{ "uniprot_canonical_ac": "P22699-1", "uniprot_ac": "P22699", "uniprot_id": "GUN6_DICDI", "mass": { "chemical_mass": 75911.0, "monoisotopic_mass": 75911.0 }, "refseq": { "ac": "XP_645627", "name": "cellulase 270-6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645627" }, "gene_names": [ { "name": "celA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P22699", "id": "P22699" }, { "name": "DDB_G0271134", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P22699", "id": "P22699" }, { "name": "celA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645627", "id": "XP_645627" } ], "protein_names": [ { "name": "Endoglucanase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P22699" }, { "name": "3.2.1.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P22699" }, { "name": "Cellulase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P22699" }, { "name": "Endo-1,4-beta-glucanase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P22699" }, { "name": "Spore germination protein 270-6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P22699" }, { "name": "cellulase 270-6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645627", "id": "XP_645627" } ], "function": [ { "annotation": "May digest the spore cell wall during germination, to release the enclosed amoeba.", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699#function" }, { "database": "PubMed", "id": "1869562", "url": "https://glygen.org/publication/PubMed/1869562" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "celA", "url": "https://www.uniprot.org/uniprot/P22699", "locus": {} } ], "crossref": [ { "id": "CBM8", "url": "http://www.cazy.org/CBM8.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "GH9", "url": "http://www.cazy.org/GH9.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0271134", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8617819", "url": "https://www.ncbi.nlm.nih.gov/gene/8617819", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0271134", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0271134", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GGFQPFF", "url": "https://omabrowser.org/oma/group/GGFQPFF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22298:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22298:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7T7Y", "url": "https://www.rcsb.org/structure/7T7Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7T7Z", "url": "https://www.rcsb.org/structure/7T7Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00759", "url": "http://pfam.xfam.org/family/PF00759", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P22699", "url": "http://purl.obolibrary.org/obo/PR_P22699", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_645627", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_645627", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P22699-1", "url": "https://www.uniprot.org/uniprot/P22699-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKILKNCILLIIFGLLSTQLINADTDYCSLLENALMFYKMNRAGRLPDNDIPWRGNSALNDASPNSAKDANGDGNLSGGYFDAGDGVKFGLPMAYSMTMLGWSFIEYESNIAQCGLTSLYLDTIKYGTDWLIAAHTADNEFAGQVGDGNVDHSWWGPPEDMTMARPTYMLTTEAPGTEIAMEAASALAAASIAFKSSNPTYAATCLAHAKTLHNFGYTYRGVYSDSITNAQAFYNSWSGYKDDLVWGSIWLYKATQDSDYLTKAVADYASGGVGGMAQGNSHDWDNKAPGCCLLLSKLVPTTSTYKTDFEGWLNYWLPGGGVTYTPGGLAWIRQWGPARYAATAAFLGSLAGTEKGTDFTQKQVDYLIGNNPNQQSFVVGMGPNYPINPHHRAAHHSTTNDINNPVNNLYLLKGALVGGPGSNDEYTDDRTDYISNEVATDYNAGFVGALASLVNPSSTSVPTTTPTVTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETVTPTPTVTPTETPSSGESLSIYKSGLKNDFQDWSWGEHSLTDTTNVESGETNSISFTPKAYGAVFLGCFECIDTDTYNNIEFDINGGSSGAQLLRITVVKNSKSVGSKLITDLNGGTPIEANSWTKIKASFIDDFKVSGKVDGIWIQDIKGDTQSTVYISNIIATA", "length": 705, "header": "sp|P22699-1|GUN6_DICDI Isoform 1 of Endoglucanase OS=Dictyostelium discoideum OX=44689 GN=celA PE=1 SV=1 CANONICAL=P22699-1" }, "isoforms": [ { "isoform_ac": "P22699-1", "url": "", "sequence": { "sequence": "MKILKNCILLIIFGLLSTQLINADTDYCSLLENALMFYKMNRAGRLPDNDIPWRGNSALNDASPNSAKDANGDGNLSGGYFDAGDGVKFGLPMAYSMTMLGWSFIEYESNIAQCGLTSLYLDTIKYGTDWLIAAHTADNEFAGQVGDGNVDHSWWGPPEDMTMARPTYMLTTEAPGTEIAMEAASALAAASIAFKSSNPTYAATCLAHAKTLHNFGYTYRGVYSDSITNAQAFYNSWSGYKDDLVWGSIWLYKATQDSDYLTKAVADYASGGVGGMAQGNSHDWDNKAPGCCLLLSKLVPTTSTYKTDFEGWLNYWLPGGGVTYTPGGLAWIRQWGPARYAATAAFLGSLAGTEKGTDFTQKQVDYLIGNNPNQQSFVVGMGPNYPINPHHRAAHHSTTNDINNPVNNLYLLKGALVGGPGSNDEYTDDRTDYISNEVATDYNAGFVGALASLVNPSSTSVPTTTPTVTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETPTETVTPTPTVTPTETPSSGESLSIYKSGLKNDFQDWSWGEHSLTDTTNVESGETNSISFTPKAYGAVFLGCFECIDTDTYNNIEFDINGGSSGAQLLRITVVKNSKSVGSKLITDLNGGTPIEANSWTKIKASFIDDFKVSGKVDGIWIQDIKGDTQSTVYISNIIATA", "length": 705, "header": "sp|P22699-1|GUN6_DICDI Isoform 1 of Endoglucanase OS=Dictyostelium discoideum OX=44689 GN=celA PE=1 SV=1 CANONICAL=P22699-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 75, "start_aa": "Asn", "end_pos": 75, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn75", "evidence": [ { "id": "P22699", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22699#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycohydrolase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gloeckner G., Kumpf K., Lehmann R., Platzer M., Rosenthal A., Bankier A.T., Dear P.H., Szafranski K., Guigo R., Parra G., Noegel A.A., Glockner G., Tunggal B., Abril J.F., Cox E., Eichinger L., Quail M.A., Cox E.C., Baumgart C., Pachebat J.A.", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "A Dictyostelium discoideum cellulase is a member of a spore germination-specific gene family.", "journal": "J. Biol. Chem.", "date": "1991", "authors": "Blume J.E., Ennis H.L.", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "reference": [ { "type": "PubMed", "id": "1869562", "url": "https://glygen.org/publication/PubMed/1869562" } ] }, { "title": "A shared internal threonine-glutamic acid-threonine-proline repeat defines a family of Dictyostelium discoideum spore germination specific proteins.", "journal": "Biochemistry", "date": "1990", "authors": "Giorda R., Shaw D.R., Ennis H.L., Ohmachi T.", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "reference": [ { "type": "PubMed", "id": "1976383", "url": "https://glygen.org/publication/PubMed/1976383" } ] } ], "pathway": [ { "id": "ddi:DDB_G0271134", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0271134", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spore germination", "id": "GO:0009847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009847", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" }, { "name": "sporulation resulting in formation of a cellular spore", "id": "GO:0030435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030435", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" }, { "name": "cellulose catabolic process", "id": "GO:0030245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030245", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cellulase activity", "id": "GO:0008810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008810", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" }, { "name": "cellulose binding", "id": "GO:0030248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030248", "evidence": [ { "database": "UniProtKB", "id": "P22699", "url": "https://www.uniprot.org/uniprot/P22699" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }