{ "uniprot_canonical_ac": "P15509-1", "uniprot_ac": "P15509", "uniprot_id": "CSF2R_HUMAN", "mass": { "chemical_mass": 46207.0, "monoisotopic_mass": 46207.0 }, "refseq": { "ac": "NP_001155001", "name": "granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor", "summary": "The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, "gene_names": [ { "name": "CSF2RA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P15509", "id": "P15509" }, { "name": "CSF2RA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001", "id": "NP_001155001" }, { "name": "CSF2RY", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P15509", "id": "P15509" }, { "name": "CSF2R", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P15509", "id": "P15509" }, { "name": "alphaGMR; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMCSFR-alpha; GMR; GMR-alpha; SMDP4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001", "id": "NP_001155001" } ], "protein_names": [ { "name": "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P15509" }, { "name": "CDw116", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15509" }, { "name": "GM-CSF-R-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15509" }, { "name": "GMCSFR-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15509" }, { "name": "GMR-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15509" }, { "name": "granulocyte-macrophage colony-stimulating factor receptor alpha chain; CD116 antigen; GM-CSF receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); alpha-GM-CSF receptor; colony stimulating factor 2 receptor alpha subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001", "id": "NP_001155001" }, { "name": "granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001", "id": "NP_001155001" } ], "function": [ { "annotation": "A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, { "database": "PubMed", "id": "35043685", "url": "https://glygen.org/publication/PubMed/35043685" } ] }, { "annotation": "CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, { "database": "PubMed", "id": "35019940", "url": "https://glygen.org/publication/PubMed/35019940" } ] }, { "annotation": "Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, { "database": "PubMed", "id": "32365364", "url": "https://glygen.org/publication/PubMed/32365364" } ] }, { "annotation": "Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.", "evidence": [ { "database": "UniProtKB", "id": "P15509", "url": "https://www.uniprot.org/uniprot/P15509#function" } ] }, { "annotation": "MiR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation.", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, { "database": "PubMed", "id": "32473103", "url": "https://glygen.org/publication/PubMed/32473103" } ] }, { "annotation": "The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" } ] }, { "annotation": "These data show that loss of membrane GM-CSFRalpha following GM-CSF exposure does not preclude sustained GM-CSF/GM-CSFRalpha signaling and that this receptor plays a key role in ligand clearance. Hence neutrophilic activation via GM-CSFR may play an important role in neutrophilic lung inflammation even in the absence of high GM-CSF levels or GM-CSFRalpha expression.", "evidence": [ { "database": "RefSeq", "id": "NP_001155001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155001" }, { "database": "PubMed", "id": "30942918", "url": "https://glygen.org/publication/PubMed/30942918" } ] } ], "disease": [ { "disease_id": "DOID:12120", "recommended_name": { "id": "DOID:12120", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12120", "name": "pulmonary alveolar proteinosis", "description": "A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange." }, "synonyms": [ { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "surfactant metabolism dysfunction, pulmonary, 2", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "SMDP2", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "desquamative interstitial pneumonitis due to surfactant Protein C deficiency", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "interstitial lung disease due to surfactant Protein C deficiency", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "pulmonary alveolar proteinosis, congenital, 2", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "surfactant metabolism dysfunction, pulmonary, 2", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, type 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "Csf2Ra deficiency", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "Pap due to Csf2Ra deficiency", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "SMDP4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "pulmonary alveolar proteinosis, congenital, 4", "description": "" }, { "id": "MONDO:0012582", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012582", "name": "interstitial lung disease due to ABCA3 deficiency", "description": "Interstitial lung disease due to ABCA3 deficiency is a rare genetic respiratory disease characterized by a variable clinical outcome ranging from a fatal respiratory distress syndrome in the neonatal period to chronic interstitial lung disease developing in infancy or childhood with chronic cough, rapid breathing, shortness of breath and recurrent pulmonary infections. 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"https://monarchinitiative.org/disease/MONDO:0012582", "name": "pulmonary alveolar proteinosis, congenital, 3", "description": "" }, { "id": "MONDO:0012582", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012582", "name": "surfactant metabolism dysfunction, pulmonary, 3", "description": "" }, { "id": "MONDO:0013712", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013712", "name": "surfactant metabolism dysfunction, pulmonary, 5", "description": "Any hereditary pulmonary alveolar proteinosis in which the cause of the disease is a mutation in the CSF2RB gene." }, { "id": "MONDO:0013712", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013712", "name": "CSF2RB hereditary pulmonary alveolar proteinosis", "description": "" }, { "id": "MONDO:0013712", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013712", "name": "hereditary pulmonary alveolar proteinosis caused by mutation in CSF2RB", 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"name": "interstitial lung disease due to surfactant Protein C deficiency", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "pulmonary alveolar proteinosis, congenital, 2", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "surfactant metabolism dysfunction, pulmonary, 2", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, 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"https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0024465", "name": "pulmonary alveolar proteinosis, congenital, 2", "description": "" }, { "id": "MONDO:0024465", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024465", "name": "surfactant metabolism dysfunction, pulmonary, 2", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", "name": "surfactant metabolism dysfunction, pulmonary, type 4", "description": "" }, { "id": "MONDO:0010424", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010424", 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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000198223" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "78.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198223", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198223" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P15509", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15509" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": 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"https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P15509", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15509" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15509" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P15509", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P15509" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"P15509-6", "url": "https://www.uniprot.org/uniprot/P15509-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P15509-7", "url": "https://www.uniprot.org/uniprot/P15509-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P15509-8", "url": "https://www.uniprot.org/uniprot/P15509-8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYE9", "url": "https://www.uniprot.org/uniprot/V9GYE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYE9-1", "url": "https://www.uniprot.org/uniprot/V9GYE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT", "length": 400, "header": "sp|P15509-1|CSF2R_HUMAN Isoform 1 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "isoforms": [ { "isoform_ac": "A0A8Q3SIC6-1", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSGKYGNLAEPSPRPLFRCPASGDPSGYLGPSAFHL", "length": 59, "header": "tr|A0A8Q3SIC6-1|A0A8Q3SIC6_HUMAN Computationally mapped isoform of Colony stimulating factor 2 receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=4 SV=1 CANONICAL=P15509-1" }, "locus": {} }, { "isoform_ac": 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"MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT", "length": 400, "header": "sp|P15509-1|CSF2R_HUMAN Isoform 1 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1309476, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381524.8", "url": "https://www.ensembl.org/id/ENST00000381524.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000370935.3", "url": "https://www.ensembl.org/id/ENSP00000370935.3" } ] } }, { "isoform_ac": "P15509-2", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEMGPQRHHRCGWNLYPTPGPSPGSGSSPRLGSESSL", "length": 410, "header": "sp|P15509-2|CSF2R_HUMAN Isoform 2 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1305732, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381509.8", "url": "https://www.ensembl.org/id/ENST00000381509.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000370920.3", "url": "https://www.ensembl.org/id/ENSP00000370920.3" } ] } }, { "isoform_ac": "P15509-3", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSLGYSGCSRQFHRSKTN", "length": 333, "header": "sp|P15509-3|CSF2R_HUMAN Isoform 3 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1305498, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381500.6", "url": "https://www.ensembl.org/id/ENST00000381500.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000370911.1", "url": "https://www.ensembl.org/id/ENSP00000370911.1" } ] } }, { "isoform_ac": "P15509-4", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLVVLTTGTSALCTFMCS", "length": 286, "header": "sp|P15509-4|CSF2R_HUMAN Isoform 4 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": {} }, { "isoform_ac": "P15509-5", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFDHLGGIHPRGRERLPRRGLDREGNYLRPRGCRNGMDISASATRGNCFLDDAVNLYIIFYVFI", "length": 377, "header": "sp|P15509-5|CSF2R_HUMAN Isoform 5 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1309586, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000355432.8", "url": "https://www.ensembl.org/id/ENST00000355432.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000347606.3", "url": "https://www.ensembl.org/id/ENSP00000347606.3" } ] } }, { "isoform_ac": "P15509-6", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIGSLGYSGCSRQFHRSKTN", "length": 233, "header": "sp|P15509-6|CSF2R_HUMAN Isoform 6 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1305498, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000355805.7", "url": "https://www.ensembl.org/id/ENST00000355805.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000348058.2", "url": "https://www.ensembl.org/id/ENSP00000348058.2" } ] } }, { "isoform_ac": "P15509-7", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSHSVTQAGVQWHNLGSLQPPSPRLKRFSCLRLPGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT", "length": 434, "header": "sp|P15509-7|CSF2R_HUMAN Isoform 7 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1309476, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000498153.7", "url": "https://www.ensembl.org/id/ENST00000498153.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000512483.1", "url": "https://www.ensembl.org/id/ENSP00000512483.1" } ] } }, { "isoform_ac": "P15509-8", "url": "", "sequence": { "sequence": "MNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT", "length": 267, "header": "sp|P15509-8|CSF2R_HUMAN Isoform 8 of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": {} }, { "isoform_ac": "V9GYE9-1", "url": "", "sequence": { "sequence": "MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRMEFPSCCPDRTIAHQPA", "length": 90, "header": "tr|V9GYE9-1|CSF2R_HUMAN Computationally mapped isoform of Granulocyte-macrophage colony-stimulating factor receptor subunit alpha OS=Homo sapiens OX=9606 GN=CSF2RA PE=1 SV=1 CANONICAL=P15509-1" }, "locus": { "chromosome": "X", "start_pos": 1309865, "end_pos": 1282704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000494969.7", "url": "https://www.ensembl.org/id/ENST00000494969.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000476684.1", "url": "https://www.ensembl.org/id/ENSP00000476684.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 123, "start_aa": "Asn", "end_pos": 123, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn123", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 135, "start_aa": "Asn", "end_pos": 135, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn135", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 182, "start_aa": "Asn", "end_pos": 182, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn182", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 195, "start_aa": "Asn", "end_pos": 195, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn195", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 223, "start_aa": "Asn", "end_pos": 223, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn223", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 229, "start_aa": "Asn", "end_pos": 229, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn229", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" }, { "id": "18692472", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18692472" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 272, "start_aa": "Asn", "end_pos": 272, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn272", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 305, "start_aa": "Asn", "end_pos": 305, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn305", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 46, "start_aa": "Asn", "end_pos": 46, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn46", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 54, "start_aa": "Asn", "end_pos": 54, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn54", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 99, "start_aa": "Asn", "end_pos": 99, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn99", "evidence": [ { "id": "P15509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15509#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported" ], "publication": [ { "title": "The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Harmer SL, DeFranco AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-912526", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526" } ], "reference": [ { "type": "PubMed", "id": "10207047", "url": "https://glygen.org/publication/PubMed/10207047" } ] }, { "title": "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.", "journal": "Structure (London, England : 1993)", "date": "1999", "authors": "Hakansson K, Lim NK, Hoppe HJ, Reid KB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5683826" } ], "reference": [ { "type": "PubMed", "id": "10368295", "url": "https://glygen.org/publication/PubMed/10368295" } ] }, { "title": "Engagement of Gab1 and Gab2 in erythropoietin signaling.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC", "evidence": [ { "database": "Reactome", "id": "R-HSA-912526", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526" } ], "reference": [ { "type": "PubMed", "id": "10455108", "url": "https://glygen.org/publication/PubMed/10455108" } ] }, { "title": "Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis.", "journal": "Blood", "date": "1999", "authors": "Orban PC, Levings MK, Schrader JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-512988", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-512988" } ], "reference": [ { "type": "PubMed", "id": "10477686", "url": "https://glygen.org/publication/PubMed/10477686" } ] }, { "title": "Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.", "journal": "Blood", "date": "1999", "authors": "Stomski FC, Dottore M, Winnall W, Guthridge MA, Woodcock J, Bagley CJ, Thomas DT, Andrews RK, Berndt MC, Lopez AF", "evidence": [ { "database": "Reactome", "id": "R-HSA-512988", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-512988" } ], "reference": [ { "type": "PubMed", "id": "10477722", "url": "https://glygen.org/publication/PubMed/10477722" } ] }, { "title": "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5683826" } ], "reference": [ { "type": "PubMed", "id": "10485905", "url": "https://glygen.org/publication/PubMed/10485905" } ] }, { "title": "Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.", "journal": "Molecular pharmacology", "date": "1999", "authors": "Linden J, Thai T, Figler H, Jin X, Robeva AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5683826" } ], "reference": [ { "type": "PubMed", "id": "10496952", "url": "https://glygen.org/publication/PubMed/10496952" } ] }, { "title": "Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.", "journal": "The EMBO journal", "date": "1999", "authors": "Adachi M, Fukuda M, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "10508167", "url": "https://glygen.org/publication/PubMed/10508167" } ] }, { "title": "Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Ingham RJ, Okada H, Dang-Lawson M, Dinglasan J, van Der Geer P, Kurosaki T, Gold MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-912526", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526" } ], "reference": [ { "type": "PubMed", "id": "10570274", "url": "https://glygen.org/publication/PubMed/10570274" } ] }, { "title": "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.", "journal": "FEBS letters", "date": "1999", "authors": "Chuman Y, Bergman A, Ueno T, Saito S, Sakaguchi K, Alaiya AA, Franzen B, Bergman T, Arnott D, Auer G, Appella E, Jornvall H, Linder S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5683826" } ], "reference": [ { "type": "PubMed", "id": "10580105", "url": "https://glygen.org/publication/PubMed/10580105" } ] }, { "title": "GATA-6 activates transcription of surfactant protein A.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Bruno MD, Korfhagen TR, Liu C, Morrisey EE, Whitsett JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5683826" } ], "reference": [ { "type": "PubMed", "id": "10625644", "url": "https://glygen.org/publication/PubMed/10625644" } ] }, { "title": "A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Shao H, Andres DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001" } ], "reference": [ { "type": "PubMed", "id": "10869344", "url": "https://glygen.org/publication/PubMed/10869344" } ] }, { "title": "Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.", "journal": "Molecular cell", "date": "2000", "authors": "Guthridge MA, Stomski FC, Barry EF, Winnall W, Woodcock JM, McClure BJ, Dottore M, Berndt MC, Lopez AF", "evidence": [ { "database": "Reactome", "id": "R-HSA-512988", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-512988" } ], "reference": [ { "type": "PubMed", "id": "10949031", "url": "https://glygen.org/publication/PubMed/10949031" } ] }, { "title": "New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-912526", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526" } ], "reference": [ { "type": "PubMed", "id": "10982827", "url": "https://glygen.org/publication/PubMed/10982827" } ] }, { "title": "Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 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