{ "uniprot_canonical_ac": "P10860-1", "uniprot_ac": "P10860", "uniprot_id": "DHE3_RAT", "mass": { "chemical_mass": 61416.0, "monoisotopic_mass": 61416.0 }, "refseq": { "ac": "NP_036702", "name": "glutamate dehydrogenase 1, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" }, "gene_names": [ { "name": "Glud1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10860", "id": "P10860" }, { "name": "Ac2-281; Gdh1; Glud; Gludeha; MRG-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "id": "NP_036702" }, { "name": "Glud1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "id": "NP_036702" }, { "name": "Glud", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10860", "id": "P10860" } ], "protein_names": [ { "name": "Glutamate dehydrogenase 1, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10860" }, { "name": "1.4.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10860" }, { "name": "GDH 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10860" }, { "name": "MRG-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10860" }, { "name": "Memory-related gene 2 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10860" }, { "name": "glutamate dehydrogenase 1, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "id": "NP_036702" }, { "name": "glutamate dehydrogenase 1, mitochondrial; memory-related gene 2 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "id": "NP_036702" } ], "function": [ { "annotation": "Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" }, { "database": "PubMed", "id": "29784783", "url": "https://glygen.org/publication/PubMed/29784783" } ] }, { "annotation": "GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of alpha-ketoglutarate level.", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" }, { "database": "PubMed", "id": "35904584", "url": "https://glygen.org/publication/PubMed/35904584" } ] }, { "annotation": "Glutamate dehydrogenase is differentially regulated in liver and muscle of rats with transplanted Guerin's carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" }, { "database": "PubMed", "id": "24319738", "url": "https://glygen.org/publication/PubMed/24319738" } ] }, { "annotation": "Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (PubMed:9275181).", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860#function" }, { "database": "PubMed", "id": "9275181", "url": "https://glygen.org/publication/PubMed/9275181" }, { "database": "UniProtKB", "id": "P00367", "url": "https://www.uniprot.org/uniprot/P00367#function" } ] } ], "disease": [ { "disease_id": "DOID:0060892", "recommended_name": { "id": "DOID:0060892", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060892", "name": "late onset Parkinson's disease", "description": "A Parkinson's disease characterized by onset of motor symptoms typically after 60 years of age." }, "synonyms": [ { "id": "DOID:0060892", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060892", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "A Parkinson disease that begins after around the age of 50." }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "LOPD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PARK", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, age of onset, modifier, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "autosomal dominant late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson's disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "" }, { "id": "MIM:168600", "resource": "MIM", "url": "https://www.omim.org/entry/168600", "name": "Parkinson disease", "description": "Parkinson disease" } ], "evidence": [ { "id": "0060892", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060892" } ] }, { "disease_id": "DOID:0070217", "recommended_name": { "id": "DOID:0070217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070217", "name": "familial hyperinsulinemic hypoglycemia 6", "description": "A hyperinsulinemic hypoglycemia characterized by autosomal dominant inheritance of excessive insulin secretion, asymptomatic hyperammonemia and episodes of hypoglycemia induced by fasting or protein rich meals that has_material_basis_in mutation in the GLUD1 gene on chromosome 10q23.3." }, "synonyms": [ { "id": "DOID:0070217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070217", "name": "HHF6", "description": "" }, { "id": "DOID:0070217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070217", "name": "HI/HA syndrome", "description": "" }, { "id": "DOID:0070217", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070217", "name": "hyperinsulinism-hyperammonemia syndrome", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinism-hyperammonemia syndrome", "description": "Hyperinsulinism-hyperammonemia syndrome (HIHA) is a frequent form of diazoxide-sensitive diffuse hyperinsulinism, characterized by an excessive/ uncontrolled insulin secretion (inappropriate for the level of glycemia), asymptomatic hyperammonemia and recurrent episodes of profound hypoglycemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent neurological sequelae. Epilepsy and cognitive deficit that are unrelated to hypoglycemia may also occur." }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "GDH hyperinsulinism", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "GLUD1 hyperinsulinism", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "glutamate dehydrogenase 1 hyperinsulinism", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hi/HA syndrome", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinemic hypoglycemia, familial, type 6", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinism-hyperammonemia syndrome", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinism/hyperammonemia syndrome", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "HA/hi syndrome", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "HHF6", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinemic hypoglycemia familial 6", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinemic hypoglycemia, familial, 6", "description": "" }, { "id": "MONDO:0011717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011717", "name": "hyperinsulinism hyperammonemia syndrome", "description": "" }, { "id": "MIM:606762", "resource": "MIM", "url": "https://www.omim.org/entry/606762", "name": "Hyperinsulinemic hypoglycemia, familial, 6", "description": "Hyperinsulinemic hypoglycemia, familial, 6" } ], "evidence": [ { "id": "0070217", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070217" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:11832", "recommended_name": { "id": "DOID:11832", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11832", "name": "visual epilepsy", "description": "" }, "synonyms": [ { "id": "DOID:11832", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11832", "name": "epilepsy, visual", "description": "" } ], "evidence": [ { "id": "11832", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11832" } ] }, { "disease_id": "DOID:13413", "recommended_name": { "id": "DOID:13413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13413", "name": "hepatic encephalopathy", "description": "A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood." }, "synonyms": [ { "id": "DOID:13413", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13413", "name": "Portal-systemic encephalopathy", "description": "" } ], "evidence": [ { "id": "13413", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13413" } ] }, { "disease_id": "DOID:1825", "recommended_name": { "id": "DOID:1825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1825", "name": "childhood absence epilepsy", "description": "A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years." }, "synonyms": [ { "id": "DOID:1825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1825", "name": "petit mal seizure", "description": "" }, { "id": "DOID:1825", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1825", "name": "pyknolepsy", "description": "" } ], "evidence": [ { "id": "1825", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1825" } ] }, { "disease_id": "DOID:2018", "recommended_name": { "id": "DOID:2018", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2018", "name": "hyperinsulinism", "description": "" }, "synonyms": [ { "id": "DOID:2018", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2018", "name": "hyperinsulinemia", "description": "" } ], "evidence": [ { "id": "2018", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2018" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:3328", "recommended_name": { "id": "DOID:3328", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3328", "name": "temporal lobe epilepsy", "description": "A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes." }, "synonyms": [ { "id": "DOID:3328", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3328", "name": "epilepsy, temporal lobe", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, familial temporal lobe, 1", "description": "An autosomal dominant condition caused by mutation(s) in the LGI1 gene, encoding leucine-rich glioma-inactivated protein 1. It is characterized by partial seizures originating in the temporal lobe and often accompanied by auditory sensory manifestations." }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "ETL1", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, familial temporal lobe, type 1", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, lateral temporal lobe, autosomal dominant", "description": "" }, { "id": "MONDO:0700090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0700090", "name": "epilepsy, partial, with auditory features", "description": "" }, { "id": "MIM:600512", "resource": "MIM", "url": "https://www.omim.org/entry/600512", "name": "Epilepsy, familial temporal lobe, 1", "description": "Epilepsy, familial temporal lobe, 1" } ], "evidence": [ { "id": "3328", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3328" } ] }, { "disease_id": "DOID:885", "recommended_name": { "id": "DOID:885", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:885", "name": "fascioliasis", "description": "A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa." }, "synonyms": [ { "id": "DOID:885", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:885", "name": "Fasciola hepatica infection", "description": "" }, { "id": "DOID:885", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:885", "name": "Infection by Fasciola", "description": "" }, { "id": "DOID:885", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:885", "name": "Liver flukes", "description": "" }, { "id": "DOID:885", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:885", "name": "Sheep liver fluke infection", "description": "" } ], "evidence": [ { "id": "885", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:885" } ] }, { "disease_id": "DOID:9993", "recommended_name": { "id": "DOID:9993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9993", "name": "hypoglycemia", "description": "A glucose metabolism disease that is characterized by abnormally low levels of blood glucose." }, "synonyms": [ { "id": "DOID:9993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9993", "name": "Hypoglycaemia", "description": "" } ], "evidence": [ { "id": "9993", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9993" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "common_name": "Rat" } ], "gene": [ { "name": "Glud1", "url": "https://www.uniprot.org/uniprot/P10860", "locus": { "chromosome": "16", "start_pos": 9673957, "end_pos": 9640312, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000057367", "url": "https://www.ensembl.org/id/ENSRNOG00000057367" } ] } } ], "crossref": [ { "id": "ENSRNOG00000057367", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057367", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.4.1.3", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.4.1.3&UniProtAcc=P10860", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01076", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2176833", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2176833", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "24399", "url": "https://www.ncbi.nlm.nih.gov/gene/24399", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P10860", "url": "https://www.ebi.ac.uk/intact/interactors/id:P10860*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24399", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24399", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "P10860", "url": "https://oglcnac.org/atlas/detail/P10860", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P10860", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PCFAAFP", "url": "https://omabrowser.org/oma/group/PCFAAFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "45283at2759", "url": "http://www.orthodb.org/?query=45283at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11606", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11606", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11606:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11606:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00208", "url": "http://pfam.xfam.org/family/PF00208", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02812", "url": "http://pfam.xfam.org/family/PF02812", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10860", "url": "http://purl.obolibrary.org/obo/PR_P10860", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-2151201", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2151201", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8964539", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8964539", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2708", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2708", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "11612", "url": "https://www.rhea-db.org/rhea/11612", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "15133", "url": "https://www.rhea-db.org/rhea/15133", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6AGI7", "url": "https://www.uniprot.org/uniprot/A0A8I6AGI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AGI7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AGI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10860-1", "url": "https://www.uniprot.org/uniprot/P10860-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT", "length": 558, "header": "sp|P10860-1|DHE3_RAT Isoform 1 of Glutamate dehydrogenase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Glud1 PE=1 SV=2 CANONICAL=P10860-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AGI7-1", "url": "", "sequence": { "sequence": "MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKVKTIIKTSQQYRCGRDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT", "length": 546, "header": "tr|A0A8I6AGI7-1|A0A8I6AGI7_RAT Computationally mapped isoform of glutamate dehydrogenase [NAD(P)(+)] OS=Rattus norvegicus OX=10116 GN=Glud1 PE=1 SV=1 CANONICAL=P10860-1" }, "locus": { "chromosome": "16", "start_pos": 9672828, "end_pos": 9640482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108378.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108378.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091891.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091891.1" } ] } }, { "isoform_ac": "P10860-1", "url": "", "sequence": { "sequence": "MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT", "length": 558, "header": "sp|P10860-1|DHE3_RAT Isoform 1 of Glutamate dehydrogenase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Glud1 PE=1 SV=2 CANONICAL=P10860-1" }, "locus": { "chromosome": "16", "start_pos": 9672828, "end_pos": 9640482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083446", "url": "https://www.ensembl.org/id/ENSRNOT00000083446" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075032", "url": "https://www.ensembl.org/id/ENSRNOP00000075032" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 153, "start_aa": "Ser", "end_pos": 153, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser153", "evidence": [ { "id": "P10860", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "P10860", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P10860" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 228, "start_aa": "Thr", "end_pos": 228, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr228", "evidence": [ { "id": "P10860", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "P10860", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P10860" } ] } ], "phosphorylation": [ { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P10860", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10860" } ], "site_lbl": "Ser128" }, { "start_pos": 135, "end_pos": 135, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "site_lbl": "Tyr135" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "site_lbl": "Ser227" }, { "start_pos": 384, "end_pos": 384, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "site_lbl": "Ser384" }, { "start_pos": 410, "end_pos": 410, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P10860", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10860" } ], "site_lbl": "Thr410" }, { "start_pos": 512, "end_pos": 512, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "site_lbl": "Tyr512" }, { "start_pos": 79, "end_pos": 79, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P10860", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10860" } ], "site_lbl": "Ser79" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins.", "journal": "Biochem. J.", "date": "1991", "authors": "Moller U., Huth W., Schwerdt G.", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "reference": [ { "type": "PubMed", "id": "1684101", "url": "https://glygen.org/publication/PubMed/1684101" } ] }, { "title": "Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.", "journal": "Journal of the American Chemical Society", "date": "2008", "authors": "Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10860", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860" } ], "reference": [ { "type": "PubMed", "id": "18683930", "url": "https://glygen.org/publication/PubMed/18683930" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" }, { "database": "iPTMnet", "id": "P10860", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10860" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Effects of low-dose radiation on glutamate dehydrogenase activity in tissues of rats with transplanted Guerin's carcinoma.", "journal": "Bulletin of experimental biology and medicine", "date": "2013", "authors": "Voloshchuk ON, Marchenko MM", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" } ], "reference": [ { "type": "PubMed", "id": "24319738", "url": "https://glygen.org/publication/PubMed/24319738" } ] }, { "title": "O-GlcNAcomic Profiling Identifies Widespread O-Linked beta-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Ma J, Liu T, Wei AC, Banerjee P, O'Rourke B, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10860", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860" }, { "database": "O-GlcNAc Atlas", "id": "P10860", "url": "https://oglcnac.org/atlas/detail/P10860" } ], "reference": [ { "type": "PubMed", "id": "26446791", "url": "https://glygen.org/publication/PubMed/26446791" } ] }, { "title": "Nucleotide sequence of rat liver glutamate dehydrogenase cDNA.", "journal": "Nucleic Acids Res.", "date": "1989", "authors": "Das AT, Moerer P, Charles R, Moorman AF, Lamers WH", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "reference": [ { "type": "PubMed", "id": "2704624", "url": "https://glygen.org/publication/PubMed/2704624" } ] }, { "title": "Nucleotide sequence of rat liver glutamate dehydrogenase cDNA.", "journal": "Nucleic Acids Res.", "date": "1989", "authors": "Amuro N, Ooki K, Ito A, Goto Y, Okazaki T", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "reference": [ { "type": "PubMed", "id": "2704625", "url": "https://glygen.org/publication/PubMed/2704625" } ] }, { "title": "Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts.", "journal": "Journal of proteome research", "date": "2016", "authors": "Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10860", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10860" }, { "database": "O-GlcNAc Atlas", "id": "P10860", "url": "https://oglcnac.org/atlas/detail/P10860" } ], "reference": [ { "type": "PubMed", "id": "27213235", "url": "https://glygen.org/publication/PubMed/27213235" } ] }, { "title": "Postsynaptic delta1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2018", "authors": "Tao W, Diaz-Alonso J, Sheng N, Nicoll RA", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" } ], "reference": [ { "type": "PubMed", "id": "29784783", "url": "https://glygen.org/publication/PubMed/29784783" } ] }, { "title": "GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of \u03b1-ketoglutarate level.", "journal": "Naunyn-Schmiedeberg's archives of pharmacology", "date": "2022-11", "authors": "Lin Zhi-Rong, Li Zhen-Zhen, Cao Yan-Jun, Yu Wen-Jing, Ye Jian-Tao, Liu Pei-Qing", "evidence": [ { "database": "RefSeq", "id": "NP_036702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036702" } ], "reference": [ { "type": "PubMed", "id": "35904584", "url": "https://glygen.org/publication/PubMed/35904584" } ] }, { "title": "Isolation and characterization of the rat gene encoding glutamate dehydrogenase.", "journal": "Eur. J. Biochem.", "date": "1993", "authors": "Das A.T., Lamers W.H., Moorman A.F.M., Moerer P., Arnberg A.C., Charles R., Malingre H.", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "reference": [ { "type": "PubMed", "id": "8094669", "url": "https://glygen.org/publication/PubMed/8094669" } ] }, { "title": "Late memory-related genes in the hippocampus revealed by RNA fingerprinting.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1997", "authors": "Ma W., Goldberg J., Cavallaro S., Musco S., Alkon D.L., Meiri N., Yi C.-L.", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "reference": [ { "type": "PubMed", "id": "9275181", "url": "https://glygen.org/publication/PubMed/9275181" } ] } ], "pathway": [ { "id": "rno:24399", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24399", "resource": "KEGG Pathway" }, { "id": "R-RNO-2151201", "name": "Transcriptional activation of mitochondrial biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2151201", "resource": "Reactome", "description": "Transcriptional activation of mitochondrial biogenesis" }, { "id": "R-RNO-8964539", "name": "Glutamate and glutamine metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8964539", "resource": "Reactome", "description": "Glutamate and glutamine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "P00367-1", "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "GLUD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT", "length": 558 }, "evidence": [ { "id": "45236825", "url": "http://www.informatics.jax.org/homology/45236825", "database": "MGI" }, { "id": "P10860", "url": "https://omabrowser.org/oma/group/P10860/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P07262-1", "protein_name": "NADP-specific glutamate dehydrogenase 1", "gene_name": "GDH1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSEPEFQQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQYNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIRRICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGYGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGTVVSLSDSKGCIISETGITSEQVADISSAKVNFKSLEQIVNEYSTFSENKVQYIAGARPWTHVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAVFETARSTATGPSEAVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDYAKKYTKDGKVLPSLVKGANIASFIKVSDAMFDQGDVF", "length": 454 }, "evidence": [ { "id": "P10860", "url": "https://omabrowser.org/oma/group/P10860/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "P26443-1", "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "Glud1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPGLTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT", "length": 558 }, "evidence": [ { "id": "45236825", "url": "http://www.informatics.jax.org/homology/45236825", "database": "MGI" }, { "id": "P10860", "url": "https://omabrowser.org/oma/group/P10860/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49448-1", "protein_name": "Glutamate dehydrogenase 2, mitochondrial", "gene_name": "GLUD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT", "length": 558 }, "evidence": [ { "id": "45236825", "url": "http://www.informatics.jax.org/homology/45236825", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P54385-1", "protein_name": "Glutamate dehydrogenase, mitochondrial", "gene_name": "Gdh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYHLKSLARQGARRQQELATLAKALPTAVMQSSRGYATEHQIPDRLKDVPTAKDPRFFDMVEYFFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF", "length": 562 }, "evidence": [ { "id": "P10860", "url": "https://omabrowser.org/oma/group/P10860/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "ADP binding", "id": "GO:0043531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043531", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "NAD+ binding", "id": "GO:0070403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070403", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamate dehydrogenase (NAD+) activity", "id": "GO:0004352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004352", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamate dehydrogenase [NAD(P)+] activity", "id": "GO:0004353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004353", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "leucine binding", "id": "GO:0070728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070728", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamate dehydrogenase (NADP+) activity", "id": "GO:0004354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004354", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "id": "GO:0016639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016639", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "response to aluminum ion", "id": "GO:0010044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010044", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "long-term memory", "id": "GO:0007616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007616", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamine metabolic process", "id": "GO:0006541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006541", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "cerebellum development", "id": "GO:0021549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021549", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamate biosynthetic process", "id": "GO:0006537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006537", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "glutamate catabolic process", "id": "GO:0006538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006538", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "tricarboxylic acid metabolic process", "id": "GO:0072350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072350", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" }, { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity. Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.", "evidence": [ { "database": "UniProtKB", "id": "P10860", "url": "https://www.uniprot.org/uniprot/P10860" }, { "database": "PubMed", "id": "P00367", "url": "https://glygen.org/publication/PubMed/P00367" } ] } ], "interactions": [], "reactions": [ { "id": "11612", "name": "", "equation": "H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10860-1", "P49448-1", "P00367-1", "P26443-1", "P07262-1", "P39708-1", "Q54KB7-1", "P54385-1" ], "evidence": [ { "id": "11612", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11612" } ] }, { "id": "15133", "name": "", "equation": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10860-1", "P49448-1", "P00367-1", "P26443-1", "P33327-1", "Q54KB7-1", "Q54VI3-1", "P54385-1" ], "evidence": [ { "id": "15133", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15133" } ] }, { "id": "R-RNO-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-RNO-70582" ], "output_participant_list": [ "R-ALL-5688274", "R-RNO-5688244" ], "enzyme_list": [ "P10860-1", "G3V641-1" ], "evidence": [ { "id": "R-RNO-5688276", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5688276" } ] }, { "id": "R-RNO-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-5688337" ], "enzyme_list": [ "P10860-1", "P07895-1", "P56574-1", "A0A8I6GJ11-1" ], "evidence": [ { "id": "R-RNO-5688289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5688289" } ] }, { "id": "R-RNO-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10860-1" ], "evidence": [ { "id": "R-RNO-70589", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70589" } ] }, { "id": "R-RNO-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-113561" ], "enzyme_list": [ "P10860-1" ], "evidence": [ { "id": "R-RNO-70600", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70600" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113561", "participant_name": "NH4+ [mitochondrial matrix]", "crossref": [ { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" }, { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-5688274", "participant_name": "NAM [mitochondrial matrix]", "crossref": [ { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "C00153", "database": "COMPOUND", "url": "" }, { "id": "17154", "database": "ChEBI", "url": "" }, { "id": "HMDB0001406", "database": "HMDB Metabolite", "url": "" }, { "id": "000000005878", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-5688337", "participant_name": "2'-O-acetyl-ADP-ribose [mitochondrial matrix]", "crossref": [ { "id": "76279", "database": "ChEBI", "url": "" }, { "id": "6333", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000096095472", "database": "ZINC", "url": "" }, { "id": "000058638658", "database": "ZINC", "url": "" }, { "id": "76279", "database": "ChEBI", "url": "" }, { "id": "6333", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000096095472", "database": "ZINC", "url": "" }, { "id": "000058638658", "database": "ZINC", "url": "" }, { "id": "76279", "database": "ChEBI", "url": "" }, { "id": "6333", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000096095472", "database": "ZINC", "url": "" }, { "id": "000058638658", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-RNO-5688244", "participant_name": "phospho-RibC-GLUD1 [mitochondrial matrix]", "crossref": [ { "id": "P10860", "database": "UniProt", "url": "" }, { "id": "P10860", "database": "PRO", "url": "" }, { "id": "ENSRNOT00000083446", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000075032", "database": "Ensembl", "url": "" }, { "id": "2708", "database": "RGD", "url": "" }, { "id": "ENSRNOG00000057367", "database": "Ensembl", 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