{ "uniprot_canonical_ac": "P09810-1", "uniprot_ac": "P09810", "uniprot_id": "TPH1_RAT", "mass": { "chemical_mass": 51068.0, "monoisotopic_mass": 51068.0 }, "refseq": { "ac": "NP_001094104", "name": "tryptophan 5-hydroxylase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, "gene_names": [ { "name": "Tph1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09810", "id": "P09810" }, { "name": "Tph1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "id": "NP_001094104" }, { "name": "Tph", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "id": "NP_001094104" }, { "name": "Tph", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09810", "id": "P09810" } ], "protein_names": [ { "name": "Tryptophan 5-hydroxylase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09810" }, { "name": "1.14.16.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09810" }, { "name": "Tryptophan 5-monooxygenase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09810" }, { "name": "tryptophan 5-hydroxylase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "id": "NP_001094104" }, { "name": "tryptophan 5-monooxygenase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "id": "NP_001094104" } ], "function": [ { "annotation": "Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. Erratum:[PLoS One. 2022 Apr 27;17(4):e0267927. PMID: 35476793] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, { "database": "PubMed", "id": "33750988", "url": "https://glygen.org/publication/PubMed/33750988" } ] }, { "annotation": "Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810#function" }, { "database": "PubMed", "id": "12354109", "url": "https://glygen.org/publication/PubMed/12354109" } ] }, { "annotation": "Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, { "database": "PubMed", "id": "32641996", "url": "https://glygen.org/publication/PubMed/32641996" } ] }, { "annotation": "The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase.", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, { "database": "PubMed", "id": "31124080", "url": "https://glygen.org/publication/PubMed/31124080" } ] }, { "annotation": "Tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Further histochemical analysis revealed that the induction of TPH1 in the liver could be attributed to infiltration of mast cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, { "database": "PubMed", "id": "31997472", "url": "https://glygen.org/publication/PubMed/31997472" } ] }, { "annotation": "Ursolic acid derivatives targeted to tryptophan hydroxylase 1 prevented bone loss by suppressing serotonin biosynthesis without estrogenic side-effects in ovariectomized rats.", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" }, { "database": "PubMed", "id": "25930119", "url": "https://glygen.org/publication/PubMed/25930119" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0060249", "recommended_name": { "id": "DOID:0060249", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060249", "name": "scoliosis", "description": "A bone structure disease characterized by an appreciable lateral deviation in the normally straight vertical line of the spine." }, "synonyms": [], "evidence": [ { "id": "0060249", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060249" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:10930", "recommended_name": { "id": "DOID:10930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10930", "name": "borderline personality disorder", "description": "A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods." }, "synonyms": [], "evidence": [ { "id": "10930", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10930" } ] }, { "disease_id": "DOID:1094", "recommended_name": { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit hyperactivity disorder", "description": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age." }, "synonyms": [ { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "ADHD", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit disorder", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "hyperkinetic disorder", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "ADHD3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "ADHD2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "ADHD1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "ADHD4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0100518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100518", "name": "hereditary attention deficit-hyperactivity disorder", "description": "An instance of attention deficit-hyperactivity disorder that is caused by an inherited genomic modification in an individual." }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "ADHD6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "digit span quantitative trait locus", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "ADHD5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "motor timing quantitative trait locus", "description": "" } ], "evidence": [ { "id": "1094", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1094" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "evidence": [ { "id": "1574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] }, { "disease_id": "DOID:1596", "recommended_name": { "id": "DOID:1596", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1596", "name": "depressive disorder", "description": "A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function." }, "synonyms": 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perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia, susceptibility to", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "evidence": [ { "id": "5419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] }, { "disease_id": "DOID:9478", "recommended_name": { "id": "DOID:9478", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9478", "name": "postpartum depression", "description": "An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth." }, "synonyms": [ { "id": "DOID:9478", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9478", "name": "Maternity blues", "description": "" }, { "id": "DOID:9478", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9478", "name": "postnatal depression", "description": "" } ], "evidence": [ { "id": "9478", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9478" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tph1", "url": "https://www.uniprot.org/uniprot/P09810", "locus": { "chromosome": "1", "start_pos": 97157409, "end_pos": 97178344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011672", "url": "https://www.ensembl.org/id/ENSRNOG00000011672" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011672", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011672", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03346", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03346", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04929", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04929", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4809", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4809", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "24848", "url": "https://www.ncbi.nlm.nih.gov/gene/24848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24848", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VTCQEEC", "url": "https://omabrowser.org/oma/group/VTCQEEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275463at2759", "url": "http://www.orthodb.org/?query=275463at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11473", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11473", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11473:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11473:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00351", "url": "http://pfam.xfam.org/family/PF00351", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P09810", "url": "http://purl.obolibrary.org/obo/PR_P09810", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-209931", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-209931", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "3895", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3895", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "16709", "url": "https://www.rhea-db.org/rhea/16709", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P09810-1", "url": "https://www.uniprot.org/uniprot/P09810-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV", "length": 444, "header": "sp|P09810-1|TPH1_RAT Isoform 1 of Tryptophan 5-hydroxylase 1 OS=Rattus norvegicus OX=10116 GN=Tph1 PE=1 SV=2 CANONICAL=P09810-1" }, "isoforms": [ { "isoform_ac": "P09810-1", "url": "", "sequence": { "sequence": "MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV", "length": 444, "header": "sp|P09810-1|TPH1_RAT Isoform 1 of Tryptophan 5-hydroxylase 1 OS=Rattus norvegicus OX=10116 GN=Tph1 PE=1 SV=2 CANONICAL=P09810-1" }, "locus": { "chromosome": "1", "start_pos": 97176193, "end_pos": 97159856, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000056109", "url": "https://www.ensembl.org/id/ENSRNOT00000056109" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000052959", "url": "https://www.ensembl.org/id/ENSRNOP00000052959" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" }, { "database": "phospho.ELM", "id": "P09810", "url": "http://phospho.elm.eu.org/byAccession/P09810.html" }, { "database": "iPTMnet", "id": "P09810", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09810" }, { "database": "PubMed", "id": "9109552", "url": "https://glygen.org/publication/PubMed/9109552" }, { "database": "PubMed", "id": "18705647", "url": "https://glygen.org/publication/PubMed/18705647" } ], "site_lbl": "Ser58" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.", "journal": "Eur. J. Biochem.", "date": "2002", "authors": "Iida Y, Sawabe K, Kojima M, Oguro K, Nakanishi N, Hasegawa H", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "reference": [ { "type": "PubMed", "id": "12354109", "url": "https://glygen.org/publication/PubMed/12354109" } ] }, { "title": "Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons.", "journal": "Brain Res. Mol. Brain Res.", "date": "1991", "authors": "Kim KS, Wessel TC, Stone DM, Carver CH, Joh TH, Park DH", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "reference": [ { "type": "PubMed", "id": "1645430", "url": "https://glygen.org/publication/PubMed/1645430" } ] }, { "title": "Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland.", "journal": "Journal of pineal research", "date": "2008", "authors": "Huang Z, Liu T, Chattoraj A, Ahmed S, Wang MM, Deng J, Sun X, Borjigin J", "evidence": [ { "database": "iPTMnet", "id": "P09810", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09810" } ], "reference": [ { "type": "PubMed", "id": "18705647", "url": "https://glygen.org/publication/PubMed/18705647" } ] }, { "title": "Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).", "journal": "European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences", "date": "2015", "authors": "Fu HJ, Zhao Y, Zhou YR, Bao BH, Du Y, Li JX", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" } ], "reference": [ { "type": "PubMed", "id": "25930119", "url": "https://glygen.org/publication/PubMed/25930119" } ] }, { "title": "Isolation of a rat pineal gland cDNA clone homologous to tyrosine and phenylalanine hydroxylases.", "journal": "FEBS Lett.", "date": "1986", "authors": "Darmon MC, Grima B, Cash CD, Maitre M, Mallet J", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "reference": [ { "type": "PubMed", "id": "2875901", "url": "https://glygen.org/publication/PubMed/2875901" } ] }, { "title": "The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1 (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase) mRNA Expressions in Rat Testes.", "journal": "Molecular neurobiology", "date": "2019", "authors": "Coelho LA, Andrade-Silva J, Motta-Teixeira LC, Amaral FG, Reiter RJ, Cipolla-Neto J", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" } ], "reference": [ { "type": "PubMed", "id": "31124080", "url": "https://glygen.org/publication/PubMed/31124080" } ] }, { "title": "Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.", "journal": "Cancer science", "date": "2020", "authors": "Hagiwara A, Nakamura Y, Nishimoto R, Ueno S, Miyagi Y", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" } ], "reference": [ { "type": "PubMed", "id": "31997472", "url": "https://glygen.org/publication/PubMed/31997472" } ] }, { "title": "Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.", "journal": "Theranostics", "date": "2020", "authors": "Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L, Wang X", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" } ], "reference": [ { "type": "PubMed", "id": "32641996", "url": "https://glygen.org/publication/PubMed/32641996" } ] }, { "title": "Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.", "journal": "PloS one", "date": "2021", "authors": "Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, Ohno H", "evidence": [ { "database": "RefSeq", "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104" } ], "reference": [ { "type": "PubMed", "id": "33750988", "url": "https://glygen.org/publication/PubMed/33750988" } ] }, { "title": "Sequence of two mRNAs encoding active rat tryptophan hydroxylase.", "journal": "J. Neurochem.", "date": "1988", "authors": "Mallet J., Guibert B., Darmon M.C., Ehret M., Leviel V., Maitre M.", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "reference": [ { "type": "PubMed", "id": "3379411", "url": "https://glygen.org/publication/PubMed/3379411" } ] }, { "title": "Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.", "journal": "Journal of neurochemistry", "date": "1997", "authors": "Kuhn DM, Arthur R Jr, States JC", "evidence": [ { "database": "iPTMnet", "id": "P09810", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09810" } ], "reference": [ { "type": "PubMed", "id": "9109552", "url": "https://glygen.org/publication/PubMed/9109552" } ] } ], "pathway": [ { "id": "rno:24848", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24848", "resource": "KEGG Pathway" }, { "id": "R-RNO-209931", "name": "Serotonin and melatonin biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-209931", "resource": "Reactome", "description": "Serotonin and melatonin biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P17532-1", "protein_name": "Tryptophan 5-hydroxylase 1", "gene_name": "Tph1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEDNKENKENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQLTAKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALARVTRWPSV", "length": 447 }, "evidence": [ { "id": "45225177", "url": "http://www.informatics.jax.org/homology/45225177", "database": "MGI" }, { "id": "P09810", "url": "https://omabrowser.org/oma/group/P09810/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P17752-1", "protein_name": "Tryptophan 5-hydroxylase 1", "gene_name": "TPH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI", "length": 444 }, "evidence": [ { "id": "45225177", "url": "http://www.informatics.jax.org/homology/45225177", "database": "MGI" }, { "id": "P09810", "url": "https://omabrowser.org/oma/group/P09810/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "tryptophan 5-monooxygenase activity", "id": "GO:0004510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004510", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "platelet degranulation", "id": "GO:0002576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002576", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "positive regulation of fat cell differentiation", "id": "GO:0045600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "bone remodeling", "id": "GO:0046849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046849", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "mammary gland alveolus development", "id": "GO:0060749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060749", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "negative regulation of ossification", "id": "GO:0030279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "serotonin biosynthetic process", "id": "GO:0042427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042427", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "serotonin biosynthetic process from tryptophan", "id": "GO:0006587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006587", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "regulation of hemostasis", "id": "GO:1900046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900046", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylated; triggering degradation by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" }, { "database": "PubMed", "id": "12354109", "url": "https://glygen.org/publication/PubMed/12354109" } ] }, { "annotation": "Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P09810", "url": "https://www.uniprot.org/uniprot/P09810" }, { "database": "PubMed", "id": "12354109", "url": "https://glygen.org/publication/PubMed/12354109" } ] } ], "interactions": [], "reactions": [ { "id": "16709", "name": "", "equation": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CGU9-1", "P09810-1", "Q8IWU9-1", "P17752-1", "P17532-1", "Q8CGV2-1", "Q54XS1-1", "P17276-1", "Q9W0K2-1" ], "evidence": [ { "id": "16709", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16709" } ] }, { "id": "R-RNO-209828", "name": "Tryptophan is hydroxylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29870", "R-ALL-29500" ], "output_participant_list": [ "R-ALL-209911" ], "enzyme_list": [ "Q8CGU9-1", "P09810-1" ], "evidence": [ { "id": "R-RNO-209828", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-209828" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-209911", "participant_name": "5HTP [cytosol]", "crossref": [ { "id": "58266", "database": "ChEBI", "url": "" }, { "id": "C00643", "database": "COMPOUND", "url": "" }, { "id": "000000895330", "database": "ZINC", "url": "" }, { "id": "C00643", "database": "COMPOUND", "url": "" }, { "id": "58266", "database": "ChEBI", "url": "" }, { "id": "000000895330", "database": "ZINC", "url": "" }, { "id": "000000895330", "database": "ZINC", "url": "" }, { "id": "C00643", "database": "COMPOUND", "url": "" }, { "id": "58266", "database": "ChEBI", "url": "" }, { "id": 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