{ "uniprot_canonical_ac": "P12969-1", "uniprot_ac": "P12969", "uniprot_id": "IAPP_RAT", "mass": { "chemical_mass": 10015.0, "monoisotopic_mass": 10015.0 }, "refseq": { "ac": "NP_036718", "name": "islet amyloid polypeptide preproprotein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, "gene_names": [ { "name": "Iapp", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P12969", "id": "P12969" }, { "name": "Iapp", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718", "id": "NP_036718" } ], "protein_names": [ { "name": "Islet amyloid polypeptide", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P12969" }, { "name": "Amylin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12969" }, { "name": "DAP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12969" }, { "name": "Diabetes-associated peptide", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P12969" }, { "name": "amylin; DAP; diabetes-associated peptide", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718", "id": "NP_036718" }, { "name": "islet amyloid polypeptide preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718", "id": "NP_036718" } ], "function": [ { "annotation": "Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, { "database": "PubMed", "id": "32587390", "url": "https://glygen.org/publication/PubMed/32587390" } ] }, { "annotation": "Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, { "database": "PubMed", "id": "37126782", "url": "https://glygen.org/publication/PubMed/37126782" } ] }, { "annotation": "Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, { "database": "PubMed", "id": "32436936", "url": "https://glygen.org/publication/PubMed/32436936" } ] }, { "annotation": "Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969#function" } ] }, { "annotation": "Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes.", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, { "database": "PubMed", "id": "34264642", "url": "https://glygen.org/publication/PubMed/34264642" } ] }, { "annotation": "The study presents the characterization of the structure ensemble of human IAPP, as well as the differences between human IAPP and its non-amyloidogenic homologous such as rat IAPP and illuminates the amyloidosis mechanism of IAPP.", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" }, { "database": "PubMed", "id": "30803034", "url": "https://glygen.org/publication/PubMed/30803034" } ] } ], "disease": [ { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] }, { "disease_id": "DOID:9744", "recommended_name": { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production." }, "synonyms": [ { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "IDDM", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type I diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes mellitus", "description": "A chronic condition characterized by minimal or absent production of insulin by the pancreas." }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "IDDM", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type 1", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type I", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "immune mediated diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "juvenile diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes mellitus", "description": "" }, { "id": "MIM:222100", "resource": "MIM", "url": "https://www.omim.org/entry/222100", "name": "Type 1 diabetes mellitus", "description": "Type 1 diabetes mellitus" } ], "evidence": [ { "id": "9744", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "common_name": "Rat" } ], "gene": [ { "name": "Iapp", "url": "https://www.uniprot.org/uniprot/P12969", "locus": { "chromosome": "4", "start_pos": 175242920, "end_pos": 175237115, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012417", "url": "https://www.ensembl.org/id/ENSRNOG00000012417" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012417", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "24476", "url": "https://www.ncbi.nlm.nih.gov/gene/24476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001693", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001693", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24476", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CATQRLT", "url": "https://omabrowser.org/oma/group/CATQRLT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3910643at2759", "url": "http://www.orthodb.org/?query=3910643at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10505:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10505:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2KJ7", "url": "https://www.rcsb.org/structure/2KJ7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7TYF", "url": "https://www.rcsb.org/structure/7TYF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7TYI", "url": "https://www.rcsb.org/structure/7TYI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7TYL", "url": "https://www.rcsb.org/structure/7TYL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7TYX", "url": "https://www.rcsb.org/structure/7TYX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7TZF", "url": "https://www.rcsb.org/structure/7TZF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00214", "url": "http://pfam.xfam.org/family/PF00214", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P12969", "url": "http://purl.obolibrary.org/obo/PR_P12969", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-419812", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-419812", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2854", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2854", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P12969-1", "url": "https://www.uniprot.org/uniprot/P12969-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCISRLPAVLLILSVALGHLRATPVGSGTNPQVDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNVAEDPNRESLDFLLL", "length": 93, "header": "sp|P12969-1|IAPP_RAT Isoform 1 of Islet amyloid polypeptide OS=Rattus norvegicus OX=10116 GN=Iapp PE=1 SV=1 CANONICAL=P12969-1" }, "isoforms": [ { "isoform_ac": "P12969-1", "url": "", "sequence": { "sequence": "MRCISRLPAVLLILSVALGHLRATPVGSGTNPQVDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNVAEDPNRESLDFLLL", "length": 93, "header": "sp|P12969-1|IAPP_RAT Isoform 1 of Islet amyloid polypeptide OS=Rattus norvegicus OX=10116 GN=Iapp PE=1 SV=1 CANONICAL=P12969-1" }, "locus": { "chromosome": "4", "start_pos": 175242402, "end_pos": 175237490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000016614", "url": "https://www.ensembl.org/id/ENSRNOT00000016614" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000016614", "url": "https://www.ensembl.org/id/ENSRNOP00000016614" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Amyloidogenesis abolished by proline substitutions but enhanced by lipid binding.", "journal": "PLoS Comput. Biol.", "date": "2009", "authors": "Xu W., Jiang P., Mu Y.", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "19360098", "url": "https://glygen.org/publication/PubMed/19360098" } ] }, { "title": "Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.", "journal": "J. Am. Chem. Soc.", "date": "2009", "authors": "Hartman K., Xu J., Subramanian V., Ramamoorthy A., Brender J.R., Nanga R.P.", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "19456151", "url": "https://glygen.org/publication/PubMed/19456151" } ] }, { "title": "Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man.", "journal": "Biochim. Biophys. Acta", "date": "1990", "authors": "van Mansfeld AD, Mosselman S, Hoppener JW, Zandberg J, van Teeffelen HA, Baas PD, Lips CJ, Jansz HS", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2223885", "url": "https://glygen.org/publication/PubMed/2223885" } ] }, { "title": "Regional distribution and molecular forms of rat islet amyloid polypeptide.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1990", "authors": "Matsuo H., Kangawa K., Nakazato M., Matsukura S., Miyazato M., Asai J.", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2357234", "url": "https://glygen.org/publication/PubMed/2357234" } ] }, { "title": "Rat amylin: cloning and tissue-specific expression in pancreatic islets.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1989", "authors": "Leffert JD, Newgard CB, Okamoto H, Milburn JL, Luskey KL", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2654937", "url": "https://glygen.org/publication/PubMed/2654937" } ] }, { "title": "Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species.", "journal": "FEBS Lett.", "date": "1989", "authors": "Betsholtz C, Christmansson L, Engstrom U, Rorsman F, Svensson V, Johnson KH, Westermark P", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2666169", "url": "https://glygen.org/publication/PubMed/2666169" } ] }, { "title": "Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1989", "authors": "Nishi M, Chan SJ, Nagamatsu S, Bell GI, Steiner DF", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2668946", "url": "https://glygen.org/publication/PubMed/2668946" } ] }, { "title": "Isolation and sequence determination of rat islet amyloid polypeptide.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1989", "authors": "Asai J, Nakazato M, Kangawa K, Matsukura S, Matsuo H", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "reference": [ { "type": "PubMed", "id": "2679555", "url": "https://glygen.org/publication/PubMed/2679555" } ] }, { "title": "All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints.", "journal": "Proteins", "date": "2019", "authors": "Su X, Wang K, Liu N, Chen J, Li Y, Duan M", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" } ], "reference": [ { "type": "PubMed", "id": "30803034", "url": "https://glygen.org/publication/PubMed/30803034" } ] }, { "title": "Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.", "journal": "Bioscience reports", "date": "2020", "authors": "Liu X, Yang R, Bai W, Xu X, Bi F, Hao Y, Yang Q, Li H", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" } ], "reference": [ { "type": "PubMed", "id": "32436936", "url": "https://glygen.org/publication/PubMed/32436936" } ] }, { "title": "Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.", "journal": "Scientific reports", "date": "2020", "authors": "Bharadwaj P, Solomon T, Sahoo BR, Ignasiak K, Gaskin S, Rowles J, Verdile G, Howard MJ, Bond CS, Ramamoorthy A, Martins RN, Newsholme P", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" } ], "reference": [ { "type": "PubMed", "id": "32587390", "url": "https://glygen.org/publication/PubMed/32587390" } ] }, { "title": "Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes.", "journal": "Biochemistry", "date": "2021", "authors": "Babych M, Nguyen PT, Cote-Cyr M, Kihal N, Quittot N, Golizeh M, Sleno L, Bourgault S", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" } ], "reference": [ { "type": "PubMed", "id": "34264642", "url": "https://glygen.org/publication/PubMed/34264642" } ] }, { "title": "Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.", "journal": "Journal of the American Society for Mass Spectrometry", "date": "2023-04-26", "authors": "Sanders Henry M, Chalyavi Farzaneh, Fields Caitlyn R, Kostelic Marius M, Li Ming-Hao, Raleigh Daniel P, Zanni Martin T, Marty Michael T", "evidence": [ { "database": "RefSeq", "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718" } ], "reference": [ { "type": "PubMed", "id": "37126782", "url": "https://glygen.org/publication/PubMed/37126782" } ] } ], "pathway": [ { "id": "rno:24476", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24476", "resource": "KEGG Pathway" }, { "id": "R-RNO-419812", "name": "Calcitonin-like ligand receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-419812", "resource": "Reactome", "description": "Calcitonin-like ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P10997-1", "protein_name": "Islet amyloid polypeptide", "gene_name": "IAPP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL", "length": 89 }, "evidence": [ { "id": "45241527", "url": "http://www.informatics.jax.org/homology/45241527", "database": "MGI" }, { "id": "P12969", "url": "https://omabrowser.org/oma/group/P12969/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P12968-1", "protein_name": "Islet amyloid polypeptide", "gene_name": "Iapp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMCISKLPAVLLILSVALNHLRATPVRSGSNPQMDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNAAGDPNRESLDFLLV", "length": 93 }, "evidence": [ { "id": "45241527", "url": "http://www.informatics.jax.org/homology/45241527", "database": "MGI" }, { "id": "P12969", "url": "https://omabrowser.org/oma/group/P12969/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "osteoclast differentiation", "id": "GO:0030316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030316", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "sensory perception of pain", "id": "GO:0019233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019233", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "eating behavior", "id": "GO:0042755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042755", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "glucose metabolic process", "id": "GO:0006006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006006", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "bone resorption", "id": "GO:0045453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045453", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "amylin receptor signaling pathway", "id": "GO:0097647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097647", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "negative regulation of osteoclast differentiation", "id": "GO:0045671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045671", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "negative regulation of bone resorption", "id": "GO:0045779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045779", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "P12969", "url": "https://www.uniprot.org/uniprot/P12969" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 13 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }