{ "uniprot_canonical_ac": "P10586-1", "uniprot_ac": "P10586", "uniprot_id": "PTPRF_HUMAN", "mass": { "chemical_mass": 212879.0, "monoisotopic_mass": 212879.0 }, "refseq": { "ac": "NP_002831", "name": "receptor-type tyrosine-protein phosphatase F isoform 1 precursor", "summary": "The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, "gene_names": [ { "name": "PTPRF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10586", "id": "P10586" }, { "name": "BNAH2; LAR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831", "id": "NP_002831" }, { "name": "LAR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10586", "id": "P10586" }, { "name": "PTPRF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831", "id": "NP_002831" } ], "protein_names": [ { "name": "Receptor-type tyrosine-protein phosphatase F", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10586" }, { "name": "3.1.3.48", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10586" }, { "name": "LAR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10586" }, { "name": "Leukocyte common antigen related", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10586" }, { "name": "leukocyte antigen-related (LAR) PTP receptor; receptor-linked protein-tyrosine phosphatase LAR; LCA-homolog; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; leukocyte common antigen related", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831", "id": "NP_002831" }, { "name": "receptor-type tyrosine-protein phosphatase F isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831", "id": "NP_002831" } ], "function": [ { "annotation": "Crystal and solution structures of fragments of the human leucocyte common antigen-related protein.", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, { "database": "PubMed", "id": "32355037", "url": "https://glygen.org/publication/PubMed/32355037" } ] }, { "annotation": "Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization.", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, { "database": "PubMed", "id": "35735010", "url": "https://glygen.org/publication/PubMed/35735010" } ] }, { "annotation": "Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, { "database": "PubMed", "id": "32973331", "url": "https://glygen.org/publication/PubMed/32973331" } ] }, { "annotation": "MiR-647 inhibits hepatocellular carcinoma cell progression by targeting protein tyrosine phosphatase receptor type F.", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, { "database": "PubMed", "id": "34969357", "url": "https://glygen.org/publication/PubMed/34969357" } ] }, { "annotation": "PPARgamma inhibits breast cancer progression by upregulating PTPRF expression.", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" }, { "database": "PubMed", "id": "31799666", "url": "https://glygen.org/publication/PubMed/31799666" } ] }, { "annotation": "Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586#function" } ] }, { "annotation": "The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586#function" } ] }, { "annotation": "The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831" } ] } ], "disease": [ { "disease_id": "MONDO:0014450", "recommended_name": { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "breasts and/or nipples, aplasia or hypoplasia of, 2", "description": "Any isolated congenital breast hypoplasia/aplasia in which the cause of the disease is a mutation in the PTPRF gene." }, "synonyms": [ { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "PTPRF isolated congenital breast hypoplasia/aplasia", "description": "" }, { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "breasts and/or nipples, aplasia or hypoplasia of, 2", "description": "" }, { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "breasts and/or nipples, aplasia or hypoplasia of, type 2", "description": "" }, { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "isolated congenital breast hypoplasia/aplasia caused by mutation in PTPRF", "description": "" }, { "id": "MONDO:0014450", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014450", "name": "BNAH2", "description": "" }, { "id": "MIM:616001", "resource": "MIM", "url": "https://www.omim.org/entry/616001", "name": "Aplasia or hypoplasia of the breasts and/or nipples 2", "description": "Aplasia or hypoplasia of the breasts and/or nipples 2" } ], "evidence": [ { "id": "616001", "database": "MIM", "url": "https://www.omim.org/entry/616001" } ] } ], "snv": [ { "evidence": [ { "id": "rs1236358043", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1236358043" }, { "id": "rs1236358043", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1236358043" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1025, "end_pos": 1025, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KTS->NTS).", "chr_id": "1", "chr_pos": "43604940", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K1025", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1489613514", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1489613514" }, { "id": "rs1489613514", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1489613514" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1038, "end_pos": 1038, "sequence_org": "Y", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (YKS->NKS).", "chr_id": "1", "chr_pos": "43604977", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "Y1038", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P10586", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10586" }, { "id": "rs372991117", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372991117" }, { "id": "rs372991117", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372991117" }, { "id": "rs372991117", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372991117" }, { "id": "rs372991117", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs372991117#frequency_tab" }, { "id": "rs372991117", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs372991117" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1117, "end_pos": 1117, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "1", "chr_pos": "43605403", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D1117", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi" ] }, { "evidence": [ { "id": "rs763208022", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763208022" }, { "id": "rs763208022", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763208022" }, { "id": "rs763208022", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763208022" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 117, "end_pos": 117, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTS->STS).", "chr_id": "1", "chr_pos": "43591401", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N117", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs773686451", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773686451" }, { "id": "rs773686451", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773686451" }, { "id": "rs773686451", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs773686451" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1289, "end_pos": 1289, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (THS->NHS).", "chr_id": "1", "chr_pos": "43609391", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1289", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P10586", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10586" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1303, "end_pos": 1303, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KDS->NDS).", "chr_id": "1", "chr_pos": "43609434", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "K1303", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", 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"Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P10586", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10586" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1349, "end_pos": 1349, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NDG->NDS).", "chr_id": "1", "chr_pos": "43613689", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G1349", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1163327417", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1163327417" }, { "id": "rs1163327417", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1163327417#frequency_tab" }, { "id": "rs1163327417", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1163327417" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1621, "end_pos": 1621, 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"http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": 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"https://www.ensembl.org/id/rs1570496457" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 721, "end_pos": 721, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->DST).", "chr_id": "1", "chr_pos": "43598761", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N721", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P10586", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10586" }, { "id": "rs1396031076", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1396031076" }, { "id": "rs1396031076", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1396031076" }, { "id": "rs1396031076", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1396031076#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 884, 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"https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P10586", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10586" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P10586", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10586" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "common_name": "Human" } ], "gene": [ { "name": "PTPRF", "url": "https://www.uniprot.org/uniprot/P10586", "locus": { "chromosome": "1", "start_pos": 43623666, "end_pos": 43525187, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000142949", "url": "https://www.ensembl.org/id/ENSG00000142949" } ] } } ], "crossref": [ { "id": "ENSG00000142949", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000142949", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P10586", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10586", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "3.1.3.48", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48&UniProtAcc=P10586", "database": "BRENDA", 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"categories": [ "3D Structure" ] }, { "id": "PF00041", "url": "http://pfam.xfam.org/family/PF00041", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00102", "url": "http://pfam.xfam.org/family/PF00102", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P10586", "url": "https://pharos.nih.gov/targets/P10586", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000054758", "url": "https://proconsortium.org/app/entry/PR:000054758", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_P10586", "url": "http://purl.obolibrary.org/obo/PR_P10586", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-388844", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388844", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-77387", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-77387", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8849932", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8849932", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_002831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002831", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P10586", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "A2A437", "url": "https://www.uniprot.org/uniprot/A2A437", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2A437-1", "url": "https://www.uniprot.org/uniprot/A2A437-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y380", "url": "https://www.uniprot.org/uniprot/H0Y380", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y380-1", "url": "https://www.uniprot.org/uniprot/H0Y380-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y4H1", "url": "https://www.uniprot.org/uniprot/H0Y4H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y4H1-1", "url": "https://www.uniprot.org/uniprot/H0Y4H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y6Z7", "url": "https://www.uniprot.org/uniprot/H0Y6Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y6Z7-1", "url": "https://www.uniprot.org/uniprot/H0Y6Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y7Z9", "url": "https://www.uniprot.org/uniprot/H0Y7Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y7Z9-1", "url": "https://www.uniprot.org/uniprot/H0Y7Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10586-1", "url": "https://www.uniprot.org/uniprot/P10586-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10586-2", "url": "https://www.uniprot.org/uniprot/P10586-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1907, "header": "sp|P10586-1|PTPRF_HUMAN Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2 CANONICAL=P10586-1" }, "isoforms": [ { "isoform_ac": "A2A437-1", "url": "", "sequence": { "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRGLAAWARSPMGIWSHPIRLLGVCACVCAHTGTLICV", "length": 262, "header": "tr|A2A437-1|PTPRF_HUMAN Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=1 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43579282, "end_pos": 43545076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000617451.4", "url": "https://www.ensembl.org/id/ENST00000617451.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000483557.1", "url": "https://www.ensembl.org/id/ENSP00000483557.1" } ] } }, { "isoform_ac": "H0Y380-1", "url": "", "sequence": { "sequence": "TYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 979, "header": "tr|H0Y380-1|PTPRF_HUMAN Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=1 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622000, "end_pos": 43598839, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000372407.4", "url": "https://www.ensembl.org/id/ENST00000372407.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000361484.4", "url": "https://www.ensembl.org/id/ENSP00000361484.4" } ] } }, { "isoform_ac": "H0Y4H1-1", "url": "", "sequence": { "sequence": "XSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSMPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1291, "header": "tr|H0Y4H1-1|PTPRF_HUMAN Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=1 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622002, "end_pos": 43591021, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000412568.6", "url": "https://www.ensembl.org/id/ENST00000412568.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000391764.2", "url": "https://www.ensembl.org/id/ENSP00000391764.2" } ] } }, { "isoform_ac": "H0Y6Z7-1", "url": "", "sequence": { "sequence": "XEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1553, "header": "tr|H0Y6Z7-1|H0Y6Z7_HUMAN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=1 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622001, "end_pos": 43591053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429895.5", "url": "https://www.ensembl.org/id/ENST00000429895.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000408952.1", "url": "https://www.ensembl.org/id/ENSP00000408952.1" } ] } }, { "isoform_ac": "H0Y7Z9-1", "url": "", "sequence": { "sequence": "XSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSMPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1332, "header": "tr|H0Y7Z9-1|H0Y7Z9_HUMAN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=1 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622002, "end_pos": 43591450, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414879.5", "url": "https://www.ensembl.org/id/ENST00000414879.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416343.1", "url": "https://www.ensembl.org/id/ENSP00000416343.1" } ] } }, { "isoform_ac": "P10586-1", "url": "", "sequence": { "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1907, "header": "sp|P10586-1|PTPRF_HUMAN Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622000, "end_pos": 43545076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000359947.9", "url": "https://www.ensembl.org/id/ENST00000359947.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000353030.4", "url": "https://www.ensembl.org/id/ENSP00000353030.4" } ] } }, { "isoform_ac": "P10586-2", "url": "", "sequence": { "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT", "length": 1898, "header": "sp|P10586-2|PTPRF_HUMAN Isoform 2 of Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2 CANONICAL=P10586-1" }, "locus": { "chromosome": "1", "start_pos": 43622000, "end_pos": 43545076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000438120.5", "url": "https://www.ensembl.org/id/ENST00000438120.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398822.1", "url": "https://www.ensembl.org/id/ENSP00000398822.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 117, "start_aa": "Asn", "end_pos": 117, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn117", "evidence": [ { "id": "P10586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10586#ptm_processing" } ] }, { "glytoucan_ac": "G13694XX", "type": 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Mol. Biol.", "date": "2004", "authors": "Homma K, Kikuno RF, Nagase T, Ohara O, Nishikawa K", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "reference": [ { "type": "PubMed", "id": "15491607", "url": "https://glygen.org/publication/PubMed/15491607" } ] }, { "title": "LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses.", "journal": "Nature neuroscience", "date": "2005", "authors": "Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta A, Liu G, Sheng M", "evidence": [ { "database": "Reactome", "id": "R-HSA-388844", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388844" } ], "reference": [ { "type": "PubMed", "id": "15750591", "url": "https://glygen.org/publication/PubMed/15750591" } ] }, { "title": "Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.", "journal": "Structure (London, 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Biol. Chem.", "date": "1997", "authors": "Ahmad F, Goldstein BJ", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" }, { "database": "Reactome", "id": "R-HSA-77387", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-77387" } ], "reference": [ { "type": "PubMed", "id": "8995282", "url": "https://glygen.org/publication/PubMed/8995282" } ] }, { "title": "Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action.", "journal": "Molecular and cellular biochemistry", "date": "1998", "authors": "Drake PG, Posner BI", "evidence": [ { "database": "Reactome", "id": "R-HSA-77387", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-77387" } ], "reference": [ { "type": "PubMed", "id": "9609117", "url": "https://glygen.org/publication/PubMed/9609117" } ] }, { "title": "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.", "journal": "J. Biol. 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"id": "GO:0048679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048679", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine phosphatase signaling pathway", "id": "GO:0007185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007185", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "neuron projection regeneration", "id": "GO:0031102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031102", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "negative regulation of receptor binding", "id": "GO:1900121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900121", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "synaptic membrane adhesion", "id": "GO:0099560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099560", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine phosphatase activity", "id": "GO:0005001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005001", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan binding", "id": "GO:0035373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035373", "evidence": [ { "database": "UniProtKB", "id": "P10586", "url": "https://www.uniprot.org/uniprot/P10586" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "receptor-type tyrosine-protein phosphatase F N-glycosylated 1 (human)", "definition": "A receptor-type tyrosine-protein phosphatase F (human) that has been N-glycosylated at the residue equivalent to Asn-721 of the amino acid sequence represented by UniProtKB:P10586-1, in which the glycan composition is represented by GlyTouCan:G37399XV. Example: UniProtKB:P10586-1, Asn-721, MOD:00160~GNO:G37399XV. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000054758", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000054758" } ] } ], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1696, "end_pos": 1698, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1731, "end_pos": 1733, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 721, "end_pos": 723, "annotation": "n_glycosylation_sequon" }, { "start_pos": 966, "end_pos": 968, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P9X4-1", "O08617-1", "B4F7B7-1", "Q03348-1", "Q64346-1", "Q5FVI9-1", "P0C595-1", "Q6AXW7-1", "Q62767-1", "Q63340-1", "O54838-1", "O54857-1", "Q91XQ2-1", "Q64623-1", "Q9JIM4-1", "B2RZ50-1", "P48965-1", "P48966-1", "Q5XIS1-1", "Q62728-1", "Q62656-1", "Q63475-1", "O88488-1", "O88902-1", "P04157-1", "P81718-1", "Q64604-1", "Q64605-1", "P0C089-1", "Q641Z2-1", "B2GV87-1", "D3ZDK7-1", "P35233-1", "P35234-1", "P20417-1", "P41498-1", "P41499-2", "P49445-1", "A1L1L3-1", "Q64612-1", "A0A8I5ZV35-1", "A0A0G2K3H0-1", "A0A0G2K2N0-1", "F1LP13-1", "A0A0G2K1T5-1", "A0A8I6A1V1-1", "Q5PQT2-1", "Q62797-1", "A0A8I6AF61-1", "Q78EG7-1", "A0A0G2K8V0-1", "A0A0G2JZ01-1", "A0A8I6B402-1", "A0A0G2K9N1-1", "D3ZVI5-1", "A0A8I6GK94-1", "F1LQQ5-1", "G3V6B9-1", "Q2YDV1-1", "G3V7Q4-1", "A0A8I5ZW41-1", "G3V9S3-1", "D4ADT2-1", "P20646-1", "A0A8I6G7Q4-1", "A6HQ12-1", "Q9UMZ3-1", "P18031-1", "Q99502-1", "O75061-1", "Q9UNH5-1", "A4D256-1", "O60729-1", "Q16667-1", "P51452-1", "Q9BV47-1", "Q99504-1", "O95677-1", "Q9H596-1", "O00167-1", "Q6B8I1-1", "Q9NRW4-1", "Q16828-1", "Q4G0W2-1", "Q99956-1", "Q8NEJ0-1", "O95147-1", "P28562-1", "Q9BVJ7-1", "Q9H1R2-1", "Q9UII6-1", "Q16690-1", "Q13115-1", "Q9UNI6-1", "Q9BY84-1", "Q9Y6W6-1", "Q05923-1", "B3EWF7-1", "Q68J44-1", "Q16829-1", "Q8WTR2-1", "Q13202-1", "P30307-1", "P30304-1", "Q86V88-1", "P30305-1", "Q9NYA4-1", "Q13615-1", "Q15678-1", "Q9Y2R2-1", "P60484-1", "Q15256-1", "Q16827-1", "Q06124-2", "Q15262-1", "Q4JDL3-1", "P54829-1", "O14522-3", "P28827-1", "P35236-1", "Q99952-1", "Q05209-1", "P29350-1", "Q12913-1", "P23467-1", "P08575-3", "P18433-5", "Q9HD43-1", "P23470-1", "Q92932-1", "A6NDG6-1", "Q8WUK0-1", "P43378-1", "P23468-1", "Q16825-1", "Q9H3S7-1", "P29074-1", "P17706-1", "P26045-1", "P10586-1", "Q92729-1", "P24666-1", "P23469-1", "Q12923-1", "P23471-1", "Q13332-1", "P56180-1", "O75365-1", "Q76I76-1", "Q12974-1", "Q8TE77-1", "Q93096-1", "Q8TF42-1", "Q8WYL5-1", "P15309-1", "Q63HR2-1", "Q9Z191-1", "P97767-1", "Q80TZ3-1", "Q810P3-1", "Q6GQT0-1", "Q6PFY9-1", "Q99N11-1", "Q8BTR5-1", "Q9DBB1-1", "Q9QYJ7-1", "Q8R4V2-1", "Q8VE01-1", "Q91Z46-1", "O09112-1", "P28563-1", "Q8K4T5-1", "Q6NT99-1", "O08575-1", "Q8BK84-1", "Q8BFV3-1", "Q9WUA5-1", "Q9JLY7-1", "Q05922-1", "P97480-1", "Q9D0T2-1", "Q9D700-1", "Q9D7X3-1", "Q9D9D8-1", "Q9ESS0-1", "Q9D967-1", "P48967-1", "P30306-1", "P48964-1", "Q91XS1-1", "Q8K296-1", "Q8CHP8-1", "Q9D358-1", "P54830-1", "Q62132-1", "Q64487-4", "O70274-1", "Q9D658-1", "P29352-1", "Q62130-1", "Q63739-1", "P28828-1", "P29351-1", "Q9WU22-1", "Q8K330-1", "Q62136-1", "A2A8L5-1", "B0V2N1-1", "B2RU80-1", "B9EKR1-1", "E9Q0N2-1", "E9Q612-1", "O08586-1", "B1AUH1-1", "O35239-1", "P35831-1", "P49446-1", "P35821-1", "P35822-1", "Q8BUM3-1", "Q8BGG7-1", "A2ALK8-1", "O55082-1", "P18052-1", "Q6PB44-1", "Q64512-1", "P06800-4", "P0C5E4-1", "P35235-2", "P80560-1", "Q05909-1", "Q06180-1", "Q61152-1", "Q5SW75-1", "Q64455-1", "Q66GT5-1", "Q76I79-1", "Q99M80-1", "P70289-1", "Q7TNL7-1", "Q1HL35-1", "Q8CE08-1", "Q8CGB6-1", "A0A991ELE1-1", "P25044-1", "Q00684-1", "P29461-1", "P23748-1", "P38148-1", "P50946-1", "P38590-1", "P40048-1", "P40347-1", "P40479-1", "Q02256-1", "P40081-1", "Q12454-1", "Q54T76-1", "Q1ZXG8-1", "Q54DU9-1", "Q54R42-1", "Q55BI8-1", "Q55CS8-1", "Q55E39-1", "Q55GW2-1", "Q86IL4-1", "P34137-1", "P34138-1", "P54637-1", "Q54QM6-1", "Q54Y32-1", "Q556Y8-1", "Q55CS7-1", "Q8T9S7-1", "P82890-1", "P35832-1", "P29349-1", "P35992-5", "Q6NN85-1", "Q86BN8-1", "Q7KMQ6-1", "P82891-1", "A1ZAB3-1", "P16621-1", "O61722-1", "Q9W0G1-1", "Q03019-1", "P20483-1", "X2JEB8-1", "Q9VVW5-1", "Q05201-1", "P16620-1", "Q9VWF4-1", "Q9W4F5-1", "Q9W0R3-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-HSA-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "equation": "", "summary": "All the three LAR-RPTP transmembrane tyrosine phosphatases associate with liprin proteins and colocalize with liprin-alpha1 at the proximal edges of focal adhesions. Based on sequence similarities and binding characteristics, liprins are subdivided into alpha-type and beta-type liprins. The C-terminal, non-coiled coil regions of alpha-liprins bind to the membrane-distal phosphatase domains of LAR family members, as well as to the C-terminal, non-coiled coil region of beta-liprins. Liprin is required for normal presynaptic differentiation in C. elegans and controls synapse morphogenesis in Drosophila. In mammalian synapses the functional significance of liprin and LAR-RPTP interaction is unknown (Pages et al. 1998, Dunah et al. 2005).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P23468-1", "P10586-1", "Q13332-1" ], "evidence": [ { "id": "R-HSA-388824", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-388824" } ] }, { "id": "R-HSA-6798258", "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "equation": "", "summary": "Leucine-rich repeat-containing protein 4B (LRRC4B, NGL-3) is a member of the netrin-G ligand (NGL, LRRC4) family that is widely expressed in the brain. LRRC4B binds with high affinity to Protein tyrosine Receptor-type tyrosine-protein phosphatase F (PTPRF, LAR), Protein tyrosine Receptor-type tyrosine-protein phosphatase sigma (PTPRS) and Protein tyrosine Receptor-type tyrosine-protein phosphatase delta (PTPRD). It binds to the first two fibronectin III (FnIII) domains of the PTPRs, thus it is likely to interact with all PTPRs splice variants. LRRC4B may induce both excitatory and inhibitory presynaptic differentiation in contacting axons (Woo et al. 2009, 2010).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P23468-1", "P10586-1", "Q13332-1" ], "evidence": [ { "id": "R-HSA-6798258", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798258" } ] }, { "id": "R-HSA-74733", "name": "Insulin receptor de-phosphorylation", "equation": "", "summary": "Endosomal protein tyrosine phosphatases (PTPs) dephosphorylate the insulin receptor, which cannot rephosphorylate itself as insulin is removed leaving the receptor in its inactive conformation (Bevan et al. 1996; Drake & Posner 1998). The identity of these PTPs is not definitively established, but structural studies and studies of cell lines and gene-knockout mice indicate that PTPRF / LAR (Ahmed & Goldstein 1997) and PTPN1 / PTP1B (Li et al. 2005) are each capable of mediating this reaction.

The dephosphorylated receptor recycles to the plasma membrane.;", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06213-1", "P18031-1", "P10586-1" ], "evidence": [ { "id": "R-HSA-74733", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-74733" } ] }, { "id": "R-HSA-8855648", "name": "SALM3 binds LAR-RPTP", "equation": "", "summary": "SALM3 interacts with LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) in a transynaptic manner that is dependent upon a splice insert in LAR-RPTPs. This interaction regulates SALM3 dependent presynaptic differentiation (Li et al. 2015). SALM3 knockout mice have fewer excitatory synapsese, but normal plasticity in the hippocampus. However, they are hypoactive, suggesting SALM3 influences locomotion behavior (Li et al. 2015).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P23468-1", "P10586-1", "Q13332-1" ], "evidence": [ { "id": "R-HSA-8855648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8855648" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JZ01", "gene_name": "Eya3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2JZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2JZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01" } ] } ] }, { "uniprot_ac": "A0A0G2K1T5", "gene_name": "Eya2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K1T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1T5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K1T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K1T5" } ] } ] }, { "uniprot_ac": "A0A0G2K2N0", "gene_name": "Ptpn14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K2N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2N0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K2N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2N0" } ] } ] }, { "uniprot_ac": "A0A0G2K3H0", "gene_name": "Ptpru", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K3H0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K3H0" } ] } ] }, { "uniprot_ac": "A0A0G2K8V0", "gene_name": "Ptprm", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K8V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K8V0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K8V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K8V0" } ] } ] }, { "uniprot_ac": "A0A0G2K9N1", "gene_name": "Dusp13b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] } ] }, { "uniprot_ac": "A0A8I5ZV35", "gene_name": "Ptprb", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I5ZV35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV35" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I5ZV35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV35" } ] } ] }, { "uniprot_ac": "A0A8I5ZW41", "gene_name": "Ptprt", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I5ZW41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZW41" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I5ZW41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZW41" } ] } ] }, { "uniprot_ac": "A0A8I6A1V1", "gene_name": "Ptprd", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6A1V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A1V1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6A1V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A1V1" } ] } ] }, { "uniprot_ac": "A0A8I6AF61", "gene_name": "Dusp3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] } ] }, { "uniprot_ac": "A0A8I6B402", "gene_name": "Eya4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6B402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6B402" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6B402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6B402" } ] } ] }, { "uniprot_ac": "A0A8I6G7Q4", "gene_name": "AABR07036974.1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] } ] }, { "uniprot_ac": "A0A8I6GK94", "gene_name": "Ptprj", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] } ] }, { "uniprot_ac": "A0A991ELE1", "gene_name": "Ptprg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A991ELE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A991ELE1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A991ELE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A991ELE1" } ] } ] }, { "uniprot_ac": "A1L1L3", "gene_name": "Ptpn20", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A1L1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A1L1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1L3" } ] } ] }, { "uniprot_ac": "A1ZAB3", "gene_name": "Ptp52F", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] } ] }, { "uniprot_ac": "A2A8L5", "gene_name": "Ptprf", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2A8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2A8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L5" } ] } ] }, { "uniprot_ac": "A2ALK8", "gene_name": "Ptpn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2ALK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ALK8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2ALK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ALK8" } ] } ] }, { "uniprot_ac": "A4D256", "gene_name": "CDC14C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] } ] }, { "uniprot_ac": "A6HQ12", "gene_name": "Dusp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] } ] }, { "uniprot_ac": "A6NDG6", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] } ] }, { "uniprot_ac": "B0V2N1", "gene_name": "Ptprs", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B0V2N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0V2N1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B0V2N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0V2N1" } ] } ] }, { "uniprot_ac": "B1AUH1", "gene_name": "Ptpru", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B1AUH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AUH1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B1AUH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AUH1" } ] } ] }, { "uniprot_ac": "B2GV87", "gene_name": "Ptpre", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2GV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV87" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2GV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV87" } ] } ] }, { "uniprot_ac": "B2RU80", "gene_name": "Ptprb", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2RU80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RU80" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2RU80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RU80" } ] } ] }, { "uniprot_ac": "B2RZ50", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] } ] }, { "uniprot_ac": "B3EWF7", "gene_name": "EPM2A", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] } ] }, { "uniprot_ac": "B4F7B7", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] } ] }, { "uniprot_ac": "B9EKR1", "gene_name": "Ptprz1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B9EKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B9EKR1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B9EKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B9EKR1" } ] } ] }, { "uniprot_ac": "D3ZDK7", "gene_name": "Pgp", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] } ] }, { "uniprot_ac": "D3ZVI5", "gene_name": "Eya1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZVI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVI5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "D3ZVI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVI5" } ] } ] }, { "uniprot_ac": "D4ADT2", "gene_name": "Cdc25c", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D4ADT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "D4ADT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT2" } ] } ] }, { "uniprot_ac": "E9Q0N2", "gene_name": "Ptprh", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E9Q0N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q0N2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E9Q0N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q0N2" } ] } ] }, { "uniprot_ac": "E9Q612", "gene_name": "Ptpro", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E9Q612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q612" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E9Q612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q612" } ] } ] }, { "uniprot_ac": "F1LP13", "gene_name": "Ptprg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1LP13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP13" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1LP13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP13" } ] } ] }, { "uniprot_ac": "F1LQQ5", "gene_name": "Ptpn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1LQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQQ5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1LQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQQ5" } ] } ] }, { "uniprot_ac": "G3V6B9", "gene_name": "Ptpn4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V6B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6B9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V6B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6B9" } ] } ] }, { "uniprot_ac": "G3V7Q4", "gene_name": "Ptpn12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7Q4" } ] } ] }, { "uniprot_ac": "G3V9S3", "gene_name": "Ptpn13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9S3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9S3" } ] } ] }, { "uniprot_ac": "O00167", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O00167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00167" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O00167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00167" } ] } ] }, { "uniprot_ac": "O08575", "gene_name": "Eya2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08575" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08575" } ] } ] }, { "uniprot_ac": "O08586", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] } ] }, { "uniprot_ac": "O08617", "gene_name": "Ptprr", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08617" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08617" } ] } ] }, { "uniprot_ac": "O09112", "gene_name": "Dusp8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] } ] }, { "uniprot_ac": "O14522", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O14522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14522" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O14522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14522" } ] } ] }, { "uniprot_ac": "O35239", "gene_name": "Ptpn9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O35239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35239" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O35239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35239" } ] } ] }, { "uniprot_ac": "O54838", "gene_name": "Dusp5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] } ] }, { "uniprot_ac": "O54857", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] } ] }, { "uniprot_ac": "O55082", "gene_name": "Ptpn20", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O55082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55082" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O55082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55082" } ] } ] }, { "uniprot_ac": "O60729", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] } ] }, { "uniprot_ac": "O61722", "gene_name": "PRL-1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O61722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61722" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O61722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61722" } ] } ] }, { "uniprot_ac": "O70274", "gene_name": "Ptp4a2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O70274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70274" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O70274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70274" } ] } ] }, { "uniprot_ac": "O75061", "gene_name": "DNAJC6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O75061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75061" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O75061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75061" } ] } ] }, { "uniprot_ac": "O75365", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O75365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75365" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O75365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75365" } ] } ] }, { "uniprot_ac": "O88488", "gene_name": "Ptprq", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] } ] }, { "uniprot_ac": "O88902", "gene_name": "Ptpn23", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O88902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88902" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O88902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88902" } ] } ] }, { "uniprot_ac": "O95147", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] } ] }, { "uniprot_ac": "O95677", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O95677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95677" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O95677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95677" } ] } ] }, { "uniprot_ac": "P04157", "gene_name": "Ptprc", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06800", "gene_name": "Ptprc", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P06800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06800" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P06800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06800" } ] } ] }, { "uniprot_ac": "P08575", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08575" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08575" } ] } ] }, { "uniprot_ac": "P0C089", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] } ] }, { "uniprot_ac": "P0C595", "gene_name": "Dusp29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] } ] }, { "uniprot_ac": "P0C5E4", "gene_name": "Ptprq", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P0C5E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5E4" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C5E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5E4" } ] } ] }, { "uniprot_ac": "P10586", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P10586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10586" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P10586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10586" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P16620", "gene_name": "Ptp69D", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16620" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16620" } ] } ] }, { "uniprot_ac": "P16621", "gene_name": "Lar", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] } ] }, { "uniprot_ac": "P17706", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P17706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17706" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P17706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17706" } ] } ] }, { "uniprot_ac": "P18031", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18031" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18031" } ] } ] }, { "uniprot_ac": "P18052", "gene_name": "Ptpra", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18052" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18052" } ] } ] }, { "uniprot_ac": "P18433", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] } ] }, { "uniprot_ac": "P20417", "gene_name": "Ptpn1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20417" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P20417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20417" } ] } ] }, { "uniprot_ac": "P20483", "gene_name": "stg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20483" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P20483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20483" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] } ] }, { "uniprot_ac": "P23467", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23467" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23467" } ] } ] }, { "uniprot_ac": "P23468", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23468", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23468" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23468", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23468" } ] } ] }, { "uniprot_ac": "P23469", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23469" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23469" } ] } ] }, { "uniprot_ac": "P23470", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23470" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23470" } ] } ] }, { "uniprot_ac": "P23471", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23471" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23471" } ] } ] }, { "uniprot_ac": "P23748", "gene_name": "MIH1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23748" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23748" } ] } ] }, { "uniprot_ac": "P24666", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] } ] }, { "uniprot_ac": "P25044", "gene_name": "PTP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P25044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25044" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P25044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25044" } ] } ] }, { "uniprot_ac": "P26045", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P26045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26045" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P26045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26045" } ] } ] }, { "uniprot_ac": "P28562", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] } ] }, { "uniprot_ac": "P28563", "gene_name": "Dusp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] } ] }, { "uniprot_ac": "P28827", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] }, { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] } ] }, { "uniprot_ac": "P28828", "gene_name": "Ptprm", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28828" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28828" } ] } ] }, { "uniprot_ac": "P29074", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29074" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29074" } ] } ] }, { "uniprot_ac": "P29349", "gene_name": "csw", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29349" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29349" } ] } ] }, { "uniprot_ac": "P29350", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29350" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29350" } ] } ] }, { "uniprot_ac": "P29351", "gene_name": "Ptpn6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] } ] }, { "uniprot_ac": "P29352", "gene_name": "Ptpn22", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29352" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29352" } ] } ] }, { "uniprot_ac": "P29461", "gene_name": "PTP2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29461" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29461" } ] } ] }, { "uniprot_ac": "P30304", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] } ] }, { "uniprot_ac": "P30305", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] } ] }, { "uniprot_ac": "P30306", "gene_name": "Cdc25b", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30306" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30306" } ] } ] }, { "uniprot_ac": "P30307", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] } ] }, { "uniprot_ac": "P34137", "gene_name": "ptpA1-2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P34137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34137" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P34137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34137" } ] } ] }, { "uniprot_ac": "P34138", "gene_name": "ptpB", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P34138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34138" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P34138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34138" } ] } ] }, { "uniprot_ac": "P35233", "gene_name": "Ptpn2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35233" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35233" } ] } ] }, { "uniprot_ac": "P35234", "gene_name": "Ptpn5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35234" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35234" } ] } ] }, { "uniprot_ac": "P35235", "gene_name": "Ptpn11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35235" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35235" } ] } ] }, { "uniprot_ac": "P35236", "gene_name": "PTPN7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35236" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35236" } ] } ] }, { "uniprot_ac": "P35821", "gene_name": "Ptpn1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35821" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35821" } ] } ] }, { "uniprot_ac": "P35822", "gene_name": "Ptprk", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35822" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35822" } ] } ] }, { "uniprot_ac": "P35831", "gene_name": "Ptpn12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35831" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35831" } ] } ] }, { "uniprot_ac": "P35832", "gene_name": "Ptp99A", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35832" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35832" } ] } ] }, { "uniprot_ac": "P35992", "gene_name": "Ptp10D", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35992" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35992" } ] } ] }, { "uniprot_ac": "P38148", "gene_name": "PPS1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] } ] }, { "uniprot_ac": "P38590", "gene_name": "MSG5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P38590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38590" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P38590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38590" } ] } ] }, { "uniprot_ac": "P40048", "gene_name": "PTP3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40048" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40048" } ] } ] }, { "uniprot_ac": "P40081", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40081" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40081" } ] } ] }, { "uniprot_ac": "P40347", "gene_name": "LTP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] } ] }, { "uniprot_ac": "P40479", "gene_name": "SDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40479" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40479" } ] } ] }, { "uniprot_ac": "P41498", "gene_name": "Acp1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] } ] }, { "uniprot_ac": "P41499", "gene_name": "Ptpn11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] } ] }, { "uniprot_ac": "P43378", "gene_name": "PTPN9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P43378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43378" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P43378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43378" } ] } ] }, { "uniprot_ac": "P48964", "gene_name": "Cdc25a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48964" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48964" } ] } ] }, { "uniprot_ac": "P48965", "gene_name": "Cdc25a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48965" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48965" } ] } ] }, { "uniprot_ac": "P48966", "gene_name": "Cdc25b", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48966" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48966" } ] } ] }, { "uniprot_ac": "P48967", "gene_name": "Cdc25c", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48967" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48967" } ] } ] }, { "uniprot_ac": "P49445", "gene_name": "Ptpn7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P49445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49445" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P49445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49445" } ] } ] }, { "uniprot_ac": "P49446", "gene_name": "Ptpre", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P49446", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49446" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P49446", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49446" } ] } ] }, { "uniprot_ac": "P50946", "gene_name": "OCA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P50946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50946" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P50946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50946" } ] } ] }, { "uniprot_ac": "P51452", "gene_name": "DUSP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] } ] }, { "uniprot_ac": "P54637", "gene_name": "ptpC", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54637" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54637" } ] } ] }, { "uniprot_ac": "P54829", "gene_name": "PTPN5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54829" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54829" } ] } ] }, { "uniprot_ac": "P54830", "gene_name": "Ptpn5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54830" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54830" } ] } ] }, { "uniprot_ac": "P56180", "gene_name": "TPTE", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P56180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56180" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P56180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56180" } ] } ] }, { "uniprot_ac": "P60484", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] } ] }, { "uniprot_ac": "P70289", "gene_name": "Ptprv", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P70289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70289" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P70289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70289" } ] } ] }, { "uniprot_ac": "P80560", "gene_name": "Ptprn2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] } ] }, { "uniprot_ac": "P81718", "gene_name": "Ptpn6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P81718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81718" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P81718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81718" } ] } ] }, { "uniprot_ac": "P82890", "gene_name": "primo-1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] } ] }, { "uniprot_ac": "P82891", "gene_name": "primo-2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] } ] }, { "uniprot_ac": "P97480", "gene_name": "Eya3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P97480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97480" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P97480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97480" } ] } ] }, { "uniprot_ac": "P97767", "gene_name": "Eya1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] } ] }, { "uniprot_ac": "Q00684", "gene_name": "CDC14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q00684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00684" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q00684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00684" } ] } ] }, { "uniprot_ac": "Q02256", "gene_name": "YVH1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q02256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q02256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02256" } ] } ] }, { "uniprot_ac": "Q03019", "gene_name": "twe", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q03019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03019" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q03019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03019" } ] } ] }, { "uniprot_ac": "Q03348", "gene_name": "Ptpra", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q03348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03348" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q03348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03348" } ] } ] }, { "uniprot_ac": "Q05201", "gene_name": "eya", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05201" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05201" } ] } ] }, { "uniprot_ac": "Q05209", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05209" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05209" } ] } ] }, { "uniprot_ac": "Q05909", "gene_name": "Ptprg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05909" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05909" } ] } ] }, { "uniprot_ac": "Q05922", "gene_name": "Dusp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] } ] }, { "uniprot_ac": "Q05923", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] } ] }, { "uniprot_ac": "Q06124", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] } ] }, { "uniprot_ac": "Q06180", "gene_name": "Ptpn2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06180" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06180" } ] } ] }, { "uniprot_ac": "Q12454", "gene_name": "OCA6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12454" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12454" } ] } ] }, { "uniprot_ac": "Q12913", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12913" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12913" } ] } ] }, { "uniprot_ac": "Q12923", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12923" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12923" } ] } ] }, { "uniprot_ac": "Q12974", "gene_name": "PTP4A2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12974" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12974" } ] } ] }, { "uniprot_ac": "Q13115", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] } ] }, { "uniprot_ac": "Q13202", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] } ] }, { "uniprot_ac": "Q13332", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13332" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13332" } ] } ] }, { "uniprot_ac": "Q13615", "gene_name": "MTMR3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] } ] }, { "uniprot_ac": "Q15256", "gene_name": "PTPRR", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q15256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q15256", "database": 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"gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] } ] }, { "uniprot_ac": "Q16690", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": 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"https://www.uniprot.org/uniprot/Q55E39" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q55E39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55E39" } ] } ] }, { "uniprot_ac": "Q55GW2", "gene_name": "acp1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q55GW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GW2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q55GW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GW2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q55GW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GW2" } ] } ] }, { "uniprot_ac": "Q5FVI9", "gene_name": "Dusp26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5FVI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVI9" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5FVI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVI9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5FVI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVI9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5FVI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVI9" } ] } ] }, { "uniprot_ac": "Q5PQT2", "gene_name": "Mtmr3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] } ] }, { "uniprot_ac": "Q5SW75", "gene_name": "Ssh2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] } ] }, { "uniprot_ac": "Q5XIS1", "gene_name": "Ssh3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] } ] }, { "uniprot_ac": "Q61152", "gene_name": "Ptpn18", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q61152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61152" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q61152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61152" } ] } ] }, { "uniprot_ac": "Q62130", "gene_name": "Ptpn14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62130" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62130" } ] } ] }, { "uniprot_ac": "Q62132", "gene_name": "Ptprr", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62132" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62132" } ] } ] }, { "uniprot_ac": "Q62136", "gene_name": "Ptpn21", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62136" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62136" } ] } ] }, { "uniprot_ac": "Q62656", "gene_name": "Ptprz1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62656" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62656" } ] } ] }, { "uniprot_ac": "Q62728", "gene_name": "Ptpn21", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62728" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62728" } ] } ] }, { "uniprot_ac": "Q62767", "gene_name": "Dusp4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] } ] }, { "uniprot_ac": "Q62797", "gene_name": "Ptpro", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62797" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62797" } ] } ] }, { "uniprot_ac": "Q63340", "gene_name": "Dusp7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] } ] }, { "uniprot_ac": "Q63475", "gene_name": "Ptprn2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] } ] }, { "uniprot_ac": "Q63739", "gene_name": "Ptp4a1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63739" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63739" } ] } ] }, { "uniprot_ac": "Q63HR2", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63HR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HR2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63HR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HR2" } ] } ] }, { "uniprot_ac": "Q641Z2", "gene_name": "Ptpn9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q641Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Z2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q641Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Z2" } ] } ] }, { "uniprot_ac": "Q64346", "gene_name": "Dusp6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] } ] }, { "uniprot_ac": "Q64455", "gene_name": "Ptprj", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64455" } ] } ] }, { "uniprot_ac": "Q64487", "gene_name": "Ptprd", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64487" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64487" } ] } ] }, { "uniprot_ac": "Q64512", "gene_name": "Ptpn13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64512" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64512" } ] } ] }, { "uniprot_ac": "Q64604", "gene_name": "Ptprf", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64604" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64604" } ] } ] }, { "uniprot_ac": "Q64605", "gene_name": "Ptprs", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64605" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64605" } ] } ] }, { "uniprot_ac": "Q64612", "gene_name": "Ptprv", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64612" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64612" } ] } ] }, { "uniprot_ac": "Q64623", "gene_name": "Dusp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] } ] }, { "uniprot_ac": "Q66GT5", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] } ] }, { "uniprot_ac": "Q68J44", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q68J44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68J44" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q68J44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68J44" } ] } ] }, { "uniprot_ac": "Q6AXW7", "gene_name": "Dusp18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] } ] }, { "uniprot_ac": "Q6B8I1", "gene_name": "DUSP13A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] } ] }, { "uniprot_ac": "Q6GQT0", "gene_name": "Cdc14a", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] } ] }, { "uniprot_ac": "Q6NN85", "gene_name": "ssh", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] } ] }, { "uniprot_ac": "Q6NT99", "gene_name": "Dusp23", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] } ] }, { "uniprot_ac": "Q6P9X4", "gene_name": "Ptp4a2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6P9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P9X4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6P9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P9X4" } ] } ] }, { "uniprot_ac": "Q6PB44", "gene_name": "Ptpn23", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PB44" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6PB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PB44" } ] } ] }, { "uniprot_ac": "Q6PFY9", "gene_name": "Cdc14b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] } ] }, { "uniprot_ac": "Q76I76", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] } ] }, { "uniprot_ac": "Q76I79", "gene_name": "Ssh1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] } ] }, { "uniprot_ac": "Q78EG7", "gene_name": "Ptp4a1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q78EG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EG7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q78EG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EG7" } ] } ] }, { "uniprot_ac": "Q7KMQ6", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] } ] }, { "uniprot_ac": "Q7TNL7", "gene_name": "Dusp9", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] } ] }, { "uniprot_ac": "Q80TZ3", "gene_name": "Dnajc6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q80TZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q80TZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TZ3" } ] } ] }, { "uniprot_ac": "Q810P3", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] } ] }, { "uniprot_ac": "Q86BN8", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] } ] }, { "uniprot_ac": "Q86IL4", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] } ] }, { "uniprot_ac": "Q86V88", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] } ] }, { "uniprot_ac": "Q8BFV3", "gene_name": "Dusp4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": 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[ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] } ] }, { "uniprot_ac": "Q8BTR5", "gene_name": "Dusp28", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] } ] }, { "uniprot_ac": "Q8BUM3", "gene_name": "Ptpn7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BUM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUM3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BUM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUM3" } ] } ] }, { "uniprot_ac": "Q8CE08", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] } ] }, { "uniprot_ac": "Q8CGB6", "gene_name": "Tns2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8CGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGB6" } ] } ] }, { "uniprot_ac": "Q8CHP8", "gene_name": "Pgp", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] } ] }, { "uniprot_ac": "Q8K296", "gene_name": "Mtmr3", "activity": [ { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] } ] }, { "uniprot_ac": "Q8K330", "gene_name": "Ssh3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] } ] }, { "uniprot_ac": "Q8K4T5", "gene_name": "Dusp19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] } ] }, { "uniprot_ac": "Q8NEJ0", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] } ] }, { "uniprot_ac": "Q8R4V2", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] } ] }, { "uniprot_ac": "Q8T9S7", "gene_name": "pteN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] } ] }, { "uniprot_ac": "Q8TE77", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] } ] }, { "uniprot_ac": "Q8TF42", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF42" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8TF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF42" } ] } ] }, { "uniprot_ac": "Q8VE01", "gene_name": "Dusp18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] } ] }, { "uniprot_ac": "Q8WTR2", "gene_name": "DUSP19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] } ] }, { "uniprot_ac": "Q8WUK0", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] } ] }, { "uniprot_ac": "Q8WYL5", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] } ] }, { "uniprot_ac": "Q91XQ2", "gene_name": "Epm2a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] } ] }, { "uniprot_ac": "Q91XS1", "gene_name": "Mtmr4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91XS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS1" } ] } ] }, { "uniprot_ac": "Q91Z46", 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"activity": "", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] } ] }, { "uniprot_ac": "Q99504", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99504" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99504" } ] } ] }, { "uniprot_ac": "Q99952", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99952" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99952", "database": "UniProtKB", "url": 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} ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] } ] }, { "uniprot_ac": "Q9BV47", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] } ] }, { 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phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] } ] }, { "uniprot_ac": "Q9D0T2", "gene_name": "Dusp12", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] } ] }, { "uniprot_ac": "Q9D358", "gene_name": "Acp1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q9D358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D358" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q9D358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D358" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D358" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D358" } ] } ] }, { "uniprot_ac": "Q9D658", "gene_name": "Ptp4a3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D658" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D658" } ] } ] }, { "uniprot_ac": "Q9D700", "gene_name": "Dusp26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] } ] }, { "uniprot_ac": "Q9D7X3", "gene_name": "Dusp3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7X3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": 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}, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 28 }, { "field": "total_sites", "count": 27 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 19 }, { "field": "total_sites", "count": 18 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 61 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }