{
    "uniprot_canonical_ac": "P17267-1",
    "uniprot_ac": "P17267",
    "uniprot_id": "IF_RAT",
    "mass": {
        "chemical_mass": 45956.0,
        "monoisotopic_mass": 45956.0
    },
    "refseq": {
        "ac": "NP_058858",
        "name": "cobalamin binding intrinsic factor precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858"
    },
    "gene_names": [
        {
            "name": "Cblif",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P17267",
            "id": "P17267"
        },
        {
            "name": "Cblif",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858",
            "id": "NP_058858"
        },
        {
            "name": "Gif",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858",
            "id": "NP_058858"
        },
        {
            "name": "Gif",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P17267",
            "id": "P17267"
        }
    ],
    "protein_names": [
        {
            "name": "Cobalamin binding intrinsic factor",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P17267"
        },
        {
            "name": "Gastric intrinsic factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P17267"
        },
        {
            "name": "IF; INF; intrinsic factor; gastric intrinsic factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858",
            "id": "NP_058858"
        },
        {
            "name": "IF",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P17267"
        },
        {
            "name": "INF",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P17267"
        },
        {
            "name": "Intrinsic factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P17267"
        },
        {
            "name": "cobalamin binding intrinsic factor precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858",
            "id": "NP_058858"
        }
    ],
    "function": [
        {
            "annotation": "Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050734",
            "recommended_name": {
                "id": "DOID:0050734",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050734",
                "name": "congenital intrinsic factor deficiency",
                "description": "A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption."
            },
            "synonyms": [
                {
                    "id": "DOID:0050734",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050734",
                    "name": "hereditary intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "hereditary intrinsic factor deficiency",
                    "description": "Congenital intrinsic factor deficiency (IFD) is a rare disorder of vitamin B12 (cobalamin) absorption that is characterized by megaloblastic anemia and neurological abnormalities."
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "IFD",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "congenital intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "congenital pernicious anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "congenital pernicious anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "gastric intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "hereditary juvenile megaloblastic anaemia due to intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "hereditary juvenile megaloblastic anemia due to intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "congenital pernicious anaemia due to defect of intrinsic factor",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "congenital pernicious anemia due to defect of intrinsic factor",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "intrinsic factor, congenital deficiency of",
                    "description": ""
                },
                {
                    "id": "MONDO:0009852",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009852",
                    "name": "pernicious Anemia, congenital, due to defect of intrinsic Factor",
                    "description": ""
                },
                {
                    "id": "MIM:261000",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/261000",
                    "name": "Hereditary intrinsic factor deficiency",
                    "description": "Hereditary intrinsic factor deficiency"
                }
            ],
            "evidence": [
                {
                    "id": "0050734",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050734"
                }
            ]
        },
        {
            "disease_id": "DOID:10808",
            "recommended_name": {
                "id": "DOID:10808",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:10808",
                "name": "gastric ulcer",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "chronic gastric ulcer without hemorrhage AND without perforation but with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer without hemorrhage, without perforation AND without obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage and obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with perforation, with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with perforation",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "bleeding acute gastric ulcer",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage AND with perforation but without obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "chronic gastric ulcer without hemorrhage AND without perforation",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage, with perforation AND with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with perforation AND obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage, with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage and perforation, without mention of obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage and perforation",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with hemorrhage and perforation, with obstruction",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer without hemorrhage and without perforation",
                    "description": ""
                },
                {
                    "id": "DOID:10808",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10808",
                    "name": "acute gastric ulcer with haemorrhage and perforation",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "10808",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:10808"
                }
            ]
        },
        {
            "disease_id": "DOID:13381",
            "recommended_name": {
                "id": "DOID:13381",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:13381",
                "name": "pernicious anemia",
                "description": "A nutritional deficiency disease that is characterized by a decrease in red blood cells due to malabsorption of vitamin B12, has_symptom fatigue, pallor, shortness of breath, glossitis, ataxia, and/or paresthesia, has_material_basis_in atrophic gastritis, autoimmune disorder affecting the production or function of intrinsic factor, and/or genetic factors."
            },
            "synonyms": [
                {
                    "id": "DOID:13381",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13381",
                    "name": "ANEMIA PERNICIOUS",
                    "description": ""
                },
                {
                    "id": "DOID:13381",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13381",
                    "name": "Addison's anaemia",
                    "description": ""
                },
                {
                    "id": "DOID:13381",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13381",
                    "name": "Biermer's anaemia",
                    "description": ""
                },
                {
                    "id": "DOID:13381",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13381",
                    "name": "Biermer's anemia",
                    "description": ""
                },
                {
                    "id": "DOID:13381",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:13381",
                    "name": "pernicious anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "pernicious anemia",
                    "description": "Megaloblastic anemia caused by vitamin B-12 deficiency due to impaired absorption. The impaired absorption of vitamin B-12 is secondary to atrophic gastritis and loss of gastric parietal cells."
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison's anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison's anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison-Biermer anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Addison-Biermer anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Biermer anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Biermer anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Biermer disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Biermer's anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "Biermer's anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "acquired pernicious anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "acquired pernicious anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "anaemia pernicious",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "anemia pernicious",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "intrinsic factor deficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "juvenile onset pernicious anaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "juvenile onset pernicious anemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008228",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008228",
                    "name": "pernicious anemia",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "13381",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:13381"
                }
            ]
        },
        {
            "disease_id": "DOID:4029",
            "recommended_name": {
                "id": "DOID:4029",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4029",
                "name": "gastritis",
                "description": "A stomach disease that is an inflammation of the lining of the stomach."
            },
            "synonyms": [
                {
                    "id": "DOID:4029",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4029",
                    "name": "Erosive Gastritis",
                    "description": ""
                },
                {
                    "id": "DOID:4029",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4029",
                    "name": "Erosive gastropathy",
                    "description": ""
                },
                {
                    "id": "DOID:4029",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4029",
                    "name": "acute gastric mucosal erosion",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "4029",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4029"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Cblif",
            "url": "https://www.uniprot.org/uniprot/P17267",
            "locus": {
                "chromosome": "1",
                "start_pos": 208620344,
                "end_pos": 208605983,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000021001",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000021001"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000021001",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021001",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "29319",
            "url": "https://www.ncbi.nlm.nih.gov/gene/29319",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR002157",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002157",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:29319",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29319",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AYNVEAQ",
            "url": "https://omabrowser.org/oma/group/AYNVEAQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5361436at2759",
            "url": "http://www.orthodb.org/?query=5361436at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10559",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10559",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10559:SF15",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10559:SF15",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01122",
            "url": "http://pfam.xfam.org/family/PF01122",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P17267",
            "url": "http://purl.obolibrary.org/obo/PR_P17267",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-9758881",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758881",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_058858",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058858",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "62084",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=62084",
            "database": "RGD",
            "categories": [
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            ]
        },
        {
            "id": "A0A0G2JSS6",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSS6",
            "database": "UniProtKB",
            "categories": [
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            ]
        },
        {
            "id": "A0A0G2JSS6-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSS6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P17267",
            "url": "https://www.uniprot.org/uniprot/P17267",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P17267-1",
            "url": "https://www.uniprot.org/uniprot/P17267-1",
            "database": "UniProtKB",
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                "Protein"
            ]
        }
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        "length": 417,
        "header": "sp|P17267-1|IF_RAT Isoform 1 of Cobalamin binding intrinsic factor  OS=Rattus norvegicus OX=10116 GN=Cblif PE=1 SV=2 CANONICAL=P17267-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JSS6-1",
            "url": "",
            "sequence": {
                "sequence": "MWKGMAWLSFYLLNVLWAVAGTSTRAQRSCSVPPDQQPWVNGLQLLMENSVTESDLPNPSILIAMNLASTYNLEAQKLLTYQLMASDSADLTNGQLALTIMALTSSCRDPGSKVSILQKNMESWTPSNLGAESSSFYGPALAILALCQKNSEATLPIAVRFAKTLMMESSPFSVDTGAVATLALTCMYNRIPVGSQENYRDLFGQALKVIVDNISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKEWDCEKTMYTILKEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSISNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRRNHMFKFETTMTSWGLIVSSINNIAENVKHKTYWEFLSGKTPLGEGVAYYIPFNYEHITANFTQY",
                "length": 421,
                "header": "tr|A0A0G2JSS6-1|A0A0G2JSS6_RAT Computationally mapped isoform of Cobalamin binding intrinsic factor  OS=Rattus norvegicus OX=10116 GN=Cblif PE=1 SV=1 CANONICAL=P17267-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 208620153,
                "end_pos": 208605994,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000028507.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028507.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000028507.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028507.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P17267-1",
            "url": "",
            "sequence": {
                "sequence": "MAWLSFYLLNVLWAVAGTSTRAQRSCSVPPDQQPWVNGLQLLMENSVTESDLPNPSILIAMNLASTYNLEAQKLLTYQLMASDSADLTNGQLALTIMALTSSCRDPGSKVSILQKNMESWTPSNLGAESSSFYGPALAILALCQKNSEATLPIAVRFAKTLMMESSPFSVDTGAVATLALTCMYNRIPVGSQENYRDLFGQALKVIVDNISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKEWDCEKTMYTILKEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSISNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRRNHMFKFETTMTSWGLIVSSINNIAENVKHKTYWEFLSGKTPLGEGVAYYIPFNYEHITANFTQY",
                "length": 417,
                "header": "sp|P17267-1|IF_RAT Isoform 1 of Cobalamin binding intrinsic factor  OS=Rattus norvegicus OX=10116 GN=Cblif PE=1 SV=2 CANONICAL=P17267-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 209,
            "start_aa": "Asn",
            "end_pos": 209,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn209",
            "evidence": [
                {
                    "id": "P17267",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P17267#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 311,
            "start_aa": "Asn",
            "end_pos": 311,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn311",
            "evidence": [
                {
                    "id": "P17267",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P17267#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 330,
            "start_aa": "Asn",
            "end_pos": 330,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn330",
            "evidence": [
                {
                    "id": "P17267",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P17267#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 413,
            "start_aa": "Asn",
            "end_pos": 413,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn413",
            "evidence": [
                {
                    "id": "P17267",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P17267#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 191,
            "end_pos": 191,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "P17267",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P17267"
                }
            ],
            "site_lbl": "Ser191"
        }
    ],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JSS6",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JSS6"
                },
                {
                    "database": "iPTMnet",
                    "id": "P17267",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P17267"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        },
        {
            "title": "Isolation and structural characterization of a cDNA clone encoding rat gastric intrinsic factor.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "1988",
            "authors": "Dieckgraefe BK, Seetharam B, Banaszak L, Leykam JF, Alpers DH",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "3422425",
                    "url": "https://glygen.org/publication/PubMed/3422425"
                }
            ]
        },
        {
            "title": "The rat intrinsic factor gene: its 5'-upstream region and chief cell-specific transcription.",
            "journal": "J. Biochem.",
            "date": "1995",
            "authors": "Nishi T., Tohyama M., Chiba T., Maeda M., Oka T., Shimada S., Futai M., Mushiake S., Asahara S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P17267",
                    "url": "https://www.uniprot.org/uniprot/P17267"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7490275",
                    "url": "https://glygen.org/publication/PubMed/7490275"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:29319",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29319",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-9758881",
            "name": "Uptake of dietary cobalamins into enterocytes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758881",
            "resource": "Reactome",
            "description": "Uptake of dietary cobalamins into enterocytes"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P27352-1",
            "protein_name": "Cobalamin binding intrinsic factor",
            "gene_name": "CBLIF",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY",
                "length": 417
            },
            "evidence": [
                {
                    "id": "45240665",
                    "url": "http://www.informatics.jax.org/homology/45240665",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P52787-1",
            "protein_name": "Cobalamin binding intrinsic factor",
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            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAWLTLYLLSVLWAVAGTSTRAQSSCSVPPDQQPWVDGLQALMENSVTDSDFPNPSILIAMNLAGAYNVEAQKLLTYQLMASDSADLTSGQLALTVMALTSSCRDPGSKVSTLLKKMENWSPSSPGAESSAFYGPGLAILALCQKSSEATLPIAVRFAKTLMMEPSPFNVDTGAVATLALTCMYNKIPVGSQENYRDLFGQALKAIVEKISLRIKADGIIGDIYSTGLAMQALSVTPEQPTKKWDCEKTMHTILNEIKQGKFQNPMSIAQILPSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSVSNITVIYTINNQLRGVDLLFNVTIEVSVKSGSVLLAVLEEAQRKNSMFKFETTMTSWGLIVSSINNIAENVNHKTYWEFLSGKTPLDEGVAYYIPFNHEHITANFTQY",
                "length": 417
            },
            "evidence": [
                {
                    "id": "45240665",
                    "url": "http://www.informatics.jax.org/homology/45240665",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "vitamin binding",
                        "id": "GO:0019842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cobalamin binding",
                        "id": "GO:0031419",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031419",
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                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cargo receptor ligand activity",
                        "id": "GO:0140355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140355",
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                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endosome",
                        "id": "GO:0005768",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apical plasma membrane",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324",
                        "evidence": [
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                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microvillus",
                        "id": "GO:0005902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
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                    {
                        "name": "cobalamin transport",
                        "id": "GO:0015889",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015889",
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                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cobalt ion transport",
                        "id": "GO:0006824",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006824",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P17267",
                                "url": "https://www.uniprot.org/uniprot/P17267"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
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        {
            "start_pos": 209,
            "end_pos": 211,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 311,
            "end_pos": 313,
            "annotation": "n_glycosylation_sequon"
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        {
            "start_pos": 330,
            "end_pos": 332,
            "annotation": "n_glycosylation_sequon"
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        {
            "start_pos": 413,
            "end_pos": 415,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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