The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [ "R-ALL-2142772" ], "output_participant_list": [ "R-ALL-2142726" ], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-2161768", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2161768" } ] }, { "id": "R-RNO-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-2161907", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2161907" } ] }, { "id": "R-RNO-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-2161917", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2161917" } ] }, { "id": "R-RNO-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [], "output_participant_list": [ "R-ALL-266010" ], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-265296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-265296" } ] }, { "id": "R-RNO-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [], "output_participant_list": [ "R-ALL-266066" ], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-266050", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-266050" } ] }, { "id": "R-RNO-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q925U2-1", "P12527-1" ], "evidence": [ { "id": "R-RNO-266051", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-266051" } ] }, { "id": "R-RNO-429016", "name": "ALOX5 is phosphorylated by MAPKAP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P12527-1", "Q80ZF4-1" ], "evidence": [ { "id": "R-RNO-429016", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-429016" } ] }, { "id": "R-RNO-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P82995-1", "Q6P6U0-1", "P05197-1", "P63018-1", "P09811-1", "P05065-1", "Q6P6V0-1", "P36972-1", "P46462-1", "P09117-1", "D4AEH9-1", "F1M1H0-1", "F7FLB2-1", "P04762-1", "P32038-1", "D3ZLZ7-1", "E9PU28-1", "O35331-1", "P19804-1", "P27926-1", "P41562-1", "M0RD14-1", "G3V817-1", "D4ADE8-1", "D4AC20-1", "O09178-1", "P62630-1", "P10111-1", "P25113-1", "P30835-1", "P85973-1", "Q9JHW0-1", "Q9Z0V5-1", "Q63644-1", "O35264-1", "P12527-1", "O08730-1", "P04906-1", "P06214-1", "P30904-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798748" } ] }, { "id": "R-RNO-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P82995-1", "P05197-1", "Q8K4Y7-1", "P63018-1", "P63086-1", "P38652-1", "P09811-1", "P16638-1", "P05065-1", "P50430-1", "Q6P6V0-1", "P97571-1", "P46462-1", "P09117-1", "D4AEH9-1", "F1M1H0-1", "F7FLB2-1", "Q32KJ5-1", "P50282-1", "D3ZUM4-1", "P00787-1", "P04762-1", "P06760-1", "P24268-1", "P32038-1", "Q6P7S1-1", "D3ZLZ7-1", "E9PU28-1", "P19804-1", "P27926-1", "P30349-1", "P41562-1", "D4AC85-1", "M0RD14-1", "D4ADE8-1", "D4AC20-1", "O09178-1", "P13676-1", "P19132-1", "P62630-1", "P10111-1", "P25113-1", "P30835-1", "P85973-1", "Q9JHW0-1", "Q9Z0V5-1", "Q02765-1", "Q9R1T3-1", "O35264-1", "P12527-1", "O08730-1", "P04906-1", "P06214-1", "P30904-1", "P70618-1" ], "evidence": [ { "id": "R-RNO-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6800434" } ] }, { "id": "R-RNO-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9020602" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9018858", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018858" } ] }, { "id": "R-RNO-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9022655" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9018859", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018859" } ] }, { "id": "R-RNO-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9023702" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9018863", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018863" } ] }, { "id": "R-RNO-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9023708" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9018894", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9018894" } ] }, { "id": "R-RNO-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024479" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020251", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020251" } ] }, { "id": "R-RNO-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024768" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020255", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020255" } ] }, { "id": "R-RNO-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024602" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020256", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020256" } ] }, { "id": "R-RNO-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024576" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020259", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020259" } ] }, { "id": "R-RNO-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024797" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020264", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020264" } ] }, { "id": "R-RNO-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024781" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020277", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020277" } ] }, { "id": "R-RNO-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024577" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020278", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020278" } ] }, { "id": "R-RNO-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024765" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9020282", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020282" } ] }, { "id": "R-RNO-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9024989" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9024997", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9024997" } ] }, { "id": "R-RNO-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9026050" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9025995", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9025995" } ] }, { "id": "R-RNO-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9026034" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9025996", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9025996" } ] }, { "id": "R-RNO-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9026046" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9025999", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9025999" } ] }, { "id": "R-RNO-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9026311" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9026005", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9026005" } ] }, { "id": "R-RNO-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9026405", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9026405" } ] }, { "id": "R-RNO-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9028274" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9027624", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9027624" } ] }, { "id": "R-RNO-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9028283" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9027628", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9027628" } ] }, { "id": "R-RNO-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-9028240" ], "enzyme_list": [ "P12527-1" ], "evidence": [ { "id": "R-RNO-9027633", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9027633" } ] }, { "id": "R-RNO-9707186", "name": "ALOX5 binds ALOX5 inhibitors", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "D3ZLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLZ7" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "D3ZLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLZ7" } ] } ] }, { "uniprot_ac": "D3ZQF9", "gene_name": "Alox12e", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "D3ZQF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF9" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "D3ZQF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF9" } ] } ] }, { "uniprot_ac": "D3ZUM4", "gene_name": "Glb1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "D3ZUM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUM4" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "D3ZUM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUM4" } ] } ] }, { "uniprot_ac": "D4AC20", "gene_name": "Cda", "activity": [ { "ec_number": "3.5.4.5", "activity": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+).", "evidence": [ { "id": "D4AC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC20" } ] }, { "ec_number": "3.5.4.5", "activity": "", "evidence": [ { "id": "D4AC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC20" } ] } ] }, { "uniprot_ac": "D4AC85", "gene_name": "Qpct", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "D4AC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC85" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "D4AC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AC85" } ] } ] }, { "uniprot_ac": "D4ADE8", "gene_name": "Ddx3x", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADE8" } ] } ] }, { "uniprot_ac": "D4AEH9", "gene_name": "Agl", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "D4AEH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEH9" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "D4AEH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEH9" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "D4AEH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEH9" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "D4AEH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEH9" } ] } ] }, { "uniprot_ac": "E9PU28", "gene_name": "Impdh2", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "E9PU28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU28" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "E9PU28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU28" } ] } ] }, { "uniprot_ac": "F1LQ70", "gene_name": "Alox12", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "F1LQ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQ70" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "F1LQ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQ70" } ] }, { "ec_number": "3.3.2.-", "activity": "", "evidence": [ { "id": "F1LQ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQ70" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "F1LQ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQ70" } ] } ] }, { "uniprot_ac": "F1M1H0", "gene_name": "Dera", "activity": [ { "ec_number": "4.1.2.4", "activity": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate.", "evidence": [ { "id": "F1M1H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M1H0" } ] }, { "ec_number": "4.1.2.4", "activity": "", "evidence": [ { "id": "F1M1H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M1H0" } ] } ] }, { "uniprot_ac": "F7FLB2", "gene_name": "Pgm2", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.", "evidence": [ { "id": "F7FLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FLB2" } ] }, { "ec_number": "5.4.2.2", "activity": "", "evidence": [ { "id": "F7FLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FLB2" } ] } ] }, { "uniprot_ac": "G3V817", "gene_name": "Xrcc5", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "G3V817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V817" } ] } ] }, { "uniprot_ac": "M0RD14", "gene_name": "LOC100362738", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "M0RD14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD14" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "M0RD14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD14" } ] } ] }, { "uniprot_ac": "O08730", "gene_name": "Gyg1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "O08730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08730" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "O08730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08730" } ] } ] }, { "uniprot_ac": "O09178", "gene_name": "Ampd3", "activity": [ { "ec_number": "3.5.4.6", "activity": "AMP + H(+) + H2O = IMP + NH4(+).", "evidence": [ { "id": "O09178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09178" } ] }, { "ec_number": "3.5.4.6", "activity": "", "evidence": [ { "id": "O09178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09178" } ] } ] }, { "uniprot_ac": "O35264", "gene_name": "Pafah1b2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] } ] }, { "uniprot_ac": "O35331", "gene_name": "Pdxk", "activity": [ { "ec_number": "2.7.1.35", "activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.", "evidence": [ { "id": "O35331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35331" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "O35331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35331" } ] } ] }, { "uniprot_ac": "O35936", "gene_name": "Alox8", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "O35936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35936" } ] }, { "ec_number": "1.13.11.58", "activity": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate.", "evidence": [ { "id": "O35936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35936" } ] } ] }, { "uniprot_ac": "P00787", "gene_name": "Ctsb", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P00787", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00787" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P00787", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00787" } ] } ] }, { "uniprot_ac": "P04762", "gene_name": "Cat", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P04762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04762" } ] } ] }, { "uniprot_ac": "P04906", "gene_name": "Gstp1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "P04906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04906" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P04906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04906" } ] } ] }, { "uniprot_ac": "P05065", "gene_name": "Aldoa", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "P05065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05065" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "P05065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05065" } ] } ] }, { "uniprot_ac": "P05197", "gene_name": "Eef2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05197" } ] } ] }, { "uniprot_ac": "P06214", "gene_name": "Alad", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen.", "evidence": [ { "id": "P06214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06214" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "P06214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06214" } ] } ] }, { "uniprot_ac": "P06760", "gene_name": "Gusb", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "P06760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06760" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "P06760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06760" } ] } ] }, { "uniprot_ac": "P09117", "gene_name": "Aldoc", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "P09117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09117" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "P09117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09117" } ] } ] }, { "uniprot_ac": "P09811", "gene_name": "Pygl", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P09811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09811" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P09811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09811" } ] } ] }, { "uniprot_ac": "P09917", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P09917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09917" } ] }, { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4.", "evidence": [ { "id": "P09917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09917" } ] } ] }, { "uniprot_ac": "P10111", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] } ] }, { "uniprot_ac": "P12527", "gene_name": "Alox5", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P12527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12527" } ] }, { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4.", "evidence": [ { "id": "P12527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12527" } ] } ] }, { "uniprot_ac": "P13676", "gene_name": "Apeh", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P13676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13676" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P13676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13676" } ] } ] }, { "uniprot_ac": "P16050", "gene_name": "ALOX15", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P16050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16050" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "P16050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16050" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "P16050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16050" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "P16050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16050" } ] } ] }, { "uniprot_ac": "P16638", "gene_name": "Acly", "activity": [ { "ec_number": "2.3.3.8", "activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.", "evidence": [ { "id": "P16638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16638" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "P16638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16638" } ] } ] }, { "uniprot_ac": "P18054", "gene_name": "ALOX12", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P18054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18054" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "P18054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18054" } ] }, { "ec_number": "3.3.2.-", "activity": "", "evidence": [ { "id": "P18054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18054" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "P18054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18054" } ] } ] }, { "uniprot_ac": "P19132", "gene_name": "Fth1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "P19132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19132" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "P19132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19132" } ] } ] }, { "uniprot_ac": "P19804", "gene_name": "Nme2", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P19804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19804" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P19804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19804" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P19804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19804" } ] } ] }, { "uniprot_ac": "P24268", "gene_name": "Ctsd", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "P24268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24268" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "P24268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24268" } ] } ] }, { "uniprot_ac": "P25113", "gene_name": "Pgam1", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "P25113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25113" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "P25113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25113" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "P25113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25113" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "P25113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25113" } ] } ] }, { "uniprot_ac": "P27926", "gene_name": "Hk3", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "P27926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27926" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "P27926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27926" } ] } ] }, { "uniprot_ac": "P30349", "gene_name": "Lta4h", "activity": [ { "ec_number": "3.3.2.6", "activity": "H2O + leukotriene A4 = leukotriene B4.", "evidence": [ { "id": "P30349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30349" } ] }, { "ec_number": "3.4.11.4", "activity": "Release of the N-terminal residue from a tripeptide.", "evidence": [ { "id": "P30349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30349" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "P30349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30349" } ] } ] }, { "uniprot_ac": "P30835", "gene_name": "Pfkl", "activity": [ { "ec_number": "2.7.1.11", "activity": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+).", "evidence": [ { "id": "P30835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30835" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "P30835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30835" } ] } ] }, { "uniprot_ac": "P30904", "gene_name": "Mif", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P30904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30904" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P30904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30904" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P30904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30904" } ] } ] }, { "uniprot_ac": "P32038", "gene_name": "Cfd", "activity": [ { "ec_number": "3.4.21.46", "activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.", "evidence": [ { "id": "P32038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32038" } ] }, { "ec_number": "3.4.21.46", "activity": "", "evidence": [ { "id": "P32038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32038" } ] } ] }, { "uniprot_ac": "P36972", "gene_name": "Aprt", "activity": [ { "ec_number": "2.4.2.7", "activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.", "evidence": [ { "id": "P36972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36972" } ] }, { "ec_number": "2.4.2.7", "activity": "", "evidence": [ { "id": "P36972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36972" } ] } ] }, { "uniprot_ac": "P38652", "gene_name": "Pgm1", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.", "evidence": [ { "id": "P38652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38652" } ] }, { "ec_number": "5.4.2.2", "activity": "", "evidence": [ { "id": "P38652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38652" } ] } ] }, { "uniprot_ac": "P39654", "gene_name": "Alox15", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P39654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39654" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "P39654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39654" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "P39654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39654" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "P39654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39654" } ] } ] }, { "uniprot_ac": "P39655", "gene_name": "Alox12", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P39655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39655" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "P39655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39655" } ] }, { "ec_number": "3.3.2.-", "activity": "", "evidence": [ { "id": "P39655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39655" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "P39655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39655" } ] } ] }, { "uniprot_ac": "P41562", "gene_name": "Idh1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "P41562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41562" } ] } ] }, { "uniprot_ac": "P46462", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] } ] }, { "uniprot_ac": "P48999", "gene_name": "Alox5", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P48999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48999" } ] }, { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4.", "evidence": [ { "id": "P48999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48999" } ] } ] }, { "uniprot_ac": "P50282", "gene_name": "Mmp9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P50282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50282" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P50282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50282" } ] } ] }, { "uniprot_ac": "P50430", "gene_name": "Arsb", "activity": [ { "ec_number": "3.1.6.12", "activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] }, { "ec_number": "3.1.6.12", "activity": "", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] } ] }, { "uniprot_ac": "P55249", "gene_name": "Alox12e", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P55249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55249" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "P55249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55249" } ] } ] }, { "uniprot_ac": "P62630", "gene_name": "Eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P62630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62630" } ] } ] }, { "uniprot_ac": "P63018", "gene_name": "Hspa8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] } ] }, { "uniprot_ac": "P63086", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] } ] }, { "uniprot_ac": "P70618", "gene_name": "Mapk14", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] } ] }, { "uniprot_ac": "P82995", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] } ] }, { "uniprot_ac": "P85973", "gene_name": "Pnp", "activity": [ { "ec_number": "2.4.2.1", "activity": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase.", "evidence": [ { "id": "P85973", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P85973" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "P85973", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P85973" } ] } ] }, { "uniprot_ac": "P97571", "gene_name": "Capn1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "P97571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97571" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "P97571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97571" } ] } ] }, { "uniprot_ac": "Q02759", "gene_name": "Alox15", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "Q02759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02759" } ] }, { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "Q02759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02759" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "Q02759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02759" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "Q02759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02759" } ] } ] }, { "uniprot_ac": "Q02765", "gene_name": "Ctss", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "Q02765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02765" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "Q02765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02765" } ] } ] }, { "uniprot_ac": "Q32KJ5", "gene_name": "Gns", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "Q32KJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ5" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "Q32KJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ5" } ] } ] }, { "uniprot_ac": "Q63644", "gene_name": "Rock1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] } ] }, { "uniprot_ac": "Q6P6U0", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] } ] }, { "uniprot_ac": "Q6P6V0", "gene_name": "Gpi", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "Q6P6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6V0" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "Q6P6V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6V0" } ] } ] }, { "uniprot_ac": "Q6P7S1", "gene_name": "Asah1", "activity": [ { "ec_number": "3.5.1.23", "activity": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine.", "evidence": [ { "id": "Q6P7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7S1" } ] }, { "ec_number": "3.5.1.23", "activity": "", "evidence": [ { "id": "Q6P7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7S1" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q6P7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7S1" } ] } ] }, { "uniprot_ac": "Q80ZF4", "gene_name": "Mapkapk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80ZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZF4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80ZF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZF4" } ] } ] }, { "uniprot_ac": "Q8K4Y7", "gene_name": "Cant1", "activity": [ { "ec_number": "3.6.1.6", "activity": "ADP + H2O = AMP + H(+) + phosphate.", "evidence": [ { "id": "Q8K4Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4Y7" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "Q8K4Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4Y7" } ] } ] }, { "uniprot_ac": "Q925U2", "gene_name": "Ltc4s", "activity": [ { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = glutathione + leukotriene A4.", "evidence": [ { "id": "Q925U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925U2" } ] }, { "ec_number": "2.5.1.-", "activity": "", "evidence": [ { "id": "Q925U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925U2" } ] }, { "ec_number": "4.4.1.20", "activity": "", "evidence": [ { "id": "Q925U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925U2" } ] } ] }, { "uniprot_ac": "Q9JHW0", "gene_name": "Psmb7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q9JHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q9JHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW0" } ] } ] }, { "uniprot_ac": "Q9R1T3", "gene_name": "Ctsz", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "Q9R1T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R1T3" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "Q9R1T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R1T3" } ] } ] }, { "uniprot_ac": "Q9Z0V5", "gene_name": "Prdx4", "activity": [ { "ec_number": "1.11.1.24", "activity": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O.", "evidence": [ { "id": "Q9Z0V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0V5" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q9Z0V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0V5" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }