{ "uniprot_canonical_ac": "P21623-1", "uniprot_ac": "P21623", "uniprot_id": "DIT1_YEAST", "mass": { "chemical_mass": 61391.0, "monoisotopic_mass": 61391.0 }, "refseq": { "ac": "NP_010691", "name": "Dit1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010691" }, "gene_names": [ { "name": "DIT1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P21623", "id": "P21623" }, { "name": "D9509.21", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P21623", "id": "P21623" }, { "name": "DIT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010691", "id": "NP_010691" } ], "protein_names": [ { "name": "Spore wall maturation protein DIT1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P21623" }, { "name": "Dit1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010691", "id": "NP_010691" } ], "function": [ { "annotation": "Involved in spore wall maturation. Catalyzes a two step reaction that leads to the LL-dityrosine containing precursor of the spore wall.", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "common_name": "Yeast" } ], "gene": [ { "name": "DIT1", "url": "https://www.uniprot.org/uniprot/P21623", "locus": {} } ], "crossref": [ { "id": "852012", "url": "https://www.ncbi.nlm.nih.gov/gene/852012", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P21623", "url": "https://www.ebi.ac.uk/intact/interactors/id:P21623*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR007817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YDR403W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR403W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VAFEMIK", "url": "https://omabrowser.org/oma/group/VAFEMIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1591446at2759", "url": "http://www.orthodb.org/?query=1591446at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37285:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37285:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05141", "url": "http://pfam.xfam.org/family/PF05141", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P21623", "url": "http://purl.obolibrary.org/obo/PR_P21623", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_010691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010691", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000002811", "url": "https://www.yeastgenome.org/locus/S000002811", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P21623-1", "url": "https://www.uniprot.org/uniprot/P21623-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTFTSNLPSSSEQSISPPASSFSSSTDTLKDIDIPHNGADLSTYSKFLALYCRSDKCDDFYSLEEKQNCKFGDQWLDFINTIHNLDFSESEVSGRVSERILPASLANKFTNNLGVAIKISEYTRDDERQIRGCVTTVENENSFNNWFVYHILDQSQLSLSEHPIVTKEVKYHELFADFFEKNLKNTIVNDQWNFGGRDYFIERSRYFTDRYLRIECILPAFPCKSSNEQKVYGSVPDKGEELALKRLIKATQDLVKIYPPGMKIWIVSDGHVFSDCIGVDDDVVSTYTTKLHELYKRVAIPGVDAIGFCGLNDLFFSGAASKVFDPKWVSDVEVAHYTGTQICPKSDLSRQILMKGCDTDAGRLRKQIAIEGHPRLHLYRGFSRFMMEDLSLLEHFQSYSRKKFKKIISMIAFNMIKRNDAYSNLVELIFPHHLRISIHAHTNSGPKFGIKVISNEQCSIVSSLEDLDEPKFEDFLHIPTPWHNCVVKVEDEKEKYFLTKSKVVKEALEKGMYDGVWKDTRFDIGEGGHFVIKKIS", "length": 536, "header": "sp|P21623-1|DIT1_YEAST Isoform 1 of Spore wall maturation protein DIT1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=DIT1 PE=1 SV=2 CANONICAL=P21623-1" }, "isoforms": [ { "isoform_ac": "P21623-1", "url": "", "sequence": { "sequence": "MTFTSNLPSSSEQSISPPASSFSSSTDTLKDIDIPHNGADLSTYSKFLALYCRSDKCDDFYSLEEKQNCKFGDQWLDFINTIHNLDFSESEVSGRVSERILPASLANKFTNNLGVAIKISEYTRDDERQIRGCVTTVENENSFNNWFVYHILDQSQLSLSEHPIVTKEVKYHELFADFFEKNLKNTIVNDQWNFGGRDYFIERSRYFTDRYLRIECILPAFPCKSSNEQKVYGSVPDKGEELALKRLIKATQDLVKIYPPGMKIWIVSDGHVFSDCIGVDDDVVSTYTTKLHELYKRVAIPGVDAIGFCGLNDLFFSGAASKVFDPKWVSDVEVAHYTGTQICPKSDLSRQILMKGCDTDAGRLRKQIAIEGHPRLHLYRGFSRFMMEDLSLLEHFQSYSRKKFKKIISMIAFNMIKRNDAYSNLVELIFPHHLRISIHAHTNSGPKFGIKVISNEQCSIVSSLEDLDEPKFEDFLHIPTPWHNCVVKVEDEKEKYFLTKSKVVKEALEKGMYDGVWKDTRFDIGEGGHFVIKKIS", "length": 536, "header": "sp|P21623-1|DIT1_YEAST Isoform 1 of Spore wall maturation protein DIT1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=DIT1 PE=1 SV=2 CANONICAL=P21623-1" }, "locus": { "chromosome": "IV", "start_pos": 1276209, "end_pos": 1274602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YDR403W_mRNA", "url": "https://www.ensembl.org/id/YDR403W_mRNA" }, { "database": "Ensembl Peptide", "id": "YDR403W", "url": "https://www.ensembl.org/id/YDR403W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Isolation of two developmentally regulated genes involved in spore wall maturation in Saccharomyces cerevisiae.", "journal": "Genes Dev.", "date": "1990", "authors": "Breitenbach M., Ellinger A., Briza P., Segall J.", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "reference": [ { "type": "PubMed", "id": "2249774", "url": "https://glygen.org/publication/PubMed/2249774" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1994", "authors": "Breitenbach M., Briza P., Eckerstorfer M.", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "reference": [ { "type": "PubMed", "id": "8183942", "url": "https://glygen.org/publication/PubMed/8183942" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.", "journal": "Nature", "date": "1997", "authors": "Andrews S., Bahr A., Bloecker H., Brandt P., Connor R., Du Z., Fulton L., Gentles S., Hawkins J., Hillier L.W., Johnson D., Latreille P., Mardis E., Mewes H.-W., Miller N., Niblett D., Oliver K., Schaefer M., Scharfe M., Vaudin M., Wambutt R., Waterston R., Wedler H., Wilson R., Chen E., Le T., Verhasselt P., Bowman S., Hunt S., Wagner G., Chung E., Nakahara K., Botstein D., Brueckner M., Davis R.W., Lin D., Hankeln T., Schneider C., Schmidt E.R., Duncan M., Favello A., Kucaba T., Rifkin L., Trevaskis E., Wohldman P., Barrell B.G., Rieger M., Berno A., Schroeder M., Ding H., Oh C., Oefner P., Schwarz S., Woelfl S., Kleine K., Becker A., Prydz H., Cooper J., Arnold W., Eide L.G., Kraemer C., Lashkari D., Allen E., Jimenez A., Kuester H., Hoheisel J.D., Pauley A., Paulin L., Brown D., Jaeger W., Volckaert G., Hyman R.W., Andre B., Perez-Alonso M., Araujo R., Komp C., Lew H., Namath A., Roberts D., Paricio N., Boskovic J., Louis E.J., Mulligan J.T., Delaveau T., Greco T., Johnston L., Nhan M., Jones L., Odell C., Menezes S., Johnston M., Pohl T.M., Harris D.E., Schramm S., McDonald S., Salom D., Bargues M., Cherry J.M., Ballesta J.P.G., Churcher C.M., Dedman K., Dietrich F.S., Dujon B., Goffeau A., Hamlin N., Hani J., Jacq C., Mueller-Auer S., Perea J., Perez-Ortin J.E., Rajandream M.A., Remacha M.A., Revuelta J.L., Vissers S., Walsh S.V., Zollner A., del Rey F., Jonniaux J.-L., Purnelle B., Saiz J.E., Urrestarazu L.A., Voet M., Wilcox L., Albermann K., Alt-Moerbe J., Aviles E., Baron L., Biteau N., Blugeon C., Brinkman R., Buitrago M.J., Carpenter J., Coster F., Garcia-Cantalejo J.M., Gattung S., Gomez-Peris A., Granotier C., Hallsworth K., Hanemann V., Heumann K., Hunicke-Smith S., Jier M., Kirsten J., Laamanen P., Langston Y., Legros Y., Moeller-Rieker S., Monnet A., Moro M., Mosedale D., Murphy L.D., Nussbaumer B., Peluso D., Petel F.X., Rasmussen S.W., Richards C., Riles L., Saluz H.P., Saren A.-M., Scholler P., Shogren T., Shore L., Shroff N., Soler-Mira A., Taich A., Vignati D., Wedler E., Winant A., Yelton M.A., Zaccaria P.", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "reference": [ { "type": "PubMed", "id": "9169867", "url": "https://glygen.org/publication/PubMed/9169867" } ] } ], "pathway": [ { "id": "sce:YDR403W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR403W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ascospore wall assembly", "id": "GO:0030476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030476", "evidence": [ { "database": "UniProtKB", "id": "P21623", "url": "https://www.uniprot.org/uniprot/P21623" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }