{ "uniprot_canonical_ac": "P10688-1", "uniprot_ac": "P10688", "uniprot_id": "PLCD1_RAT", "mass": { "chemical_mass": 85962.0, "monoisotopic_mass": 85962.0 }, "refseq": { "ac": "NP_058731", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" }, "gene_names": [ { "name": "Plcd1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10688", "id": "P10688" }, { "name": "Plc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244125", "id": "XP_006244125" }, { "name": "Plcd1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244125", "id": "XP_006244125" } ], "protein_names": [ { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10688" }, { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244125", "id": "XP_006244125" }, { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731", "id": "NP_058731" }, { "name": "3.1.4.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "PLC-III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "PLC-delta-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "Phosphoinositide phospholipase C-delta-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "Phospholipase C-III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "Phospholipase C-delta-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10688" }, { "name": "phospholipase C delta 1 long form; PLC-III; PLC-delta-1; phosphoinositide phospholipase C; phospholipase C-III; phosphoinositide phospholipase C-delta-1; Phospholipase C-delta1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731", "id": "NP_058731" } ], "function": [ { "annotation": "Ca2+-independent binding of anionic phospholipids by phospholipase C delta1 EF-hand domain.", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" }, { "database": "PubMed", "id": "24235144", "url": "https://glygen.org/publication/PubMed/24235144" } ] }, { "annotation": "Data suggest that these phospholipase C delta-1 (PLCdelta1) mutations associated with hereditary leukonychia do not uniformly alter the enzymatic ability of this protein leading to loss/gain of function, but result in significantly divergent enzymatic properties.", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" }, { "database": "PubMed", "id": "27783455", "url": "https://glygen.org/publication/PubMed/27783455" } ] }, { "annotation": "Phospholipase C delta 1 regulates interleukin-1beta and tumor necrosis factor-alpha mRNA expression.", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" }, { "database": "PubMed", "id": "22710061", "url": "https://glygen.org/publication/PubMed/22710061" } ] }, { "annotation": "Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" }, { "database": "PubMed", "id": "24810051", "url": "https://glygen.org/publication/PubMed/24810051" } ] }, { "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:16000311). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688#function" }, { "database": "UniProtKB", "id": "P51178", "url": "https://www.uniprot.org/uniprot/P51178#function" }, { "database": "PubMed", "id": "16000311", "url": "https://glygen.org/publication/PubMed/16000311" }, { "database": "UniProtKB", "id": "Q8R3B1", "url": "https://www.uniprot.org/uniprot/Q8R3B1#function" } ] } ], "disease": [ { "disease_id": "DOID:0080081", "recommended_name": { "id": "DOID:0080081", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080081", "name": "nonsyndromic congenital nail disorder 3", "description": "A nonsyndromic congenital nail disorder that is characterized by white discoloration of the nails." }, "synonyms": [ { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "nonsyndromic congenital nail 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"https://monarchinitiative.org/disease/MONDO:0007900", "name": "nonsyndromic congenital nail disorder type 3", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "Gorlin Bushkell Jensen syndrome", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "NDNC3", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "leukonychia Striatus", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "leukonychia punctata", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "leukonychia totalis and/or partialis", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "leukonychia totalis multiple sebaceous cysts renal calculi", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "nail disorder, nonsyndromic congenital, 3", "description": "" }, { "id": "MONDO:0007900", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007900", "name": "porcelain nails", "description": "" }, { "id": "MIM:151600", "resource": "MIM", "url": "https://www.omim.org/entry/151600", "name": "Nail disorder, non-syndromic congenital, 3", "description": "Nail disorder, non-syndromic congenital, 3" } ], "evidence": [ { "id": "0080081", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080081" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "evidence": [ { "id": "6000", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 311, "end_pos": 311, "sequence_org": "H", "sequence_mut": "A", "comment": "Lowers activity 10000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 312, "end_pos": 312, "sequence_org": "N", "sequence_mut": "A", "comment": "Lowers activity 10000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 320, "end_pos": 320, "sequence_org": "L", "sequence_mut": "A", "comment": "Lowers activity 3-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 341, "end_pos": 341, "sequence_org": "E", "sequence_mut": "A", "comment": "Lowers activity 200000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 341, "end_pos": 341, "sequence_org": "E", "sequence_mut": "H", "comment": "Lowers activity 200000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 341, "end_pos": 341, "sequence_org": "E", "sequence_mut": "Q", "comment": "Lowers activity 200000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 343, "end_pos": 343, "sequence_org": "D", "sequence_mut": "A", "comment": "Lowers activity 1000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 343, "end_pos": 343, "sequence_org": "D", "sequence_mut": "R", "comment": "Lowers activity 100000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 356, "end_pos": 356, "sequence_org": "H", "sequence_mut": "A", "comment": "Lowers activity 1000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 360, "end_pos": 360, "sequence_org": "F", "sequence_mut": "A", "comment": "Lowers activity 4-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 390, "end_pos": 390, "sequence_org": "E", "sequence_mut": "A", "comment": "Lowers activity 1000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 390, "end_pos": 390, "sequence_org": "E", "sequence_mut": "H", "comment": "Lowers activity 1000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 390, "end_pos": 390, "sequence_org": "E", "sequence_mut": "K", "comment": "Lowers activity 1000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 390, "end_pos": 390, "sequence_org": "E", "sequence_mut": "Q", "comment": "Lowers activity 200-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 438, "end_pos": 438, "sequence_org": "K", "sequence_mut": "A", "comment": "Lowers activity very slightly.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 440, "end_pos": 440, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on activity towards phosphatidylinositol 4-monophosphate. Lowers activity 5-fold towards phosphatidylinositol 4,5-bisphosphate.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 522, "end_pos": 522, "sequence_org": "S", "sequence_mut": "A", "comment": "Lowers activity 10000-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 549, "end_pos": 549, "sequence_org": "R", "sequence_mut": "A", "comment": "Lowers activity 600-fold.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] }, { "start_pos": 551, "end_pos": 551, "sequence_org": "Y", 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"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16217", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL1914273", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1914273", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "24655", "url": "https://www.ncbi.nlm.nih.gov/gene/24655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24655", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "P10688", "url": "https://oglcnac.org/atlas/detail/P10688", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "VRWTVWN", "url": "https://omabrowser.org/oma/group/VRWTVWN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2900494at2759", "url": "http://www.orthodb.org/?query=2900494at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336:SF80", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF80", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1DJG", "url": "https://www.rcsb.org/structure/1DJG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJH", "url": "https://www.rcsb.org/structure/1DJH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJI", "url": "https://www.rcsb.org/structure/1DJI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJW", "url": "https://www.rcsb.org/structure/1DJW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJX", "url": "https://www.rcsb.org/structure/1DJX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJY", "url": "https://www.rcsb.org/structure/1DJY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DJZ", "url": "https://www.rcsb.org/structure/1DJZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1MAI", "url": "https://www.rcsb.org/structure/1MAI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1QAS", "url": "https://www.rcsb.org/structure/1QAS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1QAT", "url": "https://www.rcsb.org/structure/1QAT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2ISD", "url": "https://www.rcsb.org/structure/2ISD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00168", "url": "http://pfam.xfam.org/family/PF00168", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00387", "url": "http://pfam.xfam.org/family/PF00387", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00388", "url": "http://pfam.xfam.org/family/PF00388", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09279", "url": "http://pfam.xfam.org/family/PF09279", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16457", "url": "http://pfam.xfam.org/family/PF16457", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10688", "url": "http://purl.obolibrary.org/obo/PR_P10688", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "3346", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3346", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43484", "url": "https://www.rhea-db.org/rhea/43484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5Y0I7", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5Y0I7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0I7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GIK0", "url": "https://www.uniprot.org/uniprot/A0A8I6GIK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GIK0-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GIK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V9D1", "url": "https://www.uniprot.org/uniprot/G3V9D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V9D1-1", "url": "https://www.uniprot.org/uniprot/G3V9D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10688-1", "url": "https://www.uniprot.org/uniprot/P10688-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD", "length": 756, "header": "sp|P10688-1|PLCD1_RAT Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Rattus norvegicus OX=10116 GN=Plcd1 PE=1 SV=1 CANONICAL=P10688-1" }, "isoforms": [ { "isoform_ac": "A0A8I5Y0I7-1", "url": "", "sequence": { "sequence": "MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPMLLDQPLDGVTSSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWAPKRLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTASRQTAVITNNGIVCVGSALGQAAGTVGPAVDMVSDLLGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD", "length": 783, "header": "tr|A0A8I5Y0I7-1|A0A8I5Y0I7_RAT Computationally mapped isoform of Phosphoinositide phospholipase C OS=Rattus norvegicus OX=10116 GN=Plcd1 PE=1 SV=1 CANONICAL=P10688-1" }, "locus": { "chromosome": "8", "start_pos": 118817966, "end_pos": 118795478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000113471.1", "url": "https://www.ensembl.org/id/ENSRNOT00000113471.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076591.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076591.1" } ] } }, { "isoform_ac": "A0A8I6GIK0-1", "url": "", "sequence": { "sequence": "MQCLGVPSCRRRSVNRSRELYLQEQSLKVAALNGQRLGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPMLLDQPLDGVTSSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWAPKRLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTASRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD", "length": 782, "header": "tr|A0A8I6GIK0-1|PLCD1_RAT Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Rattus norvegicus OX=10116 GN=Plcd1 PE=1 SV=1 CANONICAL=P10688-1" }, "locus": { "chromosome": "8", "start_pos": 118812444, "end_pos": 118795478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000110954.1", "url": "https://www.ensembl.org/id/ENSRNOT00000110954.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090035.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090035.1" } ] } }, { "isoform_ac": "G3V9D1-1", "url": "", "sequence": { "sequence": "MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPMLLDQPLDGVTSSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWAPKRLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTASRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD", "length": 756, "header": "tr|G3V9D1-1|PLCD1_RAT Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Rattus norvegicus OX=10116 GN=Plcd1 PE=1 SV=1 CANONICAL=P10688-1" }, "locus": { "chromosome": "8", "start_pos": 118817966, "end_pos": 118795478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000045493.6", "url": "https://www.ensembl.org/id/ENSRNOT00000045493.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000042824.3", "url": "https://www.ensembl.org/id/ENSRNOP00000042824.3" } ] } }, { "isoform_ac": "P10688-1", "url": "", "sequence": { "sequence": "MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD", "length": 756, "header": "sp|P10688-1|PLCD1_RAT Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 OS=Rattus norvegicus OX=10116 GN=Plcd1 PE=1 SV=1 CANONICAL=P10688-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 191, "start_aa": "Ser", "end_pos": 191, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser191", "evidence": [ { "id": "P10688", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P10688" }, { "id": "24098488", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24098488" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 191, "start_aa": "Ser", "end_pos": 191, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser191", "evidence": [ { "id": "G3V9D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D1#ptm_processing" }, { "id": "PIRSR628391-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4" }, { "id": "A0A8I5Y0I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0I7#ptm_processing" }, { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688#ptm_processing" }, { "id": "24098488", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24098488" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 193, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "P10688", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P10688" }, { "id": "24098488", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24098488" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported", "site_seq": "T", "relation": "attached", "comment": "O-linked (GlcNAc) threonine O-GlcNAcylation", "start_pos": 193, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "G3V9D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D1#ptm_processing" }, { "id": "PIRSR628391-4", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR628391-4" }, { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688#ptm_processing" }, { "id": "24098488", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24098488" }, { "id": "A0A8I5Y0I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0I7#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "site_lbl": "Thr457" }, { "start_pos": 460, "end_pos": 460, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "site_lbl": "Ser460" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Kim D.K., Kang S.K., Damron D.S., Baek K.J., Im M.J.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "12054611", "url": "https://glygen.org/publication/PubMed/12054611" } ] }, { "title": "Putative inositol 1,4,5-trisphosphate binding proteins in rat brain cytosol.", "journal": "J. Biol. Chem.", "date": "1992", "authors": "Kanematsu T, Takeya H, Watanabe Y, Ozaki S, Yoshida M, Koga T, Iwanaga S, Hirata M", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "1313009", "url": "https://glygen.org/publication/PubMed/1313009" } ] }, { "title": "Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Swann K., Lai F.A., Nomikos M., Campbell K., Larman M.G., Saunders C.M., Blayney L.M., Rossbach A.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "16000311", "url": "https://glygen.org/publication/PubMed/16000311" } ] }, { "title": "Phospholipase C-delta gene of the spontaneously hypertensive rat harbors point mutations causing amino acid substitutions in a catalytic domain.", "journal": "J. Hypertens.", "date": "1991", "authors": "Yagisawa H, Tanase H, Nojima H", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "1684614", "url": "https://glygen.org/publication/PubMed/1684614" } ] }, { "title": "Phospholipase C-delta(1) regulates interleukin-1beta and tumor necrosis factor-alpha mRNA expression.", "journal": "Experimental cell research", "date": "2012", "authors": "Chung E, Jakinovich P, Bae A, Rebecchi M", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" } ], "reference": [ { "type": "PubMed", "id": "22710061", "url": "https://glygen.org/publication/PubMed/22710061" } ] }, { "title": "Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods.", "journal": "PloS one", "date": "2013", "authors": "Cao W, Cao J, Huang J, Yao J, Yan G, Xu H, Yang P", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688#ptm_processing" }, { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" }, { "database": "O-GlcNAc Atlas", "id": "P10688", "url": "https://oglcnac.org/atlas/detail/P10688" } ], "reference": [ { "type": "PubMed", "id": "24098488", "url": "https://glygen.org/publication/PubMed/24098488" } ] }, { "title": "Ca2+-independent binding of anionic phospholipids by phospholipase C delta1 EF-hand domain.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Cai J, Guo S, Lomasney JW, Roberts MF", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" } ], "reference": [ { "type": "PubMed", "id": "24235144", "url": "https://glygen.org/publication/PubMed/24235144" } ] }, { "title": "Simultaneous loss of phospholipase Cdelta1 and phospholipase Cdelta3 causes cardiomyocyte apoptosis and cardiomyopathy.", "journal": "Cell death & disease", "date": "2014", "authors": "Nakamura Y, Kanemaru K, Kojima R, Hashimoto Y, Marunouchi T, Oka N, Ogura T, Tanonaka K, Fukami K", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" } ], "reference": [ { "type": "PubMed", "id": "24810051", "url": "https://glygen.org/publication/PubMed/24810051" } ] }, { "title": "Mutations in PLCdelta1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.", "journal": "The FEBS journal", "date": "2016", "authors": "Nomikos M, Thanassoulas A, Beck K, Theodoridou M, Kew J, Kashir J, Calver BL, Matthews E, Rizkallah P, Sideratou Z, Nounesis G, Lai FA", "evidence": [ { "database": "RefSeq", "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731" } ], "reference": [ { "type": "PubMed", "id": "27783455", "url": "https://glygen.org/publication/PubMed/27783455" } ] }, { "title": "Cloning and sequence of multiple forms of phospholipase C.", "journal": "Cell", "date": "1988", "authors": "Ryu S.H., Suh P.-G., Rhee S.G., Suh H.W., Moon K.H.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "3390863", "url": "https://glygen.org/publication/PubMed/3390863" } ] }, { "title": "Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.", "journal": "Cell", "date": "1995", "authors": "Schlessinger J., Ferguson K.M., Lemmon M.A., Sigler P.B.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "8521504", "url": "https://glygen.org/publication/PubMed/8521504" } ] }, { "title": "Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.", "journal": "Nature", "date": "1996", "authors": "Cheung R., Perisic O., Williams R.L., Katan M., Essen L.-O.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "8602259", "url": "https://glygen.org/publication/PubMed/8602259" } ] }, { "title": "C2 domain conformational changes in phospholipase C-delta 1.", "journal": "Nat. Struct. Biol.", "date": "1996", "authors": "Hurley J.H., Williams R.L., Essen L.-O., Grobler J.A.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "8784353", "url": "https://glygen.org/publication/PubMed/8784353" } ] }, { "title": "A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.", "journal": "Biochemistry", "date": "1997", "authors": "Perisic O., Williams R.L., Katan M., Essen L.-O., Lynch D.E.", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "9062102", "url": "https://glygen.org/publication/PubMed/9062102" } ] }, { "title": "Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Ellis MV, James SR, Perisic O, Downes CP, Williams RL, Katan M", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "reference": [ { "type": "PubMed", "id": "9565585", "url": "https://glygen.org/publication/PubMed/9565585" } ] } ], "pathway": [ { "id": "rno:24655", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24655", "resource": "KEGG Pathway" }, { "id": "R-RNO-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "P51178-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "gene_name": "PLCD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD", "length": 756 }, "evidence": [ { "id": "45231853", "url": "http://www.informatics.jax.org/homology/45231853", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R3B1-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "gene_name": "Plcd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD", "length": 756 }, "evidence": [ { "id": "45231853", "url": "http://www.informatics.jax.org/homology/45231853", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "GTPase activating protein binding", "id": "GO:0032794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "inositol 1,4,5 trisphosphate binding", "id": "GO:0070679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070679", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phospholipase C activity", "id": "GO:0004629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phosphatidic acid binding", "id": "GO:0070300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070300", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "positive regulation of inositol trisphosphate biosynthetic process", "id": "GO:0032962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032962", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "positive regulation of norepinephrine secretion", "id": "GO:0010701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010701", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "regulation of phospholipase C activity", "id": "GO:1900274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900274", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to calcium ion", "id": "GO:0051592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051592", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway", "id": "GO:0051482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051482", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to aluminum ion", "id": "GO:0010044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010044", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to peptide hormone", "id": "GO:0043434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043434", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "labyrinthine layer blood vessel development", "id": "GO:0060716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060716", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to hyperoxia", "id": "GO:0055093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055093", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to organonitrogen compound", "id": "GO:0010243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010243", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" }, { "name": "response to prostaglandin F", "id": "GO:0034696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034696", "evidence": [ { "database": "UniProtKB", "id": "P10688", "url": "https://www.uniprot.org/uniprot/P10688" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5FX52-1", "Q62711-1", "O89040-1", "P10688-1", "P10686-1", "P10687-1", "P24135-1", "Q99JE6-1", "Q99P84-1", "Q9QW07-1", "A0A096MJW8-1", "Q62688-1", "F1M324-1", "D4A978-1", "A0A8I5ZPH5-1", "Q9UPR0-1", "Q15111-1", "Q86YW0-1", "Q9NQ66-1", "P16885-1", "P19174-1", "O75038-1", "Q8WTR4-1", "Q9BRC7-1", "Q9P212-1", "Q4KWH8-1", "Q8N3E9-1", "Q01970-1", "Q15147-1", "Q00722-1", "P51178-1", "Q8K4S1-1", "Q640M6-1", "Q62077-1", "Q8K2J0-1", "Q8K4D7-1", "Q8K3R3-1", "Q8R3B1-1", "A2AP18-1", "A3KGF7-1", "P51432-1", "Q9Z1B3-1", "Q8CIH5-1", "Q4KWH5-1", "Q91UZ1-1", "P32383-1", "Q02158-1", "P25455-3", "P13217-1", "Q9VXH3-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] }, { "id": "43484", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O89040-1", "P10688-1", "P10686-1", "Q62711-1", "Q99JE6-1", "Q9QW07-1", "P10687-1", "Q9NQ66-1", "P19174-1", "Q01970-1", "Q15147-1", "Q00722-1", "P51178-1", "Q9BRC7-1", "Q91UZ1-1", "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q62077-1", "Q8K3R3-1", "Q8R3B1-1" ], "evidence": [ { "id": "43484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43484" } ] }, { "id": "R-RNO-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10688-1", "P24135-1", "P10686-1", "A0A8I5ZPH5-1", "A0A096MJW8-1", "Q99P84-1", "D4A978-1" ], "evidence": [ { "id": "R-RNO-1855221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855221" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJW8", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] } ] }, { "uniprot_ac": "A0A8I5ZPH5", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A8I5ZPH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A8I5ZPH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZPH5" } ] } ] }, { "uniprot_ac": "A2AP18", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] } ] }, { "uniprot_ac": "A3KGF7", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] } ] }, { "uniprot_ac": "D4A978", "gene_name": "Plcd3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] } ] }, { "uniprot_ac": "F1M324", "gene_name": "Plcl2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] } ] }, { "uniprot_ac": "O75038", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] } ] }, { "uniprot_ac": "O89040", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] } ] }, { "uniprot_ac": "P10686", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] } ] }, { "uniprot_ac": "P10687", "gene_name": "Plcb1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] } ] }, { "uniprot_ac": "P10688", "gene_name": "Plcd1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] } ] }, { "uniprot_ac": "P13217", "gene_name": "norpA", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] } ] }, { "uniprot_ac": "P16885", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] } ] }, { "uniprot_ac": "P19174", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] } ] }, { "uniprot_ac": "P24135", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] } ] }, { "uniprot_ac": "P25455", "gene_name": "Plc21C", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] } ] }, { "uniprot_ac": "P32383", "gene_name": "PLC1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P32383", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32383" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P32383", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32383" } ] } ] }, { "uniprot_ac": "P51178", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] } ] }, { "uniprot_ac": "P51432", "gene_name": "Plcb3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] } ] }, { "uniprot_ac": "Q00722", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] } ] }, { "uniprot_ac": "Q01970", "gene_name": "PLCB3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] } ] }, { "uniprot_ac": "Q02158", "gene_name": "plc", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q02158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02158" } ] }, { "ec_number": 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