{ "uniprot_canonical_ac": "P10760-1", "uniprot_ac": "P10760", "uniprot_id": "SAHH_RAT", "mass": { "chemical_mass": 47538.0, "monoisotopic_mass": 47538.0 }, "refseq": { "ac": "NP_058897", "name": "adenosylhomocysteinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897" }, "gene_names": [ { "name": "Ahcy", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10760", "id": "P10760" }, { "name": "Ahcy", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897", "id": "NP_058897" } ], "protein_names": [ { "name": "Adenosylhomocysteinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10760" }, { "name": "3.13.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10760" }, { "name": "AdoHcyase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10760" }, { "name": "S-adenosyl-L-homocysteine hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10760" }, { "name": "S-adenosylhomocysteine hydrolase; adoHcyase; S-adenosyl-L-homocysteine hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897", "id": "NP_058897" }, { "name": "adenosylhomocysteinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897", "id": "NP_058897" } ], "function": [ { "annotation": "Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:11927587). Binds copper ions (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760#function" }, { "database": "UniProtKB", "id": "P50247", "url": "https://www.uniprot.org/uniprot/P50247#function" }, { "database": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "annotation": "Report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase.", "evidence": [ { "database": "RefSeq", "id": "NP_058897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897" }, { "database": "PubMed", "id": "19805518", "url": "https://glygen.org/publication/PubMed/19805518" } ] } ], "disease": [ { "disease_id": "DOID:0080208", "recommended_name": { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are:(1) Body mass index 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents.(2) Fasting serum glucose 5.6 mmol/L, 2-hr post-load glucose levels 7.8 mmol/L, glycated hemoglobin (HbA1c) 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose 11.1 mmol/L (pediatric only).(3) Blood pressure lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age 13 years); or specific hypertensive drug treatment.(4) Plasma triglycerides 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age 10 years); or lipid lowering treatment.(5) Plasma high-density lipoprotein cholesterol 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment." }, "synonyms": [ { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "non-alcoholic fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "NAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-related steatotic liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MASLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic-associated fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "nonalcoholic fatty liver disease", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "NAFLD2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "fatty liver disease, nonalcoholic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "liver disease, alcoholic, susceptibility to, 1", "description": "" }, { "id": "MIM:613282", "resource": "MIM", "url": "https://www.omim.org/entry/613282", "name": "Non-alcoholic fatty liver disease 1", "description": "Non-alcoholic fatty liver disease 1" } ], "evidence": [ { "id": "0080208", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ] }, { "disease_id": "DOID:0111039", "recommended_name": { "id": "DOID:0111039", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111039", "name": "hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase", "description": "A hypermethioninemia characterized by autosomal recessive inheritance of psychomotor delay, severe myopathy, hypermethioninaemia and elevated serum creatine kinase levels that has_material_basis_in compound heterozygous mutation in the AHCY gene on chromosome 20q11." }, "synonyms": [ { "id": "DOID:0111039", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111039", "name": "psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency", "description": "" }, { "id": "DOID:0111039", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111039", "name": "hypermethioninemia due to S-adenosylhomocysteine hydrolase deficiency", "description": "" }, { "id": "MONDO:0013404", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013404", "name": "hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase", "description": "Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency is characterized by psychomotor delay and severe myopathy (hypotonia, absent tendon reflexes and delayed myelination) from birth, associated with hypermethioninaemia and elevated serum creatine kinase levels." }, { "id": "MONDO:0013404", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013404", "name": "hypermethioninemia due to S-adenosylhomocysteine hydrolase deficiency", "description": "" }, { "id": "MONDO:0013404", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013404", "name": "hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase", "description": "" }, { "id": "MONDO:0013404", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013404", "name": "psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency", "description": "" }, { "id": "MONDO:0013404", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013404", "name": "hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency", "description": "" }, { "id": "MIM:613752", "resource": "MIM", "url": "https://www.omim.org/entry/613752", "name": "Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency", "description": "Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency" } ], "evidence": [ { "id": "0111039", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111039" } ] }, { "disease_id": "DOID:8455", "recommended_name": { "id": "DOID:8455", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8455", "name": "pyridoxine deficiency anemia", "description": "A nutritional deficiency disease that is characterized by normocytic anemia associated with deficiency of pyridoxine (vitamin B6), and has_material_basis_in decreased intake, malabsorption, increased clearance or breakdown, and certain medications (eg isoniazid)." }, "synonyms": [ { "id": "DOID:8455", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8455", "name": "vitamin B6 deficiency syndrome", "description": "" } ], "evidence": [ { "id": "8455", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8455" } ] }, { "disease_id": "DOID:9279", "recommended_name": { "id": "DOID:9279", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9279", "name": "hyperhomocysteinemia", "description": "An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood." }, "synonyms": [ { "id": "MONDO:0004743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0004743", "name": "hyperhomocysteinemia", "description": "A serious metabolic condition caused by mutations in the MTHFR gene, medications, or nutritional deficiency. It results in increased levels of homocysteine in the blood. Patients with this condition are at an increased risk for recurrent blood clots formation and cardiovascular accidents." }, { "id": "MONDO:0004743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0004743", "name": "homocysteinemia", "description": "" }, { "id": "MONDO:0004743", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0004743", "name": "hyperhomocysteinemia", "description": "" } ], "evidence": [ { "id": "9279", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9279" } ] }, { "disease_id": "DOID:9452", "recommended_name": { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes." }, "synonyms": [ { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "SLD", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "fatty liver disease", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Fatty change of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Steatosis of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "alcoholic fatty liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic lipidosis", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "White liver disease", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatal neonatal hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty liver disease, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty metamorphosis of viscera", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "steatosis of liver", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis", "description": "" } ], "evidence": [ { "id": "9452", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 131, "end_pos": 131, "sequence_org": "D", "sequence_mut": "N", "comment": "Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" }, { "database": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "start_pos": 186, "end_pos": 186, "sequence_org": "K", "sequence_mut": "N", "comment": "Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" }, { "database": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "start_pos": 190, "end_pos": 190, "sequence_org": "D", "sequence_mut": "N", "comment": "Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" }, { "database": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "start_pos": 191, "end_pos": 191, "sequence_org": "N", "sequence_mut": "S", "comment": "Strongly reduces S-adenosyl-L-homocysteine hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" }, { "database": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "start_pos": 245, "end_pos": 245, "sequence_org": "D", "sequence_mut": "E", "comment": "Changes active site geometry and alters affinity for NAD.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ahcy", "url": "https://www.uniprot.org/uniprot/P10760", "locus": { "chromosome": "3", "start_pos": 143569094, "end_pos": 143584393, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017777", "url": "https://www.ensembl.org/id/ENSRNOG00000017777" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017777", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017777", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.3.1.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.3.1.1&UniProtAcc=P10760", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00401", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00401", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3118", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3118", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "29443", "url": "https://www.ncbi.nlm.nih.gov/gene/29443", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P10760", "url": "https://www.ebi.ac.uk/intact/interactors/id:P10760*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:29443", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29443", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIGVTVE", "url": "https://omabrowser.org/oma/group/YIGVTVE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "120477at2759", "url": "http://www.orthodb.org/?query=120477at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23420", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23420", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23420:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23420:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1B3R", "url": "https://www.rcsb.org/structure/1B3R", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1D4F", "url": "https://www.rcsb.org/structure/1D4F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1K0U", "url": "https://www.rcsb.org/structure/1K0U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1KY4", "url": "https://www.rcsb.org/structure/1KY4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1KY5", "url": "https://www.rcsb.org/structure/1KY5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1XWF", "url": "https://www.rcsb.org/structure/1XWF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2H5L", "url": "https://www.rcsb.org/structure/2H5L", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00670", "url": "http://pfam.xfam.org/family/PF00670", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05221", "url": "http://pfam.xfam.org/family/PF05221", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10760", "url": "http://purl.obolibrary.org/obo/PR_P10760", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-156581", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-156581", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1614635", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1614635", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_058897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "69260", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=69260", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "21708", "url": "https://www.rhea-db.org/rhea/21708", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZM95", "url": "https://www.uniprot.org/uniprot/A0A8I5ZM95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZM95-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZM95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10760-1", "url": "https://www.uniprot.org/uniprot/P10760-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY", "length": 432, "header": "sp|P10760-1|SAHH_RAT Isoform 1 of Adenosylhomocysteinase OS=Rattus norvegicus OX=10116 GN=Ahcy PE=1 SV=3 CANONICAL=P10760-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZM95-1", "url": "", "sequence": { "sequence": "VTDIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY", "length": 424, "header": "tr|A0A8I5ZM95-1|A0A8I5ZM95_RAT Computationally mapped isoform of Adenosylhomocysteinase OS=Rattus norvegicus OX=10116 GN=Ahcy PE=1 SV=1 CANONICAL=P10760-1" }, "locus": { "chromosome": "3", "start_pos": 143578409, "end_pos": 143569841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114905.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114905.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000079171.1", "url": "https://www.ensembl.org/id/ENSRNOP00000079171.1" } ] } }, { "isoform_ac": "P10760-1", "url": "", "sequence": { "sequence": "MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY", "length": 432, "header": "sp|P10760-1|SAHH_RAT Isoform 1 of Adenosylhomocysteinase OS=Rattus norvegicus OX=10116 GN=Ahcy PE=1 SV=3 CANONICAL=P10760-1" }, "locus": { "chromosome": "3", "start_pos": 143584333, "end_pos": 143569841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000024310", "url": "https://www.ensembl.org/id/ENSRNOT00000024310" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000024310", "url": "https://www.ensembl.org/id/ENSRNOP00000024310" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "site_lbl": "Ser183" }, { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "site_lbl": "Tyr193" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.", "journal": "Biochemistry", "date": "1999", "authors": "Hu Y, Komoto J, Huang Y, Gomi T, Ogawa H, Takata Y, Fujioka M, Takusagawa F", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "10387078", "url": "https://glygen.org/publication/PubMed/10387078" } ] }, { "title": "Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Komoto J, Huang Y, Gomi T, Ogawa H, Takata Y, Fujioka M, Takusagawa F", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "10913437", "url": "https://glygen.org/publication/PubMed/10913437" } ] }, { "title": "Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Huang Y, Komoto J, Takata Y, Powell DR, Gomi T, Ogawa H, Fujioka M, Takusagawa F", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "11741948", "url": "https://glygen.org/publication/PubMed/11741948" } ] }, { "title": "Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Takata Y, Yamada T, Huang Y, Komoto J, Gomi T, Ogawa H, Fujioka M, Takusagawa F", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "11927587", "url": "https://glygen.org/publication/PubMed/11927587" } ] }, { "title": "S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH", "evidence": [ { "database": "RefSeq", "id": "NP_058897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897" } ], "reference": [ { "type": "PubMed", "id": "19805518", "url": "https://glygen.org/publication/PubMed/19805518" } ] }, { "title": "Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from rat liver as derived from the cDNA sequence.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Ogawa H, Gomi T, Mueckler MM, Fujioka M, Backlund PS Jr, Aksamit RR, Unson CG, Cantoni GL", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "3027698", "url": "https://glygen.org/publication/PubMed/3027698" } ] }, { "title": "S-adenosylhomocysteinase from rat liver. Amino acid sequences of the peptides containing active site cysteine residues modified by treatment with 5'-p-fluorosulfonylbenzoyladenosine.", "journal": "J. Biol. Chem.", "date": "1986", "authors": "Ogawa H., Fujioka M., Gomi T.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "3759971", "url": "https://glygen.org/publication/PubMed/3759971" } ] }, { "title": "The gene and pseudogenes of rat S-adenosyl-L-homocysteine hydrolase.", "journal": "Eur. J. Biochem.", "date": "1995", "authors": "Kasir J., Aksamit R.R., Cantoni G.L., Merta A.", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "reference": [ { "type": "PubMed", "id": "7744082", "url": "https://glygen.org/publication/PubMed/7744082" } ] } ], "pathway": [ { "id": "rno:29443", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:29443", "resource": "KEGG Pathway" }, { "id": "R-RNO-156581", "name": "Methylation", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-156581", "resource": "Reactome", "description": "Methylation" }, { "id": "R-RNO-1614635", "name": "Sulfur amino acid metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1614635", "resource": "Reactome", "description": "Sulfur amino acid metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "P23526-1", "protein_name": "Adenosylhomocysteinase", "gene_name": "AHCY", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY", "length": 432 }, "evidence": [ { "id": "45225497", "url": "http://www.informatics.jax.org/homology/45225497", "database": "MGI" }, { "id": "45225496", "url": "http://www.informatics.jax.org/homology/45225496", "database": "MGI" }, { "id": "P10760", "url": "https://omabrowser.org/oma/group/P10760/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P39954-1", "protein_name": "Adenosylhomocysteinase", "gene_name": "SAH1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY", "length": 449 }, "evidence": [ { "id": "P10760", "url": "https://omabrowser.org/oma/group/P10760/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "P50247-1", "protein_name": "Adenosylhomocysteinase", "gene_name": "Ahcy", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY", "length": 432 }, "evidence": [ { "id": "45225496", "url": "http://www.informatics.jax.org/homology/45225496", "database": "MGI" }, { "id": "P10760", "url": "https://omabrowser.org/oma/group/P10760/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q27580-1", "protein_name": "Adenosylhomocysteinase", "gene_name": "Ahcy", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKPSYKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIETLVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMILDDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKSDKYAVGVHVLPKILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY", "length": 432 }, "evidence": [ { "id": "P10760", "url": "https://omabrowser.org/oma/group/P10760/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "one-carbon metabolic process", "id": "GO:0006730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "chronic inflammatory response to antigenic stimulus", "id": "GO:0002439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002439", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "S-adenosylhomocysteine catabolic process", "id": "GO:0019510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019510", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "circadian sleep/wake cycle", "id": "GO:0042745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042745", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "S-adenosylmethionine cycle", "id": "GO:0033353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033353", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "protein self-association", "id": "GO:0043621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "adenosylhomocysteinase activity", "id": "GO:0004013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004013", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "adenyl nucleotide binding", "id": "GO:0030554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030554", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" }, { "name": "adenosylselenohomocysteinase activity", "id": "GO:0098604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098604", "evidence": [ { "database": "UniProtKB", "id": "P10760", "url": "https://www.uniprot.org/uniprot/P10760" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21708", "name": "", "equation": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10760-1", "P23526-1", "Q96HN2-1", "P50247-1", "Q68FL4-1", "P39954-1", "P10819-1", "Q27580-1" ], "evidence": [ { "id": "21708", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21708" } ] }, { "id": "R-RNO-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-174369", "R-ALL-83909" ], "enzyme_list": [ "P10760-1" ], "evidence": [ { "id": "R-RNO-174401", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174401" } ] }, { "id": "R-RNO-2408512", "name": "AdeSeHCys is hydrolysed to SeHCys by Ahcy", "equation": "", "summary": "In rat cytosol, adenosylhomocysteinase (Ahcy) is involved in the hydrolysis of adenosylselenohomocysteine (AdeSeHCys) into adenosine and selenohomocysteine (SeHCys) (Kajander et al. 1991, Kajander and Raina 1981).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-5357702" ], "enzyme_list": [ "P10760-1" ], "evidence": [ { "id": "R-RNO-2408512", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2408512" } ] } ], "reaction_participants": [ { 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