{ "uniprot_canonical_ac": "P19328-1", "uniprot_ac": "P19328", "uniprot_id": "ADA2B_RAT", "mass": { "chemical_mass": 50369.0, "monoisotopic_mass": 50369.0 }, "refseq": { "ac": "NP_612514", "name": "alpha-2B adrenergic receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, "gene_names": [ { "name": "Adra2b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P19328", "id": "P19328" }, { "name": "Adra2b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514", "id": "NP_612514" } ], "protein_names": [ { "name": "Alpha-2B adrenergic receptor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P19328" }, { "name": "Alpha-2B adrenoceptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P19328" }, { "name": "Alpha-2B adrenoreceptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P19328" }, { "name": "Alpha-2BAR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P19328" }, { "name": "alpha-2B adrenergic receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514", "id": "NP_612514" }, { "name": "alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR; Adrenergic, alpha2B-, receptor class III; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514", "id": "NP_612514" } ], "function": [ { "annotation": "Adra2b signaling is impaired in the cardiomyocytes of spontaneously hypertensive rats starting from 2 months old.", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, { "database": "PubMed", "id": "30929926", "url": "https://glygen.org/publication/PubMed/30929926" } ] }, { "annotation": "Alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, { "database": "PubMed", "id": "11891218", "url": "https://glygen.org/publication/PubMed/11891218" } ] }, { "annotation": "Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328#function" } ] }, { "annotation": "Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, { "database": "PubMed", "id": "21357695", "url": "https://glygen.org/publication/PubMed/21357695" } ] }, { "annotation": "Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, { "database": "PubMed", "id": "32340145", "url": "https://glygen.org/publication/PubMed/32340145" } ] }, { "annotation": "Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" }, { "database": "PubMed", "id": "25407049", "url": "https://glygen.org/publication/PubMed/25407049" } ] } ], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] }, { "disease_id": "DOID:9743", "recommended_name": { "id": "DOID:9743", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9743", "name": "diabetic neuropathy", "description": "" }, "synonyms": [], "evidence": [ { "id": "9743", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9743" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "common_name": "Rat" } ], "gene": [ { "name": "Adra2b", "url": "https://www.uniprot.org/uniprot/P19328", "locus": { "chromosome": "3", "start_pos": 114589355, "end_pos": 114585169, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000013887", "url": "https://www.ensembl.org/id/ENSRNOG00000013887" } ] } } ], "crossref": [ { "id": "ENSRNOG00000013887", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000013887", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15321", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15321", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL266", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL266", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "24174", "url": "https://www.ncbi.nlm.nih.gov/gene/24174", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P19328", "url": "https://www.ebi.ac.uk/intact/interactors/id:P19328*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24174", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24174", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEPQAVP", "url": "https://omabrowser.org/oma/group/CEPQAVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3087922at2759", "url": "http://www.orthodb.org/?query=3087922at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P19328", "url": "http://purl.obolibrary.org/obo/PR_P19328", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-390696", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390696", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-392023", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392023", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-418597", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418597", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2057", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2057", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P19328-1", "url": "https://www.uniprot.org/uniprot/P19328-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW", "length": 453, "header": "sp|P19328-1|ADA2B_RAT Isoform 1 of Alpha-2B adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adra2b PE=1 SV=2 CANONICAL=P19328-1" }, "isoforms": [ { "isoform_ac": "P19328-1", "url": "", "sequence": { "sequence": "MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW", "length": 453, "header": "sp|P19328-1|ADA2B_RAT Isoform 1 of Alpha-2B adrenergic receptor OS=Rattus norvegicus OX=10116 GN=Adra2b PE=1 SV=2 CANONICAL=P19328-1" }, "locus": { "chromosome": "3", "start_pos": 114586900, "end_pos": 114585542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000018584", "url": "https://www.ensembl.org/id/ENSRNOT00000018584" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000018584", "url": "https://www.ensembl.org/id/ENSRNOP00000018584" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Cussac D, Schaak S, Denis C, Paris H", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" } ], "reference": [ { "type": "PubMed", "id": "11891218", "url": "https://glygen.org/publication/PubMed/11891218" } ] }, { "title": "Cloning and functional characterization of the rat alpha2B-adrenergic receptor gene promoter region: evidence for binding sites for erythropoiesis-related transcription factors GATA1 and NF-E2.", "journal": "Biochem. Pharmacol.", "date": "2005", "authors": "Paris H., Schaak S., Cussac D., Mignotte V., Labialle S.", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "reference": [ { "type": "PubMed", "id": "15993847", "url": "https://glygen.org/publication/PubMed/15993847" } ] }, { "title": "Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Duvernay MT, Wang H, Dong C, Guidry JJ, Sackett DL, Wu G", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" } ], "reference": [ { "type": "PubMed", "id": "21357695", "url": "https://glygen.org/publication/PubMed/21357695" } ] }, { "title": "Molecular characterization of a rat alpha 2B-adrenergic receptor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1990", "authors": "Zeng DW, Harrison JK, D'Angelo DD, Barber CM, Tucker AL, Lu ZH, Lynch KR", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "reference": [ { "type": "PubMed", "id": "2158103", "url": "https://glygen.org/publication/PubMed/2158103" } ] }, { "title": "Specific role of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.", "journal": "Basic & clinical pharmacology & toxicology", "date": "2015", "authors": "Altamirano-Espinoza AH, Manrique-Maldonado G, Marichal-Cancino BA, Villalon CM", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" } ], "reference": [ { "type": "PubMed", "id": "25407049", "url": "https://glygen.org/publication/PubMed/25407049" } ] }, { "title": "alpha2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age.", "journal": "Biochemical and biophysical research communications", "date": "2019", "authors": "Maltsev AV, Evdokimovskii EV, Kokoz YM", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" } ], "reference": [ { "type": "PubMed", "id": "30929926", "url": "https://glygen.org/publication/PubMed/30929926" } ] }, { "title": "Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor.", "journal": "Cells", "date": "2020", "authors": "Torres A, Munoz K, Nahuelpan Y, R Saez AP, Mendoza P, Jara C, Cappelli C, Suarez R, Oyarzun C, Quezada C, San Martin R", "evidence": [ { "database": "RefSeq", "id": "NP_612514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612514" } ], "reference": [ { "type": "PubMed", "id": "32340145", "url": "https://glygen.org/publication/PubMed/32340145" } ] }, { "title": "Differential sodium regulation between salt-sensitive and salt-resistant Sabra rats is not due to any mutation in the renal alpha 2B-adrenoceptor gene.", "journal": "Am. J. Hypertens.", "date": "1995", "authors": "Le Jossec M, Cloix JF, Pecquery R, Giudicelli Y, Dausse JP", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "reference": [ { "type": "PubMed", "id": "7755946", "url": "https://glygen.org/publication/PubMed/7755946" } ] } ], "pathway": [ { "id": "rno:24174", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24174", "resource": "KEGG Pathway" }, { "id": "R-RNO-390696", "name": "Adrenoceptors", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390696", "resource": "Reactome", "description": "Adrenoceptors" }, { "id": "R-RNO-392023", "name": "Adrenaline signalling through Alpha-2 adrenergic receptor", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392023", "resource": "Reactome", "description": "Adrenaline signalling through Alpha-2 adrenergic receptor" }, { "id": "R-RNO-418594", "name": "G alpha (i) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-RNO-418597", "name": "G alpha (z) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418597", "resource": "Reactome", "description": "G alpha (z) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "P18089-1", "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "ADRA2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW", "length": 450 }, "evidence": [ { "id": "45225682", "url": "http://www.informatics.jax.org/homology/45225682", "database": "MGI" }, { "id": "P19328", "url": "https://omabrowser.org/oma/group/P19328/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P30545-1", "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "Adra2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW", "length": 453 }, "evidence": [ { "id": "45225682", "url": "http://www.informatics.jax.org/homology/45225682", "database": "MGI" }, { "id": "P19328", "url": "https://omabrowser.org/oma/group/P19328/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "regulation of vascular associated smooth muscle contraction", "id": "GO:0003056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003056", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "positive regulation of neuron differentiation", "id": "GO:0045666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045666", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "positive regulation of blood pressure", "id": "GO:0045777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045777", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "adenylate cyclase-activating adrenergic receptor signaling pathway", "id": "GO:0071880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071880", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "platelet activation", "id": "GO:0030168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030168", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "activation of protein kinase B activity", "id": "GO:0032148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032148", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "adrenergic receptor signaling pathway", "id": "GO:0071875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071875", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "positive regulation of uterine smooth muscle contraction", "id": "GO:0070474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070474", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "receptor transactivation", "id": "GO:0035624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035624", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "alpha2-adrenergic receptor activity", "id": "GO:0004938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004938", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "epinephrine binding", "id": "GO:0051379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051379", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" }, { "name": "adrenergic receptor activity", "id": "GO:0004935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004935", "evidence": [ { "database": "UniProtKB", "id": "P19328", "url": "https://www.uniprot.org/uniprot/P19328" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }