{
    "uniprot_canonical_ac": "P15375-1",
    "uniprot_ac": "P15375",
    "uniprot_id": "MYF6_MOUSE",
    "mass": {
        "chemical_mass": 26987.0,
        "monoisotopic_mass": 26987.0
    },
    "refseq": {
        "ac": "NP_032683",
        "name": "myogenic factor 6",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683"
    },
    "gene_names": [
        {
            "name": "Myf6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P15375",
            "id": "P15375"
        },
        {
            "name": "Mrf4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P15375",
            "id": "P15375"
        },
        {
            "name": "Myf-6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P15375",
            "id": "P15375"
        },
        {
            "name": "Myf6",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683",
            "id": "NP_032683"
        },
        {
            "name": "bHLHc4; herculin; MRF4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683",
            "id": "NP_032683"
        }
    ],
    "protein_names": [
        {
            "name": "Myogenic factor 6",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P15375"
        },
        {
            "name": "Herculin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P15375"
        },
        {
            "name": "Muscle-specific regulatory factor 4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P15375"
        },
        {
            "name": "Myf-6",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P15375"
        },
        {
            "name": "muscle-specific regulatory factor 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683",
            "id": "NP_032683"
        },
        {
            "name": "myogenic factor 6",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683",
            "id": "NP_032683"
        }
    ],
    "function": [
        {
            "annotation": "Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P15375",
                    "url": "https://www.uniprot.org/uniprot/P15375#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:11723",
            "recommended_name": {
                "id": "DOID:11723",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11723",
                "name": "Duchenne muscular dystrophy",
                "description": "A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy."
            },
            "synonyms": [
                {
                    "id": "DOID:11723",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11723",
                    "name": "Muscular dystrophy, Duchenne",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "Duchenne muscular dystrophy",
                    "description": "Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by rapidly progressive muscle weakness and wasting due to degeneration of skeletal, smooth and cardiac muscle."
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "DMD",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "Duchenne muscular dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "Duchenne muscular dystrophy, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "muscular dystrophy, Duchenne",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "severe dystrophinopathy, Duchenne type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "muscular dystrophy, Duchenne type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010679",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010679",
                    "name": "muscular dystrophy, pseudohypertrophic progressive, Duchenne type",
                    "description": ""
                },
                {
                    "id": "MIM:310200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/310200",
                    "name": "Duchenne muscular dystrophy",
                    "description": "Duchenne muscular dystrophy"
                }
            ],
            "evidence": [
                {
                    "id": "11723",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:11723"
                }
            ]
        },
        {
            "disease_id": "DOID:422",
            "recommended_name": {
                "id": "DOID:422",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:422",
                "name": "congenital structural myopathy",
                "description": "A myopathy that is characterized by hypotonia, muscle weakness, and delayed development of motor skills."
            },
            "synonyms": [],
            "evidence": [
                {
                    "id": "422",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:422"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P15375",
                    "url": "https://www.uniprot.org/uniprot/P15375"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Myf6",
            "url": "https://www.uniprot.org/uniprot/P15375",
            "locus": {
                "chromosome": "10",
                "start_pos": 107328714,
                "end_pos": 107330598,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000035923",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000035923"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000035923",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035923",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd18934",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18934",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "17878",
            "url": "https://www.ncbi.nlm.nih.gov/gene/17878",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P15375",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P15375*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR002546",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002546",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011598",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036638",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039704",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039704",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:17878",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17878",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "97253",
            "url": "http://www.informatics.jax.org/marker/MGI:97253",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "SPCQDQI",
            "url": "https://omabrowser.org/oma/group/SPCQDQI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5392786at2759",
            "url": "http://www.orthodb.org/?query=5392786at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11534",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11534",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11534:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11534:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00010",
            "url": "http://pfam.xfam.org/family/PF00010",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01586",
            "url": "http://pfam.xfam.org/family/PF01586",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P15375",
            "url": "http://purl.obolibrary.org/obo/PR_P15375",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-525793",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-525793",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_032683",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032683",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P15375",
            "url": "https://www.uniprot.org/uniprot/P15375",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P15375-1",
            "url": "https://www.uniprot.org/uniprot/P15375-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFLRTCSPQWPSVSDHSRGLVITAKEGGANVDASASSSLQRLSSIVDSISSEERKLPSVEEVVEK",
        "length": 242,
        "header": "sp|P15375-1|MYF6_MOUSE Isoform 1 of Myogenic factor 6  OS=Mus musculus OX=10090 GN=Myf6 PE=2 SV=1 CANONICAL=P15375-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P15375-1",
            "url": "",
            "sequence": {
                "sequence": "MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFLRTCSPQWPSVSDHSRGLVITAKEGGANVDASASSSLQRLSSIVDSISSEERKLPSVEEVVEK",
                "length": 242,
                "header": "sp|P15375-1|MYF6_MOUSE Isoform 1 of Myogenic factor 6  OS=Mus musculus OX=10090 GN=Myf6 PE=2 SV=1 CANONICAL=P15375-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 107330565,
                "end_pos": 107329218,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000044210",
                        "url": "https://www.ensembl.org/id/ENSMUST00000044210"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000047529",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000047529"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.",
            "journal": "J. Cell Biol.",
            "date": "1991",
            "authors": "Bober E., Braun T., Cossu G., Buckingham M., Arnold H.-H., Lyons G.L.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P15375",
                    "url": "https://www.uniprot.org/uniprot/P15375"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2045411",
                    "url": "https://glygen.org/publication/PubMed/2045411"
                }
            ]
        },
        {
            "title": "Herculin, a fourth member of the MyoD family of myogenic regulatory genes.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "1990",
            "authors": "Miner J.H., Wold B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P15375",
                    "url": "https://www.uniprot.org/uniprot/P15375"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2300571",
                    "url": "https://glygen.org/publication/PubMed/2300571"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:17878",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17878",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-525793",
            "name": "Myogenesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-525793",
            "resource": "Reactome",
            "description": "Myogenesis"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P19335-1",
            "protein_name": "Myogenic factor 6",
            "gene_name": "Myf6",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAINYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFLRTCSPQWPSVSDHSRGLVITAKEGGASVDASASSSLQRLSSIVDSISSEERKLPSVEEVVEK",
                "length": 242
            },
            "evidence": [
                {
                    "id": "45225688",
                    "url": "http://www.informatics.jax.org/homology/45225688",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P23409-1",
            "protein_name": "Myogenic factor 6",
            "gene_name": "MYF6",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPPEAGSDSSGEEHVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRTVANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPFSYRPKQENLEGADFLRTCSSQWPSVSDHSRGLVITAKEGGASIDSSASSSLRCLSSIVDSISSEERKLPCVEEVVEK",
                "length": 242
            },
            "evidence": [
                {
                    "id": "45225688",
                    "url": "http://www.informatics.jax.org/homology/45225688",
                    "database": "MGI"
                },
                {
                    "id": "P15375",
                    "url": "https://omabrowser.org/oma/group/P15375/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "skeletal muscle tissue regeneration",
                        "id": "GO:0043403",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043403",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of DNA-templated transcription",
                        "id": "GO:0045892",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of DNA-templated transcription",
                        "id": "GO:0045893",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "somitogenesis",
                        "id": "GO:0001756",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001756",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "skeletal muscle cell differentiation",
                        "id": "GO:0035914",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "skeletal muscle tissue development",
                        "id": "GO:0007519",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of skeletal muscle fiber development",
                        "id": "GO:0048743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of myoblast differentiation",
                        "id": "GO:0045663",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045663",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "muscle tissue morphogenesis",
                        "id": "GO:0060415",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060415",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
                                "url": "https://www.uniprot.org/uniprot/P15375"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P15375",
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