{ "uniprot_canonical_ac": "P20239-1", "uniprot_ac": "P20239", "uniprot_id": "ZP2_MOUSE", "mass": { "chemical_mass": 80210.0, "monoisotopic_mass": 80210.0 }, "refseq": { "ac": "NP_035905", "name": "zona pellucida sperm-binding protein 2 isoform 1 preproprotein", "summary": "This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" }, "gene_names": [ { "name": "Zp2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P20239", "id": "P20239" }, { "name": "Zp-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "id": "NP_035905" }, { "name": "Zp-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P20239", "id": "P20239" }, { "name": "Zp2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "id": "NP_035905" }, { "name": "Zpa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P20239", "id": "P20239" } ], "protein_names": [ { "name": "Zona pellucida sperm-binding protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P20239" }, { "name": "Zona pellucida glycoprotein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P20239" }, { "name": "Zona pellucida protein A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P20239" }, { "name": "Zp-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P20239" }, { "name": "zona pellucida sperm-binding protein 2 isoform 1 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "id": "NP_035905" }, { "name": "zona pellucida sperm-binding protein 2; zona pellucida protein A; zona pellucida glycoprotein ZP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "id": "NP_035905" } ], "function": [ { "annotation": "Characterization of native mouse zona pellucida proteins by mass spectrometry", "evidence": [ { "database": "RefSeq", "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" }, { "database": "PubMed", "id": "12799386", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "annotation": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239#function" }, { "database": "PubMed", "id": "22472438", "url": "https://glygen.org/publication/PubMed/22472438" } ] }, { "annotation": "Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.", "evidence": [ { "database": "RefSeq", "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" }, { "database": "PubMed", "id": "35211729", "url": "https://glygen.org/publication/PubMed/35211729" } ] }, { "annotation": "This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 634, "end_pos": 635, "sequence_org": "KR", "sequence_mut": "NA", "comment": "Abolishes proteolytic cleavage of the propeptide.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "PubMed", "id": "26811476", "url": "https://glygen.org/publication/PubMed/26811476" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Zp2", "url": "https://www.uniprot.org/uniprot/P20239", "locus": { "chromosome": "7", "start_pos": 119725995, "end_pos": 119744514, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000030911", "url": "https://www.ensembl.org/id/ENSMUSG00000030911" } ] } } ], "crossref": [ { "id": "ENSMUSG00000030911", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030911", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "22787", "url": "https://www.ncbi.nlm.nih.gov/gene/22787", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "630", "url": "https://glyconnect.expasy.org/browser/proteins/630", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "IPR001507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:22787", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22787", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "99214", "url": "http://www.informatics.jax.org/marker/MGI:99214", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RPYGDKE", "url": "https://omabrowser.org/oma/group/RPYGDKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4589644at2759", "url": "http://www.orthodb.org/?query=4589644at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23343:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23343:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5BUP", "url": "https://www.rcsb.org/structure/5BUP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5II6", "url": "https://www.rcsb.org/structure/5II6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00100", "url": "http://pfam.xfam.org/family/PF00100", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P20239", "url": "http://purl.obolibrary.org/obo/PR_P20239", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2534343", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2534343", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140LIR5", "url": "https://www.uniprot.org/uniprot/A0A140LIR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140LIR5-1", "url": "https://www.uniprot.org/uniprot/A0A140LIR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P20239-1", "url": "https://www.uniprot.org/uniprot/P20239-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UX44", "url": "https://www.uniprot.org/uniprot/Q3UX44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3UX44-1", "url": "https://www.uniprot.org/uniprot/Q3UX44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNYRTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCSVTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKGVDPSSSEITKDIIAKDIASKTLGAVAALVGSAVILGFICYLYKKRTIRFNH", "length": 713, "header": "sp|P20239-1|ZP2_MOUSE Isoform 1 of Zona pellucida sperm-binding protein 2 OS=Mus musculus OX=10090 GN=Zp2 PE=1 SV=1 CANONICAL=P20239-1" }, "isoforms": [ { "isoform_ac": "A0A140LIR5-1", "url": "", "sequence": { "sequence": "MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKVSSNLW", "length": 428, "header": "tr|A0A140LIR5-1|A0A140LIR5_MOUSE Computationally mapped isoform of Zona pellucida glycoprotein 2 OS=Mus musculus OX=10090 GN=Zp2 PE=1 SV=1 CANONICAL=P20239-1" }, "locus": { "chromosome": "7", "start_pos": 119744483, "end_pos": 119735088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000207726.2", "url": "https://www.ensembl.org/id/ENSMUST00000207726.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146926.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146926.2" } ] } }, { "isoform_ac": "P20239-1", "url": "", "sequence": { "sequence": "MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNYRTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCSVTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKGVDPSSSEITKDIIAKDIASKTLGAVAALVGSAVILGFICYLYKKRTIRFNH", "length": 713, "header": "sp|P20239-1|ZP2_MOUSE Isoform 1 of Zona pellucida sperm-binding protein 2 OS=Mus musculus OX=10090 GN=Zp2 PE=1 SV=1 CANONICAL=P20239-1" }, "locus": { "chromosome": "7", "start_pos": 119744483, "end_pos": 119731615, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000033207", "url": "https://www.ensembl.org/id/ENSMUST00000033207" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000033207", "url": "https://www.ensembl.org/id/ENSMUSP00000033207" } ] } }, { "isoform_ac": "Q3UX44-1", "url": "", "sequence": { "sequence": "MARWQRKASVSSPCGRSIYRFLSLLFTLVTSVNSVSLPQSENPAFPGTLICDKDEVRIEFSSRFDMEKWNPSVVDTLGSEILNCTYALDLERFVLKFPYETCTIKVVGGYQVNIRVGDTTTDVRYKDDMYHFFCPAIQAETHEISEIVVCRRDLISFSFPQLFSRLADENQNVSEMGWIVKIGNGTRAHILPLKDAIVQGFNLLIDSQKVTLHVPANATGIVHYVQESSYLYTVQLELLFSTTGQKIVFSSHAICAPDLSVACNATHMTLTIPEFPGKLESVDFGQWSIPEDQWHANGIDKEATNGLRLNFRKSLLKTKPSEKCPFYQFYLSSLKLTFYFQGNMLSTVIDPECHCESPVSIDELCAQDGFMDFEVYSHQTKPALNLDTLLVGNSSCQPIFKVQSVGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIVFRNSEFRMTVRCYYIRDSMLLNAHVKGHPSPEAFVKPGPLVLVLQTYPDQSYQRPYRKDEYPLVRYLRQPIYMEVKVLSRNDPNIKLVLDDCWATSSEDPASAPQWQIVMDGCEYELDNYRTTFHPAGSSAAHSGHYQRFDVKTFAFVSEARGLSSLIYFHCSALICNQVSLDSPLCSVTCPASLRSKREANKEDTMTVSLPGPILLLSDVSSSKDANEVCFPWCCGTFF", "length": 676, "header": "tr|Q3UX44-1|ZP2_MOUSE Computationally mapped isoform of Zona pellucida sperm-binding protein 2 OS=Mus musculus OX=10090 GN=Zp2 PE=1 SV=1 CANONICAL=P20239-1" }, "locus": { "chromosome": "7", "start_pos": 119744483, "end_pos": 119726171, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208874.2", "url": "https://www.ensembl.org/id/ENSMUST00000208874.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147097.2", "url": "https://www.ensembl.org/id/ENSMUSP00000147097.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 172, "start_aa": "Asn", "end_pos": 172, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn172", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 217, "start_aa": "Asn", "end_pos": 217, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn217", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 264, "start_aa": "Asn", "end_pos": 264, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn264", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 393, "start_aa": "Asn", "end_pos": 393, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn393", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "predicted", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 455, "start_aa": "Thr", "end_pos": 455, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr455", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 83, "start_aa": "Asn", "end_pos": 83, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn83", "evidence": [ { "id": "P20239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "id": "12799386", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "glytoucan_ac": "G00031MO", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "630", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/630" }, { "id": "14673092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14673092" } ] }, { "glytoucan_ac": "G00033MO", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "630", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/630" }, { "id": "14673092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14673092" } ] }, { "glytoucan_ac": "G02368JK", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "630", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/630" }, { "id": "14673092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14673092" } ] }, { "glytoucan_ac": "G02397SF", "type": "N-linked", "subtype": "", 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"10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G84452RH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G85012LW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G86130AV", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G86221TG", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G87889NL", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G91591MO", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G91636VS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G91819LE", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G93284HQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "glytoucan_ac": "G93822DY", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "635", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/635" }, { "id": "10713085", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10713085" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Structural analysis of murine zona pellucida glycans. Evidence for the expression of core 2-type O-glycans and the Sd(a) antigen.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Easton RL, Patankar MS, Lattanzio FA, Leaven TH, Morris HR, Clark GF, Dell A", "evidence": [ { "database": "GlyConnect", "id": "635", "url": "https://glyconnect.expasy.org/browser/proteins/635" } ], "reference": [ { "type": "PubMed", "id": "10713085", "url": "https://glygen.org/publication/PubMed/10713085" } ] }, { "title": "Structural characterization of native mouse zona pellucida proteins using mass spectrometry.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Boja ES, Hoodbhoy T, Fales HM, Dean J", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239#ptm_processing" }, { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "RefSeq", "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" } ], "reference": [ { "type": "PubMed", "id": "12799386", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "title": "Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Dell A, Chalabi S, Easton RL, Haslam SM, Sutton-Smith M, Patankar MS, Lattanzio F, Panico M, Morris HR, Clark GF", "evidence": [ { "database": "GlyConnect", "id": "630", "url": "https://glyconnect.expasy.org/browser/proteins/630" } ], "reference": [ { "type": "PubMed", "id": "14673092", "url": "https://glygen.org/publication/PubMed/14673092" } ] }, { "title": "Oocyte-specific expression of mouse Zp-2: developmental regulation of the zona pellucida genes.", "journal": "Mol. Cell. Biol.", "date": "1990", "authors": "Dean J., Liang L.-F., Chamow S.M.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "1690843", "url": "https://glygen.org/publication/PubMed/1690843" } ] }, { "title": "Purified mouse egg zona pellucida glycoproteins polymerize into homomeric fibrils under non-denaturing conditions.", "journal": "J. Cell. Physiol.", "date": "2008", "authors": "Wassarman P.M., Darie C.C., Janssen W.G., Litscher E.S.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "17559063", "url": "https://glygen.org/publication/PubMed/17559063" } ] }, { "title": "Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.", "journal": "J. Cell Biol.", "date": "2012", "authors": "Burkart AD, Xiong B, Baibakov B, Jimenez-Movilla M, Dean J", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "22472438", "url": "https://glygen.org/publication/PubMed/22472438" } ] }, { "title": "A structured interdomain linker directs self-polymerization of human uromodulin.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2016", "authors": "Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "26811476", "url": "https://glygen.org/publication/PubMed/26811476" } ] }, { "title": "Structural basis of egg coat-sperm recognition at fertilization.", "journal": "Cell", "date": "2017", "authors": "Han L., Nishimura K., Villa A., Jovine L., de Sanctis D., Sadat Al Hosseini H., Dioguardi E., Raj I.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "28622512", "url": "https://glygen.org/publication/PubMed/28622512" } ] }, { "title": "Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.", "journal": "Human reproduction (Oxford, England)", "date": "2022", "authors": "Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y, Lin G, Wang Z, Xu W", "evidence": [ { "database": "RefSeq", "id": "NP_035905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035905" } ], "reference": [ { "type": "PubMed", "id": "35211729", "url": "https://glygen.org/publication/PubMed/35211729" } ] }, { "title": "Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat.", "journal": "J. Mol. Biol.", "date": "1985", "authors": "Greve J.M., Wassarman P.M.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "reference": [ { "type": "PubMed", "id": "3845123", "url": "https://glygen.org/publication/PubMed/3845123" } ] } ], "pathway": [ { "id": "mmu:22787", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22787", "resource": "KEGG Pathway" }, { "id": "R-MMU-2534343", "name": "Interaction With Cumulus Cells And The Zona Pellucida", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2534343", "resource": "Reactome", "description": "Interaction With Cumulus Cells And The Zona Pellucida" } ], "orthologs": [ { "uniprot_canonical_ac": "O54767-1", "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "Zp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARWQRVYWLRSLFFALVTSVNSLSLPQSENPAFPGTLICDKDEVRVEFSSRFDMEKWNPSLVDTFGNEISNCTYALDLEKFILKFPYETCTIKVIGGYQVNIRVQDTNADVSYKDDVHHFFCPAIQAEIHEVSEIVVCMEDLISFSFPQLFSRLADENQNVSEMGWIIKIGNGTRVHTLPLKDAIVQGFNLLIDSQKITLHVPANATGVAHYVQESSYLYTVQLKLLFSSPGQKITFSSQAICAPDLSVACNVTHMSLTIPEFPGKLKSVGFGQRNIPEDQWHANGIDKEATNGLRLHFRKSLLKTKPSEKCPFYQFYFSSLELTFNFQGDMLSTVIDPECHCESPVSIDELCTRDGFMDFEVYSHQTKPALNLESLLVGNSSCQPIFKVQSLGLARFHIPLNGCGTRQKFEGDKVIYENEIHALWENPPSNIIFRNSEFRMTVRCHYIRDSMLLRAHIKSHSSPVASVKPGPLALVLQTYPDISYQRPYRKNEYPLVRYLRQPIYMEVTVLNRNDPNIKLVLDDCWATTFEDPASVPQWQIIMDGCEYELDNYRTTFHAANSSAAHSGHYQRFDVKTFAFVSESRGLSSLIYFHCSALICNQASPLCSVTCPAPLRNKREASKEGTMTVSLPGPIILLSDDSSSKGVMNPDSYEITKDIASKTLGAVAALVGSAVIIGFICYLHKKRIVRFNS", "length": 695 }, "evidence": [ { "id": "45244623", "url": "http://www.informatics.jax.org/homology/45244623", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q05996-1", "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "ZP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACRQRGGSWSPSGWFNAGWSTYRSISLFFALVTSGNSIDVSQLVNPAFPGTVTCDEREITVEFPSSPGTKKWHASVVDPLGLDMPNCTYILDPEKLTLRATYDNCTRRVHGGHQMTIRVMNNSAALRHGAVMYQFFCPAMQVEETQGLSASTICQKDFMSFSLPRVFSGLADDSKGTKVQMGWSIEVGDGARAKTLTLPEAMKEGFSLLIDNHRMTFHVPFNATGVTHYVQGNSHLYMVSLKLTFISPGQKVIFSSQAICAPDPVTCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDLEATNGMKLHFSKTLLKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH", "length": 745 }, "evidence": [ { "id": "45244623", "url": "http://www.informatics.jax.org/homology/45244623", "database": "MGI" }, { "id": "P20239", "url": "https://omabrowser.org/oma/group/P20239/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "egg coat", "id": "GO:0035805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035805", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "structural constituent of egg coat", "id": "GO:0035804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035804", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "acrosin binding", "id": "GO:0032190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032190", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" }, { "name": "prevention of polyspermy", "id": "GO:0060468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060468", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "PubMed", "id": "12799386", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "annotation": "O-glycosylated; contains sulfate-substituted glycans.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "PubMed", "id": "12799386", "url": "https://glygen.org/publication/PubMed/12799386" } ] }, { "annotation": "Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "PubMed", "id": "22472438", "url": "https://glygen.org/publication/PubMed/22472438" }, { "database": "PubMed", "id": "26811476", "url": "https://glygen.org/publication/PubMed/26811476" } ] }, { "annotation": "Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.", "evidence": [ { "database": "UniProtKB", "id": "P20239", "url": "https://www.uniprot.org/uniprot/P20239" }, { "database": "PubMed", "id": "22472438", "url": "https://glygen.org/publication/PubMed/22472438" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 77 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 48 }, { "field": "n_linked_glycan_sites", "count": 6 }, { "field": "o_linked_glycans", "count": 22 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 6 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 70 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 48 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 22 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }