{
"uniprot_canonical_ac": "P15907-1",
"uniprot_ac": "P15907",
"uniprot_id": "SIAT1_HUMAN",
"mass": {
"chemical_mass": 46605.0,
"monoisotopic_mass": 46605.0
},
"refseq": {
"ac": "NP_003023",
"name": "beta-galactoside alpha-2,6-sialyltransferase 1 isoform a",
"summary": "This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
"gene_names": [
{
"name": "ST6GAL1",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P15907",
"id": "P15907"
},
{
"name": "CDw75; SIAT1; ST6GalI; ST6N",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023",
"id": "NP_003023"
},
{
"name": "SIAT1",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P15907",
"id": "P15907"
},
{
"name": "ST6GAL1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023",
"id": "NP_003023"
}
],
"protein_names": [
{
"name": "Beta-galactoside alpha-2,6-sialyltransferase 1",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P15907"
},
{
"name": "2.4.3.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "Alpha 2,6-ST 1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "B-cell antigen CD75",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "ST6Gal I",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "ST6GalI",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "Sialyltransferase 1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P15907"
},
{
"name": "beta-galactoside alpha-2,6-sialyltransferase 1 isoform a",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023",
"id": "NP_003023"
},
{
"name": "sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase); CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; beta-galactoside alpha-2,6-sialyltransferase 1; alpha 2,6-ST 1; B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023",
"id": "NP_003023"
}
],
"function": [
{
"annotation": "Extracellular ST6GAL1 regulates monocyte-macrophage development and survival.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
{
"database": "PubMed",
"id": "35661210",
"url": "https://glygen.org/publication/PubMed/35661210"
}
]
},
{
"annotation": "Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
{
"database": "PubMed",
"id": "35676533",
"url": "https://glygen.org/publication/PubMed/35676533"
}
]
},
{
"annotation": "Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
{
"database": "PubMed",
"id": "36646912",
"url": "https://glygen.org/publication/PubMed/36646912"
}
]
},
{
"annotation": "ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
{
"database": "PubMed",
"id": "36528750",
"url": "https://glygen.org/publication/PubMed/36528750"
}
]
},
{
"annotation": "ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
},
{
"database": "PubMed",
"id": "37550801",
"url": "https://glygen.org/publication/PubMed/37550801"
}
]
},
{
"annotation": "This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_003023",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_003023"
}
]
},
{
"annotation": "Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907#function"
},
{
"database": "PubMed",
"id": "21081508",
"url": "https://glygen.org/publication/PubMed/21081508"
},
{
"database": "PubMed",
"id": "23999306",
"url": "https://glygen.org/publication/PubMed/23999306"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "rs1560173635",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1560173635"
},
{
"id": "rs1560173635",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs1560173635"
},
{
"id": "rs1560173635",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1560173635"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 100,
"end_pos": 100,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).",
"chr_id": "3",
"chr_pos": "187043002",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S100",
"keywords": [
"ebi",
"somatic"
]
},
{
"evidence": [
{
"id": "rs1366467487",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1366467487"
},
{
"id": "rs1366467487",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1366467487"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 149,
"end_pos": 149,
"sequence_org": "N",
"sequence_mut": "D",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVS->DVS).",
"chr_id": "3",
"chr_pos": "187043148",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N149",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs751485938",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs751485938"
},
{
"id": "rs751485938",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs751485938"
},
{
"id": "rs751485938",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs751485938"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 151,
"end_pos": 151,
"sequence_org": "S",
"sequence_mut": "C",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVS->NVC).",
"chr_id": "3",
"chr_pos": "187043155",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S151",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs778969734",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969734"
},
{
"id": "rs778969734",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969734"
},
{
"id": "rs778969734",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs778969734"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 161,
"end_pos": 161,
"sequence_org": "N",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTS->STS).",
"chr_id": "3",
"chr_pos": "187043185",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N161",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs778969734",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969734"
},
{
"id": "rs778969734",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778969734"
},
{
"id": "rs778969734",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs778969734"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 161,
"end_pos": 161,
"sequence_org": "N",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTS->TTS).",
"chr_id": "3",
"chr_pos": "187043185",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N161",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1398454149",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1398454149"
},
{
"id": "rs1398454149",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1398454149"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 171,
"end_pos": 171,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KES->NES).",
"chr_id": "3",
"chr_pos": "187043216",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K171",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs747048020",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747048020"
},
{
"id": "rs747048020",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747048020"
},
{
"id": "rs747048020",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs747048020"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 292,
"end_pos": 292,
"sequence_org": "P",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NQP->NQS).",
"chr_id": "3",
"chr_pos": "187074228",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "P292",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs905099697",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs905099697"
},
{
"id": "rs905099697",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs905099697#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 35,
"end_pos": 35,
"sequence_org": "Y",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (YDS->NDS).",
"chr_id": "3",
"chr_pos": "187042806",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "Y35",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs778777723",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778777723"
},
{
"id": "rs778777723",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778777723"
},
{
"id": "rs778777723",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs778777723"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 68,
"end_pos": 68,
"sequence_org": "T",
"sequence_mut": "A",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).",
"chr_id": "3",
"chr_pos": "187042905",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T68",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs771931718",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771931718"
},
{
"id": "rs771931718",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771931718"
},
{
"id": "rs771931718",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771931718"
},
{
"id": "rs771931718",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs771931718#frequency_tab"
},
{
"id": "rs771931718",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs771931718"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 68,
"end_pos": 68,
"sequence_org": "T",
"sequence_mut": "I",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).",
"chr_id": "3",
"chr_pos": "187042906",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T68",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs200944757",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200944757"
},
{
"id": "rs200944757",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs200944757#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 99,
"end_pos": 99,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DSS->NSS).",
"chr_id": "3",
"chr_pos": "187043310",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D99",
"keywords": [
"ebi",
"germline"
]
}
],
"mutagenesis": [
{
"start_pos": 24,
"end_pos": 24,
"sequence_org": "C",
"sequence_mut": "G",
"comment": "No effect on dimerization and on location at the Golgi stack.",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
},
{
"database": "PubMed",
"id": "20378551",
"url": "https://glygen.org/publication/PubMed/20378551"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "94.17",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "85.73",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "93.84",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "93.3",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "85.36",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "96.08",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "90.98",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "82.34",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "86.75",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "93.05",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "99.26",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "92.77",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "87.59",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000073849",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000073849"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
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{
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{
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{
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{
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{
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
"id": "MONDO:0001056",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P15907",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15907"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"title": "Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Angata K, Nakayama J, Fredette B, Chong K, Ranscht B, Fukuda M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-975577",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975577"
}
],
"reference": [
{
"type": "PubMed",
"id": "9054414",
"url": "https://glygen.org/publication/PubMed/9054414"
}
]
},
{
"title": "Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V).",
"journal": "Biochemical and biophysical research communications",
"date": "1997",
"authors": "Kim YJ, Kim KS, Do S, Kim CH, Kim SK, Lee YC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-4085001",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4085001"
}
],
"reference": [
{
"type": "PubMed",
"id": "9199191",
"url": "https://glygen.org/publication/PubMed/9199191"
}
]
},
{
"title": "The expanding beta 4-galactosyltransferase gene family: messages from the databanks.",
"journal": "Glycobiology",
"date": "1998",
"authors": "Lo NW, Shaper JH, Pevsner J, Shaper NL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-975577",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975577"
}
],
"reference": [
{
"type": "PubMed",
"id": "9597550",
"url": "https://glygen.org/publication/PubMed/9597550"
}
]
},
{
"title": "Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Ishii A, Ohta M, Watanabe Y, Matsuda K, Ishiyama K, Sakoe K, Nakamura M, Inokuchi J, Sanai Y, Saito M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-4085001",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4085001"
}
],
"reference": [
{
"type": "PubMed",
"id": "9822625",
"url": "https://glygen.org/publication/PubMed/9822625"
}
]
},
{
"title": "Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III).",
"journal": "Archives of biochemistry and biophysics",
"date": "1998",
"authors": "Lee YC, Kim YJ, Lee KY, Kim KS, Kim BU, Kim HN, Kim CH, Do SI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-4085001",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4085001"
}
],
"reference": [
{
"type": "PubMed",
"id": "9826427",
"url": "https://glygen.org/publication/PubMed/9826427"
}
]
}
],
"pathway": [
{
"id": "hsa:6480",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6480",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-4085001",
"name": "Sialic acid metabolism",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4085001",
"resource": "Reactome",
"description": "Sialic acid metabolism"
},
{
"id": "R-HSA-9683673",
"name": "Maturation of protein 3a",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9683673",
"resource": "Reactome",
"description": "Maturation of protein 3a"
},
{
"id": "R-HSA-9694548",
"name": "Maturation of spike protein",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694548",
"resource": "Reactome",
"description": "Maturation of spike protein"
},
{
"id": "R-HSA-9694719",
"name": "Maturation of protein 3a",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694719",
"resource": "Reactome",
"description": "Maturation of protein 3a"
},
{
"id": "R-HSA-975577",
"name": "N-Glycan antennae elongation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975577",
"resource": "Reactome",
"description": "N-Glycan antennae elongation"
},
{
"id": "R-HSA-977068",
"name": "Termination of O-glycan biosynthesis",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977068",
"resource": "Reactome",
"description": "Termination of O-glycan biosynthesis"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "P13721-1",
"protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1",
"gene_name": "St6gal1",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MIHTNLKKKFSLFILVFLLFAVICVWKKGSDYEALTLQAKEFQMPKSQEKVAMGSASQVVFSNSKQDPKEDIPILSYHRVTAKVKPQPSFQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNIRC",
"length": 403
},
"evidence": [
{
"id": "45228012",
"url": "http://www.informatics.jax.org/homology/45228012",
"database": "MGI"
},
{
"id": "P15907",
"url": "https://omabrowser.org/oma/group/P15907/",
"database": "OMA"
}
],
"common_name": "Rat"
},
{
"uniprot_canonical_ac": "Q64685-1",
"protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1",
"gene_name": "St6gal1",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC",
"length": 403
},
"evidence": [
{
"id": "45228012",
"url": "http://www.informatics.jax.org/homology/45228012",
"database": "MGI"
},
{
"id": "P15907",
"url": "https://omabrowser.org/oma/group/P15907/",
"database": "OMA"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 13,
"go_terms": [
{
"name": "positive regulation of mononuclear cell proliferation",
"id": "GO:0032946",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032946",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "regulation of substrate adhesion-dependent cell spreading",
"id": "GO:1900024",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900024",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "N-acetylneuraminate metabolic process",
"id": "GO:0006054",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006054",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "negative regulation of chemotaxis",
"id": "GO:0050922",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050922",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "viral protein processing",
"id": "GO:0019082",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019082",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "response to ethanol",
"id": "GO:0045471",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045471",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "O-glycan processing",
"id": "GO:0016266",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016266",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "protein N-linked glycosylation via asparagine",
"id": "GO:0018279",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018279",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "humoral immune response",
"id": "GO:0006959",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006959",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "sialylation",
"id": "GO:0097503",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097503",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "protein sialylation",
"id": "GO:1990743",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990743",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "negative regulation of macrophage apoptotic process",
"id": "GO:2000110",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000110",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "protein glycosylation",
"id": "GO:0006486",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 7,
"go_terms": [
{
"name": "Golgi membrane",
"id": "GO:0000139",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "extracellular region",
"id": "GO:0005576",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "Golgi apparatus",
"id": "GO:0005794",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "Golgi cisterna membrane",
"id": "GO:0032580",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "Golgi medial cisterna",
"id": "GO:0005797",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005797",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "Golgi trans cisterna",
"id": "GO:0000138",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000138",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "membrane",
"id": "GO:0016020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 3,
"go_terms": [
{
"name": "protein homodimerization activity",
"id": "GO:0042803",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "sialyltransferase activity",
"id": "GO:0008373",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008373",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
},
{
"name": "beta-galactoside alpha-2,6-sialyltransferase activity",
"id": "GO:0003835",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003835",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 149,
"end_pos": 151,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 161,
"end_pos": 163,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "N-glycosylated.",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
},
{
"database": "PubMed",
"id": "23999306",
"url": "https://glygen.org/publication/PubMed/23999306"
}
]
},
{
"annotation": "The soluble form derives from the membrane form by proteolytic processing.",
"evidence": [
{
"database": "UniProtKB",
"id": "P15907",
"url": "https://www.uniprot.org/uniprot/P15907"
},
{
"database": "PubMed",
"id": "P13721",
"url": "https://glygen.org/publication/PubMed/P13721"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "52104",
"name": "",
"equation": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q701R3-1",
"P13721-1",
"P15907-1",
"Q96JF0-1",
"Q64685-1",
"Q76K27-1"
],
"evidence": [
{
"id": "52104",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52104"
}
]
},
{
"id": "R-HSA-4085033",
"name": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)",
"equation": "",
"summary": "The beta-galactoside alpha-2,6-sialyltransferases 1 and 2 (ST6GAL1,2) are able to transfer a sialic acid (Neu5Ac) moiety to the terminal galactosyl (Gal-R) residue of O-glycosylated proteins and some gangliosides. Neu5Ac is added to Gal-R via an alpha-2,6 linkage (Wu et al. 2011, Takashima et al. 2002, Krzewinski-Recchi et al. 2003). Once sialylated, glycoconjugates translocate to the plasma membrane by an unknown mechanism. For simplicity, Gal is shown in a generic form where R represents other sugars O-linked to proteins. Highest activity is observed toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups.",
"cellular_location": "Golgi lumen, Golgi membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-4086294"
],
"enzyme_list": [
"Q96JF0-1",
"P15907-1"
],
"evidence": [
{
"id": "R-HSA-4085033",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4085033"
}
]
},
{
"id": "R-HSA-9683769",
"name": "O-glycosylation of 3a is terminated",
"equation": "",
"summary": "A sialyltransferase adds a terminal sialic acid moiety to protein 3a with an O-linked glycosyl side chain. This glycosylated form later is associated with the virion (Oostra et al, 2006).",
"cellular_location": "endoplasmic reticulum-Golgi intermediate compartment",
"input_participant_list": [
"R-ALL-9699093",
"R-COV-9683709"
],
"output_participant_list": [
"R-ALL-9699094",
"R-COV-9683640"
],
"enzyme_list": [
"Q11201-1",
"Q11206-1",
"Q16842-1",
"Q8NDV1-1",
"Q11203-1",
"P15907-1",
"Q9H4F1-1",
"Q9UJ37-1"
],
"evidence": [
{
"id": "R-HSA-9683769",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9683769"
}
]
},
{
"id": "R-HSA-9694718",
"name": "O-glycosylation of 3a is terminated",
"equation": "",
"summary": "This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
A sialyltransferase adds a terminal sialic acid moiety to protein 3a with an O-linked glycosyl side chain. This glycosylated form later is associated with the virion (Oostra et al, 2006)",
"cellular_location": "endoplasmic reticulum-Golgi intermediate compartment",
"input_participant_list": [
"R-COV-9694658"
],
"output_participant_list": [
"R-COV-9694386"
],
"enzyme_list": [
"Q11201-1",
"Q11206-1",
"Q16842-1",
"Q8NDV1-1",
"Q11203-1",
"P15907-1",
"Q9H4F1-1",
"Q9UJ37-1"
],
"evidence": [
{
"id": "R-HSA-9694718",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694718"
}
]
},
{
"id": "R-HSA-9697018",
"name": "Addition of sialic acids on some Spike glycosyl sidechains",
"equation": "",
"summary": "Glycosyl sidechains at Asn-1158 and Asn-1194 are sialylated, presumably by the cell's sialyltransferases (Watanabe et al, 2020).",
"cellular_location": "endoplasmic reticulum-Golgi intermediate compartment",
"input_participant_list": [
"R-COV-9697194"
],
"output_participant_list": [
"R-COV-9697197"
],
"enzyme_list": [
"Q11201-1",
"Q11206-1",
"Q16842-1",
"Q8NDV1-1",
"Q11203-1",
"P15907-1",
"Q9H4F1-1",
"Q9UJ37-1"
],
"evidence": [
{
"id": "R-HSA-9697018",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9697018"
}
]
},
{
"id": "R-HSA-975902",
"name": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans",
"equation": "",
"summary": "Addition of sialic acid to galactose-containing N-glycan. Sialic acid is usually found at terminal positions of the N-glycan. This imparts a negative charge at neutral pH which affects the chemico-physical and biological properties of the N-glycans (for review, see Schauer 2000); moreover, this modification can lead to the addition of extraordinarily long antennae such as polysialic acid (hundreds of sials) or polylactosamine repeats (dozens of disaccharide repeats) (Harduin-Lepers 2001), while the number of modifications on the antennae of N-glycans is usually lower.
There are over 20 sialyltransferases known in humans, 5 of which are known to act on N-glycans. Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) is the only sialyltransferase known to transfer sialic acid to galactose on N-Glycans (Dall'Olio 2000). A second beta-galactoside alpha-2,6-sialyltransferase has been characterized, but this enzyme acts mainly on oligosaccharides (Krzewinski-Recchi et al. 2003). Neu5Ac can also be added via an alpha-2,3-linkage to galactose on N-glycans by CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4) (Ellies et al. 2002). ST8Sia II (ST8SIA2), ST8Sia III (ST8SIA3), and ST8Sia IV (ST8SIA6) have alpha-2,8-activity (Angata et al. 1997, Angata et al. 2000, Angata & Fuduka 2003).",
"cellular_location": "Golgi lumen, Golgi membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P15907-1"
],
"evidence": [
{
"id": "R-HSA-975902",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975902"
}
]
},
{
"id": "R-HSA-977071",
"name": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens",
"equation": "",
"summary": "Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as Tn antigens (Stamenkovic et al. 1990, Marcos et al. 2004). The resultant sialyl Tn antigens are highly expressed in several human carcinomas and are associated with carcinoma aggressiveness and poor prognosis (Sewell et al. 2006, Lakshmanan et al. 2021).",
"cellular_location": "Golgi lumen, Golgi membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P15907-1"
],
"evidence": [
{
"id": "R-HSA-977071",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977071"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-4086294",
"participant_name": "Neu5Ac-2,6-Gal-R [Golgi lumen]",
"crossref": [
{
"id": "75129",
"database": "ChEBI",
"url": ""
},
{
"id": "75129",
"database": "ChEBI",
"url": ""
},
{
"id": "75129",
"database": "ChEBI",
"url": ""
},
{
"id": "75129",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-ALL-9699093",
"participant_name": "CMP-Neu5Ac [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "000008215638",
"database": "ZINC",
"url": ""
},
{
"id": "57812",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-ALL-9699094",
"participant_name": "CMP [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "C00055",
"database": "COMPOUND",
"url": ""
},
{
"id": "17361",
"database": "ChEBI",
"url": ""
},
{
"id": "8144170",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000003861744",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0000095",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-COV-9683640",
"participant_name": "O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]",
"crossref": [
{
"id": "P59632",
"database": "UniProt",
"url": ""
},
{
"id": "8EQS",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-COV-9683709",
"participant_name": "GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "P59632",
"database": "UniProt",
"url": ""
},
{
"id": "8EQS",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-COV-9694386",
"participant_name": "O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]",
"crossref": [
{
"id": "P0DTC3",
"database": "UniProt",
"url": ""
},
{
"id": "8EQU",
"database": "PDB",
"url": ""
},
{
"id": "6XDC",
"database": "PDB",
"url": ""
},
{
"id": "7KJR",
"database": "PDB",
"url": ""
},
{
"id": "8EQJ",
"database": "PDB",
"url": ""
},
{
"id": "8EQT",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-COV-9694658",
"participant_name": "GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "6XDC",
"database": "PDB",
"url": ""
},
{
"id": "P0DTC3",
"database": "UniProt",
"url": ""
},
{
"id": "8EQJ",
"database": "PDB",
"url": ""
},
{
"id": "8EQT",
"database": "PDB",
"url": ""
},
{
"id": "8EQU",
"database": "PDB",
"url": ""
},
{
"id": "7KJR",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-COV-9697194",
"participant_name": "tri-antennary N-glycan-PALM-Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "CPX-7042",
"database": "ComplexPortal",
"url": ""
},
{
"id": "CPX-5682",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-COV-9697197",
"participant_name": "fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]",
"crossref": [
{
"id": "CPX-5682",
"database": "ComplexPortal",
"url": ""
},
{
"id": "CPX-7042",
"database": "ComplexPortal",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "P13721",
"gene_name": "St6gal1",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "P13721",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13721"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "P13721",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13721"
}
]
}
]
},
{
"uniprot_ac": "P15907",
"gene_name": "ST6GAL1",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "P15907",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15907"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "P15907",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15907"
}
]
}
]
},
{
"uniprot_ac": "Q11201",
"gene_name": "ST3GAL1",
"activity": [
{
"ec_number": "2.4.3.2",
"activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).",
"evidence": [
{
"id": "Q11201",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11201"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q11201",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11201"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "",
"evidence": [
{
"id": "Q11201",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11201"
}
]
}
]
},
{
"uniprot_ac": "Q11203",
"gene_name": "ST3GAL3",
"activity": [
{
"ec_number": "2.4.3.6",
"activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q11203",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11203"
}
]
},
{
"ec_number": "2.4.3.6",
"activity": "",
"evidence": [
{
"id": "Q11203",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11203"
}
]
}
]
},
{
"uniprot_ac": "Q11206",
"gene_name": "ST3GAL4",
"activity": [
{
"ec_number": "2.4.3.2",
"activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).",
"evidence": [
{
"id": "Q11206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11206"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q11206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11206"
}
]
},
{
"ec_number": "2.4.3.6",
"activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q11206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11206"
}
]
},
{
"ec_number": "2.4.3.2",
"activity": "",
"evidence": [
{
"id": "Q11206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11206"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "",
"evidence": [
{
"id": "Q11206",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q11206"
}
]
}
]
},
{
"uniprot_ac": "Q16842",
"gene_name": "ST3GAL2",
"activity": [
{
"ec_number": "2.4.3.2",
"activity": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+).",
"evidence": [
{
"id": "Q16842",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16842"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q16842",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16842"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "",
"evidence": [
{
"id": "Q16842",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16842"
}
]
}
]
},
{
"uniprot_ac": "Q64685",
"gene_name": "St6gal1",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "Q64685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64685"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "Q64685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64685"
}
]
}
]
},
{
"uniprot_ac": "Q701R3",
"gene_name": "St6gal2",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "Q701R3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q701R3"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "Q701R3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q701R3"
}
]
}
]
},
{
"uniprot_ac": "Q76K27",
"gene_name": "St6gal2",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "Q76K27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76K27"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "Q76K27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76K27"
}
]
}
]
},
{
"uniprot_ac": "Q8NDV1",
"gene_name": "ST6GALNAC3",
"activity": [
{
"ec_number": "2.4.3.7",
"activity": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+).",
"evidence": [
{
"id": "Q8NDV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NDV1"
}
]
},
{
"ec_number": "2.4.3.7",
"activity": "",
"evidence": [
{
"id": "Q8NDV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NDV1"
}
]
}
]
},
{
"uniprot_ac": "Q96JF0",
"gene_name": "ST6GAL2",
"activity": [
{
"ec_number": "2.4.3.1",
"activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.",
"evidence": [
{
"id": "Q96JF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96JF0"
}
]
},
{
"ec_number": "2.4.3.1",
"activity": "",
"evidence": [
{
"id": "Q96JF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96JF0"
}
]
}
]
},
{
"uniprot_ac": "Q9H4F1",
"gene_name": "ST6GALNAC4",
"activity": [
{
"ec_number": "2.4.3.7",
"activity": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+).",
"evidence": [
{
"id": "Q9H4F1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4F1"
}
]
},
{
"ec_number": "2.4.3.7",
"activity": "",
"evidence": [
{
"id": "Q9H4F1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4F1"
}
]
}
]
},
{
"uniprot_ac": "Q9UJ37",
"gene_name": "ST6GALNAC2",
"activity": [
{
"ec_number": "2.4.3.3",
"activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "Q9UJ37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJ37"
}
]
},
{
"ec_number": "2.4.3.3",
"activity": "",
"evidence": [
{
"id": "Q9UJ37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UJ37"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [
{
"glytoucan_ac": "G00113FP",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G00321UH",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G00383NC",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G00413UF",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00420CS",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00480KJ",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G00514XC",
"type": "N-linked",
"subtype": "Tetraantennary"
},
{
"glytoucan_ac": "G00519UD",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G00520NI",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G00646SN",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00662IB",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00662UH",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00666EC",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00706AL",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G00738BQ",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G00745CN",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G00886GB",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G00910WD",
"type": "N-linked",
"subtype": "Tetraantennary"
},
{
"glytoucan_ac": "G00980BE",
"type": "O-linked",
"subtype": "Core 2"
},
{
"glytoucan_ac": "G01050GH",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G01069AK",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G01260KO",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G01310VF",
"type": "N-linked",
"subtype": "Tetraantennary"
},
{
"glytoucan_ac": "G01325OU",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G01354KL",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G01361CV",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G01665LU",
"type": "O-linked",
"subtype": "Core 3"
},
{
"glytoucan_ac": "G01670UQ",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G01727PW",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G01789AQ",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G01827FA",
"type": "N-linked",
"subtype": "Triantennary"
},
{
"glytoucan_ac": "G01856RL",
"type": "N-linked",
"subtype": "Complex"
},
{
"glytoucan_ac": "G01891JS",
"type": "N-linked",
"subtype": "Other"
},
{
"glytoucan_ac": "G01923XE",
"type": "N-linked",
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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],
"cluster_types": [
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},
{
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},
{
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