{
    "uniprot_canonical_ac": "P06336-1",
    "uniprot_ac": "P06336",
    "uniprot_id": "IGHE_MOUSE",
    "mass": {
        "chemical_mass": 47321.0,
        "monoisotopic_mass": 47321.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "IGHE",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P06336",
            "id": "P06336"
        },
        {
            "name": "Ighe",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P06336",
            "id": "P06336"
        }
    ],
    "protein_names": [
        {
            "name": "Immunoglobulin heavy constant epsilon",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P06336"
        },
        {
            "name": "Ig epsilon chain C region",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P06336"
        }
    ],
    "function": [
        {
            "annotation": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P06336",
                    "url": "https://www.uniprot.org/uniprot/P06336#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "P01854",
                    "url": "https://www.uniprot.org/uniprot/P01854#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P06336",
                    "url": "https://www.uniprot.org/uniprot/P06336"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "IGHE",
            "url": "https://www.uniprot.org/uniprot/P06336",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000087642",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000087642",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd05768",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05768",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd05847",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05847",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd07696",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07696",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003006",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003597",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR007110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013151",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013783",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036179",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2685746",
            "url": "http://www.informatics.jax.org/marker/MGI:2685746",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "QGQWVSE",
            "url": "https://omabrowser.org/oma/group/QGQWVSE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23411",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23411",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23411:SF30",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23411:SF30",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00047",
            "url": "http://pfam.xfam.org/family/PF00047",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07654",
            "url": "http://pfam.xfam.org/family/PF07654",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P06336",
            "url": "http://purl.obolibrary.org/obo/PR_P06336",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-2454202",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2454202",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2730905",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730905",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2871796",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871796",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2871809",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-2871837",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871837",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1Y7VJX7",
            "url": "https://www.uniprot.org/uniprot/A0A1Y7VJX7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1Y7VJX7-1",
            "url": "https://www.uniprot.org/uniprot/A0A1Y7VJX7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6W6U3",
            "url": "https://www.uniprot.org/uniprot/F6W6U3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6W6U3-1",
            "url": "https://www.uniprot.org/uniprot/F6W6U3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P06336",
            "url": "https://www.uniprot.org/uniprot/P06336",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P06336-1",
            "url": "https://www.uniprot.org/uniprot/P06336-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDLESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEKTISTSLGNTSLRPS",
        "length": 421,
        "header": "sp|P06336-1|IGHE_MOUSE Isoform 1 of Immunoglobulin heavy constant epsilon  OS=Mus musculus OX=10090 GN=IGHE PE=3 SV=2 CANONICAL=P06336-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1Y7VJX7-1",
            "url": "",
            "sequence": {
                "sequence": "XSIRNPQLYPLKPCKGTASMTLGCLVKDYFPGPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDLESEKNVNVTWNQEKKTPVSASQWYTKHHHNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLEDGKLISNSHHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEKTISTSLELDLQDLCIEEVEGEELEELWTSICVFITLFLLSVSYGATVTVLKVKWVFSTPMQDTPQTFQDYANIFQTRA",
                "length": 486,
                "header": "tr|A0A1Y7VJX7-1|IGHE_MOUSE Computationally mapped isoform of Immunoglobulin heavy constant epsilon  OS=Mus musculus OX=10090 GN=IGHE PE=3 SV=1 CANONICAL=P06336-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 113236868,
                "end_pos": 113232882,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000223335.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000223335.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000152628.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152628.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6W6U3-1",
            "url": "",
            "sequence": {
                "sequence": "XSIRNPQLYPLKPCKGTASMTLGCLVKDYFPGPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDLESEKNVNVTWNQEKKTPVSASQWYTKHHHNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLEDGKLISNSHHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEKTISTSLGNTSLHPS",
                "length": 422,
                "header": "tr|F6W6U3-1|F6W6U3_MOUSE Computationally mapped isoform of Immunoglobulin heavy constant epsilon  OS=Mus musculus OX=10090 GN=Ighe PE=1 SV=2 CANONICAL=P06336-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 113236868,
                "end_pos": 113234895,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000137336.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000137336.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000118012.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000118012.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P06336-1",
            "url": "",
            "sequence": {
                "sequence": "SIRNPQLYPLKPCKGTASMTLGCLVKDYFPNPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVRPVNITEPTLELLHSSCDPNAFHSTIQLYCFIYGHILNDVSVSWLMDDREITDTLAQTVLIKEEGKLASTCSKLNITEQQWMSESTFTCKVTSQGVDYLAHTRRCPDHEPRGVITYLIPPSPLDLYQNGAPKLTCLVVDLESEKNVNVTWNQEKKTSVSASQWYTKHHNNATTSITSILPVVAKDWIEGYGYQCIVDHPDFPKPIVRSITKTPGQRSAPEVYVFPPPEEESEDKRTLTCLIQNFFPEDISVQWLGDGKLISNSQHSTTTPLKSNGSNQGFFIFSRLEVAKTLWTQRKQFTCQVIHEALQKPRKLEKTISTSLGNTSLRPS",
                "length": 421,
                "header": "sp|P06336-1|IGHE_MOUSE Isoform 1 of Immunoglobulin heavy constant epsilon  OS=Mus musculus OX=10090 GN=IGHE PE=3 SV=2 CANONICAL=P06336-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 166,
            "start_aa": "Asn",
            "end_pos": 166,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn166",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 238,
            "start_aa": "Asn",
            "end_pos": 238,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn238",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 261,
            "start_aa": "Asn",
            "end_pos": 261,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn261",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 365,
            "start_aa": "Asn",
            "end_pos": 365,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn365",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 415,
            "start_aa": "Asn",
            "end_pos": 415,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn415",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 43,
            "start_aa": "Asn",
            "end_pos": 43,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn43",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 72,
            "start_aa": "Asn",
            "end_pos": 72,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn72",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 84,
            "start_aa": "Asn",
            "end_pos": 84,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn84",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 95,
            "start_aa": "Asn",
            "end_pos": 95,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn95",
            "evidence": [
                {
                    "id": "P06336",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P06336#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.",
            "journal": "EMBO J.",
            "date": "1982",
            "authors": "Ueda S., Miyata T., Honjo T., Ishida N., Hayashida H.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P06336",
                    "url": "https://www.uniprot.org/uniprot/P06336"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "6329728",
                    "url": "https://glygen.org/publication/PubMed/6329728"
                }
            ]
        },
        {
            "title": "Cloning and nucleotide sequence of mouse immunoglobulin epsilon chain cDNA.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "1982",
            "authors": "Albrandt K., Sutcliffe J.G., Liu F.-T., Katz D.H.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P06336",
                    "url": "https://www.uniprot.org/uniprot/P06336"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "6818553",
                    "url": "https://glygen.org/publication/PubMed/6818553"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "R-MMU-2454202",
            "name": "Fc epsilon receptor (FCERI) signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2454202",
            "resource": "Reactome",
            "description": "Fc epsilon receptor (FCERI) signaling"
        },
        {
            "id": "R-MMU-2730905",
            "name": "Role of LAT2/NTAL/LAB on calcium mobilization",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2730905",
            "resource": "Reactome",
            "description": "Role of LAT2/NTAL/LAB on calcium mobilization"
        },
        {
            "id": "R-MMU-2871796",
            "name": "FCERI mediated MAPK activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871796",
            "resource": "Reactome",
            "description": "FCERI mediated MAPK activation"
        },
        {
            "id": "R-MMU-2871809",
            "name": "FCERI mediated Ca+2 mobilization",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871809",
            "resource": "Reactome",
            "description": "FCERI mediated Ca+2 mobilization"
        },
        {
            "id": "R-MMU-2871837",
            "name": "FCERI mediated NF-kB activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2871837",
            "resource": "Reactome",
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