url": "https://www.uniprot.org/uniprot/A0A494B9I0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P23116-1", "url": "https://www.uniprot.org/uniprot/P23116-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFSVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPVGPHLQSMPSEQIRNQLTAMSSVLAKALEVIRPAHILQEKEEQHQLAVNAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHSRLEDRKRQRKEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGPDEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDERGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRGPWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAREESWGPPRESRPSEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR", "length": 1344, "header": "sp|P23116-1|EIF3A_MOUSE Isoform 1 of Eukaryotic translation initiation factor 3 subunit A OS=Mus musculus OX=10090 GN=Eif3a PE=1 SV=5 CANONICAL=P23116-1" }, "isoforms": [ { "isoform_ac": "A0A494B9I0-1", "url": "", "sequence": { "sequence": "XYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDNIQTPERDEGGWRRGPAEESSSWRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR", "length": 194, "header": "tr|A0A494B9I0-1|EIF3A_MOUSE Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit A OS=Mus musculus OX=10090 GN=Eif3a PE=1 SV=1 CANONICAL=P23116-1" }, "locus": { "chromosome": "19", "start_pos": 60770628, "end_pos": 60750521, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238125.2", "url": "https://www.ensembl.org/id/ENSMUST00000238125.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157622.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157622.2" } ] } }, { "isoform_ac": "P23116-1", "url": "", "sequence": { "sequence": "MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFSVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPVGPHLQSMPSEQIRNQLTAMSSVLAKALEVIRPAHILQEKEEQHQLAVNAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHSRLEDRKRQRKEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGPDEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDERGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRGPWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAREESWGPPRESRPSEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR", "length": 1344, "header": "sp|P23116-1|EIF3A_MOUSE Isoform 1 of Eukaryotic translation initiation factor 3 subunit A OS=Mus musculus OX=10090 GN=Eif3a PE=1 SV=5 CANONICAL=P23116-1" }, "locus": { "chromosome": "19", "start_pos": 60778955, "end_pos": 60750522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000025955", "url": "https://www.ensembl.org/id/ENSMUST00000025955" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000025955", "url": "https://www.ensembl.org/id/ENSMUSP00000025955" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 225, "start_aa": "Ser", "end_pos": 225, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser225", "evidence": [ { "id": "P23116", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 239, "start_aa": "Ser", "end_pos": 239, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser239", "evidence": [ { "id": "P23116", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P23116" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 336, "start_aa": "Thr", "end_pos": 336, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr336", "evidence": [ { "id": "P23116", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "phosphorylation": [ { "start_pos": 1028, "end_pos": 1028, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1028" }, { "start_pos": 1149, "end_pos": 1149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1149" }, { "start_pos": 1159, "end_pos": 1159, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1159" }, { "start_pos": 1223, "end_pos": 1223, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1223" }, { "start_pos": 1300, "end_pos": 1300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1300" }, { "start_pos": 1326, "end_pos": 1326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser1326" }, { "start_pos": 492, "end_pos": 492, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser492" }, { "start_pos": 584, "end_pos": 584, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P23116", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23116" } ], "site_lbl": "Ser584" }, { "start_pos": 895, "end_pos": 895, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser895" }, { "start_pos": 949, "end_pos": 949, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "site_lbl": "Ser949" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).", "journal": "FEBS letters", "date": "2002", "authors": "Mayeur GL, Hershey JW", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" } ], "reference": [ { "type": "PubMed", "id": "11904180", "url": "https://glygen.org/publication/PubMed/11904180" } ] }, { "title": "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.", "journal": "EMBO J.", "date": "2006", "authors": "Chi A., Hunt D.F., Shabanowitz J., Lawrence J.C. Jr., Rhoads R.E., Harris T.E.", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "reference": [ { "type": "PubMed", "id": "16541103", "url": "https://glygen.org/publication/PubMed/16541103" } ] }, { "title": "Reconstitution reveals the functional core of mammalian eIF3.", "journal": "EMBO J.", "date": "2007", "authors": "Masutani M, Sonenberg N, Yokoyama S, Imataka H", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "reference": [ { "type": "PubMed", "id": "17581632", "url": "https://glygen.org/publication/PubMed/17581632" } ] }, { "title": "Murine cDNAs coding for the centrosomal antigen centrosomin A.", "journal": "J. Cell Sci.", "date": "1991", "authors": "Joswig G, Petzelt C, Werner D", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "reference": [ { "type": "PubMed", "id": "1829085", "url": "https://glygen.org/publication/PubMed/1829085" } ] }, { "title": "MILI, a PIWI-interacting RNA-binding protein, is required for germ Line stem cell self-renewal and appears to positively regulate translation.", "journal": "J. Biol. Chem.", "date": "2009", "authors": "Hao Y., Lin H., Nakano T., Yin H., Beyret E., Kuramochi-Miyagawa S., Unhavaithaya Y.", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "reference": [ { "type": "PubMed", "id": "19114715", "url": "https://glygen.org/publication/PubMed/19114715" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" }, { "database": "iPTMnet", "id": "P23116", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P23116" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2011", "authors": "Gildea DE, Luetkemeier ES, Bao X, Loftus SK, Mackem S, Yang Y, Pavan WJ, Biesecker LG", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" } ], "reference": [ { "type": "PubMed", "id": "21292980", "url": "https://glygen.org/publication/PubMed/21292980" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" }, { "database": "O-GlcNAc Atlas", "id": "P23116", "url": "https://oglcnac.org/atlas/detail/P23116" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.", "journal": "Nature chemical biology", "date": "2022", "authors": "Shu XE, Mao Y, Jia L, Qian SB", "evidence": [ { "database": "O-GlcNAc Database", "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" } ], "reference": [ { "type": "PubMed", "id": "34887587", "url": "https://glygen.org/publication/PubMed/34887587" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P23116", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P23116" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] }, { "title": "[IL-33 up-regulates eIF3a expression by activating NF-\u03baB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].", "journal": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology", "date": "2023-08", "authors": "Gao Yunxing, Fu Yu, Chen Xiao, Li Zepeng, He Xiaowei, Li Xianwei", "evidence": [ { "database": "RefSeq", "id": "NP_034253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034253" } ], "reference": [ { "type": "PubMed", "id": "37515335", "url": "https://glygen.org/publication/PubMed/37515335" } ] }, { "title": "The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing.", "journal": "J. Cell Sci.", "date": "1997", "authors": "Petzelt C, Joswig G, Mincheva A, Lichter P, Stammer H, Werner D", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "reference": [ { "type": "PubMed", "id": "9372446", "url": "https://glygen.org/publication/PubMed/9372446" } ] } ], "pathway": [ { "id": "mmu:13669", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13669", "resource": "KEGG Pathway" }, { "id": "R-MMU-156827", "name": "L13a-mediated translational silencing of Ceruloplasmin expression", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-MMU-72649", "name": "Translation initiation complex formation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": 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"MAPPPFRPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTVEPVVFKFLEIGVELKKGKLLKDGLHQYKKLIQGSTEGLVSVGAVARKFIDLVESKIASEQTRADELQKQEIDDDLEGGVTPENLLISVYESDQSVAGFNDEAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVKKTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSKSGNNLVDLSDADTLQRYLDQRFQQVDVSVKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSGDPLLHTTAWKKFYKLYSTNPRATEEEFKTYSSTIFLSAISTQLDEIPSIGYDPHLRMYRLLNLDAKPTRKEMLQSIIEDESIYGKVDEELKELYDIIEVNFDVDTVKQQLENLLVKLSSKTYFSQYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITIDHESAKVTFAKDPFDIFASTASKEVSEEENTEPEVQEEKEETDEALGPQETEDGEEKEEESDPVIIRNSYIHNKLLELSNVLHDVDSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVELPLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPDKAKLDMIAQKQREMEEAIEQRLAGRTAGGSSPATPATPATPATPTPSSGPKKMTMAEKLRAKRLAKGGR", "length": 964 }, "evidence": [ { 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"length": 1382 }, "evidence": [ { "id": "45235866", "url": "http://www.informatics.jax.org/homology/45235866", "database": "MGI" }, { "id": "P23116", "url": "https://omabrowser.org/oma/group/P23116/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q1JU68-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "Eif3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1354 }, "evidence": [ { "id": "45235866", "url": "http://www.informatics.jax.org/homology/45235866", "database": "MGI" }, { "id": "P23116", "url": "https://omabrowser.org/oma/group/P23116/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VN25-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "eIF3a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"length": 1140 }, "evidence": [ { "id": "P23116", "url": "https://omabrowser.org/oma/group/P23116/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "eukaryotic translation initiation factor 3 complex", "id": "GO:0005852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005852", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "P23116", "url": "https://www.uniprot.org/uniprot/P23116" } ], "pmid": "" }, { "name": "cytosol", "id": 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