{ "uniprot_canonical_ac": "P15108-1", "uniprot_ac": "P15108", "uniprot_id": "HSC82_YEAST", "mass": { "chemical_mass": 80900.0, "monoisotopic_mass": 80900.0 }, "refseq": { "ac": "NP_013911", "name": "Hsp90 family chaperone HSC82", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013911" }, "gene_names": [ { "name": "HSC82", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P15108", "id": "P15108" }, { "name": "HSC82", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013911", "id": "NP_013911" }, { "name": "HSP90", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013911", "id": "NP_013911" }, { "name": "YM8010.16", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P15108", "id": "P15108" } ], "protein_names": [ { "name": "ATP-dependent molecular chaperone HSC82", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P15108" }, { "name": "82 kDa heat shock cognate protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15108" }, { "name": "Heat shock protein Hsp90 constitutive isoform", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P15108" }, { "name": "Hsp90 family chaperone HSC82", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013911", "id": "NP_013911" } ], "function": [ { "annotation": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction such as CNA2. Undergoes a functional cycle that is linked to its ATPase activity (By similarity). Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108#function" }, { "database": "PubMed", "id": "11094077", "url": "https://glygen.org/publication/PubMed/11094077" } ] } ], "disease": [ { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:10762", "recommended_name": { "id": "DOID:10762", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10762", "name": "portal hypertension", "description": "" }, "synonyms": [], "evidence": [ { "id": "10762", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10762" } ] }, { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "evidence": [ { "id": "162", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] }, { "disease_id": "DOID:219", "recommended_name": { "id": "DOID:219", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon." }, "synonyms": [], "evidence": [ { "id": "219", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:219" } ] }, { "disease_id": "DOID:2377", "recommended_name": { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring." }, "synonyms": [ { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "Generalized multiple sclerosis", "description": "" }, { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "insular sclerosis", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "MS3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "MS2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "MS4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MIM:612595", "resource": "MIM", "url": "https://www.omim.org/entry/612595", "name": "Multiple sclerosis 3", "description": "Multiple sclerosis 3" } ], "evidence": [ { "id": "2377", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ] }, { "disease_id": "DOID:3770", "recommended_name": { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation." }, "synonyms": [ { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "Fibrosis of lung", "description": "" } ], "evidence": [ { "id": "3770", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ] }, { "disease_id": "DOID:4928", "recommended_name": { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "intrahepatic cholangiocarcinoma", "description": "A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree." }, "synonyms": [ { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "Intrahepatic bile duct carcinoma", "description": "" }, { "id": "DOID:4928", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4928", "name": "peripheral Cholangiocarcinoma", "description": "" } ], "evidence": [ { "id": "4928", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4928" } ] }, { "disease_id": "DOID:4989", "recommended_name": { "id": "DOID:4989", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4989", "name": "pancreatitis", "description": "A pancreas disease that is characterized by inflammation of the pancreas." }, "synonyms": [ { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary chronic pancreatitis", "description": "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas." }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary chronic pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "hereditary pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "HPC", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "Hp", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "PCTT", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "autosomal dominant hereditary pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "familial pancreatitis", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, calcific", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, calcific, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, protection against", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, protection against, included", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, chronic, susceptibility to", "description": "" }, { "id": "MONDO:0008185", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008185", "name": "pancreatitis, hereditary", "description": "" }, { "id": "MIM:167800", "resource": "MIM", "url": "https://www.omim.org/entry/167800", "name": "Pancreatitis, hereditary", "description": "Pancreatitis, hereditary" } ], "evidence": [ { "id": "4989", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4989" } ] }, { "disease_id": "DOID:7148", "recommended_name": { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint." }, "synonyms": [ { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "Arthritis or polyarthritis, rheumatic", "description": "" }, { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "atrophic Arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis", "description": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor." }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "atrophic arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "RA", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "arthritis or polyarthritis, rheumatic", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "arthritis, rheumatoid", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "autoimmune arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis, progression of", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis, susceptibility to", "description": "" }, { "id": "MIM:180300", "resource": "MIM", "url": "https://www.omim.org/entry/180300", "name": "Rheumatoid arthritis", "description": "Rheumatoid arthritis" } ], "evidence": [ { "id": "7148", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ] }, { "disease_id": "DOID:767", "recommended_name": { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "muscular atrophy", "description": "" }, "synonyms": [ { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Amyotrophia", "description": "" }, { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Muscle wasting", "description": "" }, { "id": "DOID:767", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:767", "name": "Wasting - muscle", "description": "" } ], "evidence": [ { "id": "767", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:767" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 453, "end_pos": 453, "sequence_org": "L", "sequence_mut": "A", "comment": "Leads to growth defect at 37 degrees Celsius, probably by disrupting the intramolecular interaction of the N-termini with the middle domains; when associated with A-493.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" }, { "database": "PubMed", "id": "12121981", "url": "https://glygen.org/publication/PubMed/12121981" } ] }, { "start_pos": 493, "end_pos": 493, "sequence_org": "E", "sequence_mut": "A", "comment": "Leads to growth defect at 37 degrees Celsius, probably by disrupting the intramolecular interaction of the N-termini with the middle domains; when associated with A-453.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" }, { "database": "PubMed", "id": "12121981", "url": "https://glygen.org/publication/PubMed/12121981" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "common_name": "Yeast" } ], "gene": [ { "name": "HSC82", "url": "https://www.uniprot.org/uniprot/P15108", "locus": { "chromosome": "XIII", "start_pos": 634472, "end_pos": 632355, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "YMR186W", "url": "https://www.ensembl.org/id/YMR186W" } ] } } ], "crossref": [ { "id": "cd16927", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16927", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4199", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4199", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "855224", "url": "https://www.ncbi.nlm.nih.gov/gene/855224", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P15108", "url": "https://www.ebi.ac.uk/intact/interactors/id:P15108*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YMR186W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YMR186W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRMKAEQ", "url": "https://omabrowser.org/oma/group/TRMKAEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "547579at2759", "url": "http://www.orthodb.org/?query=547579at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11528", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11528", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11528:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11528:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6XLB", "url": "https://www.rcsb.org/structure/6XLB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLC", "url": "https://www.rcsb.org/structure/6XLC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLD", "url": "https://www.rcsb.org/structure/6XLD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLE", "url": "https://www.rcsb.org/structure/6XLE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLF", "url": "https://www.rcsb.org/structure/6XLF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLG", "url": "https://www.rcsb.org/structure/6XLG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XLH", "url": "https://www.rcsb.org/structure/6XLH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00183", "url": "http://pfam.xfam.org/family/PF00183", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02518", "url": "http://pfam.xfam.org/family/PF02518", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P15108", "url": "http://purl.obolibrary.org/obo/PR_P15108", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013911", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004798", "url": "https://www.yeastgenome.org/locus/S000004798", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P15108-1", "url": "https://www.uniprot.org/uniprot/P15108-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNAGGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLLVTKEVEKEVPIPEEEKKDEEKKDEDDKKPKLEEVDEEEEEKKPKTKKVKEEVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNIDEDEETETAPEASTEAPVEEVPADTEMEEVD", "length": 705, "header": "sp|P15108-1|HSC82_YEAST Isoform 1 of ATP-dependent molecular chaperone HSC82 OS=Saccharomyces cerevisiae S288C OX=559292 GN=HSC82 PE=1 SV=4 CANONICAL=P15108-1" }, "isoforms": [ { "isoform_ac": "P15108-1", "url": "", "sequence": { "sequence": "MAGETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNAGGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLLVTKEVEKEVPIPEEEKKDEEKKDEDDKKPKLEEVDEEEEEKKPKTKKVKEEVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNIDEDEETETAPEASTEAPVEEVPADTEMEEVD", "length": 705, "header": "sp|P15108-1|HSC82_YEAST Isoform 1 of ATP-dependent molecular chaperone HSC82 OS=Saccharomyces cerevisiae S288C OX=559292 GN=HSC82 PE=1 SV=4 CANONICAL=P15108-1" }, "locus": { "chromosome": "XIII", "start_pos": 634469, "end_pos": 632355, "strand": "-", "evidence": [ 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"https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser278" }, { "start_pos": 281, "end_pos": 281, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P15108", "url": "https://www.yeastgenome.org/locus/P15108" } ], "site_lbl": "Thr281" }, { "start_pos": 291, "end_pos": 291, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "21126336", "url": 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"https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser375" }, { "start_pos": 429, "end_pos": 429, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "SGD", "id": "P15108", "url": "https://www.yeastgenome.org/locus/P15108" }, { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr429" }, { "start_pos": 446, "end_pos": 446, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P15108", "url": "https://www.yeastgenome.org/locus/P15108" } ], "site_lbl": "Ser446" }, { "start_pos": 452, "end_pos": 452, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P15108", "url": "https://www.yeastgenome.org/locus/P15108" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser452" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" }, { 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Cell. Biol.", "date": "2000", "authors": "Imai J., Yahara I.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "11094077", "url": "https://glygen.org/publication/PubMed/11094077" } ] }, { "title": "Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperone.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Matsumoto Shigeki, Tanaka Etsuko, Nemoto Takayuki K, Ono Toshio, Takagi Takashi, Imai Jun, Kimura Yoko, Yahara Ichiro, Kobayakawa Takeshi, Ayuse Takao, Oi Kumiko, Mizuno Akio", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "12121981", "url": "https://glygen.org/publication/PubMed/12121981" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The proteome of Saccharomyces cerevisiae mitochondria.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Sickmann A., Zahedi R.P., Rehling P., Chacinska A., Guiard B., Meyer H.E., Meisinger C., Reinders J., Pfanner N., Joppich C., Perschil I., Schoenfisch B., Wagner Y.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "14576278", "url": "https://glygen.org/publication/PubMed/14576278" } ] }, { "title": "Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex.", "journal": "Mol. Cell. Biol.", "date": "2004", "authors": "Kitagawa K., Bansal P.K., Abdulle R.", "evidence": [ { "database": "UniProtKB", "id": "P15108", "url": "https://www.uniprot.org/uniprot/P15108" } ], "reference": [ { "type": "PubMed", "id": "15340069", "url": "https://glygen.org/publication/PubMed/15340069" } ] }, { "title": "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-02-13", "authors": "Chi An, Huttenhower Curtis, Geer Lewis Y, Coon Joshua J, Syka John E P, Bai Dina L, Shabanowitz Jeffrey, Burke Daniel J, Troyanskaya Olga G, Hunt Donald F", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" } ], "reference": [ { "type": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "Phosphorylation by casein kinase 2 regulates Nap1 localization and function.", "journal": "Mol. 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"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "iPTMnet", "id": "P15108", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P15108" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.", "journal": "Molecular cell", "date": "2010-02-12", "authors": "Mollapour Mehdi, Tsutsumi Shinji, Donnelly Alison C, Beebe Kristin, Tokita Mari J, Lee Min-Jung, Lee Sunmin, Morra Giulia, Bourboulia Dimitra, Scroggins Bradley T, Colombo Giorgio, Blagg Brian S, Panaretou Barry, Stetler-Stevenson William G, Trepel Jane B, Piper Peter W, Prodromou Chrisostomos, Pearl Laurence 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