{ "uniprot_canonical_ac": "P10321-1", "uniprot_ac": "P10321", "uniprot_id": "HLAC_HUMAN", "mass": { "chemical_mass": 40649.0, "monoisotopic_mass": 40649.0 }, "refseq": { "ac": "NP_002108", "name": "HLA class I histocompatibility antigen, C alpha chain precursor", "summary": "HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" }, "gene_names": [ { "name": "HLA-C", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10321", "id": "P10321" }, { "name": "D6S204; HLA-JY3; HLAC; HLC-C; MHC; PSORS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108", "id": "NP_002108" }, { "name": "HLA-Cw", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10321", "id": "P10321" }, { "name": "HLA-C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108", "id": "NP_002108" }, { "name": "HLAC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10321", "id": "P10321" } ], "protein_names": [ { "name": "HLA class I histocompatibility antigen, C alpha chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10321" }, { "name": "HLA class I histocompatibility antigen, C alpha chain precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971", "id": "NP_001229971" }, { "name": "HLA class I histocompatibility antigen, C alpha chain; MHC class I antigen heavy chain HLA-C; major histocompatibility antigen HLA-C; human leukocyte antigen-C alpha chain; HLA-C antigen", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971", "id": "NP_001229971" }, { "name": "HLA-Cw", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10321" }, { "name": "HLA-C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10321" }, { "name": "Human leukocyte antigen C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10321" } ], "function": [ { "annotation": "A novel HLA-C*06 allele, HLA-C*06:02:96, identified by next-generation sequencing in a Chinese family.", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "PubMed", "id": "36846874", "url": "https://glygen.org/publication/PubMed/36846874" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] }, { "annotation": "ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002).", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "20439706", "url": "https://glygen.org/publication/PubMed/20439706" }, { "database": "PubMed", "id": "12947002", "url": "https://glygen.org/publication/PubMed/12947002" } ] }, { "annotation": "ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002).", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "12947002", "url": "https://glygen.org/publication/PubMed/12947002" }, { "database": "PubMed", "id": "20104487", "url": "https://glygen.org/publication/PubMed/20104487" } ] }, { "annotation": "ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "11172028", "url": "https://glygen.org/publication/PubMed/11172028" } ] }, { "annotation": "ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "24091323", "url": "https://glygen.org/publication/PubMed/24091323" } ] }, { "annotation": "ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "29312307", "url": "https://glygen.org/publication/PubMed/29312307" } ] }, { "annotation": "ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "24990997", "url": "https://glygen.org/publication/PubMed/24990997" }, { "database": "PubMed", "id": "12947002", "url": "https://glygen.org/publication/PubMed/12947002" } ] }, { "annotation": "ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "12947002", "url": "https://glygen.org/publication/PubMed/12947002" } ] }, { "annotation": "ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "12947002", "url": "https://glygen.org/publication/PubMed/12947002" } ] }, { "annotation": "Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:20972337, PubMed:24091323, PubMed:20439706, PubMed:11172028, PubMed:20104487, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:8265661, PubMed:25311805).", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321#function" }, { "database": "PubMed", "id": "20972337", "url": "https://glygen.org/publication/PubMed/20972337" }, { "database": "UniProtKB", "id": "P04439", "url": "https://www.uniprot.org/uniprot/P04439#function" }, { "database": "PubMed", "id": "20439706", "url": "https://glygen.org/publication/PubMed/20439706" }, { "database": "PubMed", "id": "16141329", "url": "https://glygen.org/publication/PubMed/16141329" }, { "database": "PubMed", "id": "24091323", "url": "https://glygen.org/publication/PubMed/24091323" }, { "database": "PubMed", "id": "8265661", "url": "https://glygen.org/publication/PubMed/8265661" }, { "database": "PubMed", "id": "11172028", "url": "https://glygen.org/publication/PubMed/11172028" }, { "database": "PubMed", "id": "29312307", "url": "https://glygen.org/publication/PubMed/29312307" }, { "database": "PubMed", "id": "20104487", "url": "https://glygen.org/publication/PubMed/20104487" }, { "database": "PubMed", "id": "25311805", "url": "https://glygen.org/publication/PubMed/25311805" }, { "database": "PubMed", "id": "28649982", "url": "https://glygen.org/publication/PubMed/28649982" } ] }, { "annotation": "Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression.", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "PubMed", "id": "37246469", "url": "https://glygen.org/publication/PubMed/37246469" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] }, { "annotation": "Genetic Influence on Treatment Response in Psoriasis: New Insights into Personalized Medicine. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "PubMed", "id": "37372997", "url": "https://glygen.org/publication/PubMed/37372997" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] }, { "annotation": "HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020].", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] }, { "annotation": "Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population.", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "PubMed", "id": "36804966", "url": "https://glygen.org/publication/PubMed/36804966" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] }, { "annotation": "The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C *07 Expression in Patients with Endometriosis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001229971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229971" }, { "database": "PubMed", "id": "36974156", "url": "https://glygen.org/publication/PubMed/36974156" }, { "database": "RefSeq", "id": "NP_002108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002108" } ] } ], "disease": [ { "disease_id": "DOID:0111286", "recommended_name": { "id": "DOID:0111286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111286", "name": "psoriasis 1", "description": "A psoriasis that has_material_basis_in variation in HLA-C on chromosome 6p21.33." }, "synonyms": [ { "id": "DOID:0111286", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111286", "name": "PSORS1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "Any psoriasis in which the cause of the disease is a mutation in the HLA-C gene." }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "HLA-C psoriasis", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis caused by mutation in HLA-C", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis susceptibility 1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "PSORS1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "susceptibility to psoriasis 1", "description": "" }, { "id": "MIM:177900", "resource": "MIM", "url": "https://www.omim.org/entry/177900", "name": "Psoriasis 1", "description": "Psoriasis 1" } ], "evidence": [ { "id": "177900", "database": "MIM", "url": "https://www.omim.org/entry/177900" } ] }, { "disease_id": "DOID:8893", "recommended_name": { "id": "DOID:8893", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales." }, "synonyms": [ { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "Any psoriasis in which the cause of the disease is a mutation in the HLA-C gene." }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "HLA-C psoriasis", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis caused by mutation in HLA-C", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis susceptibility 1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "PSORS1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "susceptibility to psoriasis 1", "description": "" }, { "id": "MIM:177900", "resource": "MIM", "url": "https://www.omim.org/entry/177900", "name": "Psoriasis 1", "description": "Psoriasis 1" } ], "evidence": [ { "id": "177900", "database": "MIM", "url": "https://www.omim.org/entry/177900" } ] } ], "snv": [ { "evidence": [ { "id": "rs281860431", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860431" }, { "id": "rs281860431", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs281860431" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 112, "end_pos": 112, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQS->NQN); o-glyco-site-loss (S->N).", "chr_id": "6", "chr_pos": "31271607", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S112", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs281860432", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860432" }, { "id": "rs281860432", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs281860432" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 112, "end_pos": 112, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQS->NQR); o-glyco-site-loss (S->R).", "chr_id": "6", "chr_pos": "31271606", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S112", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs281860426", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860426" }, { "id": "rs281860426", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs281860426" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 110, "end_pos": 110, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQS->DQS).", "chr_id": "6", "chr_pos": "31271614", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N110", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs281860427", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860427" }, { "id": "rs281860427", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs281860427" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 110, "end_pos": 110, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQS->KQS).", "chr_id": "6", "chr_pos": "31271612", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N110", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs281860435", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860435" }, { "id": "rs281860435", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs281860435" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 114, "end_pos": 114, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "6", "chr_pos": "31271602", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D114", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2308575", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2308575" }, { "id": "rs2308575", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs2308575" }, { "id": "rs2308575", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2308575" }, { "id": "rs2308575", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs2308575#frequency_tab" }, { "id": "rs2308575", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs2308575" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 138, "end_pos": 138, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DQS->NQS).", "chr_id": "6", "chr_pos": "31271280", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.2568", "site_lbl": "D138", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs281860554", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs281860554" }, { "id": "rs281860554", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs281860554" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 224, "end_pos": 224, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "6", "chr_pos": "31270435", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs200200386", "database": "dbSNP", "url": 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"http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P10321", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10321" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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"MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P10321", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10321" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10321" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P10321", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10321" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9J9-1", "url": "https://www.uniprot.org/uniprot/A0A140T9J9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9L3", "url": "https://www.uniprot.org/uniprot/A0A140T9L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9L3-1", "url": "https://www.uniprot.org/uniprot/A0A140T9L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9M0", "url": "https://www.uniprot.org/uniprot/A0A140T9M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9M0-1", "url": "https://www.uniprot.org/uniprot/A0A140T9M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9M5", "url": "https://www.uniprot.org/uniprot/A0A140T9M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9M5-1", "url": "https://www.uniprot.org/uniprot/A0A140T9M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Q4", "url": "https://www.uniprot.org/uniprot/A0A140T9Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Q4-1", "url": "https://www.uniprot.org/uniprot/A0A140T9Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9S7", "url": "https://www.uniprot.org/uniprot/A0A140T9S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9S7-1", "url": "https://www.uniprot.org/uniprot/A0A140T9S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9T1", "url": "https://www.uniprot.org/uniprot/A0A140T9T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9T1-1", "url": "https://www.uniprot.org/uniprot/A0A140T9T1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9U0", "url": "https://www.uniprot.org/uniprot/A0A140T9U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9U0-1", "url": "https://www.uniprot.org/uniprot/A0A140T9U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9U8", "url": "https://www.uniprot.org/uniprot/A0A140T9U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9U8-1", "url": "https://www.uniprot.org/uniprot/A0A140T9U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9W2", "url": "https://www.uniprot.org/uniprot/A0A140T9W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9W2-1", "url": "https://www.uniprot.org/uniprot/A0A140T9W2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Z4", "url": "https://www.uniprot.org/uniprot/A0A140T9Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Z4-1", "url": "https://www.uniprot.org/uniprot/A0A140T9Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Z7", "url": "https://www.uniprot.org/uniprot/A0A140T9Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T9Z7-1", "url": "https://www.uniprot.org/uniprot/A0A140T9Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA03", "url": "https://www.uniprot.org/uniprot/A0A140TA03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA03-1", "url": "https://www.uniprot.org/uniprot/A0A140TA03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA05", "url": "https://www.uniprot.org/uniprot/A0A140TA05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA05-1", "url": "https://www.uniprot.org/uniprot/A0A140TA05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA12", "url": "https://www.uniprot.org/uniprot/A0A140TA12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA12-1", "url": "https://www.uniprot.org/uniprot/A0A140TA12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA19", "url": "https://www.uniprot.org/uniprot/A0A140TA19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140TA19-1", "url": "https://www.uniprot.org/uniprot/A0A140TA19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PNZ7", "url": "https://www.uniprot.org/uniprot/A0A1W2PNZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PNZ7-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PNZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PP77", "url": "https://www.uniprot.org/uniprot/A0A1W2PP77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PP77-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PP77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR11", "url": "https://www.uniprot.org/uniprot/A0A1W2PR11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR11-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PR11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRX1", "url": "https://www.uniprot.org/uniprot/A0A1W2PRX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRX1-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PRX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRZ0", "url": "https://www.uniprot.org/uniprot/A0A1W2PRZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRZ0-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PRZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PS56", "url": "https://www.uniprot.org/uniprot/A0A1W2PS56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PS56-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PS56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AEA2", "url": "https://www.uniprot.org/uniprot/A2AEA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AEA2-1", "url": "https://www.uniprot.org/uniprot/A2AEA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2BF26", "url": "https://www.uniprot.org/uniprot/A2BF26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2BF26-1", "url": "https://www.uniprot.org/uniprot/A2BF26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8W9Z8", "url": "https://www.uniprot.org/uniprot/F8W9Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8W9Z8-1", "url": "https://www.uniprot.org/uniprot/F8W9Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O19617", "url": "https://www.uniprot.org/uniprot/O19617", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O19617-1", "url": "https://www.uniprot.org/uniprot/O19617-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O78179", "url": "https://www.uniprot.org/uniprot/O78179", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O78179-1", "url": "https://www.uniprot.org/uniprot/O78179-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10321-1", "url": "https://www.uniprot.org/uniprot/P10321-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10321-2", "url": "https://www.uniprot.org/uniprot/P10321-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53YP1", "url": "https://www.uniprot.org/uniprot/Q53YP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q53YP1-1", "url": "https://www.uniprot.org/uniprot/Q53YP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QT33", "url": "https://www.uniprot.org/uniprot/Q5QT33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QT33-1", "url": "https://www.uniprot.org/uniprot/Q5QT33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5RIP0", "url": "https://www.uniprot.org/uniprot/Q5RIP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5RIP0-1", "url": "https://www.uniprot.org/uniprot/Q5RIP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 366, "header": "sp|P10321-1|HLAC_HUMAN Isoform 1 of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3 CANONICAL=P10321-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JH50-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGHFLPTGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 372, "header": "tr|A0A0G2JH50-1|A0A0G2JH50_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261900, "end_pos": 31259009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383323.6", "url": "https://www.ensembl.org/id/ENST00000383323.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000372813.2", "url": "https://www.ensembl.org/id/ENSP00000372813.2" } ] } }, { "isoform_ac": "A0A0G2JIF0-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 368, "header": "tr|A0A0G2JIF0-1|A0A0G2JIF0_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261900, "end_pos": 31258912, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434884.6", "url": "https://www.ensembl.org/id/ENST00000434884.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000398169.2", "url": "https://www.ensembl.org/id/ENSP00000398169.2" } ] } }, { "isoform_ac": "A0A0G2JKJ1-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAEDVWLRPGARRAPPPRV", "length": 131, "header": "tr|A0A0G2JKJ1-1|A0A0G2JKJ1_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261900, "end_pos": 31261115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000469544.5", "url": "https://www.ensembl.org/id/ENST00000469544.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000436915.1", "url": "https://www.ensembl.org/id/ENSP00000436915.1" } ] } }, { "isoform_ac": "A0A0G2JPB1-1", "url": "", "sequence": { "sequence": "AVVVPSGQEQRYTCHMQHEGLQEPLTLSWGGKGGSCSQAACSNSAQGSD", "length": 49, "header": "tr|A0A0G2JPB1-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31261342, "end_pos": 31260405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000621261.1", "url": "https://www.ensembl.org/id/ENST00000621261.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000483304.1", "url": "https://www.ensembl.org/id/ENSP00000483304.1" } ] } }, { "isoform_ac": "A0A0G2JPT2-1", "url": "", "sequence": { "sequence": "AVVVPSGEEQRYTCHVQHEGLPEPLTLRWGGKGGSCSQAASSNSAQGSD", "length": 49, "header": "tr|A0A0G2JPT2-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31260130, "end_pos": 31259197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000618255.1", "url": "https://www.ensembl.org/id/ENST00000618255.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000484208.1", "url": "https://www.ensembl.org/id/ENSP00000484208.1" } ] } }, { "isoform_ac": "A0A140T912-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGHFLPTGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 372, "header": "tr|A0A140T912-1|A0A140T912_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31312629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000453809.6", "url": "https://www.ensembl.org/id/ENST00000453809.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000388708.2", "url": "https://www.ensembl.org/id/ENSP00000388708.2" } ] } }, { "isoform_ac": "A0A140T921-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSAACVGLRCRISSHLSFVTSRASGISFCKGV", "length": 368, "header": "tr|A0A140T921-1|A0A140T921_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31260120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000422726.6", "url": "https://www.ensembl.org/id/ENST00000422726.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000389248.2", "url": "https://www.ensembl.org/id/ENSP00000389248.2" } ] } }, { "isoform_ac": "A0A140T930-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGREGVRSGVWPATVPRALMSLSSLVKPETAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 397, "header": "tr|A0A140T930-1|A0A140T930_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31312532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414249.6", "url": "https://www.ensembl.org/id/ENST00000414249.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000390282.2", "url": "https://www.ensembl.org/id/ENSP00000390282.2" } ] } }, { "isoform_ac": "A0A140T937-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSA", "length": 339, "header": "tr|A0A140T937-1|A0A140T937_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31312629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419590.5", "url": "https://www.ensembl.org/id/ENST00000419590.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000390860.1", "url": "https://www.ensembl.org/id/ENSP00000390860.1" } ] } }, { "isoform_ac": "A0A140T942-1", "url": "", "sequence": { "sequence": "XRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEASRRWNLPEVGSCGGAFWRRAEIHVPCAARGAARAPHPE", "length": 261, "header": "tr|A0A140T942-1|A0A140T942_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264266, "end_pos": 31262415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000454033.1", "url": "https://www.ensembl.org/id/ENST00000454033.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000391250.1", "url": "https://www.ensembl.org/id/ENSP00000391250.1" } ] } }, { "isoform_ac": "A0A140T962-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 368, "header": "tr|A0A140T962-1|A0A140T962_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31261280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000456487.6", "url": "https://www.ensembl.org/id/ENST00000456487.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000393458.2", "url": "https://www.ensembl.org/id/ENSP00000393458.2" } ] } }, { "isoform_ac": "A0A140T9B3-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGREGVRSGVWPATVPRALMSLSSLVKPETAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 397, "header": "tr|A0A140T9B3-1|A0A140T9B3_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31261280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000422921.6", "url": "https://www.ensembl.org/id/ENST00000422921.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000397867.2", "url": "https://www.ensembl.org/id/ENSP00000397867.2" } ] } }, { "isoform_ac": "A0A140T9E1-1", "url": "", "sequence": { "sequence": "XRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEASRRWNLPEVGSCGGAFWTRAEIHVPYAARGAARAPHPE", "length": 261, "header": "tr|A0A140T9E1-1|A0A140T9E1_HUMAN Computationally mapped isoform of Major histocompatibility complex, class I, C OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "6", "start_pos": 31272069, "end_pos": 31270214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415537.1", "url": "https://www.ensembl.org/id/ENST00000415537.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000400410.1", "url": "https://www.ensembl.org/id/ENSP00000400410.1" } ] } }, { "isoform_ac": "A0A140T9H5-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGHFLPTGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 372, "header": "tr|A0A140T9H5-1|A0A140T9H5_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31260217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423509.6", "url": "https://www.ensembl.org/id/ENST00000423509.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000403624.2", "url": "https://www.ensembl.org/id/ENSP00000403624.2" } ] } }, { "isoform_ac": "A0A140T9J9-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGHFLPTGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 372, "header": "tr|A0A140T9J9-1|A0A140T9J9_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31261377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000458192.6", "url": "https://www.ensembl.org/id/ENST00000458192.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000404526.2", "url": "https://www.ensembl.org/id/ENSP00000404526.2" } ] } }, { "isoform_ac": "A0A140T9L3-1", "url": "", "sequence": { "sequence": "XRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEASRRWNLPEVGSCGGAFWTRAEIHVPYAARGAARAPHPE", "length": 261, "header": "tr|A0A140T9L3-1|A0A140T9L3_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263114, "end_pos": 31261259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000457806.1", "url": "https://www.ensembl.org/id/ENST00000457806.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000407051.1", "url": "https://www.ensembl.org/id/ENSP00000407051.1" } ] } }, { "isoform_ac": "A0A140T9M0-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGHFLPTGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 372, "header": "tr|A0A140T9M0-1|A0A140T9M0_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349197, "end_pos": 31346307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419135.6", "url": "https://www.ensembl.org/id/ENST00000419135.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000407431.2", "url": "https://www.ensembl.org/id/ENSP00000407431.2" } ] } }, { "isoform_ac": "A0A140T9M5-1", "url": "", "sequence": { "sequence": "XRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEASRRWNLPEVGSCGGAFWRRAEIHVPCAARGAAGAPHPE", "length": 261, "header": "tr|A0A140T9M5-1|A0A140T9M5_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315518, "end_pos": 31313667, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437368.1", "url": "https://www.ensembl.org/id/ENST00000437368.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000407494.1", "url": "https://www.ensembl.org/id/ENSP00000407494.1" } ] } }, { "isoform_ac": "A0A140T9Q4-1", "url": "", "sequence": { "sequence": "XRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEASRRWNLPEVGSCGGAFWRRAEIHVPCAARGAARAPHPE", "length": 261, "header": "tr|A0A140T9Q4-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261898, "end_pos": 31260047, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000448362.1", "url": "https://www.ensembl.org/id/ENST00000448362.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000410661.1", "url": "https://www.ensembl.org/id/ENSP00000410661.1" } ] } }, { "isoform_ac": "A0A140T9S7-1", "url": "", "sequence": { "sequence": "XRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEASRRWNLPEVGSCGGAFWRRAEIHVPCAARGAARAPHPE", "length": 261, "header": "tr|A0A140T9S7-1|A0A140T9S7_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_SSTO_CTG1", "start_pos": 31265482, "end_pos": 31263631, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000449884.1", "url": "https://www.ensembl.org/id/ENST00000449884.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000411867.1", "url": "https://www.ensembl.org/id/ENSP00000411867.1" } ] } }, { "isoform_ac": "A0A140T9T1-1", "url": "", "sequence": { "sequence": "XRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEASRRWNLPEVGSCGGAFWRRAEIHVPCAARGAAGAPHPE", "length": 261, "header": "tr|A0A140T9T1-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349195, "end_pos": 31347345, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445075.1", "url": "https://www.ensembl.org/id/ENST00000445075.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000412426.1", "url": "https://www.ensembl.org/id/ENSP00000412426.1" } ] } }, { "isoform_ac": "A0A140T9U0-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 368, "header": "tr|A0A140T9U0-1|A0A140T9U0_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349197, "end_pos": 31346210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429840.6", "url": "https://www.ensembl.org/id/ENST00000429840.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000413189.2", "url": "https://www.ensembl.org/id/ENSP00000413189.2" } ] } }, { "isoform_ac": "A0A140T9U8-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGREGVKSGVWAATVPRALMSLSSLVKPETAACVGLRCRISSHLSFVTSRASGISFCKGV", "length": 397, "header": "tr|A0A140T9U8-1|A0A140T9U8_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31260120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430940.6", "url": "https://www.ensembl.org/id/ENST00000430940.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000413992.2", "url": "https://www.ensembl.org/id/ENSP00000413992.2" } ] } }, { "isoform_ac": "A0A140T9W2-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSASNSAQGSDESLIACKA", "length": 355, "header": "tr|A0A140T9W2-1|A0A140T9W2_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349197, "end_pos": 31346307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000433153.6", "url": "https://www.ensembl.org/id/ENST00000433153.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000415025.2", "url": "https://www.ensembl.org/id/ENSP00000415025.2" } ] } }, { "isoform_ac": "A0A140T9Z4-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAVDVWLRPGARRAPPPRV", "length": 131, "header": "tr|A0A140T9Z4-1|A0A140T9Z4_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31314735, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000488273.5", "url": "https://www.ensembl.org/id/ENST00000488273.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431347.1", "url": "https://www.ensembl.org/id/ENSP00000431347.1" } ] } }, { "isoform_ac": "A0A140T9Z7-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDVDVWLRPGARRAPPPRV", "length": 131, "header": "tr|A0A140T9Z7-1|A0A140T9Z7_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31263483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000479595.5", "url": "https://www.ensembl.org/id/ENST00000479595.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433088.1", "url": "https://www.ensembl.org/id/ENSP00000433088.1" } ] } }, { "isoform_ac": "A0A140TA03-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAEDVWLRRGARRAPPPRV", "length": 131, "header": "tr|A0A140TA03-1|A0A140TA03_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349197, "end_pos": 31348413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000491984.5", "url": "https://www.ensembl.org/id/ENST00000491984.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433409.1", "url": "https://www.ensembl.org/id/ENSP00000433409.1" } ] } }, { "isoform_ac": "A0A140TA05-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAGQDQKSLFLPQRLELSNE", "length": 224, "header": "tr|A0A140TA05-1|A0A140TA05_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31261693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000464914.5", "url": "https://www.ensembl.org/id/ENST00000464914.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433897.1", "url": "https://www.ensembl.org/id/ENSP00000433897.1" } ] } }, { "isoform_ac": "A0A140TA12-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDEDVWLRPGARRAPPPRV", "length": 131, "header": "tr|A0A140TA12-1|A0A140TA12_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31262327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000476248.5", "url": "https://www.ensembl.org/id/ENST00000476248.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435957.1", "url": "https://www.ensembl.org/id/ENSP00000435957.1" } ] } }, { "isoform_ac": "A0A140TA19-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAGQDQKSLFLPQRLELSNE", "length": 224, "header": "tr|A0A140TA19-1|A0A140TA19_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_SSTO_CTG1", "start_pos": 31265484, "end_pos": 31264065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000461937.5", "url": "https://www.ensembl.org/id/ENST00000461937.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000436842.1", "url": "https://www.ensembl.org/id/ENSP00000436842.1" } ] } }, { "isoform_ac": "A0A1W2PNZ7-1", "url": "", "sequence": { "sequence": "MYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK", "length": 244, "header": "tr|A0A1W2PNZ7-1|A0A1W2PNZ7_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31348459, "end_pos": 31346474, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640555.1", "url": "https://www.ensembl.org/id/ENST00000640555.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491196.1", "url": "https://www.ensembl.org/id/ENSP00000491196.1" } ] } }, { "isoform_ac": "A0A1W2PP77-1", "url": "", "sequence": { "sequence": "MYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK", "length": 244, "header": "tr|A0A1W2PP77-1|A0A1W2PP77_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31314781, "end_pos": 31312796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639886.1", "url": "https://www.ensembl.org/id/ENST00000639886.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491276.1", "url": "https://www.ensembl.org/id/ENSP00000491276.1" } ] } }, { "isoform_ac": "A0A1W2PR11-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGGKGGSCSQAAASNSAQGSDESLIACK", "length": 325, "header": "tr|A0A1W2PR11-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31261544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640467.1", "url": "https://www.ensembl.org/id/ENST00000640467.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492424.1", "url": "https://www.ensembl.org/id/ENSP00000492424.1" } ] } }, { "isoform_ac": "A0A1W2PRX1-1", "url": "", "sequence": { "sequence": "MYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK", "length": 244, "header": "tr|A0A1W2PRX1-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31263529, "end_pos": 31261544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639331.1", "url": "https://www.ensembl.org/id/ENST00000639331.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492523.1", "url": "https://www.ensembl.org/id/ENSP00000492523.1" } ] } }, { "isoform_ac": "A0A1W2PRZ0-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGGKGGSCSQAAASNSAQGSDESLIACK", "length": 325, "header": "tr|A0A1W2PRZ0-1|A0A1W2PRZ0_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31312796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639762.1", "url": "https://www.ensembl.org/id/ENST00000639762.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492558.1", "url": "https://www.ensembl.org/id/ENSP00000492558.1" } ] } }, { "isoform_ac": "A0A1W2PS56-1", "url": "", "sequence": { "sequence": "MYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK", "length": 244, "header": "tr|A0A1W2PS56-1|A0A1W2PS56_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261161, "end_pos": 31259176, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638318.1", "url": "https://www.ensembl.org/id/ENST00000638318.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492624.1", "url": "https://www.ensembl.org/id/ENSP00000492624.1" } ] } }, { "isoform_ac": "A2AEA2-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGHFLPTGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 372, "header": "tr|A2AEA2-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=2 CANONICAL=P10321-1" }, "locus": { "chromosome": "6", "start_pos": 31272071, "end_pos": 31269172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383329.7", "url": "https://www.ensembl.org/id/ENST00000383329.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000372819.3", "url": "https://www.ensembl.org/id/ENSP00000372819.3" } ] } }, { "isoform_ac": "A2BF26-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGREGVRSGVWPATVPRALMSLSSLVKPETAACVGLRCRISSHLSFVTSRASGISFCKGI", "length": 397, "header": "tr|A2BF26-1|A2BF26_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_SSTO_CTG1", "start_pos": 31265484, "end_pos": 31262496, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383483.8", "url": "https://www.ensembl.org/id/ENST00000383483.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000372975.4", "url": "https://www.ensembl.org/id/ENSP00000372975.4" } ] } }, { "isoform_ac": "F8W9Z8-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDEDVWLRPGARRAPPPRV", "length": 131, "header": "tr|F8W9Z8-1|F8W9Z8_HUMAN Computationally mapped isoform of Major histocompatibility complex, class I, C OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "6", "start_pos": 31272071, "end_pos": 31271282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376237.8", "url": "https://www.ensembl.org/id/ENST00000376237.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000365412.4", "url": "https://www.ensembl.org/id/ENSP00000365412.4" } ] } }, { "isoform_ac": "O19617-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 366, "header": "tr|O19617-1|O19617_HUMAN Computationally mapped isoform of MHC class I antigen OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_COX_CTG1", "start_pos": 31263116, "end_pos": 31260217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424832.6", "url": "https://www.ensembl.org/id/ENST00000424832.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000414063.2", "url": "https://www.ensembl.org/id/ENSP00000414063.2" } ] } }, { "isoform_ac": "O78179-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 366, "header": "tr|O78179-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MANN_CTG1", "start_pos": 31315520, "end_pos": 31312629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000438171.6", "url": "https://www.ensembl.org/id/ENST00000438171.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000393374.2", "url": "https://www.ensembl.org/id/ENSP00000393374.2" } ] } }, { "isoform_ac": "P10321-1", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 366, "header": "sp|P10321-1|HLAC_HUMAN Isoform 1 of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3 CANONICAL=P10321-1" }, "locus": { "chromosome": "6", "start_pos": 31272071, "end_pos": 31269172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376228.10", "url": "https://www.ensembl.org/id/ENST00000376228.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000365402.5", "url": "https://www.ensembl.org/id/ENSP00000365402.5" } ] } }, { "isoform_ac": "P10321-2", "url": "", "sequence": { "sequence": "MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEHLRSCTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLRWGGKGGSCSQAACSNSAQGSDESLITCKA", "length": 326, "header": "sp|P10321-2|HLAC_HUMAN Isoform 2 of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3 CANONICAL=P10321-1" }, "locus": {} }, { "isoform_ac": "Q53YP1-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 366, "header": "tr|Q53YP1-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_MCF_CTG1", "start_pos": 31349197, "end_pos": 31346307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000457903.6", "url": "https://www.ensembl.org/id/ENST00000457903.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000390851.2", "url": "https://www.ensembl.org/id/ENSP00000390851.2" } ] } }, { "isoform_ac": "Q5QT33-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 366, "header": "tr|Q5QT33-1|Q5QT33_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_DBB_CTG1", "start_pos": 31264268, "end_pos": 31261377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420206.5", "url": "https://www.ensembl.org/id/ENST00000420206.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000410214.1", "url": "https://www.ensembl.org/id/ENSP00000410214.1" } ] } }, { "isoform_ac": "Q5RIP0-1", "url": "", "sequence": { "sequence": "MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA", "length": 366, "header": "tr|Q5RIP0-1|HLAC_HUMAN Computationally mapped isoform of HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=1 CANONICAL=P10321-1" }, "locus": { "chromosome": "CHR_HSCHR6_MHC_QBL_CTG1", "start_pos": 31261900, "end_pos": 31259009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000400394.7", "url": "https://www.ensembl.org/id/ENST00000400394.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000383244.3", "url": "https://www.ensembl.org/id/ENSP00000383244.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G39619TI", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "1363", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1363" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G48584BU", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "1363", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1363" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G64527OM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "1363", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1363" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "1363", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1363" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "P10321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10321#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 112, "start_aa": "Ser", "end_pos": 112, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser112", "evidence": [ { "id": "P10321", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10321" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "P10321", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P10321" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "THVTHHPLSDHEATLR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 211, "start_aa": "Thr", "end_pos": 226, "end_aa": "Arg", "evidence": [ { "id": "P10321", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 214, "start_aa": "Thr", "end_pos": 214, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr214", "evidence": [ { "id": "P10321", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 224, "start_aa": "Thr", "end_pos": 224, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr224", "evidence": [ { "id": "P10321", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] } ], "phosphorylation": [ { "start_pos": 357, "end_pos": 357, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "site_lbl": "Ser357" }, { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "site_lbl": "Ser360" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen .H", "evidence": [ { "database": "UniCarbKB", "id": "P10321", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily.", "journal": "The Journal of experimental medicine", "date": "1999", "authors": "Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R", "evidence": [ { "database": "Reactome", "id": "R-HSA-2172127", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2172127" } ], "reference": [ { "type": "PubMed", "id": "10049942", "url": "https://glygen.org/publication/PubMed/10049942" } ] }, { "title": "Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences.", "journal": "European journal of immunology", "date": "1999", "authors": "Ulbrecht M, Couturier A, Martinozzi S, Pla M, Srivastava R, Peterson PA, Weiss EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-983170", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983170" } ], "reference": [ { "type": "PubMed", "id": "10064069", "url": "https://glygen.org/publication/PubMed/10064069" } ] }, { "title": "Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.", "journal": "Nature", "date": "1999", "authors": "Ulloa L, Doody J, Massague J", "evidence": [ { "database": "Reactome", "id": "R-HSA-877300", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-877300" } ], "reference": [ { "type": "PubMed", "id": "10067896", "url": "https://glygen.org/publication/PubMed/10067896" } ] }, { "title": "Correction of HLA-Cw*0501 and identification of HLA-Cw*0711.", "journal": "Tissue Antigens", "date": "1999", "authors": "Baurain JF, Coulie PG", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "reference": [ { "type": "PubMed", "id": "10372547", "url": "https://glygen.org/publication/PubMed/10372547" } ] }, { "title": "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K", "evidence": [ { "database": "Reactome", "id": "R-HSA-909733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-909733" } ], "reference": [ { "type": "PubMed", "id": "10395669", "url": "https://glygen.org/publication/PubMed/10395669" } ] }, { "title": "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2172127", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2172127" } ], "reference": [ { "type": "PubMed", "id": "10449773", "url": "https://glygen.org/publication/PubMed/10449773" } ] }, { "title": "Recycling MHC class I molecules and endosomal peptide loading.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Gromme M, Uytdehaag FG, Janssen H, Calafat J, van Binnendijk RS, Kenter MJ, Tulp A, Verwoerd D, Neefjes J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236977", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236977" } ], "reference": [ { "type": "PubMed", "id": "10468607", "url": "https://glygen.org/publication/PubMed/10468607" } ] }, { "title": "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5.", "journal": "Tissue Antigens", "date": "1999", "authors": "van der Vlies SA, Voorter CE, van den Berg-Loonen EM", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "reference": [ { "type": "PubMed", "id": "10488744", "url": "https://glygen.org/publication/PubMed/10488744" } ] }, { "title": "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.", "journal": "The Journal of experimental medicine", "date": "1999", "authors": "Falco M, Biassoni R, Bottino C, Vitale M, Sivori S, Augugliaro R, Moretta L, Moretta A", "evidence": [ { "database": "Reactome", "id": "R-HSA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-198933" } ], "reference": [ { "type": "PubMed", "id": "10499918", "url": "https://glygen.org/publication/PubMed/10499918" } ] }, { "title": "Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-909733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-909733" } ], "reference": [ { "type": "PubMed", "id": "10542297", "url": "https://glygen.org/publication/PubMed/10542297" } ] }, { "title": "Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding.", "journal": "Journal of molecular biology", "date": "1999", "authors": "Neumann L, Tampe R", "evidence": [ { "database": 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-C genes.", "journal": "Genomics", "date": "1997", "authors": "Ando H., Chen L., Fukuzumi Y., Okumura K., Tashiro H., Watanabe K., Yamazaki M., Goto K., Inoko H., Ono A., Nakamura S., Ishihara M., Miyata S., Mizuki N., Ohno S., Shiina T., Ando A., Kimura M., Sugawara C., Ikemura T., Kikuti Y.Y., Taguchi S., Yonemoto J.", "evidence": [ { "database": "UniProtKB", "id": "O19617", "url": "https://www.uniprot.org/uniprot/O19617" } ], "reference": [ { "type": "PubMed", "id": "9177776", "url": "https://glygen.org/publication/PubMed/9177776" } ] }, { "title": "Cw*1701 defines a divergent african HLA-C allelic lineage.", "journal": "Immunogenetics", "date": "1997", "authors": "Wells RS, Seielstad MT, Bunce M, Tyan DB, Bekele E, Parham P", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "reference": [ { "type": "PubMed", "id": "9211742", "url": "https://glygen.org/publication/PubMed/9211742" } ] }, { "title": "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC", "evidence": [ { "database": "Reactome", "id": "R-HSA-909733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-909733" } ], "reference": [ { "type": "PubMed", "id": "9242679", "url": "https://glygen.org/publication/PubMed/9242679" } ] }, { "title": "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.", "journal": "Immunity", "date": "1997", "authors": "Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-198933" } ], "reference": [ { "type": "PubMed", "id": "9285412", "url": "https://glygen.org/publication/PubMed/9285412" } ] }, { "title": "p46, a novel natural 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"common_name": "Human" }, { "uniprot_canonical_ac": "P01898-1", "protein_name": "H-2 class I histocompatibility antigen, Q10 alpha chain", "gene_name": "H2-Q10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAMAPRTLLLLLAAALAPTQTQAGSHSMRYFETSVSRPGLGEPRFIIVGYVDDTQFVRFDSDAETPRMEPRAPWMEQEGPEYWERETQRAKGNEQSFHVSLRTLLGYYNQSESGSHTIQWMYGCKVGSDGRFLRGYLQYAYDGRDYIALNEDLKTWTAADVAAIITRRKWEQAGAAEYYRAYLEAECVEWLLRYLELGKETLLRTDPPKTHVTHHPGSEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPSTDSIMSHIADLLWPSLKLWWYL", "length": 325 }, "evidence": [ { "id": "45225857", "url": "http://www.informatics.jax.org/homology/45225857", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P01901-1", "protein_name": "H-2 class I histocompatibility antigen, K-B alpha chain", "gene_name": "H2-K1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPCTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNMATVAVLVVLGAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA", "length": 369 }, "evidence": [ { "id": "45225865", "url": "http://www.informatics.jax.org/homology/45225865", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04439-1", "protein_name": "HLA class I histocompatibility antigen, A alpha chain", "gene_name": "HLA-A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV", "length": 365 }, "evidence": [ { "id": "45225861", "url": "http://www.informatics.jax.org/homology/45225861", "database": "MGI" }, { "id": "45225862", "url": "http://www.informatics.jax.org/homology/45225862", "database": "MGI" }, { "id": "45225864", "url": "http://www.informatics.jax.org/homology/45225864", "database": "MGI" }, { "id": "45225865", "url": "http://www.informatics.jax.org/homology/45225865", "database": "MGI" }, { "id": "45225844", "url": "http://www.informatics.jax.org/homology/45225844", "database": "MGI" }, { "id": "45225842", "url": "http://www.informatics.jax.org/homology/45225842", "database": "MGI" }, { "id": "45225854", "url": "http://www.informatics.jax.org/homology/45225854", "database": "MGI" }, { "id": "45225857", "url": "http://www.informatics.jax.org/homology/45225857", "database": "MGI" }, { "id": "45225836", "url": "http://www.informatics.jax.org/homology/45225836", "database": "MGI" }, { "id": "45225839", "url": "http://www.informatics.jax.org/homology/45225839", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P13747-1", "protein_name": "HLA class I histocompatibility antigen, alpha chain E", "gene_name": "HLA-E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL", "length": 358 }, "evidence": [ { "id": "45225861", "url": "http://www.informatics.jax.org/homology/45225861", "database": "MGI" }, { "id": "45225862", "url": "http://www.informatics.jax.org/homology/45225862", "database": "MGI" }, { "id": "45225863", "url": "http://www.informatics.jax.org/homology/45225863", "database": "MGI" }, { "id": "45225864", "url": "http://www.informatics.jax.org/homology/45225864", "database": "MGI" }, { "id": "45225865", "url": "http://www.informatics.jax.org/homology/45225865", "database": "MGI" }, { "id": "45225847", "url": "http://www.informatics.jax.org/homology/45225847", "database": "MGI" }, { "id": "45225844", "url": "http://www.informatics.jax.org/homology/45225844", "database": "MGI" }, { "id": "45225845", "url": "http://www.informatics.jax.org/homology/45225845", "database": "MGI" }, { "id": "45225842", "url": "http://www.informatics.jax.org/homology/45225842", "database": "MGI" }, { "id": "45225843", "url": "http://www.informatics.jax.org/homology/45225843", "database": "MGI" }, { "id": "45225840", "url": "http://www.informatics.jax.org/homology/45225840", "database": "MGI" }, { "id": "45224697", "url": "http://www.informatics.jax.org/homology/45224697", "database": "MGI" }, { "id": "45224698", "url": "http://www.informatics.jax.org/homology/45224698", "database": "MGI" }, { "id": "45225850", "url": "http://www.informatics.jax.org/homology/45225850", "database": "MGI" }, { "id": "45225853", "url": "http://www.informatics.jax.org/homology/45225853", "database": "MGI" }, { "id": "45225852", "url": "http://www.informatics.jax.org/homology/45225852", "database": "MGI" }, { "id": "45225855", "url": "http://www.informatics.jax.org/homology/45225855", "database": "MGI" }, { "id": "45225854", "url": "http://www.informatics.jax.org/homology/45225854", "database": "MGI" }, { "id": "45225857", "url": "http://www.informatics.jax.org/homology/45225857", "database": "MGI" }, { "id": "45225859", "url": "http://www.informatics.jax.org/homology/45225859", "database": "MGI" }, { "id": "45225858", "url": "http://www.informatics.jax.org/homology/45225858", "database": "MGI" }, { "id": "45225837", "url": "http://www.informatics.jax.org/homology/45225837", "database": "MGI" }, { "id": "45225836", "url": "http://www.informatics.jax.org/homology/45225836", "database": "MGI" }, { "id": "45225834", "url": "http://www.informatics.jax.org/homology/45225834", "database": "MGI" }, { "id": "45225839", "url": "http://www.informatics.jax.org/homology/45225839", "database": "MGI" }, { "id": "45225838", "url": "http://www.informatics.jax.org/homology/45225838", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P14427-1", "protein_name": "H-2 class I histocompatibility antigen, D-P alpha chain", "gene_name": "H2-D1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPRTLLLLLAAALAPTQTRAGPHSLRYFVTAVSRPGLGKPRYMEVGYVDNTEFVRFDSDAENPRMKPRVRWMEQEGPEYWEQETQNAKDHEQSFRVSLRNLLGYYNQSKGGSHTIQGMRGCDVGSDWRLLRGYEQFAYDGPDYIALNEDLKTWTAADMAAQITRRKWEQAGAAETLRAYLEGACVEWLRRYLELGNATLLCTDPPKAHVTHHPRSEGKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAALVVPLGKEQNYTCHVEHEGLPEPLTLRWEPPPSTDSYMVIVAVLVVLGAVFIIGAVVAFVMMMRRNTGGKGGDYTLAPGSQSSEMSLRDCKVMVHDSHSLA", "length": 368 }, "evidence": [ { "id": "45225839", "url": "http://www.informatics.jax.org/homology/45225839", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P14429-1", "protein_name": "H-2 class I histocompatibility antigen, Q7 alpha chain", "gene_name": "H2-Q7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTMLLLLVAAALTLIETRAGQHSLQYFHTAVSRPGLGEPWFISVGYVDDTQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQIAKGHEQSFRGSLRTAQSYYNQSKGGSHTLQWMYGCDMGSDGRLLRGYLQFAYEGRDYIALNEDLKTWTAVDMAAQITRRKWEQAGIAEKDQAYLEGTCMQSLRRYLQLGKETLLRTDPPKAHVTHHPRSYGAVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVNHEGLPEPLTLRWGRWEPPPYTVSNMATIAVVVDLGAVAIIGAVVAFVMNRR", "length": 334 }, "evidence": [ { "id": "45225844", "url": "http://www.informatics.jax.org/homology/45225844", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P14432-1", "protein_name": "H-2 class I histocompatibility antigen, TLA(B) alpha chain", "gene_name": "H2-T3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRMGTPVPGTLLILLAASQGQTQTCPGSHSLRYFYTALSRPAISEPWYIAVGYLDDTQFVRFNSSGETATYKLSAPWVEQEGPEYWARETEIVTSNAQFFRENLQTMLDYYNLSQNGSHTIQVMYGCEVEFFGSLFRAYEQHGYDGPDYIALNEDLKTWTAADTAAEITRSKWEQAGYTELRRTYLEGPCKDSLLRYLENRKKTQECTDPPKTHVTHHPRPEGYVTLRCWALRFYPADITLTWQLNGEELIQDTELVETRPAGDGTFQKWAAVVVPLGKEQKYTCHVYHEGLPEPLTLRWEPPQTSMPNRTTVRALLGAMIILGFMSGSVMMWMRKNNGGNGDDNTAAYQNEREHLSLDPRAESEALGVEAGMKDLPSAPPLVS", "length": 384 }, "evidence": [ { "id": "45225840", "url": "http://www.informatics.jax.org/homology/45225840", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P17693-1", "protein_name": "HLA class I histocompatibility antigen, alpha chain G", "gene_name": "HLA-G", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD", "length": 338 }, "evidence": [ { "id": "45225861", "url": "http://www.informatics.jax.org/homology/45225861", "database": "MGI" }, { "id": "45225865", "url": "http://www.informatics.jax.org/homology/45225865", "database": "MGI" }, { "id": "45225847", "url": "http://www.informatics.jax.org/homology/45225847", "database": "MGI" }, { "id": "45225844", "url": "http://www.informatics.jax.org/homology/45225844", "database": "MGI" }, { "id": "45225845", "url": "http://www.informatics.jax.org/homology/45225845", "database": "MGI" }, { "id": "45225842", "url": "http://www.informatics.jax.org/homology/45225842", "database": "MGI" }, { "id": "45224698", "url": "http://www.informatics.jax.org/homology/45224698", "database": "MGI" }, { "id": "45225852", "url": "http://www.informatics.jax.org/homology/45225852", "database": "MGI" }, { "id": "45225855", "url": "http://www.informatics.jax.org/homology/45225855", "database": "MGI" }, { "id": "45225854", "url": "http://www.informatics.jax.org/homology/45225854", "database": "MGI" }, { "id": "45225857", "url": "http://www.informatics.jax.org/homology/45225857", "database": "MGI" }, { "id": "45225859", "url": "http://www.informatics.jax.org/homology/45225859", "database": "MGI" }, { "id": "45225837", "url": "http://www.informatics.jax.org/homology/45225837", "database": "MGI" }, { "id": "45225836", "url": "http://www.informatics.jax.org/homology/45225836", "database": "MGI" }, { "id": "45225834", "url": "http://www.informatics.jax.org/homology/45225834", "database": "MGI" }, { "id": "45225839", "url": "http://www.informatics.jax.org/homology/45225839", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P30511-1", "protein_name": "HLA class I histocompatibility antigen, alpha chain F", "gene_name": "HLA-F", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV", "length": 346 }, "evidence": [ { "id": "45225861", "url": "http://www.informatics.jax.org/homology/45225861", "database": "MGI" }, { "id": "45225865", "url": "http://www.informatics.jax.org/homology/45225865", "database": "MGI" }, { "id": "45225847", "url": "http://www.informatics.jax.org/homology/45225847", "database": "MGI" }, { "id": "45225844", "url": "http://www.informatics.jax.org/homology/45225844", "database": "MGI" }, { "id": "45225845", "url": "http://www.informatics.jax.org/homology/45225845", "database": "MGI" }, { "id": "45225842", "url": "http://www.informatics.jax.org/homology/45225842", "database": "MGI" }, { "id": "45224698", "url": "http://www.informatics.jax.org/homology/45224698", "database": "MGI" }, { "id": "45225852", "url": "http://www.informatics.jax.org/homology/45225852", "database": "MGI" }, { "id": "45225855", "url": "http://www.informatics.jax.org/homology/45225855", "database": "MGI" }, { "id": "45225854", "url": "http://www.informatics.jax.org/homology/45225854", "database": "MGI" }, { "id": "45225857", "url": "http://www.informatics.jax.org/homology/45225857", "database": "MGI" }, { "id": "45225859", "url": "http://www.informatics.jax.org/homology/45225859", "database": "MGI" }, { "id": "45225837", "url": "http://www.informatics.jax.org/homology/45225837", "database": "MGI" }, { "id": "45225836", "url": "http://www.informatics.jax.org/homology/45225836", "database": "MGI" }, { "id": "45225834", "url": "http://www.informatics.jax.org/homology/45225834", "database": "MGI" }, { "id": "45225839", "url": "http://www.informatics.jax.org/homology/45225839", "database": "MGI" }, { "id": "45225838", "url": "http://www.informatics.jax.org/homology/45225838", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P79568-1", "protein_name": "Histocompatibility 2, Q region locus 6", "gene_name": "H2-Q6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTTLLLLVAAALTLIETRAGPHSLRYFHTAVSWPGLVEPRFIIVGYVDNKQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQKAKGHEESFRVSLRTAQRYYNQSKGGSHTLQWMYGCDVGSDERLLRGYLQFAYEGRDYIALNEDLKTWTAADMAAQITLHKWEQAGIAERDRAYLEGACVQSLRRYLQLRKETLLCTDPPKAHVTHHPRSYGAVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVNHEGLPEPLTLRWEPPPSTVSNMANVAILVVLVAWPSLELWWIL", "length": 326 }, "evidence": [ { "id": "45225842", "url": "http://www.informatics.jax.org/homology/45225842", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q0WXH6-1", "protein_name": "MHC class Ib T9", "gene_name": "Gm7030", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTLTSCPLLLLLLATALAPTRAGKSSHSLRYFATAMSRPGLGEPRFTAVGYVDDTQFMRFDSDSENPRAEPCKPWVEQMEPEYWEQETRKFKEHTQNFRTCLYNLLHLYNQSQDGPHTIQDMHGCYVGPDGQFLHGHYQHAYDGHDYITLNEDLSSWTAADAVAQITQHKWEEAGVAEEYKAYLEGTCVETLHRLLEEAQQHSDPPNTHVTRHPRPEGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPFGEEPRYTCHVYH", "length": 285 }, "evidence": [ { "id": "45225838", "url": "http://www.informatics.jax.org/homology/45225838", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q31615-1", "protein_name": "Histocompatibility 2, T region locus 22", "gene_name": "H2-T22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSWVLRAAVVCALLLQLDARPSWTRIPLGSHSLRYFYTAVSRPGLGEPWFIIVGYVDDMQVLRFSSKEETPRMAPWLEQEEADNWEQQTRIVTIQGQLSERNLMTLVHFYNKSMDDSHTLQWLQGCDVEPDRHLCLWYNQLAYDSEDLPTLNENPSSCTVGNSTVPHISQDLKSHCSDLLQKYLEKGKERLLRSDPPKAHVTRHPRPEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQSYTCHVYHEGLPEPLILRWEPAWYQKPWIWIVAMVFILFIICLCVVCICMKKNAGGRGRRDTQEAGRDSPQDSSKTVVDDEEMGVCFWKIKSCKTCLGHSPGTSVGESLLSP", "length": 379 }, "evidence": [ { "id": "45224698", "url": "http://www.informatics.jax.org/homology/45224698", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6W9J5-1", "protein_name": "MHC class Ib antigen", "gene_name": "RT1-M2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METSAILTLHLLLSASLALTQSFKGSHSLRYFDIAVSRPGLEETHYMTLGYVDDTEFVHFNNEAVNPRFEPRVPWMEQMGQKYWDDQTRIAKVAEQQIRVYFQKLRGYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADSAAEITHREWKATNEAEFWRVYLEGPCMVWLFKYLTVGNETLLRADPPKVYVTHHPRPEGDITLRCWALGFYPSDITLIWQRDGEDLTQDMDVIETRPAGDGTFQKWAAVVVPSGKEQNYTCYVEHEGLPEPLTLRWSRPPQSFIPTIVVAVGLVLLGASVVTLVIWKKSSGGGRGSLRFLSN", "length": 344 }, "evidence": [ { "id": "45225847", "url": "http://www.informatics.jax.org/homology/45225847", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6W9L1-1", "protein_name": "MHC class Ib antigen", "gene_name": "H2-M2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METSAFFTLLFTLYLLLGASLALAQTFKGSHSLRYFDIAVSRPGLEETHYMTVGYVDDTEFVHFDNEAENPRFEPRVPWMEQMGQKYWDDQTRIAKAAEQQIRVYFQKLRDYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADAAAEITRREWEATNVAEFWRVYLEGPCMVWLFKYLTVGNETLLRTEPPKAYVTHHPRPEGDVTLRCWALGFYPSDIIMIWQRDGEDQTQDMDVIETRPAGDGTFQKWVAVVVPSGKEQNYTCHVAHEGLPEPLTLRWSRPPQSFIFIIIVAVGLVLLGASVATLVMWKKSSGGERGSL", "length": 343 }, "evidence": [ { "id": "45225847", "url": "http://www.informatics.jax.org/homology/45225847", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q85ZW5-1", "protein_name": "Histocompatibility 2, M region locus 10.6", "gene_name": "H2-M10.6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKPGPWDLLLLLMAIDLTQYCAGSHWLQIFNIVILEPGMLEARFIQVGYVDSIQFQGFDSKEPNARMQPRAAWMKQEPPEYWEKETAKALSFSLSGRRILKYMMSANKDKNNGYHTLQEVYGCNVANDGSFLEGHYRLTYYGYDSLILNEDLNSWTAEGEVGEKFKTYQEQGGMTESWRTYLLGECVERLLRCLDLGKKTLLHSDAPRTHVTHHVRPEGNVTLRCWALGFYPADITMTWKRDGKNHTQDMELPDTRPAGDGTFQKWAAVVVPPGEELRYTCHVNHEGLPGPLTLKWEPPHTIPIIAILIGLVLGALVVGTVVIFLVWKN", "length": 330 }, "evidence": [ { "id": "45225834", "url": "http://www.informatics.jax.org/homology/45225834", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q85ZW6-1", "protein_name": "Histocompatibility 2, M region locus 10.3", "gene_name": "H2-M10.3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNPGCCTLLLLLVAMDLNQYCAGSHWLQTFNIAFLEPGMINSRFIHIGYVDSIQYQGFDSKEPMAILKPRAAWMEQELPKYWNVETTKILLLSQIERRILYFMIEKYEHRMNDYHTLQEVYGCNVATDGRFLHGHFRLTYYGYDYLTLNEDLSSWTAEGKGAEYMKNRWENMSEAERWKTYLRGECVQRLLRYLDLGKETLLRSDAPRTHVTHHVRPEGNVTLRCWALGFYPADITLTWKRDGNNLTQDMELPDTRPAGDGTFQKWAAVVVPSGEELRYTCHVHHEGLPEPLTLKWEPPQTIPIIAILIGLVLGTLVVGTVVIFLVWKK", "length": 330 }, "evidence": [ { "id": "45225853", "url": "http://www.informatics.jax.org/homology/45225853", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q85ZW7-1", "protein_name": "Histocompatibility 2, M region locus 10.5", "gene_name": "H2-M10.5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNPGCCTLLLLLVAMDLIQYCAGSHWLQTFNAVILEPGMVNSRFVHIGYVDSIEYQRYDSKEPIAVLLPRVAWMEQVPMTYWTSETASVAELSQLDRRILHFMVNKNEQRMDDYHTLQEVYGCNVANDGSFLGGHFRLTYYGYDDLYLNENLSSWIAHGNAAEYVKSRWDGEGDAERWKTYLQGVCVERLLRYMVLGKEALLRSDAPRTHVTHHVRPEGNVTLRCWALGFYPADITMTWKRDGNNHTQDMELPDTRPAGDGTFQKWAAVVVPSGEELRYTCHVHHKGLPEPLKLKWEPPHTIPIIAILIGLVLGTLVVGTVVIFLVWKK", "length": 330 }, "evidence": [ { "id": "45225863", "url": "http://www.informatics.jax.org/homology/45225863", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q85ZW8-1", "protein_name": "Histocompatibility 2, M region locus 10.4", "gene_name": "H2-M10.4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNPGHFAILCLLLVTIDRPQYCEGSHWLKTFRIVIMEPGILEPRFIQVSYVDSIQYQGFDSRSETAGMQPRAAWMKQEPPEYWKNETEHAMGASLLARRTLIYMVTENNNKKNDYHTLQEVFGCNVAHDGSFLGGHYGLTYYGYDYIILNEDLNSWTTEGKVGGKFNPDRTQGSVTEGWRTYLKGECTERFLRCLDLGKETLLRSDAPRTHVTHKVTPEGNVTLRCWALGFYPADITLTWKRDGKNHTQDMELPDTRPAGDGTFQKWAAVVVPFGEELRYTCHVHHEGLPGPLTLKWGPPQTIPIIAILIGLVLVALVVGTVVIFLVWRK", "length": 331 }, "evidence": [ { "id": "45225845", "url": "http://www.informatics.jax.org/homology/45225845", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q85ZW9-1", "protein_name": "Histocompatibility 2, M region locus 10.2", "gene_name": "H2-M10.2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNPGPCNFLLLLVALDLTQYCAGSHWLQTFNTVILKHGTLEPRIIQVGYVDSIQYQGFDSKEPTARMQPRAAWMEQEPPEYWEKETAQVLRLSLTNERLLRYMMIYNEQSNEEYHTLQEVFGCNVDNDGSFLGGLYRLTYYGYEFINLNEDLSSWTAQGEAAGFLKTDLVNVGAAEGWRTYLLGECTERLLRCLDLGKETLLRSDAPRTHVTHHVRPEGNVTLRCWALGFYPADITLTWKRDGKNYTQDMELPDTRPAGDGTFQKWAAVVVPSGEELRYTCHVHHEGLPEPLTLKWEPPQTIPIIAILIGLVLGTFLVGTVVVFLVWKK", "length": 329 }, "evidence": [ { "id": "45225837", "url": "http://www.informatics.jax.org/homology/45225837", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8HWB2-1", "protein_name": "Histocompatibility 2, Q region locus 4", "gene_name": "H2-Q4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTMLLLLVAVAQTLIEIRAAPRPAPLPARSPAGGPGRSSGSHRALPPGPHLLSYFYTSVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGNEQIFRVNLRTLLSYYNQSAGGSHTIQVISGCEVGSDGRLLRGYQQFAYDGRDYIALNEDLKTWTAADMAAQITRRKWEQAGATEKSKAYLEGACVQSLRRYLELGKETLLRTDPPKAHVTCHHRSDGDVTLRCWALGFYPANIILTWQLNGEELTQDMELVETRPSGDGTFQKWASVVVPLGKEQNYTCHVHHEGLPEPLTLRWEPPPSTVSNMANVAVLVVLGAWPSLQLWWLL", "length": 354 }, "evidence": [ { "id": "45225862", "url": "http://www.informatics.jax.org/homology/45225862", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 16, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "phagocytic vesicle membrane", "id": "GO:0030670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030670", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "lumenal side of endoplasmic reticulum membrane", "id": "GO:0098553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098553", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "secretory granule membrane", "id": "GO:0030667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030667", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "MHC class I protein complex", "id": "GO:0042612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042612", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "antigen processing and presentation", "id": "GO:0019882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019882", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib", "id": "GO:0002476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002476", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "id": "GO:0002486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002486", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "peptide antigen binding", "id": "GO:0042605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042605", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" }, { "name": "TAP binding", "id": "GO:0046977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046977", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading.", "evidence": [ { "database": "UniProtKB", "id": "P10321", "url": "https://www.uniprot.org/uniprot/P10321" }, { "database": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" }, { "database": "PubMed", "id": "18420581", "url": "https://glygen.org/publication/PubMed/18420581" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": 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