{ "uniprot_canonical_ac": "P10107-1", "uniprot_ac": "P10107", "uniprot_id": "ANXA1_MOUSE", "mass": { "chemical_mass": 38734.0, "monoisotopic_mass": 38734.0 }, "refseq": { "ac": "NP_034860", "name": "annexin A1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" }, "gene_names": [ { "name": "Anxa1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10107", "id": "P10107" }, { "name": "Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "id": "NP_034860" }, { "name": "Anx1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10107", "id": "P10107" }, { "name": "Anxa1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "id": "NP_034860" }, { "name": "Lpc-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10107", "id": "P10107" }, { "name": "Lpc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10107", "id": "P10107" } ], "protein_names": [ { "name": "Annexin A1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10107" }, { "name": "Annexin I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Annexin-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Calpactin II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Calpactin-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Chromobindin-9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Lipocortin I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "Phospholipase A2 inhibitory protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" }, { "name": "annexin A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "id": "NP_034860" }, { "name": "p35; annexin I; annexin-1; calpactin II; lipocortin I; chromobindin-9; phospholipase A2 inhibitory protein; calpactin-2; lipocortin 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "id": "NP_034860" }, { "name": "p35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10107" } ], "function": [ { "annotation": "ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" }, { "database": "PubMed", "id": "37566399", "url": "https://glygen.org/publication/PubMed/37566399" } ] }, { "annotation": "ANXA1 is identified as a key gene associated with high risk and T cell infiltration in primary sclerosing cholangitis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" }, { "database": "PubMed", "id": "37735492", "url": "https://glygen.org/publication/PubMed/37735492" } ] }, { "annotation": "Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.", "evidence": [ { "database": "UniProtKB", "id": "A0A494BBD8", "url": "https://www.uniprot.org/uniprot/A0A494BBD8#function" }, { "database": "UniProtKB", "id": "ARBA00029398", "url": "https://www.uniprot.org/uniprot/ARBA00029398#function" }, { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107#function" }, { "database": "UniProtKB", "id": "P04083", "url": "https://www.uniprot.org/uniprot/P04083#function" } ] }, { "annotation": "Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:12475898). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (PubMed:12475898). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17948261). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17948261). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes (PubMed:21245195). Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (PubMed:21245195).", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107#function" }, { "database": "PubMed", "id": "17948261", "url": "https://glygen.org/publication/PubMed/17948261" }, { "database": "UniProtKB", "id": "P04083", "url": "https://www.uniprot.org/uniprot/P04083#function" }, { "database": "UniProtKB", "id": "P19619", "url": "https://www.uniprot.org/uniprot/P19619#function" }, { "database": "PubMed", "id": "21245195", "url": "https://glygen.org/publication/PubMed/21245195" }, { "database": "PubMed", "id": "12475898", "url": "https://glygen.org/publication/PubMed/12475898" }, { "database": "PubMed", "id": "25664854", "url": "https://glygen.org/publication/PubMed/25664854" } ] }, { "annotation": "Suppression of VEGF and inflammatory cytokines, modulation of Annexin A1 and organ functions by galloylquinic acids in breast cancer model. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" }, { "database": "PubMed", "id": "37507468", "url": "https://glygen.org/publication/PubMed/37507468" } ] }, { "annotation": "The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" }, { "database": "PubMed", "id": "37373303", "url": "https://glygen.org/publication/PubMed/37373303" } ] } ], "disease": [ { "disease_id": "DOID:0060074", "recommended_name": { "id": "DOID:0060074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells." }, "synonyms": [], "evidence": [ { "id": "0060074", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ] }, { "disease_id": "DOID:0060180", "recommended_name": { "id": "DOID:0060180", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060180", "name": "colitis", "description": "An inflammatory bowel disease that involves inflammation located_in colon." }, "synonyms": [], "evidence": [ { "id": "0060180", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060180" } ] }, { "disease_id": "DOID:10140", "recommended_name": { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "dry eye syndrome", "description": "A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface." }, "synonyms": [ { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "Tear film insufficiency", "description": "" }, { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "dry eye disease", "description": "" } ], "evidence": [ { "id": "10140", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10140" } ] }, { "disease_id": "DOID:10247", "recommended_name": { "id": "DOID:10247", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10247", "name": "pleurisy", "description": "A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs." }, "synonyms": [], "evidence": [ { "id": "10247", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10247" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "evidence": [ { "id": "10534", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:13141", "recommended_name": { "id": "DOID:13141", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid." }, "synonyms": [], "evidence": [ { "id": "13141", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ] }, { "disease_id": "DOID:1350", "recommended_name": { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "paranasal sinus benign neoplasm", "description": "" }, "synonyms": [ { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "neoplasm of accessory sinus", "description": "" }, { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "tumor of Accessory sinus", "description": "" } ], "evidence": [ { "id": "1350", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1350" } ] }, { "disease_id": "DOID:1459", "recommended_name": { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone." }, "synonyms": [ { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid deficiency", "description": "" }, { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid insufficiency", "description": "" } ], "evidence": [ { "id": "1459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ] }, { "disease_id": "DOID:1749", "recommended_name": { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell carcinoma", "description": "A carcinoma that derives_from squamous epithelial cells." }, "synonyms": [ { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "epidermoid carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "malignant squamous cell tumor", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell Epithelioma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell cancer", "description": "" } ], "evidence": [ { "id": "1749", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1749" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:2671", "recommended_name": { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells." }, "synonyms": [ { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional carcinoma", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell tumor", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "urothelial cell carcinoma", "description": "" } ], "evidence": [ { "id": "2671", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ] }, { "disease_id": "DOID:2734", "recommended_name": { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "keratosis follicularis", "description": "" }, "synonyms": [ { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "DARIER-WHITE DISEASE", "description": "" }, { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "Darier's disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease", "description": "Darier disease (DD) is a keratinization disorder characterized by the development of keratotic papules in seborrheic areas and specific nail anomalies." }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier's disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier-White disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "keratosis follicularis", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "DAR", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier White disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease, acral hemorrhagic type", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease, segmental", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "dar", "description": "" }, { "id": "MIM:124200", "resource": "MIM", "url": "https://www.omim.org/entry/124200", "name": "Darier disease", "description": "Darier disease" } ], "evidence": [ { "id": "2734", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2734" } ] }, { "disease_id": "DOID:3008", "recommended_name": { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated." }, "synonyms": [ { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Infiltrating ductal carcinoma of breast", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Invasive ductal carcinoma, NST", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "ductal adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3008", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ] }, { "disease_id": "DOID:3021", "recommended_name": { "id": "DOID:3021", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3021", "name": "acute kidney failure", "description": "" }, "synonyms": [], "evidence": [ { "id": "3021", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3021" } ] }, { "disease_id": "DOID:3069", "recommended_name": { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "malignant astrocytoma", "description": "A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord." }, "synonyms": [ { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "Astrocytic tumor", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of Cerebrum", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of brain", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astroglioma", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "cerebral astrocytoma", "description": "" } ], "evidence": [ { "id": "3069", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3069" } ] }, { "disease_id": "DOID:326", "recommended_name": { "id": "DOID:326", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:326", "name": "ischemia", "description": "A vascular disease that is characterized by a restriction in blood supply to tissues." }, "synonyms": [], "evidence": [ { "id": "326", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:326" } ] }, { "disease_id": "DOID:3526", "recommended_name": { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "cerebral infarction", "description": "A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain." }, "synonyms": [ { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "CVA - Cerebral infarction", "description": "" }, { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "Cerebral infarct", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "obsolete susceptibility to ischemic stroke", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "ischemic stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebrovascular accident", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic", "description": "" }, { "id": "MIM:601367", "resource": "MIM", "url": "https://www.omim.org/entry/601367", "name": "Ischemic stroke", "description": "Ischemic stroke" } ], "evidence": [ { "id": "3526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3526" } ] }, { "disease_id": "DOID:3770", "recommended_name": { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation." }, "synonyms": [ { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "Fibrosis of lung", "description": "" } ], "evidence": [ { "id": "3770", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ] }, { "disease_id": "DOID:4450", "recommended_name": { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney." }, "synonyms": [ { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "RCC", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "adenocarcinoma of kidney", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "hypernephroma", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, papillary, 1", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "RCCX1", "description": "" } ], "evidence": [ { "id": "4450", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ] }, { "disease_id": "DOID:6498", "recommended_name": { "id": "DOID:6498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6498", "name": "seborrheic keratosis", "description": "" }, "synonyms": [ { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "seborrheic keratosis", "description": "A common benign skin neoplasm usually affecting older individuals. The lesions usually are multiple and arise in the face, chest, and shoulders. They appear as black or brown, slightly elevated skin lesions." }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "basal cell papilloma", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis Seborrheica", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis, seborrheic, somatic", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis, seborrheic", "description": "" }, { "id": "MIM:182000", "resource": "MIM", "url": "https://www.omim.org/entry/182000", "name": "Keratosis, seborrheic", "description": "Keratosis, seborrheic" } ], "evidence": [ { "id": "6498", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6498" } ] }, { "disease_id": "DOID:7998", "recommended_name": { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "hyperthyroidism", "description": "A thyroid gland disease that involves an over production of thyroid hormone." }, "synonyms": [ { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "overactive thyroid", "description": "" } ], "evidence": [ { "id": "7998", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:7998" } ] }, { "disease_id": "DOID:83", "recommended_name": { "id": "DOID:83", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision." }, "synonyms": [ { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1 multiple types", "description": "Any cataract (disease) in which the cause of the disease is a mutation in the GJA8 gene." }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CTRCT1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "Duffy linked cataract", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "GJA8 cataract (disease)", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract (disease) caused by mutation in GJA8", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types, with or without microcornea", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CAE1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CZP1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "zonular pulverulent cataract 1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, Duffy-linked", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, zonular pulverulent, 1", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "early-onset non-syndromic cataract", "description": "Early-onset non-syndromic cataract is a rare, genetic, non-syndromic developmental defect of the eye, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected." }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "cataract, age-related nuclear", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "nuclear sclerosis of the lens", "description": "" }, { "id": "MIM:116200", "resource": "MIM", "url": "https://www.omim.org/entry/116200", "name": "Cataract 1, multiple types", "description": "Cataract 1, multiple types" } ], "evidence": [ { "id": "83", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:83" } ] }, { "disease_id": "DOID:8893", "recommended_name": { "id": "DOID:8893", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales." }, "synonyms": [ { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "Any psoriasis in which the cause of the disease is a mutation in the HLA-C gene." }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "HLA-C psoriasis", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis caused by mutation in HLA-C", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis susceptibility 1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "PSORS1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "susceptibility to psoriasis 1", "description": "" }, { "id": "MIM:177900", "resource": "MIM", "url": "https://www.omim.org/entry/177900", "name": "Psoriasis 1", "description": "Psoriasis 1" } ], "evidence": [ { "id": "8893", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 257, "end_pos": 257, "sequence_org": "K", "sequence_mut": "R", "comment": "Strongly decreased sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" }, { "database": "PubMed", "id": "23727357", "url": "https://glygen.org/publication/PubMed/23727357" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Anxa1", "url": "https://www.uniprot.org/uniprot/P10107", "locus": { "chromosome": "19", "start_pos": 20350792, "end_pos": 20368308, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000024659", "url": "https://www.ensembl.org/id/ENSMUSG00000024659" } ] } } ], "crossref": [ { "id": "ENSMUSG00000024659", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "16952", "url": "https://www.ncbi.nlm.nih.gov/gene/16952", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P10107", "url": "https://www.ebi.ac.uk/intact/interactors/id:P10107*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16952", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16952", "database": "KEGG Pathway", "categories": [ "Enzyme and 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"database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P10107", "url": "http://purl.obolibrary.org/obo/PR_P10107", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-444473", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-444473", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A494BBD8", "url": "https://www.uniprot.org/uniprot/A0A494BBD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBD8-1", "url": "https://www.uniprot.org/uniprot/A0A494BBD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10107-1", "url": "https://www.uniprot.org/uniprot/P10107-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN", "length": 346, "header": "sp|P10107-1|ANXA1_MOUSE Isoform 1 of Annexin A1 OS=Mus musculus OX=10090 GN=Anxa1 PE=1 SV=2 CANONICAL=P10107-1" }, "isoforms": [ { "isoform_ac": "A0A494BBD8-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKDITALFDLKRNMLLH", "length": 302, "header": "tr|A0A494BBD8-1|ANXA1_MOUSE Computationally mapped isoform of Annexin A1 OS=Mus musculus OX=10090 GN=Anxa1 PE=1 SV=1 CANONICAL=P10107-1" }, "locus": { "chromosome": "19", "start_pos": 20362122, "end_pos": 20353865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000171423.9", "url": "https://www.ensembl.org/id/ENSMUST00000171423.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158429.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158429.2" } ] } }, { "isoform_ac": "P10107-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN", "length": 346, "header": "sp|P10107-1|ANXA1_MOUSE Isoform 1 of Annexin A1 OS=Mus musculus OX=10090 GN=Anxa1 PE=1 SV=2 CANONICAL=P10107-1" }, "locus": { "chromosome": "19", "start_pos": 20362122, "end_pos": 20351081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235280", "url": "https://www.ensembl.org/id/ENSMUST00000235280" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158305", "url": "https://www.ensembl.org/id/ENSMUSP00000158305" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P10107", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10107" }, { "id": "21540332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21540332" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "24788674", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24788674" }, { "id": "25153642", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25153642" } ] } ], "phosphorylation": [ { "start_pos": 136, "end_pos": 136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "site_lbl": "Thr136" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" }, { "database": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" }, { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "site_lbl": "Tyr21" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKC", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" }, { "database": "phospho.ELM", "id": "P10107", "url": "http://phospho.elm.eu.org/byAccession/P10107.html" }, { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" }, { "database": "PubMed", "id": "16720734", "url": "https://glygen.org/publication/PubMed/16720734" }, { "database": "PubMed", "id": "11482905", "url": "https://glygen.org/publication/PubMed/11482905" }, { "database": "PubMed", "id": "26803520", "url": "https://glygen.org/publication/PubMed/26803520" }, { "database": "PubMed", "id": "27426034", "url": "https://glygen.org/publication/PubMed/27426034" }, { "database": "PubMed", "id": "32133417", "url": "https://glygen.org/publication/PubMed/32133417" }, { "database": "PubMed", "id": "33580028", "url": "https://glygen.org/publication/PubMed/33580028" } ], "site_lbl": "Ser27" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "site_lbl": "Ser34" }, { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "site_lbl": "Ser37" }, { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by TRPM7", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" }, { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" }, { "database": "PubMed", "id": "27426034", "url": "https://glygen.org/publication/PubMed/27426034" } ], "site_lbl": "Ser5" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Implication of annexin 1 in phagocytosis: effects of n-terminal domain deletions and point mutations of the phosphorylation site Ser-27.", "journal": "Cell biology international", "date": "2001", "authors": "Kusumawati A, Liautard JP, Sri Widada J", "evidence": [ { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "11482905", "url": "https://glygen.org/publication/PubMed/11482905" } ] }, { "title": "Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.", "journal": "FASEB J.", "date": "2003", "authors": "Perretti M., Yona S., Flower R.J., Morris J.F., Buckingham J.C., Croxtall J.D., Gavins F.N., Getting S.J., Hannon R., Paul-Clark M.J., Roviezzo F.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "12475898", "url": "https://glygen.org/publication/PubMed/12475898" } ] }, { "title": "Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH Jr", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "14506282", "url": "https://glygen.org/publication/PubMed/14506282" } ] }, { "title": "Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2006", "authors": "Solito E, Christian HC, Festa M, Mulla A, Tierney T, Flower RJ, Buckingham JC", "evidence": [ { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "16720734", "url": "https://glygen.org/publication/PubMed/16720734" } ] }, { "title": "Mouse lipocortin I gene structure and chromosomal assignment: gene duplication and the origins of a gene family.", "journal": "Genomics", "date": "1991", "authors": "Horlick KR, Cheng IC, Wong WT, Wakeland EK, Nick HS", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "1676980", "url": "https://glygen.org/publication/PubMed/1676980" } ] }, { "title": "CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway.", "journal": "Am. J. Physiol.", "date": "2007", "authors": "Paavola K.J., Reynolds P.R., Snyder J.C., Reynolds S.D., Stripp B.R., Whyte F.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "17384087", "url": "https://glygen.org/publication/PubMed/17384087" } ] }, { "title": "Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells.", "journal": "Eur. J. Immunol.", "date": "2007", "authors": "Perretti M., D'Acquisto F., Flower R.J., Merghani A., Paschalidis N., Sampaio A.L.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "17948261", "url": "https://glygen.org/publication/PubMed/17948261" } ] }, { "title": "Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.", "journal": "Br. J. Pharmacol.", "date": "2008", "authors": "Perretti M., D'Acquisto F., Flower R.J.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "18641677", "url": "https://glygen.org/publication/PubMed/18641677" } ] }, { "title": "Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.", "journal": "J. Immunol.", "date": "2008", "authors": "Koch S., Perretti M., Flower R.J., Nusrat A., Parkos C.A., Lee W.Y., Babbin B.A., Capaldo C.T., Laukoetter M.G., Nava P., Peatman E., Severson E.A.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "18802107", "url": "https://glygen.org/publication/PubMed/18802107" } ] }, { "title": "Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.", "journal": "Nat. Rev. Immunol.", "date": "2009", "authors": "Perretti M., D'Acquisto F.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "19104500", "url": "https://glygen.org/publication/PubMed/19104500" } ] }, { "title": "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" }, { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" } ] }, { "title": "Annexin A1 is a new functional linker between actin filaments and phagosomes during phagocytosis.", "journal": "J. Cell Sci.", "date": "2011", "authors": "Gerke V., Kuznetsov S.A., Ahmad S.F., Patel D.M., Weiss D.G.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "21245195", "url": "https://glygen.org/publication/PubMed/21245195" } ] }, { "title": "Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Zaro BW, Yang YY, Hang HC, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10107", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10107" } ], "reference": [ { "type": "PubMed", "id": "21540332", "url": "https://glygen.org/publication/PubMed/21540332" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10107", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10107" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation.", "journal": "Cell. Signal.", "date": "2013", "authors": "Caron D, Maaroufi H, Michaud S, Tanguay RM, Faure RL", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "23727357", "url": "https://glygen.org/publication/PubMed/23727357" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.", "journal": "PloS one", "date": "2014", "authors": "Gurel Z, Zaro BW, Pratt MR, Sheibani N", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10107", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10107" } ], "reference": [ { "type": "PubMed", "id": "24788674", "url": "https://glygen.org/publication/PubMed/24788674" } ] }, { "title": "Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification.", "journal": "Journal of the American Chemical Society", "date": "2014", "authors": "Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10107", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10107" } ], "reference": [ { "type": "PubMed", "id": "25153642", "url": "https://glygen.org/publication/PubMed/25153642" } ] }, { "title": "cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1989", "authors": "Rose-John S., Fuerstenberger G., Marks F., Philipps C., Rincke G.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "2522299", "url": "https://glygen.org/publication/PubMed/2522299" } ] }, { "title": "Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.", "journal": "J. Clin. Invest.", "date": "2015", "authors": "Nishio H., Perretti M., Alam A., Argyris I., Farokhzad O.C., Fredman G., Hilgarth R.S., Jones H.R., Kamaly N., Kusters D., Leoni G., Neish A.S., Neumann P.A., Nusrat A., Parkos C.A., Quiros M., Reutelingsperger C., Rijcken E., Sumagin R.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "25664854", "url": "https://glygen.org/publication/PubMed/25664854" } ] }, { "title": "The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.", "journal": "International immunopharmacology", "date": "2016", "authors": "Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ", "evidence": [ { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "26803520", "url": "https://glygen.org/publication/PubMed/26803520" } ] }, { "title": "Annexin A1 translocates to nucleus and promotes the expression of pro-inflammatory cytokines in a PKC-dependent manner after OGD/R.", "journal": "Scientific reports", "date": "2016", "authors": "Zhao B, Wang J, Liu L, Li X, Liu S, Xia Q, Shi J", "evidence": [ { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "27426034", "url": "https://glygen.org/publication/PubMed/27426034" } ] }, { "title": "Mouse lipocortin I cDNA.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Sato K., Suzuki R., Sakata T., Teraoka H., Tsuruta Y., Hojo K., Iwagami S.", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "reference": [ { "type": "PubMed", "id": "2974946", "url": "https://glygen.org/publication/PubMed/2974946" } ] }, { "title": "Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.", "journal": "NPJ science of food", "date": "2020", "authors": "Kabe Yasuaki, Takemoto Daisuke, Kanai Ayaka, Hirai Miwa, Ono Yoshiko, Akazawa Sota, Horikawa Manabu, Kitagawa Yoshinori, Handa Hiroshi, Rogi Tomohiro, Shibata Hiroshi, Suematsu Makoto", "evidence": [ { "database": "iPTMnet", "id": "P10107", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10107" } ], "reference": [ { "type": "PubMed", "id": "32133417", "url": "https://glygen.org/publication/PubMed/32133417" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10107", "url": 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"date": "2023-07-28", "authors": "Abd El-Salam Mohamed, El-Tanbouly Ghada, Bastos Jairo, Metwaly Heba", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" } ], "reference": [ { "type": "PubMed", "id": "37507468", "url": "https://glygen.org/publication/PubMed/37507468" } ] }, { "title": "ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.", "journal": "Cancer immunology research", "date": "2023-10-04", "authors": "Xiao Ding, Zeng Ting, Zhu Wei, Yu Zheng-Zheng, Huang Wei, Yi Hong, Lu Shan-Shan, Feng Juan, Feng Xue-Ping, Wu Di, Wen Qi, Zhou Jian-Hua, Yuan Li, Zhuang Wei, Xiao Zhi-Qiang", "evidence": [ { "database": "RefSeq", "id": "NP_034860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034860" } ], "reference": [ { "type": "PubMed", "id": "37566399", "url": "https://glygen.org/publication/PubMed/37566399" } ] }, { "title": "ANXA1 is identified as a 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"" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "pmid": "" }, { "name": "peptide cross-linking", "id": "GO:0018149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018149", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "pmid": "" }, { "name": "positive regulation of vesicle fusion", "id": "GO:0031340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031340", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "pmid": "" }, { "name": "actin cytoskeleton reorganization", "id": "GO:0031532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031532", "evidence": [ { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107" } ], "pmid": "" }, { "name": "positive 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