{
    "uniprot_canonical_ac": "P18864-1",
    "uniprot_ac": "P18864",
    "uniprot_id": "HXB7_RAT",
    "mass": {
        "chemical_mass": 24243.0,
        "monoisotopic_mass": 24243.0
    },
    "refseq": {
        "ac": "NP_001017480",
        "name": "homeobox protein Hox-B7",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480"
    },
    "gene_names": [
        {
            "name": "Hoxb7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P18864",
            "id": "P18864"
        },
        {
            "name": "Hox2r1b; R1b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480",
            "id": "NP_001017480"
        },
        {
            "name": "Hoxb-7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P18864",
            "id": "P18864"
        },
        {
            "name": "Hoxb7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480",
            "id": "NP_001017480"
        },
        {
            "name": "R1b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P18864",
            "id": "P18864"
        }
    ],
    "protein_names": [
        {
            "name": "Homeobox protein Hox-B7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P18864"
        },
        {
            "name": "Homeobox protein R1B",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P18864"
        },
        {
            "name": "homeobox gene B7; homeobox protein R1B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480",
            "id": "NP_001017480"
        },
        {
            "name": "homeobox protein Hox-B7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480",
            "id": "NP_001017480"
        }
    ],
    "function": [
        {
            "annotation": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P18864",
                    "url": "https://www.uniprot.org/uniprot/P18864#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:3008",
            "recommended_name": {
                "id": "DOID:3008",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3008",
                "name": "invasive ductal carcinoma",
                "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated."
            },
            "synonyms": [
                {
                    "id": "DOID:3008",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3008",
                    "name": "Infiltrating ductal carcinoma of breast",
                    "description": ""
                },
                {
                    "id": "DOID:3008",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3008",
                    "name": "Invasive ductal carcinoma, NST",
                    "description": ""
                },
                {
                    "id": "DOID:3008",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3008",
                    "name": "ductal adenocarcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3008",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3008"
                }
            ]
        },
        {
            "disease_id": "DOID:3748",
            "recommended_name": {
                "id": "DOID:3748",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3748",
                "name": "esophagus squamous cell carcinoma",
                "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus."
            },
            "synonyms": [
                {
                    "id": "DOID:3748",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3748",
                    "name": "SCC of esophagus",
                    "description": ""
                },
                {
                    "id": "DOID:3748",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3748",
                    "name": "SCC of oesophagus",
                    "description": ""
                },
                {
                    "id": "DOID:3748",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3748",
                    "name": "oesophagus squamous cell carcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3748",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3748"
                }
            ]
        },
        {
            "disease_id": "DOID:3910",
            "recommended_name": {
                "id": "DOID:3910",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3910",
                "name": "lung adenocarcinoma",
                "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin."
            },
            "synonyms": [
                {
                    "id": "DOID:3910",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3910",
                    "name": "bronchogenic lung adenocarcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:3910",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3910",
                    "name": "nonsmall cell adenocarcinoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3910",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3910"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P18864",
                    "url": "https://www.uniprot.org/uniprot/P18864"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Hoxb7",
            "url": "https://www.uniprot.org/uniprot/P18864",
            "locus": {
                "chromosome": "10",
                "start_pos": 81256034,
                "end_pos": 81252553,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000007611",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007611"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000007611",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007611",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00086",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "497985",
            "url": "https://www.ncbi.nlm.nih.gov/gene/497985",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001356",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001827",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001827",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009057",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017970",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017995",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017995",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020479",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:497985",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:497985",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "TQRTGYG",
            "url": "https://omabrowser.org/oma/group/TQRTGYG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "728401at2759",
            "url": "http://www.orthodb.org/?query=728401at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46166",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46166",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR46166:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46166:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00046",
            "url": "http://pfam.xfam.org/family/PF00046",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P18864",
            "url": "http://purl.obolibrary.org/obo/PR_P18864",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001017480",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1559918",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559918",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P18864",
            "url": "https://www.uniprot.org/uniprot/P18864",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P18864-1",
            "url": "https://www.uniprot.org/uniprot/P18864-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGGMAGQSAAGVYEAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTERKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEADEEEEEEE",
        "length": 219,
        "header": "sp|P18864-1|HXB7_RAT Isoform 1 of Homeobox protein Hox-B7  OS=Rattus norvegicus OX=10116 GN=Hoxb7 PE=2 SV=2 CANONICAL=P18864-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P18864-1",
            "url": "",
            "sequence": {
                "sequence": "MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGGMAGQSAAGVYEAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTERKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEADEEEEEEE",
                "length": 219,
                "header": "sp|P18864-1|HXB7_RAT Isoform 1 of Homeobox protein Hox-B7  OS=Rattus norvegicus OX=10116 GN=Hoxb7 PE=2 SV=2 CANONICAL=P18864-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 81255497,
                "end_pos": 81252635,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000031035",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000031035"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000033609",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000033609"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The expression of rat homeobox-containing genes is developmentally regulated and tissue specific.",
            "journal": "Development",
            "date": "1988",
            "authors": "Falzon M, Chung SY",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P18864",
                    "url": "https://www.uniprot.org/uniprot/P18864"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2907739",
                    "url": "https://glygen.org/publication/PubMed/2907739"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:497985",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:497985",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P09024-1",
            "protein_name": "Homeobox protein Hox-B7",
            "gene_name": "Hoxb7",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYGAGPGAPFSASVQGLYSGGGAMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEAEEEEEE",
                "length": 217
            },
            "evidence": [
                {
                    "id": "45225265",
                    "url": "http://www.informatics.jax.org/homology/45225265",
                    "database": "MGI"
                },
                {
                    "id": "P18864",
                    "url": "https://omabrowser.org/oma/group/P18864/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P09629-1",
            "protein_name": "Homeobox protein Hox-B7",
            "gene_name": "HOXB7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSSLYYANTLFSKYPASSSVFATGAFPEQTSCAFASNPQRPGYGAGSGASFAASMQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE",
                "length": 217
            },
            "evidence": [
                {
                    "id": "45225265",
                    "url": "http://www.informatics.jax.org/homology/45225265",
                    "database": "MGI"
                },
                {
                    "id": "P18864",
                    "url": "https://omabrowser.org/oma/group/P18864/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
                        "id": "GO:0000978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-binding transcription activator activity, RNA polymerase II-specific",
                        "id": "GO:0001228",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequence-specific double-stranded DNA binding",
                        "id": "GO:1990837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear body",
                        "id": "GO:0016604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anterior/posterior pattern specification",
                        "id": "GO:0009952",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of branching involved in ureteric bud morphogenesis",
                        "id": "GO:0090190",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090190",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "embryonic skeletal system morphogenesis",
                        "id": "GO:0048704",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048704",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "embryonic organ development",
                        "id": "GO:0048568",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048568",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
                                "url": "https://www.uniprot.org/uniprot/P18864"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "myeloid cell differentiation",
                        "id": "GO:0030099",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030099",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P18864",
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