{
    "uniprot_canonical_ac": "P08638-1",
    "uniprot_ac": "P08638",
    "uniprot_id": "LEUR_YEAST",
    "mass": {
        "chemical_mass": 100153.0,
        "monoisotopic_mass": 100153.0
    },
    "refseq": {
        "ac": "NP_013556",
        "name": "leucine-responsive transcriptional regulator LEU3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013556"
    },
    "gene_names": [
        {
            "name": "LEU3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P08638",
            "id": "P08638"
        },
        {
            "name": "L9324.1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P08638",
            "id": "P08638"
        },
        {
            "name": "LEU3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013556",
            "id": "NP_013556"
        }
    ],
    "protein_names": [
        {
            "name": "Regulatory protein LEU3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P08638"
        },
        {
            "name": "leucine-responsive transcriptional regulator LEU3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013556",
            "id": "NP_013556"
        }
    ],
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        {
            "annotation": "Factor for control of RNA levels of a group of leucine-specific genes.",
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                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
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            "common_name": "Yeast"
        }
    ],
    "gene": [
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            "name": "LEU3",
            "url": "https://www.uniprot.org/uniprot/P08638",
            "locus": {}
        }
    ],
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        {
            "id": "cd00067",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00067",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd12148",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12148",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "851172",
            "url": "https://www.ncbi.nlm.nih.gov/gene/851172",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P08638",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P08638*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001138",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001138",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036864",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036864",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YLR451W",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR451W",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
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        },
        {
            "id": "MLWKDVD",
            "url": "https://omabrowser.org/oma/group/MLWKDVD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2288884at2759",
            "url": "http://www.orthodb.org/?query=2288884at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31845",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31845",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31845:SF21",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31845:SF21",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2ER8",
            "url": "https://www.rcsb.org/structure/2ER8",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "2ERE",
            "url": "https://www.rcsb.org/structure/2ERE",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "2ERG",
            "url": "https://www.rcsb.org/structure/2ERG",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00172",
            "url": "http://pfam.xfam.org/family/PF00172",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P08638",
            "url": "http://purl.obolibrary.org/obo/PR_P08638",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_013556",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013556",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000004443",
            "url": "https://www.yeastgenome.org/locus/S000004443",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P08638",
            "url": "https://www.uniprot.org/uniprot/P08638",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P08638-1",
            "url": "https://www.uniprot.org/uniprot/P08638-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV",
        "length": 886,
        "header": "sp|P08638-1|LEUR_YEAST Isoform 1 of Regulatory protein LEU3  OS=Saccharomyces cerevisiae S288C OX=559292 GN=LEU3 PE=1 SV=1 CANONICAL=P08638-1"
    },
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        {
            "isoform_ac": "P08638-1",
            "url": "",
            "sequence": {
                "sequence": "MEGRSDFVATSQSGSEMSHSETRNRTGMNARKRKFACVECRQQKSKCDAHERAPEPCTKCAKKNVPCILKRDFRRTYKRARNEAIEKRFKELTRTLTNLTSDEILKKIEEEQEIVLDNSNFTKEKVKQLRKSAFETTEIEPRSYKTLRGEPISYSTNRRHTDSSPLTLLSSSTNFDPVHSTNVMTDDQLKCLPKSLGDVYLSSSDIAELFQEFATKYHQFLPVVDLSKGAERIYHLSPCLFWVILLIGLRRKFGATDLMTRLSVLVKSVLSEITISPIIRYTPSDKDEPVLNVASVYSVQAFLLYTFWPPLTSSLSADTSWNTIGTAMFQALRVGLNCAGFSKEYASANSELVNEQIRTWICCNVVSQTVASSFGFPAYVSFDYLVISSIRVPNSKSQVDIPNELRQMAQIARFENQIVNTMNSTPASVTGMVSQEEKQPLLHVLNQQLSQLEISLEENNLDDIRKFLLLVAKVHLLTYYFTDVTSQSAGKSNGNIYEGSYSIMELDTSFETKRGLVKVYNAAVNFLIHANSMWEHDPTIIKYFPGLFVLNIWQSACIISKLIHSSLHSMLDVNSGKKAYNNAISLTFNASVLKYDMAYRSSGIMRSIWSLFANMYDAWKNDQKEGGGRLNNDFNLGITIKSRMSVNVFFDCLYILKEKCGMAKLERETKVSTAYNVDEEEEEDEDEEGEEEEEEEELSSKVPENMDSQQLRTRKFTNVRHPEKKARKIIETIPLDPNPINAGSTSSGSSLTTPNSQVANTISYRGILNKMSPREQLNHANLDSSVSTDIKDTEAVNEPLPIGRNAEHPANQPPLSITQMQENTLPATQANSSLLETYPIVQSNPVTTTIKESPNSIMAGWDNWESDMVWRDVDILMNEFAFNPKV",
                "length": 886,
                "header": "sp|P08638-1|LEUR_YEAST Isoform 1 of Regulatory protein LEU3  OS=Saccharomyces cerevisiae S288C OX=559292 GN=LEU3 PE=1 SV=1 CANONICAL=P08638-1"
            },
            "locus": {
                "chromosome": "XII",
                "start_pos": 1038750,
                "end_pos": 1036093,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YLR451W_mRNA",
                        "url": "https://www.ensembl.org/id/YLR451W_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YLR451W",
                        "url": "https://www.ensembl.org/id/YLR451W"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 119,
            "end_pos": 119,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P08638",
                    "url": "https://www.yeastgenome.org/locus/P08638"
                },
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser119"
        },
        {
            "start_pos": 13,
            "end_pos": 13,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P08638",
                    "url": "https://www.yeastgenome.org/locus/P08638"
                },
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser13"
        },
        {
            "start_pos": 18,
            "end_pos": 18,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P08638",
                    "url": "https://www.yeastgenome.org/locus/P08638"
                },
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser18"
        },
        {
            "start_pos": 772,
            "end_pos": 772,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "SGD",
                    "id": "P08638",
                    "url": "https://www.yeastgenome.org/locus/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser772"
        },
        {
            "start_pos": 95,
            "end_pos": 95,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                }
            ],
            "site_lbl": "Thr95"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Global analysis of protein expression in yeast.",
            "journal": "Nature",
            "date": "2003",
            "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14562106",
                    "url": "https://glygen.org/publication/PubMed/14562106"
                }
            ]
        },
        {
            "title": "Nine-amino-acid transactivation domain: establishment and prediction utilities.",
            "journal": "Genomics",
            "date": "2007",
            "authors": "Nemethova M., Grabner M., Gregor M., Kovarik P., Piskacek M., Piskacek S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17467953",
                    "url": "https://glygen.org/publication/PubMed/17467953"
                }
            ]
        },
        {
            "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007-06-19",
            "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                }
            ]
        },
        {
            "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.",
            "journal": "Molecular & cellular proteomics : MCP",
            "date": "2008-07",
            "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                }
            ]
        },
        {
            "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.",
            "journal": "Science",
            "date": "2009",
            "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                },
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                }
            ]
        },
        {
            "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.",
            "journal": "BMC genomics",
            "date": "2010-12-02",
            "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                }
            ]
        },
        {
            "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.",
            "journal": "Nature methods",
            "date": "2013-07",
            "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P08638",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ]
        },
        {
            "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.",
            "journal": "G3 (Bethesda)",
            "date": "2014",
            "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24374639",
                    "url": "https://glygen.org/publication/PubMed/24374639"
                }
            ]
        },
        {
            "title": "LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes.",
            "journal": "Mol. Cell. Biol.",
            "date": "1987",
            "authors": "Schimmel P., Friden P.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2823102",
                    "url": "https://glygen.org/publication/PubMed/2823102"
                }
            ]
        },
        {
            "title": "Structure of yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control.",
            "journal": "Nucleic Acids Res.",
            "date": "1987",
            "authors": "Zhou K., Kohlhaw G.B., Brisco P.R.G., Hinkkanen A.E.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "3299266",
                    "url": "https://glygen.org/publication/PubMed/3299266"
                }
            ]
        },
        {
            "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.",
            "journal": "Nature",
            "date": "1997",
            "authors": "Ansorge W., Duesterhoeft A., Hillier L.W., Mewes H.-W., Obermaier B., Scharfe M., Wambutt R., Wedler H., Verhasselt P., Rose M., Benes V., Brueckner M., Rieger M., Portetelle D., Delius H., Schwarz S., Kleine K., Floeth M., Schwager C., Voss H., Hoheisel J.D., Dubois E., Volckaert G., Andre B., Koetter P., Entian K.-D., Louis E.J., Vandenbol M., Johnston M., Pohl T.M., Goffeau A., Hani J., Hilger F., Messenguy F., Miosga T., Mueller-Auer S., Scherens B., Zimmermann F.K., Zollner A., Purnelle B., Urrestarazu L.A., Vierendeels F., Voet M., Albermann K., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Moestl D., Nentwich U., Piravandi E., Rechmann S., Riles L., Rinke M., Scholler P., Underwood A.P., Wedler E.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08638",
                    "url": "https://www.uniprot.org/uniprot/P08638"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9169871",
                    "url": "https://glygen.org/publication/PubMed/9169871"
                }
            ]
        }
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