{ "uniprot_canonical_ac": "P09938-1", "uniprot_ac": "P09938", "uniprot_id": "RIR2_YEAST", "mass": { "chemical_mass": 46147.0, "monoisotopic_mass": 46147.0 }, "refseq": { "ac": "NP_012508", "name": "ribonucleotide-diphosphate reductase subunit RNR2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012508" }, "gene_names": [ { "name": "RNR2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09938", "id": "P09938" }, { "name": "CRT6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012508", "id": "NP_012508" }, { "name": "CRT6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09938", "id": "P09938" }, { "name": "J1271", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09938", "id": "P09938" }, { "name": "RNR2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012508", "id": "NP_012508" } ], "protein_names": [ { "name": "Ribonucleoside-diphosphate reductase small chain 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09938" }, { "name": "1.17.4.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09938" }, { "name": "Ribonucleotide reductase R2 subunit 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09938" }, { "name": "Ribonucleotide reductase small subunit 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09938" }, { "name": "ribonucleotide-diphosphate reductase subunit RNR2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012508", "id": "NP_012508" } ], "function": [ { "annotation": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938#function" }, { "database": "PubMed", "id": "10535923", "url": "https://glygen.org/publication/PubMed/10535923" } ] } ], "disease": [ { "disease_id": "DOID:0070331", "recommended_name": { "id": "DOID:0070331", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070331", "name": "mitochondrial DNA depletion syndrome 8b", "description": "A mitochondrial DNA depletion syndrome that is characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy, and brain MRI changes, known as the MNGIE phenotype, and has_material_basis_in autosomal recessive homozygous or compound heterozygous mutation in the ribonucleotide reductase M2 B gene on chromosome 8q22." }, "synonyms": [ { "id": "DOID:0070331", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070331", "name": "mitochondrial neurogastrointestinal encephalopathy syndrome, RRM2B-related", "description": "" } ], "evidence": [ { "id": "0070331", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070331" } ] }, { "disease_id": "DOID:0080127", "recommended_name": { "id": "DOID:0080127", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080127", "name": "mitochondrial DNA depletion syndrome 8a", "description": "A mitochondrial DNA depletion syndrome that is characterized by neonatal hypotonia, lactic acidosis, and neurologic deterioration, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the ribonucleotide reductase regulatory TP53 inducible subunit M2B gene on chromosome 8q22." }, "synonyms": [ { "id": "DOID:0080127", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080127", "name": "RRM2B-related mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome 8a", "description": "Any mitochondrial DNA depletion syndrome in which the cause of the disease is a mutation in the RRM2B gene." }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "RRM2B mitochondrial DNA depletion syndrome", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome caused by mutation in RRM2B", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome type 8a", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mtDNA depletion syndrome, encephalomyopathic form with renal tubulopathy", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "MTDPS8A", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "Mngie, Rrm2B-related", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "RRM2B-related mitochondrial DNA depletion syndrome", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "encephalomyopathic type with renal tubulopathy", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy)", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome 8B (Mngie type)", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial DNA depletion syndrome, encephalomyopathic, with renal tubulopathy, autosomal recessive", "description": "" }, { "id": "MONDO:0012792", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012792", "name": "mitochondrial neurogastrointestinal encephalopathy syndrome, Rrm2B-related", "description": "" }, { "id": "MIM:612075", "resource": "MIM", "url": "https://www.omim.org/entry/612075", "name": "Mitochondrial DNA depletion syndrome 8A", "description": "Mitochondrial DNA depletion syndrome 8A" } ], "evidence": [ { "id": "0080127", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080127" } ] }, { "disease_id": "DOID:0111518", "recommended_name": { "id": "DOID:0111518", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111518", "name": "autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5", "description": "A chronic progressive external ophthalmoplegia that has_material_basis_in heterozygous mutation in the RRM2B gene on chromosome 8q22.3." }, "synonyms": [ { "id": "DOID:0111518", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111518", "name": "autosomal dominant progressive external ophthalmoplegia 5", "description": "" }, { "id": "DOID:0111518", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111518", "name": "PEOA5", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5", "description": "Any progressive external ophthalmoplegia with mitochondrial DNA deletions in which the cause of the disease is a mutation in the RRM2B gene." }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "RRM2B progressive external ophthalmoplegia with mitochondrial DNA deletions", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions caused by mutation in RRM2B", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant type 5", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "PEOA5", "description": "" }, { "id": "MONDO:0013117", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013117", "name": "progressive external ophthalmoplegia, autosomal dominant 5", "description": "" }, { "id": "MIM:613077", "resource": "MIM", "url": "https://www.omim.org/entry/613077", "name": "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5", "description": "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5" } ], "evidence": [ { "id": "0111518", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111518" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ], "evidence": [ { "id": "11054", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:2870", "recommended_name": { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial adenocarcinoma", "description": "An endometrial carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial endometrioid adenocarcinoma with squamous differentiation", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "adenocarcinoma of endometrium", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "adenocarcinoma of the Endometrium", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "adenocarcinoma of uterus", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial adenoacanthoma", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrial endometrioid adenocarcinoma", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrioid adenoma or carcinoma", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrioid adenomas and carcinomas", "description": "" }, { "id": "DOID:2870", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2870", "name": "endometrioid carcinoma of Endometrium", "description": "" } ], "evidence": [ { "id": "2870", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2870" } ] }, { "disease_id": "DOID:3459", "recommended_name": { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "Mammary carcinoma", "description": "" }, { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "carcinoma of breast", "description": "" } ], "evidence": [ { "id": "3459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ 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Natl. Acad. Sci. U.S.A.", "date": "1999", "authors": "Ge J., Nguyen H.-H.T., Perlstein D.L., Stubbe J.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "10535923", "url": "https://glygen.org/publication/PubMed/10535923" } ] }, { "title": "Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Graeslund A., Liu A., Thelander L., Larsson G., Chabes A., Wijmenga S., Domkin V.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "10716984", "url": "https://glygen.org/publication/PubMed/10716984" } ] }, { "title": "Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2001", "authors": "Ge J., Voegtli W.C., Rosenzweig A.C., Perlstein D.L., Stubbe J.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "11526233", "url": "https://glygen.org/publication/PubMed/11526233" } ] }, { "title": "Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Huang M., Zhang Z., An X., Yao R., Perlstein D.L., Stubbe J., Bucci B.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "12732713", "url": "https://glygen.org/publication/PubMed/12732713" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers.", "journal": "Biochemistry", "date": "2004", "authors": "Ge J., Voegtli W.C., Rosenzweig A.C., Sommerhalter M., Perlstein D.L., Stubbe J.", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" } ], "reference": [ { "type": "PubMed", "id": "15196016", "url": "https://glygen.org/publication/PubMed/15196016" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-02-13", "authors": "Chi An, Huttenhower Curtis, Geer Lewis Y, Coon Joshua J, Syka John E P, Bai Dina L, Shabanowitz Jeffrey, Burke Daniel J, Troyanskaya Olga G, Hunt Donald F", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.", "journal": "Mol. Cell", "date": "2008", "authors": "Lee Yang David, Wang Jun, Stubbe Joanne, Elledge Stephen J", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "18851834", "url": "https://glygen.org/publication/PubMed/18851834" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P09938", "url": "https://www.uniprot.org/uniprot/P09938" }, { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ] }, { "title": "The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.", "journal": "Molecular biology of the cell", "date": "2010-10-01", "authors": "Soulard Alexandre, Cremonesi Alessio, Moes Suzette, Sch\u00fctz Fr\u00e9d\u00e9ric, Jen\u00f6 Paul, Hall Michael N", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.", "journal": "Science signaling", "date": "2010-12-21", "authors": "Bodenmiller Bernd, Wanka Stefanie, Kraft Claudine, Urban J\u00f6rg, Campbell David, Pedrioli Patrick G, Gerrits Bertran, Picotti Paola, Lam Henry, Vitek Olga, Brusniak Mi-Youn, Roschitzki Bernd, Zhang Chao, Shokat Kevan M, Schlapbach Ralph, Colman-Lerner Alejandro, Nolan Garry P, Nesvizhskii Alexey I, Peter Matthias, Loewith Robbie, von Mering Christian, Aebersold Ruedi", "evidence": [ { "database": "iPTMnet", "id": "P09938", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09938" } ], "reference": [ { "type": 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