{ "uniprot_canonical_ac": "P08635-1", "uniprot_ac": "P08635", "uniprot_id": "SAST_RAT", "mass": { "chemical_mass": 29471.0, "monoisotopic_mass": 29471.0 }, "refseq": { "ac": "NP_073196", "name": "S-acyl fatty acid synthase thioesterase, medium chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196" }, "gene_names": [ { "name": "Olah", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08635", "id": "P08635" }, { "name": "Mch; Thedc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "id": "NP_073196" }, { "name": "Mch", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08635", "id": "P08635" }, { "name": "Olah", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "id": "NP_073196" }, { "name": "Thedc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08635", "id": "P08635" } ], "protein_names": [ { "name": "S-acyl fatty acid synthase thioesterase, medium chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08635" }, { "name": "3.1.2.14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08635" }, { "name": "Medium-chain S-acyl fatty acid synthetase thioester hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08635" }, { "name": "Oleoyl-ACP hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08635" }, { "name": "S-acyl fatty acid synthase thioesterase, medium chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "id": "NP_073196" }, { "name": "Thioesterase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08635" }, { "name": "Thioesterase domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08635" }, { "name": "thioesterase domain-containing protein 1; medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH); thioesterase domain containing 1; thioesterase II; medium-chain S-acyl fatty acid synthetase thioester hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "id": "NP_073196" } ], "function": [ { "annotation": "Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635#function" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "annotation": "Sex differences in the response of MCH neurons to glucose correlated well with the gonadal steroid milieu.", "evidence": [ { "database": "RefSeq", "id": "NP_073196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196" }, { "database": "PubMed", "id": "15905320", "url": "https://glygen.org/publication/PubMed/15905320" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 101, "end_pos": 101, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of thioesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 101, "end_pos": 101, "sequence_org": "S", "sequence_mut": "C", "comment": "Decreased thioesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 236, "end_pos": 236, "sequence_org": "D", "sequence_mut": "A", "comment": "Moderately decreased thioesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 237, "end_pos": 237, "sequence_org": "H", "sequence_mut": "A", "comment": "Loss of thioesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 262, "end_pos": 262, "sequence_org": "L", "sequence_mut": "A", "comment": "Strongly decreased thioesterase activity with FASN-bound fatty acids. No effect on thioesterase activity with free decanoyl coenzyme A.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 262, "end_pos": 263, "sequence_org": "LT", "sequence_mut": "", "comment": "Strongly decreased thioesterase activity with FASN-bound fatty acids. No effect on thioesterase activity with free decanoyl coenzyme A.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] }, { "start_pos": 263, "end_pos": 263, "sequence_org": "T", "sequence_mut": "V", "comment": "No effect on thioesterase activity.", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" }, { "database": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "common_name": "Rat" } ], "gene": [ { "name": "Olah", "url": "https://www.uniprot.org/uniprot/P08635", "locus": { "chromosome": "17", "start_pos": 74902518, "end_pos": 74877655, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000016403", "url": "https://www.ensembl.org/id/ENSRNOG00000016403" } ] } } ], "crossref": [ { "id": "ENSRNOG00000016403", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016403", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "64669", "url": "https://www.ncbi.nlm.nih.gov/gene/64669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:64669", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64669", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKVISCF", "url": "https://omabrowser.org/oma/group/EKVISCF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2913944at2759", "url": "http://www.orthodb.org/?query=2913944at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11487", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11487", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11487:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11487:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00975", "url": "http://pfam.xfam.org/family/PF00975", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P08635", "url": "http://purl.obolibrary.org/obo/PR_P08635", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_073196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621115", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621115", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "15057", "url": "https://www.rhea-db.org/rhea/15057", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16645", "url": "https://www.rhea-db.org/rhea/16645", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30135", "url": "https://www.rhea-db.org/rhea/30135", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40059", "url": "https://www.rhea-db.org/rhea/40059", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40119", "url": "https://www.rhea-db.org/rhea/40119", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6GAB2", "url": "https://www.uniprot.org/uniprot/A0A8I6GAB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GAB2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GAB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08635-1", "url": "https://www.uniprot.org/uniprot/P08635-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT", "length": 263, "header": "sp|P08635-1|SAST_RAT Isoform 1 of S-acyl fatty acid synthase thioesterase, medium chain OS=Rattus norvegicus OX=10116 GN=Olah PE=1 SV=1 CANONICAL=P08635-1" }, "isoforms": [ { "isoform_ac": "A0A8I6GAB2-1", "url": "", "sequence": { "sequence": "LELVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT", "length": 252, "header": "tr|A0A8I6GAB2-1|A0A8I6GAB2_RAT Computationally mapped isoform of oleoyl-[acyl-carrier-protein] hydrolase OS=Rattus norvegicus OX=10116 GN=Olah PE=3 SV=1 CANONICAL=P08635-1" }, "locus": { "chromosome": "17", "start_pos": 74902087, "end_pos": 74881728, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000097965.1", "url": "https://www.ensembl.org/id/ENSRNOT00000097965.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083086.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083086.1" } ] } }, { "isoform_ac": "P08635-1", "url": "", "sequence": { "sequence": "METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRETRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVSGASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIFDKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKCLELSSLT", "length": 263, "header": "sp|P08635-1|SAST_RAT Isoform 1 of S-acyl fatty acid synthase thioesterase, medium chain OS=Rattus norvegicus OX=10116 GN=Olah PE=1 SV=1 CANONICAL=P08635-1" }, "locus": { "chromosome": "17", "start_pos": 74902087, "end_pos": 74878897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000022043", "url": "https://www.ensembl.org/id/ENSRNOT00000022043" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000022043", "url": "https://www.ensembl.org/id/ENSRNOP00000022043" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding protein.", "journal": "Endocrinology", "date": "2005", "authors": "Mogi K, Funabashi T, Mitsushima D, Hagiwara H, Kimura F", "evidence": [ { "database": "RefSeq", "id": "NP_073196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196" } ], "reference": [ { "type": "PubMed", "id": "15905320", "url": "https://glygen.org/publication/PubMed/15905320" } ] }, { "title": "Amino acid sequence of the serine active-site region of the medium-chain S-acyl fatty acid synthetase thioester hydrolase from rat mammary gland.", "journal": "Eur. J. Biochem.", "date": "1987", "authors": "Randhawa ZI, Naggert J, Blacher RW, Smith S", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "reference": [ { "type": "PubMed", "id": "3104035", "url": "https://glygen.org/publication/PubMed/3104035" } ] }, { "title": "Molecular cloning and sequence analysis of complementary DNA encoding rat mammary gland medium-chain S-acyl fatty acid synthetase thio ester hydrolase.", "journal": "Biochemistry", "date": "1987", "authors": "Safford R, de Silva J, Lucas C, Windust JH, Shedden J, James CM, Sidebottom CM, Slabas AR, Tombs MP, Hughes SG", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "reference": [ { "type": "PubMed", "id": "3105579", "url": "https://glygen.org/publication/PubMed/3105579" } ] }, { "title": "Complete amino acid sequence of the medium-chain S-acyl fatty acid synthetase thio ester hydrolase from rat mammary gland.", "journal": "Biochemistry", "date": "1987", "authors": "Randhawa ZI, Smith S", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "reference": [ { "type": "PubMed", "id": "3567174", "url": "https://glygen.org/publication/PubMed/3567174" } ] }, { "title": "Cloning and sequencing of the medium-chain S-acyl fatty acid synthetase thioester hydrolase cDNA from rat mammary gland.", "journal": "Biochem. J.", "date": "1987", "authors": "Naggert J, Williams B, Cashman DP, Smith S", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "reference": [ { "type": "PubMed", "id": "3632637", "url": "https://glygen.org/publication/PubMed/3632637" } ] }, { "title": "Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1993", "authors": "Tai MH, Chirala SS, Wakil SJ", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "reference": [ { "type": "PubMed", "id": "8446599", "url": "https://glygen.org/publication/PubMed/8446599" } ] } ], "pathway": [ { "id": "rno:64669", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64669", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8R197-1", "protein_name": "S-acyl fatty acid synthase thioesterase, medium chain", "gene_name": "Olah", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METAVYAKSTRNEKVLNCLCQKPDALFKLICFPWAGGGSTHFAKWGRKINGLLEVHAVRLAGRETRFEEPFSNDIYQIAEEVVTALLPIIRDKAFAFFGHSFGSYIAFITALHLKEKYKMEPLHIFVSSASAPHSEFRPQVPDINKLSEEQIRDHLLIFGGTPKHLIEDQDFLKQCIPLLKADVDIVKKFIFDKPSKALLSRDITCFIGSEDVVKDIEGWKDITSGKFDVLKLPGDHFYLMEPNNEDFIKNYIVKCLELSSLDYF", "length": 265 }, "evidence": [ { "id": "45238348", "url": "http://www.informatics.jax.org/homology/45238348", "database": "MGI" }, { "id": "P08635", "url": "https://omabrowser.org/oma/group/P08635/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NV23-1", "protein_name": "S-acyl fatty acid synthase thioesterase, medium chain", "gene_name": "OLAH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRLPGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQPEPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFGGTPKHFAEAKEFVKQCSPIIRADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPGGHFYLLDPANEKLIKNYIIKCLEVSSISNF", "length": 265 }, "evidence": [ { "id": "45238348", "url": "http://www.informatics.jax.org/homology/45238348", "database": "MGI" }, { "id": "P08635", "url": "https://omabrowser.org/oma/group/P08635/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid biosynthetic process", "id": "GO:0008610", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008610", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "medium-chain fatty acid biosynthetic process", "id": "GO:0051792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051792", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "palmitoyl-CoA hydrolase activity", "id": "GO:0016290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016290", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "myristoyl-CoA hydrolase activity", "id": "GO:0102991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102991", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "oleoyl-[acyl-carrier-protein] hydrolase activity", "id": "GO:0004320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004320", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "myristoyl-[acyl-carrier-protein] hydrolase activity", "id": "GO:0016295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016295", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "palmitoyl-[acyl-carrier-protein] hydrolase activity", "id": "GO:0016296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016296", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "dodecanoyl-[acyl-carrier-protein] hydrolase activity", "id": "GO:0047381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047381", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" }, { "name": "acyl-[acyl-carrier-protein] hydrolase activity", "id": "GO:0016297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016297", "evidence": [ { "database": "UniProtKB", "id": "P08635", "url": "https://www.uniprot.org/uniprot/P08635" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15057", "name": "", "equation": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08635-1", "Q9NV23-1", "Q8R197-1", "P07149-1" ], "evidence": [ { "id": "15057", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15057" } ] }, { "id": "16645", "name": "", "equation": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P80250-1", "P13437-1", "P97570-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q8N1Q8-1", "Q6ZUV0-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "O60733-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "P97819-1", "Q8R197-1", "Q9CQR4-1", "P41903-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "30135", "name": "", "equation": "dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "30135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30135" } ] }, { "id": "40059", "name": "", "equation": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "O00154-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q8BWT1-1", "Q3UUI3-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40059", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40059" } ] }, { "id": "40119", "name": "", "equation": "H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P13437-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q8N1Q8-1", "O00154-1", "Q14032-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "Q8R197-1", "Q9CQR4-1" ], "evidence": [ { "id": "40119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40119" } ] }, { "id": "R-RNO-5655945", "name": "Olah hydrolyzes decanoyl-Fasn dimer to decanoate and Fasn dimer", "equation": "", "summary": "De novo fatty acid synthesis in the lactating mammary gland yields fatty acids containing 8 to 12 carbon atoms (e.g., Carey & Dils 1972; Libertini & Smith 1978) as well as fatty acids containing 14 to 18 carbons. These medium chain length fatty acids are generated through the action of a monomeric cytosolic thiolase, Olah, whose expression is confined to this tissue. Rat Olah protein interacts transiently with Fasn (fatty acid synthase) associated with medium chain length fatty acyl moieties to catalyze their release as free fatty acids (Mikkelsen et al. 1987).

The carboxyterminal residue of rat Olah protein is ser-260 (Randhawa & Smith 1987), three residues before the termination codon in the cloned gene (Safford et al. 1987).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-879620" ], "enzyme_list": [ "P08635-1", "P12785-1" ], "evidence": [ { "id": "R-RNO-5655945", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5655945" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-879620", "participant_name": "DECA [cytosol]", "crossref": [ { "id": "30813", "database": "ChEBI", "url": "" }, { "id": "5532", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000513", "database": "HMDB Metabolite", "url": "" }, { "id": "000001529229", "database": "ZINC", "url": "" }, { "id": "C01571", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000511", "database": "HMDB Metabolite", "url": "" }, { "id": "30813", "database": "ChEBI", "url": "" }, { "id": "5532", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000513", "database": "HMDB Metabolite", "url": "" }, { "id": "000001529229", "database": "ZINC", "url": "" }, { "id": "C01571", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000511", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O00154", "gene_name": "ACOT7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] } ] }, { "uniprot_ac": "O14734", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] } ] }, { "uniprot_ac": "O55137", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "P07149", "gene_name": "FAS1", "activity": [ { "ec_number": "2.3.1.39", "activity": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP].", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "4.2.1.59", "activity": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O.", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "2.3.1.38", "activity": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA.", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "1.3.1.9", "activity": "a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH.", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "2.3.1.86", "activity": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+).", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] }, { "ec_number": "2.3.1.86", "activity": "", "evidence": [ { "id": "P07149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07149" } ] } ] }, { "uniprot_ac": "P08635", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] } ] }, { "uniprot_ac": "P12785", "gene_name": "Fasn", "activity": [ { "ec_number": "1.1.1.100", "activity": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH.", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "1.3.1.39", "activity": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH.", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.38", "activity": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA.", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.39", "activity": "holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP].", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP].", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.85", "activity": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+).", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "4.2.1.59", "activity": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O.", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "1.1.1.100", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.38", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "4.2.1.59", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.39", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "1.3.1.39", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] }, { "ec_number": "2.3.1.85", "activity": "", "evidence": [ { "id": "P12785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12785" } ] } ] }, { "uniprot_ac": "P13437", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] } ] }, { "uniprot_ac": "P41903", "gene_name": "TES1", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] } ] }, { "uniprot_ac": "P42765", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] } ] }, { "uniprot_ac": "P49753", "gene_name": "ACOT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] } ] }, { "uniprot_ac": "P58137", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] } ] }, { "uniprot_ac": "P80250", "gene_name": "", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "Q14032", "gene_name": "BAAT", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] } ] }, { "uniprot_ac": "Q3UUI3", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] } ] }, { "uniprot_ac": "Q566R0", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] } ] }, { "uniprot_ac": "Q5T1C6", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q64559", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] } ] }, { "uniprot_ac": "Q68D91", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] } ] }, { "uniprot_ac": "Q6Q2Z6", "gene_name": "Acot5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] } ] }, { "uniprot_ac": "Q6ZUV0", "gene_name": "ACOT7L", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] } ] }, { "uniprot_ac": "Q86TX2", "gene_name": "ACOT1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] } ] }, { "uniprot_ac": "Q8BL86", "gene_name": "Mblac2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] } ] }, { "uniprot_ac": "Q8BWT1", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] } ] }, { "uniprot_ac": "Q8N1Q8", "gene_name": "THEM5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] } ] }, { "uniprot_ac": "Q8N9L9", "gene_name": "ACOT4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] } ] }, { "uniprot_ac": "Q8R197", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { 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