{ "uniprot_canonical_ac": "P16970-1", "uniprot_ac": "P16970", "uniprot_id": "ABCD3_RAT", "mass": { "chemical_mass": 75316.0, "monoisotopic_mass": 75316.0 }, "refseq": { "ac": "NP_036936", "name": "ATP-binding cassette sub-family D member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936" }, "gene_names": [ { "name": "Abcd3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P16970", "id": "P16970" }, { "name": "Abcd3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936", "id": "NP_036936" }, { "name": "PMP70; Pxmp1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936", "id": "NP_036936" }, { "name": "Pmp70", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P16970", "id": "P16970" }, { "name": "Pxmp1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P16970", "id": "P16970" } ], "protein_names": [ { "name": "ATP-binding cassette sub-family D member 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P16970" }, { "name": "3.1.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P16970" }, { "name": "7.6.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P16970" }, { "name": "70 kDa peroxisomal membrane protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P16970" }, { "name": "70-kDa peroxisomal membrane protein; ATP-binding cassette, sub-family D (ALD), member 3; Peroxisomal membrane protein 1; ATP-binding cassette, subfamily D (ALD), member 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936", "id": "NP_036936" }, { "name": "ATP-binding cassette sub-family D member 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936", "id": "NP_036936" }, { "name": "PMP70", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P16970" } ], "function": [ { "annotation": "Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities (By similarity). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:10207018).", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970#function" }, { "database": "UniProtKB", "id": "P33897", "url": "https://www.uniprot.org/uniprot/P33897#function" }, { "database": "PubMed", "id": "10207018", "url": "https://glygen.org/publication/PubMed/10207018" }, { "database": "UniProtKB", "id": "P28288", "url": "https://www.uniprot.org/uniprot/P28288#function" } ] } ], "disease": [ { "disease_id": "DOID:0111066", "recommended_name": { "id": "DOID:0111066", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111066", "name": "congenital bile acid synthesis defect 5", "description": "A congenital bile acid synthesis defect characterized by hepatomegaly, liver fibrosis and failure, splenomegaly, and elevated plasma levels of bile acid intermediates that has_material_basis_in homozygous mutation in the ABCD3 gene on chromosome 1p21." }, "synonyms": [ { "id": "DOID:0111066", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111066", "name": "CBAS5", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "congenital bile acid synthesis defect 5", "description": "Any congenital bile acid synthesis defect in which the cause of the disease is a mutation in the ABCD3 gene." }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "ABCD3 congenital bile acid synthesis defect", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "CBAS5", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "bile acid synthesis defect, congenital, type 5", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "congenital bile acid synthesis defect 5", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "congenital bile acid synthesis defect caused by mutation in ABCD3", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "congenital bile acid synthesis defect type 5", "description": "" }, { "id": "MONDO:0014564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014564", "name": "bile acid synthesis defect, congenital, 5", "description": "" }, { "id": "MIM:616278", "resource": "MIM", "url": "https://www.omim.org/entry/616278", "name": "Congenital bile acid synthesis defect 5", "description": "Congenital bile acid synthesis defect 5" } ], "evidence": [ { "id": "0111066", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111066" } ] }, { "disease_id": "DOID:10588", "recommended_name": { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "adrenoleukodystrophy", "description": "A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death." }, "synonyms": [ { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "ALD", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Bronze Schilder disease", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Encephalitis periaxialis concentrica", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Encephalitis periaxialis, Schilder's", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "Siemerling-Creutzfeldt Disease", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "X-linked adrenoleukodystrophy", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "diffuse sclerosis", "description": "" }, { "id": "DOID:10588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10588", "name": "sudanophilic cerebral sclerosis", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy", "description": "A peroxisomal disorder resulting in cerebral demyelination, axonal dysfunction in the spinal cord leading to spastic paraplegia, adrenal insufficiency and in some cases testicular insufficiency." }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "ABCD1 deficiency", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "Bronze-Schilder disease", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "Siemerling-Creutzfeldt disease", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-linked ALD", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "X-linked adrenoleukodystrophy", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy, X-linked", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenoleukodystrophy, X-linked recessive", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenomyeloneuropathy, adult", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "adrenomyeloneuropathy, adult, X-linked recessive", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "diffuse cerebral sclerosis of Schilder", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "encephalitis periaxialis concentrica", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "encephalitis periaxialis, Schilder's", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "sudanophilic cerebral sclerosis", "description": "" }, { "id": "MONDO:0018544", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018544", "name": "diffuse sclerosis", "description": "" }, { "id": "MIM:300100", "resource": "MIM", "url": "https://www.omim.org/entry/300100", "name": "Adrenoleukodystrophy", "description": "Adrenoleukodystrophy" } ], "evidence": [ { "id": "10588", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10588" } ] }, { "disease_id": "DOID:905", "recommended_name": { "id": "DOID:905", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:905", "name": "Zellweger syndrome", "description": "A peroxisomal biogenesis disorder that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes." }, "synonyms": [ { "id": "DOID:905", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:905", "name": "cerebrohepatorenal syndrome", "description": "" }, { "id": "DOID:905", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:905", "name": "congenital iron overload", "description": "" } ], "evidence": [ { "id": "905", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:905" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 277, "end_pos": 278, "sequence_org": "EE", "sequence_mut": "DD", "comment": "Inhibition of palmitic acid beta-oxidation.", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" }, { "database": "PubMed", "id": "10207018", "url": "https://glygen.org/publication/PubMed/10207018" } ] }, { "start_pos": 479, "end_pos": 479, "sequence_org": "K", "sequence_mut": "A", "comment": "Inhibition of palmitic acid beta-oxidation.", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" }, { "database": "PubMed", "id": "10207018", "url": "https://glygen.org/publication/PubMed/10207018" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "common_name": "Rat" } ], "gene": [ { "name": "Abcd3", "url": "https://www.uniprot.org/uniprot/P16970", "locus": { "chromosome": "2", "start_pos": 209852087, "end_pos": 209906020, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011929", "url": "https://www.ensembl.org/id/ENSRNOG00000011929" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011929", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "25270", "url": "https://www.ncbi.nlm.nih.gov/gene/25270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P16970", "url": "https://www.ebi.ac.uk/intact/interactors/id:P16970*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:25270", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25270", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "P16970", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P16970", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "IHDMYLD", "url": "https://omabrowser.org/oma/group/IHDMYLD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "7698at2759", "url": "http://www.orthodb.org/?query=7698at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11384:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11384:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "http://pfam.xfam.org/family/PF00005", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06472", "url": "http://pfam.xfam.org/family/PF06472", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P16970", "url": "http://purl.obolibrary.org/obo/PR_P16970", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1369062", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1369062", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013106", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9603798", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036936", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2007", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2007", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "40415", "url": "https://www.rhea-db.org/rhea/40415", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67072", "url": "https://www.rhea-db.org/rhea/67072", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67080", "url": "https://www.rhea-db.org/rhea/67080", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67680", "url": "https://www.rhea-db.org/rhea/67680", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67684", "url": "https://www.rhea-db.org/rhea/67684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67688", "url": "https://www.rhea-db.org/rhea/67688", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67692", "url": "https://www.rhea-db.org/rhea/67692", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67696", "url": "https://www.rhea-db.org/rhea/67696", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67700", "url": "https://www.rhea-db.org/rhea/67700", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67704", "url": "https://www.rhea-db.org/rhea/67704", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67708", "url": "https://www.rhea-db.org/rhea/67708", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67712", "url": "https://www.rhea-db.org/rhea/67712", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZN14", "url": "https://www.uniprot.org/uniprot/A0A8I5ZN14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZN14-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZN14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A495", "url": "https://www.uniprot.org/uniprot/A0A8I6A495", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A495-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A495-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ANP9", "url": "https://www.uniprot.org/uniprot/A0A8I6ANP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ANP9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ANP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P16970-1", "url": "https://www.uniprot.org/uniprot/P16970-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 659, "header": "sp|P16970-1|ABCD3_RAT Isoform 1 of ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=3 CANONICAL=P16970-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZN14-1", "url": "", "sequence": { "sequence": "MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIRRSVALFKESFFKFIAATPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 659, "header": "tr|A0A8I5ZN14-1|ABCD3_RAT Computationally mapped isoform of ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=1 CANONICAL=P16970-1" }, "locus": { "chromosome": "2", "start_pos": 209905618, "end_pos": 209853400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000119497.1", "url": "https://www.ensembl.org/id/ENSRNOT00000119497.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079442.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079442.1" } ] } }, { "isoform_ac": "A0A8I6A495-1", "url": "", "sequence": { "sequence": "MCKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 624, "header": "tr|A0A8I6A495-1|ABCD3_RAT Computationally mapped isoform of ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=1 CANONICAL=P16970-1" }, "locus": { "chromosome": "2", "start_pos": 209889359, "end_pos": 209853400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000106914.1", "url": "https://www.ensembl.org/id/ENSRNOT00000106914.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085866.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085866.1" } ] } }, { "isoform_ac": "A0A8I6ANP9-1", "url": "", "sequence": { "sequence": "MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 549, "header": "tr|A0A8I6ANP9-1|ABCD3_RAT Computationally mapped isoform of ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=1 CANONICAL=P16970-1" }, "locus": { "chromosome": "2", "start_pos": 209905618, "end_pos": 209853400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110813.1", "url": "https://www.ensembl.org/id/ENSRNOT00000110813.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094858.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094858.1" } ] } }, { "isoform_ac": "P16970-1", "url": "", "sequence": { "sequence": "MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 659, "header": "sp|P16970-1|ABCD3_RAT Isoform 1 of ATP-binding cassette sub-family D member 3 OS=Rattus norvegicus OX=10116 GN=Abcd3 PE=1 SV=3 CANONICAL=P16970-1" }, "locus": { "chromosome": "2", "start_pos": 209905618, "end_pos": 209853400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000016739", "url": "https://www.ensembl.org/id/ENSRNOT00000016739" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000016739", "url": "https://www.ensembl.org/id/ENSRNOP00000016739" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 106, "start_aa": "Asn", "end_pos": 106, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn106", "evidence": [ { "id": "P16970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16970#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 12, "start_aa": "Asn", "end_pos": 12, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn12", "evidence": [ { "id": "P16970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16970#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 206, "start_aa": "Asn", "end_pos": 206, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn206", "evidence": [ { "id": "P16970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16970#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P16970", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P16970" }, { "id": "28100784", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28100784" } ] } ], "phosphorylation": [ { "start_pos": 424, "end_pos": 424, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "site_lbl": "Ser424" }, { "start_pos": 659, "end_pos": 659, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "site_lbl": "Ser659" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Characterization of the 70-kDa peroxisomal membrane protein, an ATP binding cassette transporter.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Imanaka T, Aihara K, Takano T, Yamashita A, Sato R, Suzuki Y, Yokota S, Osumi T", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "reference": [ { "type": "PubMed", "id": "10207018", "url": "https://glygen.org/publication/PubMed/10207018" } ] }, { "title": "Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane.", "journal": "Anal. Biochem.", "date": "1999", "authors": "Gouveia AM, Reguenga C, Oliveira ME, Eckerskorn C, Sa-Miranda C, Azevedo JE", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "reference": [ { "type": "PubMed", "id": "10527525", "url": "https://glygen.org/publication/PubMed/10527525" } ] }, { "title": "Nucleotide-induced conformational changes of PMP70, an ATP binding cassette transporter on rat liver peroxisomal membranes.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Kamijo K., Morita M., Imanaka T., Kashiwayama Y.", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "reference": [ { "type": "PubMed", "id": "11883951", "url": "https://glygen.org/publication/PubMed/11883951" } ] }, { "title": "The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.", "journal": "J. Biol. Chem.", "date": "1990", "authors": "Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "reference": [ { "type": "PubMed", "id": "1968461", "url": "https://glygen.org/publication/PubMed/1968461" } ] }, { "title": "Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Sacoman JL, Dagda RY, Burnham-Marusich AR, Dagda RK, Berninsone PM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P16970", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P16970" } ], "reference": [ { "type": "PubMed", "id": "28100784", "url": "https://glygen.org/publication/PubMed/28100784" } ] } ], "pathway": [ { "id": "rno:25270", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25270", "resource": "KEGG Pathway" }, { "id": "R-RNO-1369062", "name": "ABC transporters in lipid homeostasis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1369062", "resource": "Reactome", "description": "ABC transporters in lipid homeostasis" }, { "id": "R-RNO-8980692", "name": "RHOA GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-RNO-9013106", "name": "RHOC GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-RNO-9603798", "name": "Class I peroxisomal membrane protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798", "resource": "Reactome", "description": "Class I peroxisomal membrane protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "P28288-1", "protein_name": "ATP-binding cassette sub-family D member 3", "gene_name": "ABCD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS", "length": 659 }, "evidence": [ { "id": "45233706", "url": "http://www.informatics.jax.org/homology/45233706", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P55096-1", "protein_name": "ATP-binding cassette sub-family D member 3", "gene_name": "Abcd3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAFSKYLTARNTSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLLLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYVATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGRYERTMVSQQEKGIEGAQASPLVPGAGEIINTDNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKRGISDQVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS", "length": 659 }, "evidence": [ { "id": "45233706", "url": "http://www.informatics.jax.org/homology/45233706", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "long-chain fatty acid transporter activity", "id": "GO:0005324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005324", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "acyl-CoA hydrolase activity", "id": "GO:0047617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047617", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "protein self-association", "id": "GO:0043621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "long-chain fatty acid import into peroxisome", "id": "GO:0015910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015910", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "very long-chain fatty acid metabolic process", "id": "GO:0000038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000038", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "bile acid biosynthetic process", "id": "GO:0006699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006699", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "very long-chain fatty acid catabolic process", "id": "GO:0042760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042760", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "peroxisome organization", "id": "GO:0007031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007031", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "bile acid and bile salt transport", "id": "GO:0015721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015721", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" }, { "name": "phytanic acid metabolic process", "id": "GO:1903512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903512", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation.", "evidence": [ { "database": "UniProtKB", "id": "P16970", "url": "https://www.uniprot.org/uniprot/P16970" }, { "database": "PubMed", "id": "P28288", "url": "https://glygen.org/publication/PubMed/P28288" } ] } ], "interactions": [], "reactions": [ { "id": "40415", "name": "", "equation": "H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "Q3I5F7-1", "Q32Q92-1", "P55096-1" ], "evidence": [ { "id": "40415", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40415" } ] }, { "id": "67072", "name": "", "equation": "a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QY44-1", "P16970-1", "D3ZHR2-1", "Q9UBJ2-1", "P33897-1", "P28288-1", "P55096-1", "Q61285-1", "P48410-1" ], "evidence": [ { "id": "67072", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67072" } ] }, { "id": "67080", "name": "", "equation": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QY44-1", "P16970-1", "D3ZHR2-1", "Q9UBJ2-1", "P33897-1", "P28288-1", "P55096-1", "Q61285-1", "P48410-1" ], "evidence": [ { "id": "67080", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67080" } ] }, { "id": "67680", "name": "", "equation": "a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67680", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67680" } ] }, { "id": "67684", "name": "", "equation": "a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67684" } ] }, { "id": "67688", "name": "", "equation": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67688", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67688" } ] }, { "id": "67692", "name": "", "equation": "ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67692", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67692" } ] }, { "id": "67696", "name": "", "equation": "H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67696", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67696" } ] }, { "id": "67700", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67700", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67700" } ] }, { "id": "67704", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67704", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67704" } ] }, { "id": "67708", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67708", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67708" } ] }, { "id": "67712", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P16970-1", "P28288-1", "P55096-1" ], "evidence": [ { "id": "67712", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67712" } ] }, { "id": "R-RNO-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, peroxisomal matrix, peroxisomal membrane", "input_participant_list": [ "R-ALL-382577" ], "output_participant_list": [ "R-ALL-382571" ], "enzyme_list": [ "Q9QY44-1", "D3ZHR2-1", "P16970-1" ], "evidence": [ { "id": "R-RNO-382575", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-382575" } ] }, { "id": "R-RNO-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, peroxisomal membrane", "input_participant_list": [ "R-RNO-382608" ], "output_participant_list": [ "R-RNO-3009036" ], "enzyme_list": [ "Q9QY44-1", "D3ZHR2-1", "P16970-1" ], "evidence": [ { "id": "R-RNO-382613", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-382613" } ] }, { "id": "R-RNO-9013009", "name": "RHOA binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63433-1", "P70496-1", "P61589-1", "O08815-1", "Q62868-1", "E9PTG8-1", "P68035-1", "P23711-1", "P16970-1", "Q63644-1", "O08874-1", "E9PSL7-1" ], "evidence": [ { "id": "R-RNO-9013009", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013009" } ] }, { "id": "R-RNO-9013110", "name": "RHOC binds effectors at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63433-1", "P61589-1", "O08815-1", "Q62868-1", "E9PTG8-1", "P16970-1", "Q63644-1", "O08874-1", "E9PSL7-1", "F1LXF1-1" ], "evidence": [ { "id": "R-RNO-9013110", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013110" } ] }, { "id": "R-RNO-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30839-1", "Q505J9-1", "Q9QY44-1", "P24392-1", "D3ZHR2-1", "P16970-1" ], "evidence": [ { "id": "R-RNO-9603775", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603775" } ] }, { "id": "R-RNO-9603784", "name": "PEX19:class I PMP binds PEX3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30839-1", "Q505J9-1", "Q9QY44-1", "P24392-1", "D3ZHR2-1", "P16970-1" ], "evidence": [ { "id": "R-RNO-9603784", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603784" } ] }, { "id": "R-RNO-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30839-1", "Q505J9-1", "Q9QY44-1", "P24392-1", "D3ZHR2-1", "P16970-1" ], "evidence": [ { "id": "R-RNO-9603804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603804" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-382571", "participant_name": "LCFA [peroxisomal matrix]", "crossref": [ { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-382577", "participant_name": "LCFA [cytosol]", "crossref": [ { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "C00638", "database": "COMPOUND", "url": "" }, { "id": "15904", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-RNO-3009036", "participant_name": "Pex19 [cytosol]", "crossref": [ { "id": "Q9QYU1", "database": "UniProt", "url": "" }, { "id": "1306913", "database": "RGD", "url": "" }, { "id": "Q9QYU1", "database": "PRO", "url": "" } ] }, { "participant_id": "R-RNO-382608", "participant_name": "Pex3 [peroxisomal membrane]", "crossref": [ { "id": "Q9JJK4", "database": "PRO", "url": "" }, { "id": "Q9JJK4", "database": "UniProt", "url": "" }, { "id": "NP_112640.1", "database": "RefSeq", "url": "" }, { "id": "621636", "database": "RGD", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "D3ZHR2", "gene_name": "Abcd1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "D3ZHR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHR2" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "D3ZHR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHR2" } ] } ] }, { "uniprot_ac": "E9PSL7", "gene_name": "Cit", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PSL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSL7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PSL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSL7" } ] } ] }, { "uniprot_ac": "E9PTG8", "gene_name": "Stk10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] } ] }, { "uniprot_ac": "F1LXF1", "gene_name": "Bcr", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LXF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LXF1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LXF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LXF1" } ] } ] }, { "uniprot_ac": "O08815", "gene_name": "Slk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08815" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08815" } ] } ] }, { "uniprot_ac": "O08874", "gene_name": "Pkn2", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08874" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "O08874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08874" } ] } ] }, { "uniprot_ac": "P16970", "gene_name": "Abcd3", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P16970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16970" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P16970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16970" } ] } ] }, { "uniprot_ac": "P23711", "gene_name": "Hmox2", "activity": [ { "ec_number": "1.14.14.18", "activity": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P23711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23711" } ] }, { "ec_number": "1.14.14.18", "activity": "", "evidence": [ { "id": "P23711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23711" } ] } ] }, { "uniprot_ac": "P24392", "gene_name": "Pex2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P24392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24392" } ] } ] }, { "uniprot_ac": "P28288", "gene_name": "ABCD3", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P28288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28288" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P28288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28288" } ] } ] }, { "uniprot_ac": "P30839", "gene_name": "Aldh3a2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.94", "activity": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH.", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.94", "activity": "", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] } ] }, { "uniprot_ac": "P33897", "gene_name": "ABCD1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P33897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33897" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P33897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33897" } ] } ] }, { "uniprot_ac": "P48410", "gene_name": "Abcd1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P48410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48410" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P48410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48410" } ] } ] }, { "uniprot_ac": "P55096", "gene_name": "Abcd3", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P55096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55096" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "P55096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55096" } ] } ] }, { "uniprot_ac": "P61589", "gene_name": "Rhoa", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] } ] }, { "uniprot_ac": "P68035", "gene_name": "Actc1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68035" } ] } ] }, { "uniprot_ac": "P70496", "gene_name": "Pld1", "activity": [ { "ec_number": "3.1.4.4", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+).", "evidence": [ { "id": "P70496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70496" } ] }, { "ec_number": "3.1.4.4", "activity": "", "evidence": [ { "id": "P70496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70496" } ] } ] }, { "uniprot_ac": "Q32Q92", "gene_name": "Acot6", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q32Q92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32Q92" } ] } ] }, { "uniprot_ac": "Q3I5F7", "gene_name": "ACOT6", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3I5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3I5F7" } ] } ] }, { "uniprot_ac": "Q505J9", "gene_name": "Atad1", "activity": [ { "ec_number": "7.4.2.-", "activity": "", "evidence": [ { "id": "Q505J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q505J9" } ] } ] }, { "uniprot_ac": "Q61285", "gene_name": "Abcd2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q61285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61285" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q61285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61285" } ] } ] }, { "uniprot_ac": "Q62868", "gene_name": "Rock2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62868" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62868" } ] } ] }, { "uniprot_ac": "Q63433", "gene_name": "Pkn1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63433" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q63433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63433" } ] } ] }, { "uniprot_ac": "Q63644", "gene_name": "Rock1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] } ] }, { "uniprot_ac": "Q9QY44", "gene_name": "Abcd2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9QY44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QY44" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q9QY44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QY44" } ] } ] }, { "uniprot_ac": "Q9UBJ2", "gene_name": "ABCD2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9UBJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBJ2" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "Q9UBJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBJ2" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }