{ "uniprot_canonical_ac": "P07861-1", "uniprot_ac": "P07861", "uniprot_id": "NEP_RAT", "mass": { "chemical_mass": 85795.0, "monoisotopic_mass": 85795.0 }, "refseq": { "ac": "NP_036740", "name": "neprilysin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" }, "gene_names": [ { "name": "Mme", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07861", "id": "P07861" }, { "name": "CD10; Nep; SFE", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740", "id": "NP_036740" }, { "name": "Mme", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740", "id": "NP_036740" } ], "protein_names": [ { "name": "Neprilysin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07861" }, { "name": "3.4.24.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "Atriopeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "Enkephalinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "NEP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "Neutral endopeptidase 24.11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "Neutral endopeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "SFE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "Skin fibroblast elastase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07861" }, { "name": "membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); atriopeptidase; neutral endopeptidase 24.11; skin fibroblast elastase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740", "id": "NP_036740" }, { "name": "neprilysin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740", "id": "NP_036740" } ], "function": [ { "annotation": "Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia.", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" }, { "database": "PubMed", "id": "35344141", "url": "https://glygen.org/publication/PubMed/35344141" } ] }, { "annotation": "Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats.", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" }, { "database": "PubMed", "id": "33433852", "url": "https://glygen.org/publication/PubMed/33433852" } ] }, { "annotation": "In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary. While the highest levels of AlaAP or enkephalinase activities were measured in hypothalamus during the dark period, they were the highest in the pituitary during the light one.", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" }, { "database": "PubMed", "id": "30531704", "url": "https://glygen.org/publication/PubMed/30531704" } ] }, { "annotation": "Study shows that chronic intermittent hypoxia (CIH) induces changes on the expression and activity of neprilysin (NEP) in the brain of rats. Data show that CIH protocol increases the expression and activity of NEP selectively in the temporal cortex.", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" }, { "database": "PubMed", "id": "29702204", "url": "https://glygen.org/publication/PubMed/29702204" } ] }, { "annotation": "Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861#function" }, { "database": "PubMed", "id": "2966343", "url": "https://glygen.org/publication/PubMed/2966343" }, { "database": "UniProtKB", "id": "P08473", "url": "https://www.uniprot.org/uniprot/P08473#function" } ] } ], "disease": [ { "disease_id": "DOID:0110160", "recommended_name": { "id": "DOID:0110160", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110160", "name": "Charcot-Marie-Tooth disease axonal type 2T", "description": "A Charcot-Marie-Tooth disease type 2 that has_material_basis_in homozygous or compound heterozygous mutation in the MME gene on chromosome 3q25." }, "synonyms": [ { "id": "DOID:0110160", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110160", "name": "AR-CMT2T", "description": "" }, { "id": "DOID:0110160", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110160", "name": "CMT2T", "description": "" }, { "id": "DOID:0110160", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110160", "name": "Charcot-Marie-Tooth neuropathy type 2T", "description": "" }, { "id": "DOID:0110160", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110160", "name": "autosomal recessive axonal Charcot-Marie-Tooth disease type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease axonal type 2T", "description": "A Charcot-Marie-Tooth disease type 2 that has material basis in homozygous or compound heterozygous mutation in the MME gene on chromosome 3q25." }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "CMT2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease, axonal, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth neuropathy type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "DNAJB2-related CMT2", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "AR-CMT2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth neuropathy, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "DNAJB2-related Charcot-Marie-Tooth disease type 2", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "autosomal recessive axonal Charcot-Marie-Tooth disease type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease axonal type 2T", "description": "A Charcot-Marie-Tooth disease type 2 that has material basis in homozygous or compound heterozygous mutation in the MME gene on chromosome 3q25." }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "CMT2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease, axonal, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth neuropathy type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "DNAJB2-related CMT2", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "AR-CMT2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "Charcot-Marie-Tooth neuropathy, type 2T", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "DNAJB2-related Charcot-Marie-Tooth disease type 2", "description": "" }, { "id": "MONDO:0014866", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014866", "name": "autosomal recessive axonal Charcot-Marie-Tooth disease type 2T", "description": "" }, { "id": "MIM:617017", "resource": "MIM", "url": "https://www.omim.org/entry/617017", "name": "Charcot-Marie-Tooth disease, axonal, 2T", "description": "Charcot-Marie-Tooth disease, axonal, 2T" } ], "evidence": [ { "id": "0110160", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110160" } ] }, { "disease_id": "DOID:0111745", "recommended_name": { "id": "DOID:0111745", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111745", "name": "cerebellar ataxia type 43", "description": "An autosomal dominant cerebellar ataxia characterized by adult-onset, slowly progressive, gait and limb ataxia, often associated with peripheral neuropathy typically affecting the motor system that has_material_basis_in heterozygous mutation in MME on chromosome 3q25.2." }, "synonyms": [ { "id": "DOID:0111745", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111745", "name": "SCA43", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "spinocerebellar ataxia 43", "description": "Spinocerebellar ataxia type 43 is a rare autosomal dominant cerebellar ataxia type I disorder characterized by late adult-onset of slowly progressive cerebellar ataxia, typically presenting with balance and gait disturbances, in association with axonal peripheral neuropathy resulting in reduced/absent deep tendon reflexes and sensory impairment. Lower limb pain and amyotrophy may be present, as well as various cerebellar signs, including dysarthria, nystagmus, hypometric saccades and tremor." }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "MME autosomal dominant cerebellar ataxia", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "SCA43", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "autosomal dominant cerebellar ataxia caused by mutation in MME", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "spinocerebellar ataxia 43", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "spinocerebellar ataxia 43; SCA43", "description": "" }, { "id": "MONDO:0014867", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014867", "name": "spinocerebellar ataxia type 43", "description": "" }, { "id": "MIM:617018", "resource": "MIM", "url": "https://www.omim.org/entry/617018", "name": "Spinocerebellar ataxia 43", "description": "Spinocerebellar ataxia 43" } ], "evidence": [ { "id": "0111745", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111745" } ] }, { "disease_id": "DOID:10273", "recommended_name": { "id": "DOID:10273", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10273", "name": "heart conduction disease", "description": "A cardiovascular system disease that involves the heart's electrical conduction system." }, "synonyms": [ { "id": "DOID:10273", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10273", "name": "heart rhythm disease", "description": "" } ], "evidence": [ { "id": "10273", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10273" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:10976", "recommended_name": { "id": "DOID:10976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10976", "name": "membranous glomerulonephritis", "description": "" }, "synonyms": [ { "id": "DOID:10976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10976", "name": "membranous nephropathy", "description": "" } ], "evidence": [ { "id": "10976", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10976" } ] }, { "disease_id": "DOID:13250", "recommended_name": { "id": "DOID:13250", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13250", "name": "diarrhea", "description": "A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea." }, "synonyms": [], "evidence": [ { "id": "13250", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13250" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "evidence": [ { "id": "6000", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:824", "recommended_name": { "id": "DOID:824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:824", "name": "periodontitis", "description": "" }, "synonyms": [ { "id": "DOID:824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:824", "name": "chronic pericementitis", "description": "" 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01431", "url": "http://pfam.xfam.org/family/PF01431", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05649", "url": "http://pfam.xfam.org/family/PF05649", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P07861", "url": "http://purl.obolibrary.org/obo/PR_P07861", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-2022377", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022377", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5578768", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5578768", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036740", "url": 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] }, { "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07861-1", "url": "https://www.uniprot.org/uniprot/P07861-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW", "length": 750, "header": "sp|P07861-1|NEP_RAT Isoform 1 of Neprilysin OS=Rattus norvegicus OX=10116 GN=Mme PE=1 SV=2 CANONICAL=P07861-1" }, "locus": { "chromosome": "2", "start_pos": 147802721, "end_pos": 147726610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000042576", "url": "https://www.ensembl.org/id/ENSRNOT00000042576" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000044578", "url": "https://www.ensembl.org/id/ENSRNOP00000044578" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 145, "start_aa": "Asn", "end_pos": 145, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn145", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 211, "start_aa": "Asn", "end_pos": 211, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn211", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 285, "start_aa": "Asn", "end_pos": 285, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn285", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 311, "start_aa": "Asn", "end_pos": 311, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn311", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" }, { "id": "3555489", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3555489" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 325, "start_aa": "Asn", "end_pos": 325, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn325", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 628, "start_aa": "Asn", "end_pos": 628, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn628", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "site_lbl": "Ser4" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P07861", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07861" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Rougeot C, Messaoudi M, Hermitte V, Rigault AG, Blisnick T, Dugave C, Desor D, Rougeon F", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "reference": [ { "type": "PubMed", "id": "12835417", "url": "https://glygen.org/publication/PubMed/12835417" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" }, { "database": "iPTMnet", "id": "P07861", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07861" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.", "journal": "J. Biol. Chem.", "date": "1989", "authors": "Bateman RC Jr, Jackson D, Slaughter CA, Unnithan S, Chai YG, Moomaw C, Hersh LB", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "reference": [ { "type": "PubMed", "id": "2703483", "url": "https://glygen.org/publication/PubMed/2703483" } ] }, { "title": "Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.", "journal": "Peptides", "date": "1988", "authors": "Sonnenberg JL, Sakane Y, Jeng AY, Koehn JA, Ansell JA, Wennogle LP, Ghai RD", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "reference": [ { "type": "PubMed", "id": "2966343", "url": "https://glygen.org/publication/PubMed/2966343" } ] }, { "title": "Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC 3.4.24.11) in the brain of rats.", "journal": "Neuroscience letters", "date": "2018", "authors": "de Oliveira RW, Julian GS, Perry JC, Tufik S, Chagas JR", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" } ], "reference": [ { "type": "PubMed", "id": "29702204", "url": "https://glygen.org/publication/PubMed/29702204" } ] }, { "title": "Light-dark influence on enkephalinase activity in hypothalamus and pituitary.", "journal": "Neuro endocrinology letters", "date": "2018", "authors": "Dominguez-Vias G, Aretxaga-Maza G, Prieto I, Segarra AB, Luna JD, Gasparo M, Ramirez-Sanchez M", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" } ], "reference": [ { "type": "PubMed", "id": "30531704", "url": "https://glygen.org/publication/PubMed/30531704" } ] }, { "title": "Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats.", "journal": "Journal of molecular neuroscience : MN", "date": "2021", "authors": "Vasilev DS, Dubrovskaya NM, Zhuravin IA, Nalivaeva NN", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" } ], "reference": [ { "type": "PubMed", "id": "33433852", "url": "https://glygen.org/publication/PubMed/33433852" } ] }, { "title": "Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia.", "journal": "Journal of molecular neuroscience : MN", "date": "2022", "authors": "Vasilev D, Dubrovskaya NM, Nalivaeva NN", "evidence": [ { "database": "RefSeq", "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740" } ], "reference": [ { "type": "PubMed", "id": "35344141", "url": "https://glygen.org/publication/PubMed/35344141" } ] }, { "title": "Molecular cloning and amino acid sequence of rat enkephalinase.", "journal": "Biochemical and biophysical research communications", "date": "1987", "authors": "Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, 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vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "pmid": "" }, { "name": "neuron projection terminus", "id": "GO:0044306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044306", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 628, "end_pos": 630, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" }, { "database": "PubMed", "id": "P08473", "url": "https://glygen.org/publication/PubMed/P08473" } ] }, { "annotation": "Myristoylation is a determinant of membrane targeting.", "evidence": [ { "database": "UniProtKB", "id": "P07861", "url": "https://www.uniprot.org/uniprot/P07861" }, { "database": "PubMed", "id": "P08473", "url": "https://glygen.org/publication/PubMed/P08473" } ] } ], "interactions": [], "reactions": [ { "id": "71459", "name": "", "equation": "H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1", "P47820-1", "P12821-1", "P08473-1", "P09470-1", "Q61391-1" ], "evidence": [ { "id": "71459", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71459" } ] }, { "id": "71467", "name": "", "equation": "H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1", "P08473-1", "Q61391-1" ], "evidence": [ { "id": "71467", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71467" } ] }, { "id": "71475", "name": "", "equation": "H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1", "P47820-1", "P12821-1", "P08473-1", "P09470-1", "Q61391-1" ], "evidence": [ { "id": "71475", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71475" } ] }, { "id": "71479", "name": "", "equation": "H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1", "P08473-1", "Q61391-1" ], "evidence": [ { "id": "71479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71479" } ] }, { "id": "R-RNO-2022368", "name": "MME:Zn2+ hydrolyses AGT(34-42)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-RNO-2022351" ], "enzyme_list": [ "P07861-1" ], "evidence": [ { "id": "R-RNO-2022368", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022368" } ] }, { "id": "R-RNO-2022396", "name": "MME:Zn2+ hydrolyses AGT(34-43)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1" ], "evidence": [ { "id": "R-RNO-2022396", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2022396" } ] }, { "id": "R-RNO-6798743", "name": "Exocytosis of secretory granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, secretory granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04157-1", "P35281-1", "P61589-1", "P09527-1", "P15684-1", "Q5XI42-1", "P07861-1", "P51146-1", "Q6RUV5-1" ], "evidence": [ { "id": "R-RNO-6798743", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798743" } ] }, { "id": "R-RNO-9727607", "name": "MME:Zn2+ binds sacubitrilat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07861-1" ], "evidence": [ { "id": "R-RNO-9727607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9727607" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-2022351", "participant_name": "Agt [extracellular region]", "crossref": [ { "id": "P01015", "database": "UniProt", "url": "" }, { "id": "1SMR", "database": "PDB", "url": "" }, { "id": "XP_008770819.1", "database": "RefSeq", "url": "" }, { "id": "P01015", "database": "PRO", "url": "" }, { "id": "NP_602308.1", "database": "RefSeq", "url": "" }, { "id": "2069", "database": "RGD", "url": "" }, { "id": "2WY1", "database": "PDB", "url": "" }, { "id": "2WXZ", "database": "PDB", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P04157", "gene_name": "Ptprc", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] } ] }, { "uniprot_ac": "P07861", "gene_name": "Mme", "activity": [ { "ec_number": "3.4.24.11", "activity": "Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861" } ] }, { "ec_number": "3.4.24.11", "activity": "", "evidence": [ { "id": "P07861", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07861" } ] } ] }, { "uniprot_ac": "P08473", "gene_name": "MME", "activity": [ { "ec_number": "3.4.24.11", "activity": "Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.", "evidence": [ { "id": "P08473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08473" } ] }, { "ec_number": "3.4.24.11", "activity": "", "evidence": [ { "id": "P08473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08473" } ] } ] }, { "uniprot_ac": "P09470", "gene_name": "Ace", "activity": [ { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "P09470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09470" } ] }, { "ec_number": "3.4.15.1", "activity": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine.", "evidence": [ { "id": "P09470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09470" } ] }, { "ec_number": "3.4.15.1", "activity": "", "evidence": [ { "id": "P09470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09470" } ] } ] }, { "uniprot_ac": "P09527", "gene_name": "Rab7a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P09527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09527" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P09527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09527" } ] } ] }, { "uniprot_ac": "P12821", "gene_name": "ACE", "activity": [ { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "P12821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12821" } ] }, { "ec_number": "3.4.15.1", "activity": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine.", "evidence": [ { "id": "P12821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12821" } ] }, { "ec_number": "3.4.15.1", "activity": "", "evidence": [ { "id": "P12821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12821" } ] } ] }, { "uniprot_ac": "P15684", "gene_name": "Anpep", "activity": [ { "ec_number": "3.4.11.2", "activity": "Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.", "evidence": [ { "id": "P15684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15684" } ] }, { "ec_number": "3.4.11.2", "activity": "", "evidence": [ { "id": "P15684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15684" } ] }, { "ec_number": "3.4.11.-", "activity": "", "evidence": [ { "id": "P15684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15684" } ] } ] }, { "uniprot_ac": "P35281", "gene_name": "Rab10", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P35281", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35281" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P35281", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35281" } ] } ] }, { "uniprot_ac": "P47820", "gene_name": "Ace", "activity": [ { "ec_number": "3.4.15.1", "activity": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine.", "evidence": [ { "id": "P47820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47820" } ] }, { "ec_number": "3.4.15.1", "activity": "", "evidence": [ { "id": "P47820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47820" } ] }, { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "P47820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47820" } ] } ] }, { "uniprot_ac": "P51146", "gene_name": "Rab4b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P51146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51146" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P51146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51146" } ] } ] }, { "uniprot_ac": "P61589", "gene_name": "Rhoa", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61589" } ] } ] }, { "uniprot_ac": "Q5XI42", "gene_name": "Aldh3b1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] } ] }, { "uniprot_ac": "Q61391", "gene_name": "Mme", "activity": [ { "ec_number": "3.4.24.11", "activity": "Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.", "evidence": [ { "id": "Q61391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61391" } ] }, { "ec_number": "3.4.24.11", "activity": "", "evidence": [ { "id": "Q61391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61391" } ] } ] }, { "uniprot_ac": "Q6RUV5", "gene_name": "Rac1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q6RUV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6RUV5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q6RUV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6RUV5" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 6 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }