{ "uniprot_canonical_ac": "P22771-1", "uniprot_ac": "P22771", "uniprot_id": "GLRA2_RAT", "mass": { "chemical_mass": 52053.0, "monoisotopic_mass": 52053.0 }, "refseq": { "ac": "NP_036700", "name": "glycine receptor subunit alpha-2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" }, "gene_names": [ { "name": "Glra2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P22771", "id": "P22771" }, { "name": "Glra2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "id": "NP_036700" }, { "name": "RNNEOGLY", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "id": "NP_036700" } ], "protein_names": [ { "name": "Glycine receptor subunit alpha-2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P22771" }, { "name": "Glycine receptor strychnine-binding subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P22771" }, { "name": "glycine receptor strychnine-binding subunit; Glycine receptor alpha 2 subunit (glycine receptor, neonatal); glycine receptor subunit alpha-2-like", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "id": "NP_036700" }, { "name": "glycine receptor subunit alpha-2 isoform X2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771374", "id": "XP_008771374" }, { "name": "glycine receptor subunit alpha-2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "id": "NP_036700" } ], "function": [ { "annotation": "Alpha2 subunits determine the picrotin sensitivity of alpha1alpha2-heteromeric receptors. Direct gating of the alpha2 subunit is not required for this picrotin inhibition.", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" }, { "database": "PubMed", "id": "23079787", "url": "https://glygen.org/publication/PubMed/23079787" } ] }, { "annotation": "Data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts.", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" }, { "database": "PubMed", "id": "27382060", "url": "https://glygen.org/publication/PubMed/27382060" } ] }, { "annotation": "Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:2176511). Plays a role in synaptic plasticity. Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol.", "evidence": [ { "database": "UniProtKB", "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771#function" }, { "database": "PubMed", "id": "2176511", "url": "https://glygen.org/publication/PubMed/2176511" }, { "database": "UniProtKB", "id": "P23416", "url": "https://www.uniprot.org/uniprot/P23416#function" } ] }, { "annotation": "Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons.", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" }, { "database": "PubMed", "id": "12124753", "url": "https://glygen.org/publication/PubMed/12124753" } ] }, { "annotation": "This study demonistrated that glycine receptor alpha 2 subunit decrease in developmental brain.", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" }, { "database": "PubMed", "id": "22330726", "url": "https://glygen.org/publication/PubMed/22330726" } ] } ], "disease": [ { "disease_id": "DOID:0070422", "recommended_name": { "id": "DOID:0070422", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070422", "name": "syndromic X-linked intellectual disability Pilorge type", "description": "A syndromic X-linked intellectual disability characterized by global developmental delay with variably impaired intellectual development, speech delay, and behavioral abnormalities including autism spectrum disorder that has_material_basis_in heterozygous or hemizygous mutation in the GLRA2 gene on chromosome Xp22." }, "synonyms": [ { "id": "DOID:0070422", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070422", "name": "MRXSP", "description": "" }, { "id": "MONDO:0024772", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024772", "name": "intellectual developmental disorder, X-linked, syndromic, Pilorge type", "description": "" }, { "id": "MONDO:0024772", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024772", "name": "MRXSP", "description": "" }, { "id": "MONDO:0024772", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024772", "name": "intellectual developmental disorder, X-linked, syndromic, Pilorge type", "description": "" }, { "id": "MIM:301076", "resource": "MIM", "url": "https://www.omim.org/entry/301076", "name": "Intellectual developmental disorder, X-linked, syndromic, Pilorge type", "description": "Intellectual developmental disorder, X-linked, syndromic, Pilorge type" } ], "evidence": [ { "id": "0070422", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070422" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771" } ], "common_name": "Rat" } ], "gene": [ { "name": "Glra2", "url": "https://www.uniprot.org/uniprot/P22771", "locus": { "chromosome": "X", "start_pos": 29241666, "end_pos": 29020557, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000003313", "url": "https://www.ensembl.org/id/ENSRNOG00000003313" } ] } } ], "crossref": [ { "id": "ENSRNOG00000003313", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003313", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19060", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19060", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2328", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2328", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "24397", "url": "https://www.ncbi.nlm.nih.gov/gene/24397", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24397", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24397", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FCKDHDT", "url": "https://omabrowser.org/oma/group/FCKDHDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4265336at2759", "url": "http://www.orthodb.org/?query=4265336at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18945:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02931", "url": "http://pfam.xfam.org/family/PF02931", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02932", "url": "http://pfam.xfam.org/family/PF02932", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P22771", "url": "http://purl.obolibrary.org/obo/PR_P22771", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-112314", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112314", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2705", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2705", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JSH7", "url": "https://www.uniprot.org/uniprot/A0A0G2JSH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JSH7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JSH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTI8", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTI8-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZW10", "url": "https://www.uniprot.org/uniprot/A0A8I5ZW10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZW10-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZW10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GJI2", "url": "https://www.uniprot.org/uniprot/A0A8I6GJI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GJI2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GJI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P22771-1", "url": "https://www.uniprot.org/uniprot/P22771-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P22771-2", "url": "https://www.uniprot.org/uniprot/P22771-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 452, "header": "sp|P22771-1|GLRA2_RAT Isoform 1 of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JSH7-1", "url": "", "sequence": { "sequence": "MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 452, "header": "tr|A0A0G2JSH7-1|GLRA2_RAT Computationally mapped isoform of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "locus": { "chromosome": "X", "start_pos": 29240398, "end_pos": 29021108, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000004443.7", "url": "https://www.ensembl.org/id/ENSRNOT00000004443.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000004443.4", "url": "https://www.ensembl.org/id/ENSRNOP00000004443.4" } ] } }, { "isoform_ac": "A0A8I5ZTI8-1", "url": "", "sequence": { "sequence": "LYSINALLEINNVFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKVGRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 438, "header": "tr|A0A8I5ZTI8-1|GLRA2_RAT Computationally mapped isoform of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "locus": { "chromosome": "X", "start_pos": 29240398, "end_pos": 29022656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114133.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114133.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081734.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081734.1" } ] } }, { "isoform_ac": "A0A8I5ZW10-1", "url": "", "sequence": { "sequence": "MVEDESGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKVGLCFLSLFCQEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 435, "header": "tr|A0A8I5ZW10-1|GLRA2_RAT Computationally mapped isoform of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "locus": { "chromosome": "X", "start_pos": 29240398, "end_pos": 29022918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098582.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098582.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083002.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083002.1" } ] } }, { "isoform_ac": "A0A8I6GJI2-1", "url": "", "sequence": { "sequence": "MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 452, "header": "tr|A0A8I6GJI2-1|A0A8I6GJI2_RAT Computationally mapped isoform of Glycine receptor, alpha 2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=3 SV=1 CANONICAL=P22771-1" }, "locus": { "chromosome": "X", "start_pos": 29240398, "end_pos": 29021108, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111367.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111367.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091317.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091317.1" } ] } }, { "isoform_ac": "P22771-1", "url": "", "sequence": { "sequence": "MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 452, "header": "sp|P22771-1|GLRA2_RAT Isoform 1 of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "locus": {} }, { "isoform_ac": "P22771-2", "url": "", "sequence": { "sequence": "MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK", "length": 452, "header": "sp|P22771-2|GLRA2_RAT Isoform 2 of Glycine receptor subunit alpha-2 OS=Rattus norvegicus OX=10116 GN=Glra2 PE=1 SV=1 CANONICAL=P22771-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 103, "start_aa": "Asn", "end_pos": 103, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn103", "evidence": [ { "id": "P22771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22771#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 72, "start_aa": "Asn", "end_pos": 72, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn72", "evidence": [ { "id": "P22771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22771#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons.", "journal": "Journal of neurobiology", "date": "2002", "authors": "Kumar DV, Nighorn A, St John PA", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" } ], "reference": [ { "type": "PubMed", "id": "12124753", "url": "https://glygen.org/publication/PubMed/12124753" } ] }, { "title": "Alternative splicing generates two isoforms of the alpha 2 subunit of the inhibitory glycine receptor.", "journal": "FEBS Lett.", "date": "1991", "authors": "Kuryatov A., Betz H., Schmieden V., Kuhse J., Maulet Y., Malosio M.L.", "evidence": [ { "database": "UniProtKB", "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771" } ], "reference": [ { "type": "PubMed", "id": "1645300", "url": "https://glygen.org/publication/PubMed/1645300" } ] }, { "title": "Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development.", "journal": "FEBS Lett.", "date": "1991", "authors": "Hirai K., Akagi H., Hishinuma F.", "evidence": [ { "database": "UniProtKB", "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771" } ], "reference": [ { "type": "PubMed", "id": "1707830", "url": "https://glygen.org/publication/PubMed/1707830" } ] }, { "title": "A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit.", "journal": "Neuron", "date": "1990", "authors": "Kuhse J, Schmieden V, Betz H", "evidence": [ { "database": "UniProtKB", "id": "P22771", "url": "https://www.uniprot.org/uniprot/P22771" } ], "reference": [ { "type": "PubMed", "id": "2176511", "url": "https://glygen.org/publication/PubMed/2176511" } ] }, { "title": "Changes in glycine receptor subunit expression in forebrain regions of the Wistar rat over development.", "journal": "Brain research", "date": "2012", "authors": "Jonsson S, Morud J, Pickering C, Adermark L, Ericson M, Soderpalm B", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" } ], "reference": [ { "type": "PubMed", "id": "22330726", "url": "https://glygen.org/publication/PubMed/22330726" } ] }, { "title": "Gating effects on picrotin block of glycine receptors.", "journal": "Neuroreport", "date": "2012", "authors": "Li P, Slaughter MM", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" } ], "reference": [ { "type": "PubMed", "id": "23079787", "url": "https://glygen.org/publication/PubMed/23079787" } ] }, { "title": "Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Raltschev C, Hetsch F, Winkelmann A, Meier JC, Semtner M", "evidence": [ { "database": "RefSeq", "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700" } ], "reference": [ { "type": "PubMed", "id": "27382060", "url": "https://glygen.org/publication/PubMed/27382060" } ] } ], "pathway": [ { "id": "rno:24397", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24397", "resource": "KEGG Pathway" }, { "id": "R-RNO-112314", "name": "Neurotransmitter receptors and postsynaptic signal transmission", "url": 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