{ "uniprot_canonical_ac": "P15651-1", "uniprot_ac": "P15651", "uniprot_id": "ACADS_RAT", "mass": { "chemical_mass": 44765.0, "monoisotopic_mass": 44765.0 }, "refseq": { "ac": "NP_071957", "name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" }, "gene_names": [ { "name": "Acads", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P15651", "id": "P15651" }, { "name": "Acads", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "id": "NP_071957" }, { "name": "Scad", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "id": "NP_071957" } ], "protein_names": [ { "name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P15651" }, { "name": "1.3.8.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15651" }, { "name": "Butyryl-CoA dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15651" }, { "name": "SCAD", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15651" }, { "name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "id": "NP_071957" }, { "name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase; short chain acyl-coenzyme A dehydrogenase; acetyl-Coenzyme A dehydrogenase, short chain; short-chain acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, short chain; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; acyl-CoA dehydrogenase, C-2 to C-3 short chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "id": "NP_071957" } ], "function": [ { "annotation": "Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" }, { "database": "PubMed", "id": "36883465", "url": "https://glygen.org/publication/PubMed/36883465" } ] }, { "annotation": "Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:3968063).", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651#function" }, { "database": "PubMed", "id": "3968063", "url": "https://glygen.org/publication/PubMed/3968063" } ] }, { "annotation": "The down-regulated expression of SCAD in pathological cardiac hypertrophy may be responsible for 'the recapitulation of foetal energy metabolism'.", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" }, { "database": "PubMed", "id": "25753319", "url": "https://glygen.org/publication/PubMed/25753319" } ] }, { "annotation": "The phosphorylation of ERK1/2 inhibited the expression and activity of SCAD through the PPARalpha signaling pathway, which induced the development of pathological cardiomyocyte hypertrophy.", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" }, { "database": "PubMed", "id": "25636810", "url": "https://glygen.org/publication/PubMed/25636810" } ] }, { "annotation": "The role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis, is reported.", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" }, { "database": "PubMed", "id": "26989860", "url": "https://glygen.org/publication/PubMed/26989860" } ] } ], "disease": [ { "disease_id": "DOID:0080154", "recommended_name": { "id": "DOID:0080154", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080154", "name": "short chain acyl-CoA dehydrogenase deficiency", "description": "A lipid metabolism disorder that is characterized by deficiency of the enzyme short chain acyl-CoA dehydrogenase that results in the inability to convert short chain fatty acids." }, "synonyms": [ { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short chain acyl-CoA dehydrogenase deficiency", "description": "Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a very rare inborn error of mitochondrial fatty acid oxidation characterized by variable manifestations ranging from asymptomatic individuals (in most cases) to those with failure to thrive, hypotonia, seizures, developmental delay and progressive myopathy." }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "ACADS deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "SCAD", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "SCAD deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "SCADD", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "acyl-CoA dehydrogenase, short-chain deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short chain acyl-CoA dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short-chain acyl-CoA dehydrogenase deficiency (SCAD)", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short-chain acyl-Coenzyme A dehydrogenase deficiency (SCAD)", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "ACADSD", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "Acads deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "Scad deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "Scadh deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "acyl-CoA dehydrogenase, short-chain, deficiency OF", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "lipid-storage myopathy secondary to short-chain acyl-Coa dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short-chain acyl-CoA dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0008722", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008722", "name": "short-chain acyl-coenzyme A dehydrogenase deficiency", "description": "" }, { "id": "MIM:201470", "resource": "MIM", "url": "https://www.omim.org/entry/201470", "name": "Acyl-CoA dehydrogenase short-chain deficiency", "description": "Acyl-CoA dehydrogenase short-chain deficiency" } ], "evidence": [ { "id": "0080154", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080154" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "common_name": "Rat" } ], "gene": [ { "name": "Acads", "url": "https://www.uniprot.org/uniprot/P15651", "locus": { "chromosome": "12", "start_pos": 41502898, "end_pos": 41493626, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000001177", "url": "https://www.ensembl.org/id/ENSRNOG00000001177" } ] } } ], "crossref": [ { "id": "1.3.8.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.8.1&UniProtAcc=P15651", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01158", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01158", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2176825", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2176825", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "64304", "url": "https://www.ncbi.nlm.nih.gov/gene/64304", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P15651", "url": "https://www.ebi.ac.uk/intact/interactors/id:P15651*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:64304", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64304", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "P15651", "url": "https://oglcnac.org/atlas/detail/P15651", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P15651", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P15651", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "GKMGQRA", "url": "https://omabrowser.org/oma/group/GKMGQRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275353at2759", "url": "http://www.orthodb.org/?query=275353at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43884:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43884:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1JQI", "url": "https://www.rcsb.org/structure/1JQI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00441", "url": "http://pfam.xfam.org/family/PF00441", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02770", "url": "http://pfam.xfam.org/family/PF02770", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02771", "url": "http://pfam.xfam.org/family/PF02771", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P15651", "url": "http://purl.obolibrary.org/obo/PR_P15651", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-77350", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77350", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-77352", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77352", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620514", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620514", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "24004", "url": "https://www.rhea-db.org/rhea/24004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43456", "url": "https://www.rhea-db.org/rhea/43456", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43464", "url": "https://www.rhea-db.org/rhea/43464", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47196", "url": "https://www.rhea-db.org/rhea/47196", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6AJ45", "url": "https://www.uniprot.org/uniprot/A0A8I6AJ45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AJ45-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AJ45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GC92", "url": "https://www.uniprot.org/uniprot/A0A8I6GC92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GC92-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GC92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7F6Q6", "url": "https://www.uniprot.org/uniprot/F7F6Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7F6Q6-1", "url": "https://www.uniprot.org/uniprot/F7F6Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P15651-1", "url": "https://www.uniprot.org/uniprot/P15651-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 412, "header": "sp|P15651-1|ACADS_RAT Isoform 1 of Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=2 CANONICAL=P15651-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AJ45-1", "url": "", "sequence": { "sequence": "EPPCGCWELNSGGPLGRTVTLRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRSLTFHLLERRLMGGAGLLQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 421, "header": "tr|A0A8I6AJ45-1|ACADS_RAT Computationally mapped isoform of Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=1 CANONICAL=P15651-1" }, "locus": { "chromosome": "12", "start_pos": 41502417, "end_pos": 41494674, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098620.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098620.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093188.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093188.1" } ] } }, { "isoform_ac": "A0A8I6GC92-1", "url": "", "sequence": { "sequence": "MAMAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQVGPGFQELGTGLMEGSLTFHLLGSPLLPQPSLCHPHPSNPLPGQWEGERRLMGGAGLLQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 473, "header": "tr|A0A8I6GC92-1|A0A8I6GC92_RAT Computationally mapped isoform of Acyl-CoA dehydrogenase short chain OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=1 CANONICAL=P15651-1" }, "locus": { "chromosome": "12", "start_pos": 41502417, "end_pos": 41493676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102388.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102388.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000084893.1", "url": "https://www.ensembl.org/id/ENSRNOP00000084893.1" } ] } }, { "isoform_ac": "F7F6Q6-1", "url": "", "sequence": { "sequence": "MAMAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQVSTKPLGTAPFPSPVSGTSPSLCLFFLLGHPDPGRHGVRDRDASRALLPRCPHH", "length": 418, "header": "tr|F7F6Q6-1|ACADS_RAT Computationally mapped isoform of Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=1 CANONICAL=P15651-1" }, "locus": { "chromosome": "12", "start_pos": 41502344, "end_pos": 41493676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000001556.5", "url": "https://www.ensembl.org/id/ENSRNOT00000001556.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000001556.4", "url": "https://www.ensembl.org/id/ENSRNOP00000001556.4" } ] } }, { "isoform_ac": "P15651-1", "url": "", "sequence": { "sequence": "MAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 412, "header": "sp|P15651-1|ACADS_RAT Isoform 1 of Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acads PE=1 SV=2 CANONICAL=P15651-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 323, "start_aa": "Ser", "end_pos": 323, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser323", "evidence": [ { "id": "P15651", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P15651" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "P15651", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P15651" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 395, "start_aa": "Ser", "end_pos": 395, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser395", "evidence": [ { "id": "P15651", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P15651" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "P15651", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P15651" } ] } ], "phosphorylation": [ { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "site_lbl": "Thr27" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Battaile KP, Molin-Case J, Paschke R, Wang M, Bennett D, Vockley J, Kim JJ", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "reference": [ { "type": "PubMed", "id": "11812788", "url": "https://glygen.org/publication/PubMed/11812788" } ] }, { "title": "Effects of ERK1/2/PPARalpha/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.", "journal": "Life sciences", "date": "2015", "authors": "Huang Q, Huang J, Zeng Z, Luo J, Liu P, Chen S, Liu B, Pan X, Zang L, Zhou S", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" } ], "reference": [ { "type": "PubMed", "id": "25636810", "url": "https://glygen.org/publication/PubMed/25636810" } ] }, { "title": "Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.", "journal": "Journal of cellular and molecular medicine", "date": "2015", "authors": "Huang J, Xu L, Huang Q, Luo J, Liu P, Chen S, Yuan X, Lu Y, Wang P, Zhou S", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" } ], "reference": [ { "type": "PubMed", "id": "25753319", "url": "https://glygen.org/publication/PubMed/25753319" } ] }, { "title": "O-GlcNAcomic Profiling Identifies Widespread O-Linked beta-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Ma J, Liu T, Wei AC, Banerjee P, O'Rourke B, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P15651", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P15651" }, { "database": "O-GlcNAc Atlas", "id": "P15651", "url": "https://oglcnac.org/atlas/detail/P15651" } ], "reference": [ { "type": "PubMed", "id": "26446791", "url": "https://glygen.org/publication/PubMed/26446791" } ] }, { "title": "Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis.", "journal": "Journal of cellular and molecular medicine", "date": "2016", "authors": "Zeng Z, Huang Q, Shu Z, Liu P, Chen S, Pan X, Zang L, Zhou S", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" } ], "reference": [ { "type": "PubMed", "id": "26989860", "url": "https://glygen.org/publication/PubMed/26989860" } ] }, { "title": "Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts.", "journal": "Journal of proteome research", "date": "2016", "authors": "Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P15651", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P15651" }, { "database": "O-GlcNAc Atlas", "id": "P15651", "url": "https://oglcnac.org/atlas/detail/P15651" } ], "reference": [ { "type": "PubMed", "id": "27213235", "url": "https://glygen.org/publication/PubMed/27213235" } ] }, { "title": "Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family.", "journal": "J. Biol. Chem.", "date": "1989", "authors": "Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J, Ikeda Y, Kraus J, Tanaka K", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "reference": [ { "type": "PubMed", "id": "2777793", "url": "https://glygen.org/publication/PubMed/2777793" } ] }, { "title": "Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.", "journal": "Journal of hypertension", "date": "2023-05-01", "authors": "Zhong Xiaoyi, Li Zhonghong, Xu Qingping, Peng Huan, Su Yongshao, Le Kang, Shu Zhaohui, Liao Yingqin, Ma Zhichao, Pan Xuediao, Xu Suowen, Zhou Sigui", "evidence": [ { "database": "RefSeq", "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957" } ], "reference": [ { "type": "PubMed", "id": "36883465", "url": "https://glygen.org/publication/PubMed/36883465" } ] }, { "title": "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.", "journal": "J. Biol. Chem.", "date": "1985", "authors": "Ikeda Y., Tanaka K., Okamura-Ikeda K.", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "reference": [ { "type": "PubMed", "id": "3968063", "url": "https://glygen.org/publication/PubMed/3968063" } ] } ], "pathway": [ { "id": "rno:64304", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64304", "resource": "KEGG Pathway" }, { "id": "R-RNO-77350", "name": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77350", "resource": "Reactome", "description": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA" }, { "id": "R-RNO-77352", "name": "Beta oxidation of butanoyl-CoA to acetyl-CoA", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77352", "resource": "Reactome", "description": "Beta oxidation of butanoyl-CoA to acetyl-CoA" } ], "orthologs": [ { "uniprot_canonical_ac": "P16219-1", "protein_name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 412 }, "evidence": [ { "id": "45233073", "url": "http://www.informatics.jax.org/homology/45233073", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q07417-1", "protein_name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acads", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAALLARARGPLRRALGVRDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS", "length": 412 }, "evidence": [ { "id": "45233073", "url": "http://www.informatics.jax.org/homology/45233073", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "acyl-CoA dehydrogenase activity", "id": "GO:0003995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003995", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "butyryl-CoA dehydrogenase activity", "id": "GO:0004085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004085", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "fatty-acyl-CoA binding", "id": "GO:0000062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000062", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "fatty acid beta-oxidation using acyl-CoA dehydrogenase", "id": "GO:0033539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033539", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "response to glucocorticoid", "id": "GO:0051384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051384", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "butyrate catabolic process", "id": "GO:0046359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046359", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "carboxylic acid catabolic process", "id": "GO:0046395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046395", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" }, { "name": "primary metabolic process", "id": "GO:0044238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044238", "evidence": [ { "database": "UniProtKB", "id": "P15651", "url": "https://www.uniprot.org/uniprot/P15651" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24004", "name": "", "equation": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15651-1", "P70584-1", "P12007-1", "P16219-1", "P45954-1", "P26440-1", "Q07417-1", "Q9DBL1-1", "Q9JHI5-1", "Q9VSL9-1" ], "evidence": [ { "id": "24004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24004" } ] }, { "id": "43456", "name": "", "equation": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15651-1", "P08503-1", "P12007-1", "P16219-1", "P11310-1", "P26440-1", "Q07417-1", "Q9JHI5-1", "P45952-1", "Q9VSL9-1" ], "evidence": [ { "id": "43456", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43456" } ] }, { "id": "43464", "name": "", "equation": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15650-1", "P15651-1", "P70584-1", "P08503-1", "P12007-1", "P16219-1", "P28330-1", "P11310-1", "P45954-1", "P26440-1", "P51174-1", "Q07417-1", "Q9DBL1-1", "Q9JHI5-1", "P45952-1", "Q9VSL9-1" ], "evidence": [ { "id": "43464", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43464" } ] }, { "id": "47196", "name": "", "equation": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15651-1", "P16219-1", "Q07417-1" ], "evidence": [ { "id": "47196", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47196" } ] }, { "id": "R-RNO-77319", "name": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-77313" ], "enzyme_list": [ "P15651-1" ], "evidence": [ { "id": "R-RNO-77319", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77319" } ] }, { "id": "R-RNO-77327", "name": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-77324" ], "enzyme_list": [ "P15651-1" ], "evidence": [ { "id": "R-RNO-77327", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77327" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-77313", "participant_name": "Crotonoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "C00877", "database": "COMPOUND", "url": "" }, { "id": "57332", "database": "ChEBI", "url": "" }, { "id": "000008551257", "database": "ZINC", "url": "" }, { "id": "57332", "database": "ChEBI", "url": "" }, { "id": "000008551257", "database": "ZINC", "url": "" }, { "id": "C00877", "database": "COMPOUND", "url": "" }, { "id": "C00877", "database": "COMPOUND", "url": "" }, { "id": "57332", "database": "ChEBI", "url": "" }, { "id": "000008551257", "database": "ZINC", "url": "" }, { "id": "C00877", "database": "COMPOUND", "url": "" }, { "id": "000008551257", "database": "ZINC", "url": "" }, { "id": "57332", "database": "ChEBI", "url": "" }, { "id": "C00877", "database": "COMPOUND", "url": "" }, { "id": "57332", "database": "ChEBI", "url": "" }, { "id": "000008551257", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-77324", "participant_name": "trans-Hex-2-enoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "C05271", "database": "COMPOUND", "url": "" }, { "id": "62077", "database": "ChEBI", "url": "" }, { "id": "000008551764", "database": "ZINC", "url": "" }, { "id": "62077", "database": "ChEBI", "url": "" }, { "id": "C05271", "database": "COMPOUND", "url": "" }, { "id": "000008551764", "database": "ZINC", "url": "" }, { "id": "C05271", "database": "COMPOUND", "url": "" }, { "id": "62077", "database": "ChEBI", "url": "" }, { "id": "000008551764", "database": "ZINC", "url": "" }, { "id": "C05271", "database": "COMPOUND", "url": "" }, { "id": "000008551764", "database": "ZINC", "url": "" }, { "id": "62077", "database": "ChEBI", "url": "" }, { "id": "C05271", "database": "COMPOUND", "url": "" }, { "id": "62077", "database": "ChEBI", "url": "" }, { "id": "000008551764", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P08503", "gene_name": "Acadm", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P08503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08503" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "P08503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08503" } ] } ] }, { "uniprot_ac": "P11310", "gene_name": "ACADM", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P11310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11310" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "P11310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11310" } ] } ] }, { "uniprot_ac": "P12007", "gene_name": "Ivd", "activity": [ { "ec_number": "1.3.8.4", "activity": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P12007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12007" } ] }, { "ec_number": "1.3.8.1", "activity": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P12007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12007" } ] }, { "ec_number": "1.3.8.4", "activity": "", "evidence": [ { "id": "P12007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12007" } ] }, { "ec_number": "1.3.8.1", "activity": "", "evidence": [ { "id": "P12007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12007" } ] } ] }, { "uniprot_ac": "P15650", "gene_name": "Acadl", "activity": [ { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P15650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15650" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "P15650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15650" } ] } ] }, { "uniprot_ac": "P15651", "gene_name": "Acads", "activity": [ { "ec_number": "1.3.8.1", "activity": 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"P26440", "gene_name": "IVD", "activity": [ { "ec_number": "1.3.8.4", "activity": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P26440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26440" } ] }, { "ec_number": "1.3.8.1", "activity": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P26440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26440" } ] }, { "ec_number": "1.3.8.4", "activity": "", "evidence": [ { "id": "P26440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26440" } ] }, { "ec_number": "1.3.8.1", "activity": "", "evidence": [ { "id": "P26440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26440" } ] } ] }, { "uniprot_ac": "P28330", "gene_name": "ACADL", "activity": [ { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P28330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28330" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "P28330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28330" } ] } ] }, { "uniprot_ac": "P45952", "gene_name": "Acadm", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "P45952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45952" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "P45952", "database": 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