{ "uniprot_canonical_ac": "P14206-1", "uniprot_ac": "P14206", "uniprot_id": "RSSA_MOUSE", "mass": { "chemical_mass": 32838.0, "monoisotopic_mass": 32838.0 }, "refseq": { "ac": "NP_035159", "name": "small ribosomal subunit protein uS2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159" }, "gene_names": [ { "name": "Rpsa", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P14206", "id": "P14206" }, { "name": "67kDa; 67lr; Lamr; Lamr1; Lamrl1; MLR; P40; P40-3; P40-8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159", "id": "NP_035159" }, { "name": "Lamr1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P14206", "id": "P14206" }, { "name": "P40-8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P14206", "id": "P14206" }, { "name": "Rpsa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159", "id": "NP_035159" } ], "protein_names": [ { "name": "Small ribosomal subunit protein uS2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P14206" }, { "name": "37 kDa laminin receptor precursor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "37 kDa oncofetal antigen", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "37/67 kDa laminin receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "37LRP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "40S ribosomal protein SA; 37LRP; LRP/LR; LBP/p40; OFA/iLRP; 67 kDa laminin receptor; 37 kDa oncofetal antigen; 37/67 kDa laminin receptor; 37 kDa laminin receptor; laminin-binding protein precursor p40; P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA); 67LR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159", "id": "NP_035159" }, { "name": "40S ribosomal protein SA", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "67 kDa laminin receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "67LR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "LBP/p40", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "LRP/LR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "LamR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "Laminin receptor 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "Laminin-binding protein precursor p40", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "OFA/iLRP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P14206" }, { "name": "small ribosomal subunit protein uS2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159", "id": "NP_035159" } ], "function": [ { "annotation": "High 67-kDa laminin receptor expression is associated with obesity-induced inflammation.", "evidence": [ { "database": "RefSeq", "id": "NP_035159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159" }, { "database": "PubMed", "id": "28154178", "url": "https://glygen.org/publication/PubMed/28154178" } ] }, { "annotation": "Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206#function" }, { "database": "PubMed", "id": "1374897", "url": "https://glygen.org/publication/PubMed/1374897" }, { "database": "PubMed", "id": "10697612", "url": "https://glygen.org/publication/PubMed/10697612" }, { "database": "PubMed", "id": "6302102", "url": "https://glygen.org/publication/PubMed/6302102" }, { "database": "UniProtKB", "id": "MF_03016", "url": "https://www.uniprot.org/uniprot/MF_03016#function" }, { "database": "PubMed", "id": "6301485", "url": "https://glygen.org/publication/PubMed/6301485" }, { "database": "PubMed", "id": "16453457", "url": "https://glygen.org/publication/PubMed/16453457" } ] } ], "disease": [ { "disease_id": "DOID:0110074", "recommended_name": { "id": "DOID:0110074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110074", "name": "arrhythmogenic right ventricular dysplasia 5", "description": "An arrhythmogenic right ventricular dysplasia that has_material_basis_in heterozygous mutation in the TMEM43 gene on chromosome 3p25." }, "synonyms": [ { "id": "DOID:0110074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110074", "name": "ARVC5", "description": "" }, { "id": "DOID:0110074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110074", "name": "ARVD5", "description": "" }, { "id": "DOID:0110074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110074", "name": "arrhythmogenic right ventricular cardiomyopathy 5", "description": "" }, { "id": "DOID:0110074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110074", "name": "familial arrhythmogenic right ventricular dysplasia 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular dysplasia 5", "description": "Any arrhythmogenic right ventricular cardiomyopathy in which the cause of the disease is a mutation in the TMEM43 gene." }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "ARVC5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "ARVD5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "TMEM43 arrhythmogenic right ventricular cardiomyopathy", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular cardiomyopathy 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular cardiomyopathy caused by mutation in TMEM43", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular dysplasia 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular dysplasia type 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular dysplasia, familial, type 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "familial arrhythmogenic right ventricular dysplasia 5", "description": "" }, { "id": "MONDO:0011459", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011459", "name": "arrhythmogenic right ventricular dysplasia, familial, 5", "description": "" }, { "id": "MIM:604400", "resource": "MIM", "url": "https://www.omim.org/entry/604400", "name": "Arrhythmogenic right ventricular dysplasia, familial, 5", "description": "Arrhythmogenic right ventricular dysplasia, familial, 5" } ], "evidence": [ { "id": "0110074", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110074" } ] }, { "disease_id": "DOID:11446", "recommended_name": { "id": "DOID:11446", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11446", "name": "sciatic neuropathy", "description": "" }, "synonyms": [], "evidence": [ { "id": "11446", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ] }, { "disease_id": "DOID:1339", "recommended_name": { "id": "DOID:1339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1339", "name": "Diamond-Blackfan anemia", "description": "A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis_insufficient levels of red blood cells due to bone marrow dysfunction." }, "synonyms": [ { "id": "DOID:1339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1339", "name": "Blackfan - Diamond syndrome", "description": "" }, { "id": "DOID:1339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1339", "name": "chronic constitutional pure red cell anaemia", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan anemia 1", "description": "Any Diamond-Blackfan anemia in which the cause of the disease is a mutation in the RPS19 gene." }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "DBA", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan Anaemia type 1", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan Anemia type 1", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan anaemia caused by mutation in RPS19", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan anemia 1", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Diamond-Blackfan anemia caused by mutation in RPS19", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "RPS19 Diamond-Blackfan anaemia", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "RPS19 Diamond-Blackfan anemia", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Aase syndrome", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Aase-Smith syndrome 2", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Blackfan-Diamond syndrome", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "DBA1", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "Red cell aplasia, Pure, hereditary", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "anemia, congenital erythroid hypoplastic", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "anemia, congenital hypoplastic, of Blackfan and Diamond", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "aregenerative Anemia, chronic congenital", "description": "" }, { "id": "MONDO:0007110", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007110", "name": "erythrogenesis imperfecta", "description": "" }, { "id": "MIM:105650", "resource": "MIM", "url": "https://www.omim.org/entry/105650", "name": "Diamond-Blackfan anemia 1", "description": "Diamond-Blackfan anemia 1" } ], "evidence": [ { "id": "1339", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1339" } ] }, { "disease_id": "DOID:9778", "recommended_name": { "id": "DOID:9778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9778", "name": "irritable bowel syndrome", "description": "An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause." }, "synonyms": [ { "id": "DOID:9778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9778", "name": "IBD", "description": "" }, { "id": "DOID:9778", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9778", "name": "Irritable colon", "description": "" } ], "evidence": [ { "id": "9778", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9778" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rpsa", "url": "https://www.uniprot.org/uniprot/P14206", "locus": { "chromosome": "9", "start_pos": 119961435, "end_pos": 119956755, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000032518", "url": "https://www.ensembl.org/id/ENSMUSG00000032518" } ] } } ], "crossref": [ { "id": "ENSMUSG00000032518", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01425", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01425", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL1075301", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1075301", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "16785", "url": "https://www.ncbi.nlm.nih.gov/gene/16785", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P14206", "url": "https://www.ebi.ac.uk/intact/interactors/id:P14206*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005707", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005707", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16785", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16785", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "105381", "url": "http://www.informatics.jax.org/marker/MGI:105381", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P14206", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P14206", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QKFIEPR", "url": "https://omabrowser.org/oma/group/QKFIEPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5480124at2759", "url": "http://www.orthodb.org/?query=5480124at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11489:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11489:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7CPU", "url": "https://www.rcsb.org/structure/7CPU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7CPV", "url": "https://www.rcsb.org/structure/7CPV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7LS1", "url": "https://www.rcsb.org/structure/7LS1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7LS2", "url": "https://www.rcsb.org/structure/7LS2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00318", "url": "http://pfam.xfam.org/family/PF00318", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16122", "url": "http://pfam.xfam.org/family/PF16122", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P14206", "url": "http://purl.obolibrary.org/obo/PR_P14206", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1799339", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6791226", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72649", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72689", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72706", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_035159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1L1SRW0", "url": "https://www.uniprot.org/uniprot/A0A1L1SRW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SRW0-1", "url": "https://www.uniprot.org/uniprot/A0A1L1SRW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SUK3", "url": "https://www.uniprot.org/uniprot/A0A1L1SUK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1L1SUK3-1", "url": "https://www.uniprot.org/uniprot/A0A1L1SUK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P14206-1", "url": "https://www.uniprot.org/uniprot/P14206-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS", "length": 295, "header": "sp|P14206-1|RSSA_MOUSE Isoform 1 of Small ribosomal subunit protein uS2 OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=4 CANONICAL=P14206-1" }, "isoforms": [ { "isoform_ac": "A0A1L1SRW0-1", "url": "", "sequence": { "sequence": "RAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGSTPHARYYLP", "length": 93, "header": "tr|A0A1L1SRW0-1|RSSA_MOUSE Computationally mapped isoform of Small ribosomal subunit protein uS2 OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=1 CANONICAL=P14206-1" }, "locus": { "chromosome": "9", "start_pos": 119959907, "end_pos": 119959184, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000217352.2", "url": "https://www.ensembl.org/id/ENSMUST00000217352.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000149650.2", "url": "https://www.ensembl.org/id/ENSMUSP00000149650.2" } ] } }, { "isoform_ac": "A0A1L1SUK3-1", "url": "", "sequence": { "sequence": "MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQVTRSGYQQFPREACMIMLTQSPFKASCAEVCCCHRSHSDRWPLHTWDLH", "length": 133, "header": "tr|A0A1L1SUK3-1|RSSA_MOUSE Computationally mapped isoform of Small ribosomal subunit protein uS2 OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=1 CANONICAL=P14206-1" }, "locus": { "chromosome": "9", "start_pos": 119959257, "end_pos": 119957556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000217356.2", "url": "https://www.ensembl.org/id/ENSMUST00000217356.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000150804.2", "url": "https://www.ensembl.org/id/ENSMUSP00000150804.2" } ] } }, { "isoform_ac": "P14206-1", "url": "", "sequence": { "sequence": "MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS", "length": 295, "header": "sp|P14206-1|RSSA_MOUSE Isoform 1 of Small ribosomal subunit protein uS2 OS=Mus musculus OX=10090 GN=Rpsa PE=1 SV=4 CANONICAL=P14206-1" }, "locus": { "chromosome": "9", "start_pos": 119960557, "end_pos": 119957556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000217317", "url": "https://www.ensembl.org/id/ENSMUST00000217317" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148933", "url": "https://www.ensembl.org/id/ENSMUSP00000148933" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P14206", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P14206" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" } ] } ], "phosphorylation": [ { "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P14206", "url": "http://phospho.elm.eu.org/byAccession/P14206.html" }, { "database": "iPTMnet", "id": "P14206", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14206" }, { "database": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ], "site_lbl": "Tyr139" }, { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "site_lbl": "Ser43" }, { "start_pos": 97, "end_pos": 97, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "site_lbl": "Thr97" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "37 kilodalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T-cell inducing immunogens on primary rodent and human cancers.", "journal": "Anticancer Res.", "date": "1999", "authors": "Barsoum A.L., Coggin J.H. Jr., Rohrer J.W.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "10697612", "url": "https://glygen.org/publication/PubMed/10697612" } ] }, { "title": "Midkine binds to 37-kDa laminin binding protein precursor, leading to nuclear transport of the complex.", "journal": "Exp. Cell Res.", "date": "2001", "authors": "Kimura T., Muramatsu H., Muramatsu T., Inui T., Zou K., Salama R.H.M.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "11597123", "url": "https://glygen.org/publication/PubMed/11597123" } ] }, { "title": "The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein.", "journal": "EMBO J.", "date": "2001", "authors": "Weiss S., Deslys J.-P., Dormont D., Gauczynski S., Haik S., Hundt C., Krasemann S., Lasmezas C.I., Leucht C., Peyrin J.-M., Rieger R.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "11689427", "url": "https://glygen.org/publication/PubMed/11689427" } ] }, { "title": "A 33-kDa polypeptide with homology to the laminin receptor: component of translation machinery.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1992", "authors": "Auth D., Brawerman G.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "1374897", "url": "https://glygen.org/publication/PubMed/1374897" } ] }, { "title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.", "journal": "Nat. Biotechnol.", "date": "2005", "authors": "Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1SRW0", "url": "https://www.uniprot.org/uniprot/A0A1L1SRW0" }, { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" }, { "database": "iPTMnet", "id": "P14206", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P14206" } ], "reference": [ { "type": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ] }, { "title": "Isolation of a laminin-binding protein from muscle cell membranes.", "journal": "EMBO J.", "date": "1983", "authors": "von der Mark K., Kuehl U., Lesot H.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "16453457", "url": "https://glygen.org/publication/PubMed/16453457" } ] }, { "title": "Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins.", "journal": "Biochim. Biophys. Acta", "date": "2008", "authors": "Weiss S., Gauczynski S., Knetsch H., Ludewigs H., Nikles D., Vana K.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "18339329", "url": "https://glygen.org/publication/PubMed/18339329" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "A0A1L1SRW0", "url": "https://www.uniprot.org/uniprot/A0A1L1SRW0" }, { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "Evidence for a precursor of the high-affinity metastasis-associated murine laminin receptor.", "journal": "Biochemistry", "date": "1989", "authors": "Liotta L.A., Wewer U.M., Sobel M.E., Castronovo V., Claysmith A.P., Rao C.N., Schmitt M.C.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "2531008", "url": "https://glygen.org/publication/PubMed/2531008" } ] }, { "title": "Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, Bae J, Yamashita S, Murata M, Yamada S, Shinoda Y, Yamaguchi W, Toyoda Y, Tachibana H", "evidence": [ { "database": "RefSeq", "id": "NP_035159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035159" } ], "reference": [ { "type": "PubMed", "id": "28154178", "url": "https://glygen.org/publication/PubMed/28154178" } ] }, { "title": "Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Bandyopadhyay R., Brawerman G., Chitpatima S.T., Makrides S.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "3357791", "url": "https://glygen.org/publication/PubMed/3357791" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P14206", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P14206" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] }, { "title": "Isolation of a tumor cell laminin receptor.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1983", "authors": "Liotta L.A., Barsky S.H., Terranova V.P., Rao N.C.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "6301485", "url": "https://glygen.org/publication/PubMed/6301485" } ] }, { "title": "Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells.", "journal": "J. Cell Biol.", "date": "1983", "authors": "Wicha M.S., Malinoff H.L.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "6302102", "url": "https://glygen.org/publication/PubMed/6302102" } ] }, { "title": "Analysis of nuclear localization of laminin binding protein precursor p40 (LBP/p40).", "journal": "Biochem. Biophys. Res. Commun.", "date": "1996", "authors": "Tanaka K., Iwamatsu A., Sato M., Kaneda Y., Kinoshita K., Saeki Y.", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "reference": [ { "type": "PubMed", "id": "8954992", "url": "https://glygen.org/publication/PubMed/8954992" } ] } ], "pathway": [ { "id": "mmu:16785", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16785", "resource": "KEGG Pathway" }, { "id": "R-MMU-156827", "name": "L13a-mediated translational silencing of Ceruloplasmin expression", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-MMU-1799339", "name": "SRP-dependent cotranslational protein targeting to membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-MMU-6791226", "name": "Major pathway of rRNA processing in the nucleolus and cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-MMU-72649", "name": "Translation initiation complex formation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-MMU-72689", "name": "Formation of a pool of free 40S subunits", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-MMU-72695", "name": "Formation of the ternary complex, and subsequently, the 43S complex", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-MMU-72702", "name": "Ribosomal scanning and start codon recognition", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-MMU-72706", "name": "GTP hydrolysis and joining of the 60S ribosomal subunit", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-MMU-975956", "name": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-MMU-975957", "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "P08865-1", "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "RPSA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS", "length": 295 }, "evidence": [ { "id": "45226131", "url": "http://www.informatics.jax.org/homology/45226131", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P32905-1", "protein_name": "Small ribosomal subunit protein uS2A", "gene_name": "RPS0A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLPATFDLTPEDAQLLLAANTHLGARNVQVHQEPYVFNARPDGVHVINVGKTWEKLVLAARIIAAIPNPEDVVAISSRTFGQRAVLKFAAHTGATPIAGRFTPGSFTNYITRSFKEPRLVIVTDPRSDAQAIKEASYVNIPVIALTDLDSPSEFVDVAIPCNNRGKHSIGLIWYLLAREVLRLRGALVDRTQPWSIMPDLYFYRDPEEVEQQVAEEATTEEAGEEEAKEEVTEEQAEATEWAEENADNVEW", "length": 252 }, "evidence": [ { "id": "P14206", "url": "https://omabrowser.org/oma/group/P14206/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "P38983-1", "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "Rpsa", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS", "length": 295 }, "evidence": [ { "id": "45226131", "url": "http://www.informatics.jax.org/homology/45226131", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "P14206", "url": "https://www.uniprot.org/uniprot/P14206" } ], "pmid": "" }, { "name": "ribosomal small subunit assembly", "id": "GO:0000028", "url": 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