{ "uniprot_canonical_ac": "P11034-1", "uniprot_ac": "P11034", "uniprot_id": "MCPT1_MOUSE", "mass": { "chemical_mass": 27013.0, "monoisotopic_mass": 27013.0 }, "refseq": { "ac": "NP_032596", "name": "mast cell protease 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" }, "gene_names": [ { "name": "Mcpt1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11034", "id": "P11034" }, { "name": "Mcp-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596", "id": "NP_032596" }, { "name": "Mcpt1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596", "id": "NP_032596" } ], "protein_names": [ { "name": "Mast cell protease 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11034" }, { "name": "3.4.21.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11034" }, { "name": "MMCP-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596", "id": "NP_032596" }, { "name": "mMCP-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11034" }, { "name": "mast cell protease 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596", "id": "NP_032596" } ], "function": [ { "annotation": "CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration.", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" }, { "database": "PubMed", "id": "25339660", "url": "https://glygen.org/publication/PubMed/25339660" } ] }, { "annotation": "Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" }, { "database": "PubMed", "id": "32005755", "url": "https://glygen.org/publication/PubMed/32005755" } ] }, { "annotation": "Effective Model of Food Allergy in Mice Sensitized with Ovalbumin and Freud's Adjuvant.", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" }, { "database": "PubMed", "id": "34297293", "url": "https://glygen.org/publication/PubMed/34297293" } ] }, { "annotation": "Has a chymotrypsin-like activity.", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034#function" } ] }, { "annotation": "The anti-inflammatory and bioregulatory effects of habitual exercise in high-fat diet-induced obesity involve crown-like structures and MCP-1 in white adipose tissue.", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" }, { "database": "PubMed", "id": "37358368", "url": "https://glygen.org/publication/PubMed/37358368" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mcpt1", "url": "https://www.uniprot.org/uniprot/P11034", "locus": { "chromosome": "14", "start_pos": 56257841, "end_pos": 56255428, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022227", "url": "https://www.ensembl.org/id/ENSMUSG00000022227" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022227", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "17224", "url": "https://www.ncbi.nlm.nih.gov/gene/17224", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:17224", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17224", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "96937", "url": "http://www.informatics.jax.org/marker/MGI:96937", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RYSERTW", "url": "https://omabrowser.org/oma/group/RYSERTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2540265at2759", "url": "http://www.orthodb.org/?query=2540265at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "http://pfam.xfam.org/family/PF00089", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P11034", "url": "http://purl.obolibrary.org/obo/PR_P11034", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11034-1", "url": "https://www.uniprot.org/uniprot/P11034-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQALLFLMALLLPSGAGAEEIIGGVEARPHSRPYMAHLKIITDRGSEDRCGGFLIAPQFVLTAAHCKGREITVTLGAHDVSKSESTQQRIKVEKQIIHKNYNVSFNLYDIMLLKLEEKAELTPTVDVIPLPGPSDFIDPGKMCWTAGWGKTGEKEPTSETLREVELRIMDKEACKMYKHYDYNFQVCVGSSTKLKTAYMGDSGGPLLCAGVAHGIVSYGDSHGKPPAVFTRISAYVPWIKTVINGK", "length": 246, "header": "sp|P11034-1|MCPT1_MOUSE Isoform 1 of Mast cell protease 1 OS=Mus musculus OX=10090 GN=Mcpt1 PE=1 SV=2 CANONICAL=P11034-1" }, "isoforms": [ { "isoform_ac": "P11034-1", "url": "", "sequence": { "sequence": "MQALLFLMALLLPSGAGAEEIIGGVEARPHSRPYMAHLKIITDRGSEDRCGGFLIAPQFVLTAAHCKGREITVTLGAHDVSKSESTQQRIKVEKQIIHKNYNVSFNLYDIMLLKLEEKAELTPTVDVIPLPGPSDFIDPGKMCWTAGWGKTGEKEPTSETLREVELRIMDKEACKMYKHYDYNFQVCVGSSTKLKTAYMGDSGGPLLCAGVAHGIVSYGDSHGKPPAVFTRISAYVPWIKTVINGK", "length": 246, "header": "sp|P11034-1|MCPT1_MOUSE Isoform 1 of Mast cell protease 1 OS=Mus musculus OX=10090 GN=Mcpt1 PE=1 SV=2 CANONICAL=P11034-1" }, "locus": { "chromosome": "14", "start_pos": 56257593, "end_pos": 56255456, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000022836", "url": "https://www.ensembl.org/id/ENSMUST00000022836" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000022836", "url": "https://www.ensembl.org/id/ENSMUSP00000022836" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P11034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11034#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice.", "journal": "J. Immunol.", "date": "1992", "authors": "Ghildyal N, McNeil HP, Stechschulte S, Austen KF, Silberstein D, Gurish MF, Somerville LL, Stevens RL", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "reference": [ { "type": "PubMed", "id": "1517575", "url": "https://glygen.org/publication/PubMed/1517575" } ] }, { "title": "Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases.", "journal": "Eur. J. Immunol.", "date": "1991", "authors": "Huang R., Blom T., Hellman L.", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "reference": [ { "type": "PubMed", "id": "2060576", "url": "https://glygen.org/publication/PubMed/2060576" } ] }, { "title": "CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2014", "authors": "Zhang J, Xiao Z, Qu C, Cui W, Wang X, Du J", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" } ], "reference": [ { "type": "PubMed", "id": "25339660", "url": "https://glygen.org/publication/PubMed/25339660" } ] }, { "title": "Amino acid sequence of a mouse mucosal mast cell protease.", "journal": "Biochemistry", "date": "1989", "authors": "Charbonneau H., Neurath H., Woodbury R.G., le Trong H., Miller H.R.P., Newlands G.F.J.", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "reference": [ { "type": "PubMed", "id": "2706264", "url": "https://glygen.org/publication/PubMed/2706264" } ] }, { "title": "Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2020", "authors": "Kasakura K, Nagata K, Miura R, Iida M, Nakaya H, Okada H, Arai T, Arai T, Kawakami Y, Kawakami T, Yashiro T, Nishiyama C", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" } ], "reference": [ { "type": "PubMed", "id": "32005755", "url": "https://glygen.org/publication/PubMed/32005755" } ] }, { "title": "Effective Model of Food Allergy in Mice Sensitized with Ovalbumin and Freud's Adjuvant.", "journal": "Bulletin of experimental biology and medicine", "date": "2021", "authors": "Zhang Y, Liu JY, Shao JW, Luo QQ, Zhang YQ, Song G, Wang CY, Zhao SY, Wan C, Du XH, Xu LZ", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" } ], "reference": [ { "type": "PubMed", "id": "34297293", "url": "https://glygen.org/publication/PubMed/34297293" } ] }, { "title": "The anti-inflammatory and bioregulatory effects of habitual exercise in high-fat diet-induced obesity involve crown-like structures and MCP-1 in white adipose tissue.", "journal": "Exercise immunology review", "date": "2023", "authors": "G\u00e1lvez Isabel, Hinchado Mar\u00eda Dolores, Mart\u00edn-Cordero Leticia, Mor\u00e1n-Plata Francisco Javier, Graham Gerry, Francisco-Morcillo Javier, Ortega Eduardo", "evidence": [ { "database": "RefSeq", "id": "NP_032596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032596" } ], "reference": [ { "type": "PubMed", "id": "37358368", "url": "https://glygen.org/publication/PubMed/37358368" } ] }, { "title": "Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4).", "journal": "Biochem. J.", "date": "1993", "authors": "Pirie-Shepherd S.R., Knox D.P., Miller H.R.P., Newlands G.F.J.", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "reference": [ { "type": "PubMed", "id": "8363563", "url": "https://glygen.org/publication/PubMed/8363563" } ] } ], "pathway": [ { "id": "mmu:17224", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17224", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P00770-1", "protein_name": "Mast cell protease 2", "gene_name": "Mcpt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQALLFLMALLLPSGAGAEEIIGGVESIPHSRPYMAHLDIVTEKGLRVICGGFLISRQFVLTAAHCKGREITVILGAHDVRKRESTQQKIKVEKQIIHESYNSVPNLHDIMLLKLEKKVELTPAVNVVPLPSPSDFIHPGAMCWAAGWGKTGVRDPTSYTLREVELRIMDEKACVDYRYYEYKFQVCVGSPTTLRAAFMGDSGGPLLCAGVAHGIVSYGHPDAKPPAIFTRVSTYVPWINAVINTSS", "length": 247 }, "evidence": [ { "id": "45228526", "url": "http://www.informatics.jax.org/homology/45228526", "database": "MGI" }, { "id": "P11034", "url": "https://omabrowser.org/oma/group/P11034/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "P11034", "url": "https://www.uniprot.org/uniprot/P11034" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }