{ "uniprot_canonical_ac": "P21810-1", "uniprot_ac": "P21810", "uniprot_id": "PGS1_HUMAN", "mass": { "chemical_mass": 41654.0, "monoisotopic_mass": 41654.0 }, "refseq": { "ac": "NP_001702", "name": "biglycan preproprotein", "summary": "This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" }, "gene_names": [ { "name": "BGN", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P21810", "id": "P21810" }, { "name": "BGN", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702", "id": "NP_001702" }, { "name": "DSPG1; MRLS; PG-S1; PGI; SEMDX; SLRR1A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702", "id": "NP_001702" }, { "name": "SLRR1A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P21810", "id": "P21810" } ], "protein_names": [ { "name": "Biglycan", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P21810" }, { "name": "Bone/cartilage proteoglycan I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P21810" }, { "name": "PG-S1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P21810" }, { "name": "biglycan preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702", "id": "NP_001702" }, { "name": "small leucine-rich protein 1A; dermatan sulphate proteoglycan I; bone/cartilage proteoglycan-I", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702", "id": "NP_001702" } ], "function": [ { "annotation": "Biglycan promotes hepatic fibrosis through activating heat shock protein 47.", "evidence": [ { "database": "RefSeq", "id": "NP_001702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" }, { "database": "PubMed", "id": "36371672", "url": "https://glygen.org/publication/PubMed/36371672" } ] }, { "annotation": "Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_001702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" }, { "database": "PubMed", "id": "36377223", "url": "https://glygen.org/publication/PubMed/36377223" } ] }, { "annotation": "Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis.", "evidence": [ { "database": "RefSeq", "id": "NP_001702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" }, { "database": "PubMed", "id": "37128782", "url": "https://glygen.org/publication/PubMed/37128782" } ] }, { "annotation": "May be involved in collagen fiber assembly.", "evidence": [ { "database": "UniProtKB", "id": "C9JKG1", "url": "https://www.uniprot.org/uniprot/C9JKG1#function" }, { "database": "UniProtKB", "id": "RU364096", "url": "https://www.uniprot.org/uniprot/RU364096#function" }, { "database": "UniProtKB", "id": "P21810", "url": "https://www.uniprot.org/uniprot/P21810#function" } ] }, { "annotation": "Stroma biglycan expression can be a prognostic factor in prostate cancers.", "evidence": [ { "database": "RefSeq", "id": "NP_001702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" }, { "database": "PubMed", "id": "36305810", "url": "https://glygen.org/publication/PubMed/36305810" } ] }, { "annotation": "This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001702" } ] } ], "disease": [ { "disease_id": "DOID:0111861", "recommended_name": { "id": "DOID:0111861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111861", "name": "Meester-Loeys syndrome", "description": "A syndrome characterized by early-onset aortic aneurysm and dissection in hemizygous males and variable presentation from unaffected to fatal aortic dissection in heterozygous females, as well as facial dysmorphism, connective tissue anomalies, and features of Loeys-Dietz syndrome that has_material_basis_in mutation in BGN on chromosome Xq28." }, "synonyms": [ { "id": "DOID:0111861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111861", "name": "MRLS", "description": "" }, { "id": "MONDO:0010515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010515", "name": "Meester-Loeys syndrome", "description": "" }, { "id": "MONDO:0010515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010515", "name": "MRLS", "description": "" }, { "id": "MONDO:0010515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010515", "name": "Meester-Loeys syndrome", "description": "" }, { "id": "MONDO:0010515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010515", "name": "Meester-Loeys syndrome; 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P21810", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P21810" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P21810", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P21810" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P21810" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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Dimerization and functional activity are mediated by two crucial cysteine residues.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Ouzzine M, Gulberti S, Netter P, Magdalou J, Fournel-Gigleux S", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "10842173", "url": "https://glygen.org/publication/PubMed/10842173" } ] }, { "title": "Comparative genome sequence analysis of the Bpa/Str region in mouse and man.", "journal": "Genome Res.", "date": "2000", "authors": "Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD", "evidence": [ { 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"journal": "The Journal of biological chemistry", "date": "1997", "authors": "Ehnis T, Dieterich W, Bauer M, Kresse H, Schuppan D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9252349", "url": "https://glygen.org/publication/PubMed/9252349" } ] }, { "title": "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegard D, Schachner M, Ruoslahti E, Yamaguchi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9294172", "url": "https://glygen.org/publication/PubMed/9294172" } ] }, { "title": "Mapping of a defined neurocan binding site to distinct domains of tenascin-C.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Rauch U, Clement A, Retzler C, Frohlich L, Fassler R, Gohring W, Faissner A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9341124", "url": "https://glygen.org/publication/PubMed/9341124" } ] }, { "title": "Identification of hyaluronan-binding domains of aggrecan.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Watanabe H, Cheung SC, Itano N, Kimata K, Yamada Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9346959", "url": "https://glygen.org/publication/PubMed/9346959" } ] }, { "title": "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "9506957", "url": "https://glygen.org/publication/PubMed/9506957" } ] }, { "title": "Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.", "journal": "Biochemistry", "date": "1998", "authors": "Lukatela G, Krauss N, Theis K, Selmer T, Gieselmann V, von Figura K, Saenger W", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024101", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024101" } ], "reference": [ { "type": "PubMed", "id": "9521684", "url": "https://glygen.org/publication/PubMed/9521684" } ] }, { "title": "Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Rosenberg K, Olsson H, Morgelin M, Heinegard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9685393", "url": "https://glygen.org/publication/PubMed/9685393" } ] }, { "title": "A new multiple congenital anomaly, mental retardation syndrome with preaxial brachydactyly, hyperphalangism, deafness and orodental anomalies.", "journal": "Clinical dysmorphology", "date": "1998", "authors": "Temtamy SA, Meguid NA, Ismail SI, Ramzy MI", "evidence": [ { "database": "Reactome", "id": "R-HSA-3595177", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3595177" } ], "reference": [ { "type": "PubMed", "id": "9823490", "url": "https://glygen.org/publication/PubMed/9823490" } ] }, { "title": "Functional expression and genomic structure of human chondroitin 6-sulfotransferase.", "journal": "FEBS letters", "date": "1998", "authors": "Tsutsumi K, Shimakawa H, Kitagawa H, Sugahara K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022870", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022870" } ], "reference": [ { "type": "PubMed", "id": "9883891", "url": "https://glygen.org/publication/PubMed/9883891" } ] }, { "title": "A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "9892646", "url": "https://glygen.org/publication/PubMed/9892646" } ] }, { "title": "Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism.", "journal": "Glycobiology", "date": "1999", "authors": "Probstmeier R, Pesheva P", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9949188", "url": "https://glygen.org/publication/PubMed/9949188" } ] } ], "pathway": [ { "id": "hsa:633", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:633", "resource": "KEGG Pathway" }, { "id": "R-HSA-1971475", "name": "A tetrasaccharide linker sequence is 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constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "P21810", "url": "https://www.uniprot.org/uniprot/P21810" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent conferring compression resistance", "id": "GO:0030021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030021", "evidence": [ { "database": "UniProtKB", "id": "P21810", "url": "https://www.uniprot.org/uniprot/P21810" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "biglycan N-glycosylated 1 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G05933EN. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G05933EN. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056121", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056121" } ] }, { "name": "biglycan N-glycosylated 2 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G09197ZW. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G09197ZW. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056122", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056122" } ] }, { "name": "biglycan N-glycosylated 3 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G16175ZV. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G16175ZV. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056123", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056123" } ] }, { "name": "biglycan N-glycosylated 4 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G19379ID. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G19379ID. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056124", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056124" } ] }, { "name": "biglycan N-glycosylated 5 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G22018FP. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G22018FP. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056125", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056125" } ] }, { "name": "biglycan N-glycosylated 6 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G27126ED. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G27126ED. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056126", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056126" } ] }, { "name": "biglycan N-glycosylated 7 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G40664HB. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G40664HB. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056127", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056127" } ] }, { "name": "biglycan N-glycosylated 8 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G41126SR. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G41126SR. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056128", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056128" } ] }, { "name": "biglycan N-glycosylated 9 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G44211QA. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G44211QA. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056129", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056129" } ] }, { "name": "biglycan N-glycosylated 10 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G50073PQ. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G50073PQ. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056130", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056130" } ] }, { "name": "biglycan N-glycosylated 11 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G58001LT. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056131", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056131" } ] }, { "name": "biglycan N-glycosylated 12 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G58802FE. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G58802FE. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056132", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056132" } ] }, { "name": "biglycan N-glycosylated 13 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G60923RB. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056133", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056133" } ] }, { "name": "biglycan N-glycosylated 14 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G62595EF. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G62595EF. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056134", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056134" } ] }, { "name": "biglycan N-glycosylated 15 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G69107AL. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G69107AL. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056135", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056135" } ] }, { "name": "biglycan N-glycosylated 16 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G84492TS. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G84492TS. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056136", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056136" } ] }, { "name": "biglycan N-glycosylated 17 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-270 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G87051GH. Example: UniProtKB:P21810-1, Asn-270, MOD:00160~GNO:G87051GH. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056137", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056137" } ] }, { "name": "biglycan N-glycosylated 18 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G16175ZV. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G16175ZV. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056138", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056138" } ] }, { "name": "biglycan N-glycosylated 19 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G43669FQ. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G43669FQ. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056139", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056139" } ] }, { "name": "biglycan N-glycosylated 20 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G58001LT. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056140", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056140" } ] }, { "name": "biglycan N-glycosylated 21 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G58802FE. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G58802FE. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056141", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056141" } ] }, { "name": "biglycan N-glycosylated 22 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G62595EF. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G62595EF. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056142", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056142" } ] }, { "name": "biglycan N-glycosylated 23 (human)", "definition": "A biglycan (human) that has been N-glycosylated at the residue equivalent to Asn-311 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G85740DB. Example: UniProtKB:P21810-1, Asn-311, MOD:00160~GNO:G85740DB. [PRO:DNx, PMID:29741879]", "evidence": [ { "id": "PR:000056143", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056143" } ] }, { "name": "biglycan O-glycosylated 1 (human)", "definition": "A biglycan (human) that has been O-glycosylated at the residue equivalent to Thr-56 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P21810-1, Thr-56, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000056144", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056144" } ] }, { "name": "biglycan O-glycosylated 2 (human)", "definition": "A biglycan (human) that has been O-glycosylated at the residue equivalent to Thr-58 of the amino acid sequence represented by UniProtKB:P21810-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P21810-1, Thr-58, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000056145", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000056145" } ] } ], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 171 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 108 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 6 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 165 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 108 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 121 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }