{ "uniprot_canonical_ac": "P07150-1", "uniprot_ac": "P07150", "uniprot_id": "ANXA1_RAT", "mass": { "chemical_mass": 38829.0, "monoisotopic_mass": 38829.0 }, "refseq": { "ac": "NP_037036", "name": "annexin A1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, "gene_names": [ { "name": "Anxa1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07150", "id": "P07150" }, { "name": "Anx1; p35", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "id": "NP_037036" }, { "name": "Anx1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07150", "id": "P07150" }, { "name": "Anxa1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "id": "NP_037036" } ], "protein_names": [ { "name": "Annexin A1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07150" }, { "name": "Annexin I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Annexin-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Calpactin II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Calpactin-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Chromobindin-9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Lipocortin I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "Phospholipase A2 inhibitory protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" }, { "name": "annexin A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "id": "NP_037036" }, { "name": "annexin I; annexin-1; calpactin II; chromobindin-9; phospholipase A2 inhibitory protein; calpactin-2; Annexin 1 (p35) (Lipocortin 1); lipocortin 1; lipocortin I", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "id": "NP_037036" }, { "name": "p35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07150" } ], "function": [ { "annotation": "2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, { "database": "PubMed", "id": "33796096", "url": "https://glygen.org/publication/PubMed/33796096" } ] }, { "annotation": "Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, { "database": "PubMed", "id": "36279933", "url": "https://glygen.org/publication/PubMed/36279933" } ] }, { "annotation": "Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, { "database": "PubMed", "id": "35896374", "url": "https://glygen.org/publication/PubMed/35896374" } ] }, { "annotation": "Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, { "database": "PubMed", "id": "36269280", "url": "https://glygen.org/publication/PubMed/36269280" } ] }, { "annotation": "Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZKF7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKF7#function" }, { "database": "UniProtKB", "id": "ARBA00029398", "url": "https://www.uniprot.org/uniprot/ARBA00029398#function" }, { "database": "UniProtKB", "id": "A0A8I6GD51", "url": "https://www.uniprot.org/uniprot/A0A8I6GD51#function" }, { "database": "UniProtKB", "id": "A0A8I6GKK9", "url": "https://www.uniprot.org/uniprot/A0A8I6GKK9#function" }, { "database": "UniProtKB", "id": "A0A8L2UJV2", "url": "https://www.uniprot.org/uniprot/A0A8L2UJV2#function" }, { "database": "UniProtKB", "id": "A0A8I6A8I9", "url": "https://www.uniprot.org/uniprot/A0A8I6A8I9#function" }, { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150#function" }, { "database": "UniProtKB", "id": "P04083", "url": "https://www.uniprot.org/uniprot/P04083#function" } ] }, { "annotation": "Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:3020049). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150#function" }, { "database": "UniProtKB", "id": "P04083", "url": "https://www.uniprot.org/uniprot/P04083#function" }, { "database": "UniProtKB", "id": "P10107", "url": "https://www.uniprot.org/uniprot/P10107#function" }, { "database": "PubMed", "id": "3020049", "url": "https://glygen.org/publication/PubMed/3020049" }, { "database": "UniProtKB", "id": "P19619", "url": "https://www.uniprot.org/uniprot/P19619#function" } ] }, { "annotation": "The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats.", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" }, { "database": "PubMed", "id": "34951334", "url": "https://glygen.org/publication/PubMed/34951334" } ] } ], "disease": [ { "disease_id": "DOID:0060074", "recommended_name": { "id": "DOID:0060074", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells." }, "synonyms": [], "evidence": [ { "id": "0060074", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ] }, { "disease_id": "DOID:0060180", "recommended_name": { "id": "DOID:0060180", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060180", "name": "colitis", "description": "An inflammatory bowel disease that involves inflammation located_in colon." }, "synonyms": [], "evidence": [ { "id": "0060180", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060180" } ] }, { "disease_id": "DOID:10140", "recommended_name": { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "dry eye syndrome", "description": "A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface." }, "synonyms": [ { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "Tear film insufficiency", "description": "" }, { "id": "DOID:10140", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10140", "name": "dry eye disease", "description": "" } ], "evidence": [ { "id": "10140", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10140" } ] }, { "disease_id": "DOID:10247", "recommended_name": { "id": "DOID:10247", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10247", "name": "pleurisy", "description": "A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs." }, "synonyms": [], "evidence": [ { "id": "10247", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10247" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ], "evidence": [ { "id": "10534", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:13141", "recommended_name": { "id": "DOID:13141", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13141", "name": "uveitis", "description": "An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid." }, "synonyms": [], "evidence": [ { "id": "13141", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:13141" } ] }, { "disease_id": "DOID:1350", "recommended_name": { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "paranasal sinus benign neoplasm", "description": "" }, "synonyms": [ { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "neoplasm of accessory sinus", "description": "" }, { "id": "DOID:1350", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1350", "name": "tumor of Accessory sinus", "description": "" } ], "evidence": [ { "id": "1350", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1350" } ] }, { "disease_id": "DOID:1459", "recommended_name": { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "hypothyroidism", "description": "A thyroid gland disease which involves an underproduction of thyroid hormone." }, "synonyms": [ { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid deficiency", "description": "" }, { "id": "DOID:1459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1459", "name": "Thyroid insufficiency", "description": "" } ], "evidence": [ { "id": "1459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1459" } ] }, { "disease_id": "DOID:1749", "recommended_name": { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell carcinoma", "description": "A carcinoma that derives_from squamous epithelial cells." }, "synonyms": [ { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "epidermoid carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "malignant squamous cell tumor", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell Epithelioma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell cancer", "description": "" } ], "evidence": [ { "id": "1749", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1749" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:2671", "recommended_name": { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell carcinoma", "description": "A carcinoma that derives_from transitional epithelial cells." }, "synonyms": [ { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional carcinoma", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "transitional cell tumor", "description": "" }, { "id": "DOID:2671", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2671", "name": "urothelial cell carcinoma", "description": "" } ], "evidence": [ { "id": "2671", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2671" } ] }, { "disease_id": "DOID:2734", "recommended_name": { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "keratosis follicularis", "description": "" }, "synonyms": [ { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "DARIER-WHITE DISEASE", "description": "" }, { "id": "DOID:2734", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2734", "name": "Darier's disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease", "description": "Darier disease (DD) is a keratinization disorder characterized by the development of keratotic papules in seborrheic areas and specific nail anomalies." }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier's disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier-White disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "keratosis follicularis", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "DAR", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier White disease", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease, acral hemorrhagic type", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "Darier disease, segmental", "description": "" }, { "id": "MONDO:0007417", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007417", "name": "dar", "description": "" }, { "id": "MIM:124200", "resource": "MIM", "url": "https://www.omim.org/entry/124200", "name": "Darier disease", "description": "Darier disease" } ], "evidence": [ { "id": "2734", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2734" } ] }, { "disease_id": "DOID:3008", "recommended_name": { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated." }, "synonyms": [ { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Infiltrating ductal carcinoma of breast", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Invasive ductal carcinoma, NST", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "ductal adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3008", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ] }, { "disease_id": "DOID:3021", "recommended_name": { "id": "DOID:3021", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3021", "name": "acute kidney failure", "description": "" }, "synonyms": [], "evidence": [ { "id": "3021", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3021" } ] }, { "disease_id": "DOID:3069", "recommended_name": { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "malignant astrocytoma", "description": "A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord." }, "synonyms": [ { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "Astrocytic tumor", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of Cerebrum", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of brain", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astroglioma", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "cerebral astrocytoma", "description": "" } ], "evidence": [ { "id": "3069", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3069" } ] }, { "disease_id": "DOID:326", "recommended_name": { "id": "DOID:326", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:326", "name": "ischemia", "description": "A vascular disease that is characterized by a restriction in blood supply to tissues." }, "synonyms": [], "evidence": [ { "id": "326", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:326" } ] }, { "disease_id": "DOID:3526", "recommended_name": { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "cerebral infarction", "description": "A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain." }, "synonyms": [ { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "CVA - Cerebral infarction", "description": "" }, { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "Cerebral infarct", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "obsolete susceptibility to ischemic stroke", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "ischemic stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebrovascular accident", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic", "description": "" }, { "id": "MIM:601367", "resource": "MIM", "url": "https://www.omim.org/entry/601367", "name": "Ischemic stroke", "description": "Ischemic stroke" } ], "evidence": [ { "id": "3526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3526" } ] }, { "disease_id": "DOID:3770", "recommended_name": { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "pulmonary fibrosis", "description": "An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation." }, "synonyms": [ { "id": "DOID:3770", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3770", "name": "Fibrosis of lung", "description": "" } ], "evidence": [ { "id": "3770", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3770" } ] }, { "disease_id": "DOID:4450", "recommended_name": { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney." }, "synonyms": [ { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "RCC", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "adenocarcinoma of kidney", "description": "" }, { "id": "DOID:4450", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4450", "name": "hypernephroma", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, Xp11-associated", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "renal cell carcinoma, papillary, 1", "description": "" }, { "id": "MONDO:0010456", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010456", "name": "RCCX1", "description": "" } ], "evidence": [ { "id": "4450", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ] }, { "disease_id": "DOID:6498", "recommended_name": { "id": "DOID:6498", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6498", "name": "seborrheic keratosis", "description": "" }, "synonyms": [ { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "seborrheic keratosis", "description": "A common benign skin neoplasm usually affecting older individuals. The lesions usually are multiple and arise in the face, chest, and shoulders. They appear as black or brown, slightly elevated skin lesions." }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "basal cell papilloma", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis Seborrheica", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis, seborrheic, somatic", "description": "" }, { "id": "MONDO:0008420", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008420", "name": "keratosis, seborrheic", "description": "" }, { "id": "MIM:182000", "resource": "MIM", "url": "https://www.omim.org/entry/182000", "name": "Keratosis, seborrheic", "description": "Keratosis, seborrheic" } ], "evidence": [ { "id": "6498", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6498" } ] }, { "disease_id": "DOID:7998", "recommended_name": { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "hyperthyroidism", "description": "A thyroid gland disease that involves an over production of thyroid hormone." }, "synonyms": [ { "id": "DOID:7998", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7998", "name": "overactive thyroid", "description": "" } ], "evidence": [ { "id": "7998", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:7998" } ] }, { "disease_id": "DOID:83", "recommended_name": { "id": "DOID:83", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision." }, "synonyms": [ { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1 multiple types", "description": "Any cataract (disease) in which the cause of the disease is a mutation in the GJA8 gene." }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CTRCT1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "Duffy linked cataract", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "GJA8 cataract (disease)", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract (disease) caused by mutation in GJA8", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types, with or without microcornea", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CAE1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CZP1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "zonular pulverulent cataract 1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, Duffy-linked", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, zonular pulverulent, 1", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "early-onset non-syndromic cataract", "description": "Early-onset non-syndromic cataract is a rare, genetic, non-syndromic developmental defect of the eye, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected." }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "cataract, age-related nuclear", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "nuclear sclerosis of the lens", "description": "" }, { "id": "MIM:116200", "resource": "MIM", "url": "https://www.omim.org/entry/116200", "name": "Cataract 1, multiple types", "description": "Cataract 1, multiple types" } ], "evidence": [ { "id": "83", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:83" } ] }, { "disease_id": "DOID:8893", "recommended_name": { "id": "DOID:8893", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales." }, "synonyms": [ { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "Any psoriasis in which the cause of the disease is a mutation in the HLA-C gene." }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "HLA-C psoriasis", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis 1, susceptibility to", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis caused by mutation in HLA-C", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "psoriasis susceptibility 1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "PSORS1", "description": "" }, { "id": "MONDO:0008334", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008334", "name": "susceptibility to psoriasis 1", "description": "" }, { "id": "MIM:177900", "resource": "MIM", "url": "https://www.omim.org/entry/177900", "name": "Psoriasis 1", "description": "Psoriasis 1" } ], "evidence": [ { "id": "8893", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "common_name": "Rat" } ], "gene": [ { "name": "Anxa1", "url": "https://www.uniprot.org/uniprot/P07150", "locus": { "chromosome": "1", "start_pos": 217861175, "end_pos": 217877343, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000017469", "url": "https://www.ensembl.org/id/ENSRNOG00000017469" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017469", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "25380", "url": "https://www.ncbi.nlm.nih.gov/gene/25380", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P07150", "url": "https://www.ebi.ac.uk/intact/interactors/id:P07150*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:25380", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25380", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FMENQEQ", "url": "https://omabrowser.org/oma/group/FMENQEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1500773at2759", "url": "http://www.orthodb.org/?query=1500773at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "http://pfam.xfam.org/family/PF00191", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P07150", "url": "http://purl.obolibrary.org/obo/PR_P07150", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416476", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-444473", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-444473", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2118", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2118", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZKF7", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZKF7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A8I9", "url": "https://www.uniprot.org/uniprot/A0A8I6A8I9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A8I9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A8I9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GD51", "url": "https://www.uniprot.org/uniprot/A0A8I6GD51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GD51-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GD51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKK9", "url": "https://www.uniprot.org/uniprot/A0A8I6GKK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKK9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GKK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2UJV2", "url": "https://www.uniprot.org/uniprot/A0A8L2UJV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2UJV2-1", "url": "https://www.uniprot.org/uniprot/A0A8L2UJV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07150-1", "url": "https://www.uniprot.org/uniprot/P07150-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN", "length": 346, "header": "sp|P07150-1|ANXA1_RAT Isoform 1 of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2 CANONICAL=P07150-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZKF7-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALLLQGLSRKVALSVSLITFFE", "length": 362, "header": "tr|A0A8I5ZKF7-1|ANXA1_RAT Computationally mapped isoform of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=1 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000116454.1", "url": "https://www.ensembl.org/id/ENSRNOT00000116454.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078049.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078049.1" } ] } }, { "isoform_ac": "A0A8I6A8I9-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN", "length": 325, "header": "tr|A0A8I6A8I9-1|ANXA1_RAT Computationally mapped isoform of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=1 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096367.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096367.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000087822.1", "url": "https://www.ensembl.org/id/ENSRNOP00000087822.1" } ] } }, { "isoform_ac": "A0A8I6GD51-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIAVKCATSTPAFFAEKLYEAIFLMILQHAIYILFLHQQDETKGDYEKILVALCGGN", "length": 322, "header": "tr|A0A8I6GD51-1|ANXA1_RAT Computationally mapped isoform of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=1 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094974.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094974.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085643.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085643.1" } ] } }, { "isoform_ac": "A0A8I6GKK9-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN", "length": 344, "header": "tr|A0A8I6GKK9-1|ANXA1_RAT Computationally mapped isoform of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=1 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000109210.1", "url": "https://www.ensembl.org/id/ENSRNOT00000109210.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093263.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093263.1" } ] } }, { "isoform_ac": "A0A8L2UJV2-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAIYFSYFLELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN", "length": 321, "header": "tr|A0A8L2UJV2-1|ANXA1_RAT Computationally mapped isoform of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=1 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000023664.7", "url": "https://www.ensembl.org/id/ENSRNOT00000023664.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000023664.4", "url": "https://www.ensembl.org/id/ENSRNOP00000023664.4" } ] } }, { "isoform_ac": "P07150-1", "url": "", "sequence": { "sequence": "MAMVSEFLKQACYIEKQEQEYVQAVKSYKGGPGSAVSPYPSFNPSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLAMLKTPAQFDADELRAAMKGLGTDEDTLIEILTTRSNQQIREITRVYREELKRDLAKDITSDTSGDFRNALLALAKGDRCEDMSVNQDLADTDARALYEAGERRKGTDVNVFNTILTTRSYPHLRKVFQNYRKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDMNEIKVFYQKKYGIPLCQAILDETKGDYEKILVALCGGN", "length": 346, "header": "sp|P07150-1|ANXA1_RAT Isoform 1 of Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2 CANONICAL=P07150-1" }, "locus": { "chromosome": "1", "start_pos": 217871206, "end_pos": 217861465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096060", "url": "https://www.ensembl.org/id/ENSRNOT00000096060" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090466", "url": "https://www.ensembl.org/id/ENSRNOP00000090466" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 136, "end_pos": 136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "site_lbl": "Thr136" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by EGFR", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" }, { "database": "phospho.ELM", "id": "P07150", "url": "http://phospho.elm.eu.org/byAccession/P07150.html" }, { "database": "iPTMnet", "id": "P07150", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07150" }, { "database": "PubMed", "id": "1832554", "url": "https://glygen.org/publication/PubMed/1832554" }, { "database": "PubMed", "id": "2457028", "url": "https://glygen.org/publication/PubMed/2457028" } ], "site_lbl": "Tyr21" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKC", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" }, { "database": "iPTMnet", "id": "P07150", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07150" }, { "database": "PubMed", "id": "27634935", "url": "https://glygen.org/publication/PubMed/27634935" } ], "site_lbl": "Ser27" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "site_lbl": "Ser34" }, { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "site_lbl": "Ser37" }, { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by TRPM7", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "site_lbl": "Ser5" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Annexin 1 localisation in tissue eosinophils as detected by electron microscopy.", "journal": "Mediators Inflamm.", "date": "2002", "authors": "Perretti M., Damazo A.S., Oliani S.M.", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "12467520", "url": "https://glygen.org/publication/PubMed/12467520" } ] }, { "title": "Correlation of gene and protein structure of rat and human lipocortin I.", "journal": "Biochemistry", "date": "1991", "authors": "Kovacic RT, Tizard R, Cate RL, Frey AZ, Wallner BP", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" }, { "database": "iPTMnet", "id": "P07150", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07150" } ], "reference": [ { "type": "PubMed", "id": "1832554", "url": "https://glygen.org/publication/PubMed/1832554" } ] }, { "title": "Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.", "journal": "Br. J. Pharmacol.", "date": "2008", "authors": "Perretti M., D'Acquisto F., Flower R.J.", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "18641677", "url": "https://glygen.org/publication/PubMed/18641677" } ] }, { "title": "A systems biology approach for the investigation of the heparin/heparan sulfate interactome.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ori A, Wilkinson MC, Fernig DG", "evidence": [ { "database": "MatrixDB", "id": "GAG_1", "url": "http://matrixdb.univ-lyon1.fr/cgi-bin/current/newPort?type=biomolecule&value=GAG_1" } ], "reference": [ { "type": "PubMed", "id": "21454685", "url": "https://glygen.org/publication/PubMed/21454685" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Karasik A, Pepinsky RB, Shoelson SE, Kahn CR", "evidence": [ { "database": "iPTMnet", "id": "P07150", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07150" } ], "reference": [ { "type": "PubMed", "id": "2457028", "url": "https://glygen.org/publication/PubMed/2457028" } ] }, { "title": "Identification of two phosphorylation sites essential for annexin A1 in blood-brain barrier protection after experimental intracerebral hemorrhage in rats.", "journal": "Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism", "date": "2017", "authors": "Wang Z, Chen Z, Yang J, Yang Z, Yin J, Zuo G, Duan X, Shen H, Li H, Chen G", "evidence": [ { "database": "iPTMnet", "id": "P07150", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07150" } ], "reference": [ { "type": "PubMed", "id": "27634935", "url": "https://glygen.org/publication/PubMed/27634935" } ] }, { "title": "Rat lipocortin I cDNA.", "journal": "Nucleic Acids Res.", "date": "1987", "authors": "Sakata T., Teraoka H., Nakamura E., Shin M., Nishikubo C., Tamaki M.", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "2958780", "url": "https://glygen.org/publication/PubMed/2958780" } ] }, { "title": "Molecular cloning and expression in Escherichia coli of the cDNA coding for rat lipocortin I (calpactin II).", "journal": "Gene", "date": "1988", "authors": "Shimizu N., Yamada K., Shimizu Y., Yano S., Gushima H., Takabayashi E.", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "2969352", "url": "https://glygen.org/publication/PubMed/2969352" } ] }, { "title": "A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.", "journal": "J. Biol. Chem.", "date": "1986", "authors": "Cohen S., Misono K.S., Lukas T.J., Mroczkowski B., De B.K.", "evidence": [ { "database": "UniProtKB", "id": "P07150", "url": "https://www.uniprot.org/uniprot/P07150" } ], "reference": [ { "type": "PubMed", "id": "3020049", "url": "https://glygen.org/publication/PubMed/3020049" } ] }, { "title": "2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Liao WI, Wu SY, Tsai SH, Pao HP, Huang KL, Chu SJ", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" } ], "reference": [ { "type": "PubMed", "id": "33796096", "url": "https://glygen.org/publication/PubMed/33796096" } ] }, { "title": "The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats.", "journal": "Perfusion", "date": "2021-12-24", "authors": "He Yunzi, Zhang Yuanjie, Wu Hanhua, Luo Junli, Cheng Chi, Zhang Hong", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" } ], "reference": [ { "type": "PubMed", "id": "34951334", "url": "https://glygen.org/publication/PubMed/34951334" } ] }, { "title": "Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats.", "journal": "The Journal of veterinary medical science", "date": "2022", "authors": "Fungbun N, Sasaki H, Terashima R, Murata T, Chiba S, Kurusu S, Kawaminami M", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" } ], "reference": [ { "type": "PubMed", "id": "35896374", "url": "https://glygen.org/publication/PubMed/35896374" } ] }, { "title": "Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2022-11", "authors": "Zhao Bowen, Huang Jingqiu, Lou Xiaotong, Yao Ke, Ye Meng, Mou Qianxue, Wen Zheng, Duan Qiming, Zhang Hong, Zhao Yin", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" } ], "reference": [ { "type": "PubMed", "id": "36269280", "url": "https://glygen.org/publication/PubMed/36269280" } ] }, { "title": "Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.", "journal": "Experimental neurology", "date": "2023-01", "authors": "Flores Jerry J, Ding Yan, Sherchan Prativa, Zhang John H, Tang Jiping", "evidence": [ { "database": "RefSeq", "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036" } ], "reference": [ { "type": "PubMed", "id": "36279933", "url": "https://glygen.org/publication/PubMed/36279933" } ] } ], "pathway": [ { "id": "rno:25380", "name": "", 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