The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-9841212" ], "output_participant_list": [ "R-ALL-1609649", "R-ALL-9841230" ], "enzyme_list": [ "P15589-1" ], "evidence": [ { "id": "R-RNO-1606839", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1606839" } ] }, { "id": "R-RNO-1614362", "name": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1663154" ], "enzyme_list": [ "P50430-1", "P15589-1", "Q32KJ2-1", "Q32KJ8-1", "Q32KJ9-1", "Q32KK0-1" ], "evidence": [ { "id": "R-RNO-1614362", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1614362" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1609649", "participant_name": "SO4(2-) [endoplasmic reticulum lumen]", "crossref": [ { "id": "16189", "database": "ChEBI", "url": "" }, { "id": "C00059", "database": "COMPOUND", "url": "" }, { "id": "8144977", "database": "PubChem Substance", "url": "" }, { "id": "16189", "database": "ChEBI", "url": "" }, { "id": "C00059", "database": "COMPOUND", "url": "" }, { "id": "8144977", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-1663154", "participant_name": "H2S [endoplasmic reticulum lumen]", "crossref": [ { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9841212", "participant_name": "steroid sulfate [endoplasmic reticulum lumen]", "crossref": [ { "id": "59696", "database": "ChEBI", "url": "" }, { "id": "59696", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9841230", "participant_name": "steroid [endoplasmic reticulum lumen]", "crossref": [ { "id": "35341", "database": "ChEBI", "url": "" }, { "id": "C00377", "database": "COMPOUND", "url": "" }, { "id": "35341", "database": "ChEBI", "url": "" }, { "id": "C00377", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P08842", "gene_name": "STS", "activity": [ { "ec_number": "3.1.6.2", "activity": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate.", "evidence": [ { "id": "P08842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08842" } ] }, { "ec_number": "3.1.6.2", "activity": "", "evidence": [ { "id": "P08842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08842" } ] } ] }, { "uniprot_ac": "P15589", "gene_name": "Sts", "activity": [ { "ec_number": "3.1.6.2", "activity": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate.", "evidence": [ { "id": "P15589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15589" } ] }, { "ec_number": "3.1.6.2", "activity": "", "evidence": [ { "id": "P15589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15589" } ] } ] }, { "uniprot_ac": "P50427", "gene_name": "Sts", "activity": [ { "ec_number": "3.1.6.2", "activity": "dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate.", "evidence": [ { "id": "P50427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50427" } ] }, { "ec_number": "3.1.6.2", "activity": "", "evidence": [ { "id": "P50427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50427" } ] } ] }, { "uniprot_ac": "P50430", "gene_name": "Arsb", "activity": [ { "ec_number": "3.1.6.12", "activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] }, { "ec_number": "3.1.6.12", "activity": "", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] } ] }, { "uniprot_ac": "Q32KJ2", "gene_name": "Arsk", "activity": [ { "ec_number": "3.1.6.1", "activity": "an aryl sulfate + H2O = a phenol + H(+) + sulfate.", "evidence": [ { "id": "Q32KJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ2" } ] }, { "ec_number": "3.1.6.18", "activity": "Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.", "evidence": [ { "id": "Q32KJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ2" } ] }, { "ec_number": "3.1.6.1", "activity": "", "evidence": [ { "id": "Q32KJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ2" } ] } ] }, { "uniprot_ac": "Q32KJ8", "gene_name": "Arsi", "activity": [ { "ec_number": "3.1.6.-", "activity": "", "evidence": [ { "id": "Q32KJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ8" } ] } ] }, { "uniprot_ac": "Q32KJ9", "gene_name": "Arsg", "activity": [ { "ec_number": "3.1.6.1", "activity": "an aryl sulfate + H2O = a phenol + H(+) + sulfate.", "evidence": [ { "id": "Q32KJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ9" } ] }, { "ec_number": "3.1.6.15", "activity": "Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.", "evidence": [ { "id": "Q32KJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ9" } ] }, { "ec_number": "3.1.6.1", "activity": "", "evidence": [ { "id": "Q32KJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ9" } ] } ] }, { "uniprot_ac": "Q32KK0", "gene_name": "Arsl", "activity": [ { "ec_number": "3.1.6.1", "activity": "an aryl sulfate + H2O = a phenol + H(+) + sulfate.", "evidence": [ { "id": "Q32KK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KK0" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 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