{ "uniprot_canonical_ac": "P21520-1", "uniprot_ac": "P21520", "uniprot_id": "SCA_DROME", "mass": { "chemical_mass": 90119.0, "monoisotopic_mass": 90119.0 }, "refseq": { "ac": "NP_476710", "name": "scabrous, isoform A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476710" }, "gene_names": [ { "name": "sca", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P21520", "id": "P21520" }, { "name": "AAA28880; AAF58455; anon-EST:Liang-38; CG17579; clone 38; Dmel\\CG17579; FBpp0086968; FBpp0086969; mAb sca1; Sca; Sca1b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476710", "id": "NP_476710" }, { "name": "CG17579", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P21520", "id": "P21520" }, { "name": "sca", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476710", "id": "NP_476710" } ], "protein_names": [ { "name": "Protein scabrous", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P21520" }, { "name": "CG17579-PA; sca-PA; scabrous; Fibrinogen-related protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476710", "id": "NP_476710" }, { "name": "scabrous, isoform A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476710", "id": "NP_476710" } ], "function": [ { "annotation": "Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520#function" }, { "database": "PubMed", "id": "2175046", "url": "https://glygen.org/publication/PubMed/2175046" }, { "database": "PubMed", "id": "12756167", "url": "https://glygen.org/publication/PubMed/12756167" } ] } ], "disease": [ { "disease_id": "DOID:0050580", "recommended_name": { "id": "DOID:0050580", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050580", "name": "hereditary lymphedema", "description": "A lymphedema commonly located_in legs, caused_by congenital abnormalities in the lymphatic system." }, "synonyms": [ { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "lymphatic malformation 1", "description": "Any hereditary lymphedema in which the cause of the disease is a mutation in the FLT4 gene." }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "FLT4 hereditary lymphedema", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "LMPH1A", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "Milroy disease", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "Nonne-Milroy disease", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "Nonne-Milroy lymphedema", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "Nonne-Milroy syndrome", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "Nonnes syndrome", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "congenital hereditary lymphedema", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "congenital primary lymphedema", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "early onset lymphedema", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "hereditary lymphedema 1", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "hereditary lymphedema caused by mutation in FLT4", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "hereditary lymphedema type I", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "lymphedema, early-onset", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "lymphedema, hereditary, 1A", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "lymphedema, hereditary, type 1A", "description": "" }, { "id": "MONDO:0007919", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007919", "name": "primary congenital lymphedema", "description": "" }, { "id": "MIM:153100", "resource": "MIM", "url": "https://www.omim.org/entry/153100", "name": "Lymphatic malformation 1", "description": "Lymphatic malformation 1" } ], "evidence": [ { "id": "0050580", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050580" } ] }, { "disease_id": "DOID:0080600", "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan coronavirus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan seafood market pneumonia virus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" } ], "evidence": [ { "id": "0080600", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080600" } ] }, { "disease_id": "DOID:0111061", "recommended_name": { "id": "DOID:0111061", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111061", "name": "familial hypobetalipoproteinemia 2", "description": "A hypobetalipoproteinemia that has_material_basis_in homozygous or compound heterozygous mutation in the ANGPTL3 gene on chromosome 1p31." }, "synonyms": [ { "id": "DOID:0111061", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111061", "name": "FHBL2", "description": "" }, { "id": "DOID:0111061", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111061", "name": "combined familial hypolipidemia", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "familial hypobetalipoproteinemia 2", "description": "Any hypobetalipoproteinemia in which the cause of the disease is a mutation in the ANGPTL3 gene." }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "ANGPTL3 hypobetalipoproteinemia", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "FHBL2", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "combined familial hypolipidemia", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "familial hypobetalipoproteinemia 2", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "familial hypobetalipoproteinemia type 2", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "hypobetalipoproteinemia caused by mutation in ANGPTL3", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "hypobetalipoproteinemia, familial, type 2", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "hypobetalipoproteinemia, familial, 2", "description": "" }, { "id": "MONDO:0011505", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011505", "name": "hypolipidemia, familial, combined", "description": "" }, { "id": "MIM:605019", "resource": "MIM", "url": "https://www.omim.org/entry/605019", "name": "Hypobetalipoproteinemia, familial, 2", "description": "Hypobetalipoproteinemia, familial, 2" } ], "evidence": [ { "id": "0111061", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111061" } ] }, { "disease_id": "DOID:10286", "recommended_name": { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "prostate carcinoma", "description": "A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "cancer of prostate", "description": "" }, { "id": "DOID:10286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10286", "name": "carcinoma of prostate", "description": "" } ], "evidence": [ { "id": "10286", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10286" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:11714", "recommended_name": { "id": "DOID:11714", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11714", "name": "gestational diabetes", "description": "A diabetes mellitus that manifests during pregnancy." }, "synonyms": [ { "id": "DOID:11714", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11714", "name": "GDM", "description": "" }, { "id": "DOID:11714", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11714", "name": "Gestational diabetes mellitus", "description": "" }, { "id": "DOID:11714", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11714", "name": "Maternal gestational diabetes mellitus", "description": "" } ], "evidence": [ { "id": "11714", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11714" } ] }, { "disease_id": "DOID:14735", "recommended_name": { "id": "DOID:14735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14735", "name": "hereditary angioedema", "description": "An angioedema that is characterized by recurrent episodes of severe swelling of the skin and mucous membranes." }, "synonyms": [ { "id": "DOID:14735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14735", "name": "HANE", "description": "" }, { "id": "DOID:14735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14735", "name": "Hereditary angioneurotic edema", "description": "" } ], "evidence": [ { "id": "14735", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14735" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "evidence": [ { "id": "1574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "evidence": [ { "id": "2394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:2671", "recommended_name": { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells." }, "synonyms": [ { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional carcinoma", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell tumor", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "urothelial cell carcinoma", "description": "" } ], "evidence": [ { "id": "2671", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ] }, { "disease_id": "DOID:2870", "recommended_name": { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial adenocarcinoma", "description": "An endometrial carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial endometrioid adenocarcinoma with squamous differentiation", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "adenocarcinoma of endometrium", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "adenocarcinoma of the Endometrium", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": 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] }, { "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P21520-1", "url": "https://www.uniprot.org/uniprot/P21520-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDWQTFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLRRREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFVSVSGSAADAAPSSGATTTTTTATAAPATVTTPKTNNSVVQFVAAGQA", "length": 799, "header": "sp|P21520-1|SCA_DROME Isoform 1 of Protein scabrous OS=Drosophila melanogaster OX=7227 GN=sca PE=2 SV=3 CANONICAL=P21520-1" }, "isoforms": [ { "isoform_ac": "P21520-1", "url": "", "sequence": { "sequence": "MRDWQTFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLRRREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLVDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHALVKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANAQITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQRHPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFVSVSGSAADAAPSSGATTTTTTATAAPATVTTPKTNNSVVQFVAAGQA", "length": 799, "header": "sp|P21520-1|SCA_DROME Isoform 1 of Protein scabrous OS=Drosophila melanogaster OX=7227 GN=sca PE=2 SV=3 CANONICAL=P21520-1" }, "locus": { "chromosome": "2R", "start_pos": 12800933, "end_pos": 12780863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0087855", "url": "https://www.ensembl.org/id/FBtr0087855" }, { "database": "Ensembl Peptide", "id": "FBpp0086968", "url": "https://www.ensembl.org/id/FBpp0086968" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 372, "start_aa": "Asn", "end_pos": 372, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn372", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 587, "start_aa": "Asn", "end_pos": 587, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn587", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 618, "start_aa": "Asn", "end_pos": 618, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn618", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 660, "start_aa": "Asn", "end_pos": 660, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn660", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 744, "start_aa": "Asn", "end_pos": 744, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn744", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 787, "start_aa": "Asn", "end_pos": 787, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn787", "evidence": [ { "id": "P21520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21520#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Scabrous and Gp150 are endosomal proteins that regulate Notch activity.", "journal": "Development", "date": "2003", "authors": "Li Y., Lai Z.C., Baker N.E., Fetchko M.", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "reference": [ { "type": "PubMed", "id": "12756167", "url": "https://glygen.org/publication/PubMed/12756167" } ] }, { "title": "Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.", "journal": "Science", "date": "1990", "authors": "Rubin G.M., Mlodzik M., Baker N.E.", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "reference": [ { "type": "PubMed", "id": "2175046", "url": "https://glygen.org/publication/PubMed/2175046" } ] } ], "pathway": [ { "id": "dme:Dmel_CG17579", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG17579", "resource": "KEGG Pathway" }, { "id": "R-DME-381426", "name": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-DME-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DME-8957275", "name": "Post-translational protein phosphorylation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "response to alcohol", "id": "GO:0097305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097305", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "compound eye development", "id": "GO:0048749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048749", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "chaeta morphogenesis", "id": "GO:0008407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008407", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "imaginal disc-derived wing margin morphogenesis", "id": "GO:0008587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008587", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "ommatidial rotation", "id": "GO:0016318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016318", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "P21520", "url": "https://www.uniprot.org/uniprot/P21520" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": 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