{ "uniprot_canonical_ac": "P04167-1", "uniprot_ac": "P04167", "uniprot_id": "CP2B2_RAT", "mass": { "chemical_mass": 55933.0, "monoisotopic_mass": 55933.0 }, "refseq": { "ac": "NP_001185605", "name": "cytochrome P450 2B2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" }, "gene_names": [ { "name": "Cyp2b2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P04167", "id": "P04167" }, { "name": "Cyp2b-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P04167", "id": "P04167" }, { "name": "Cyp2b2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605", "id": "NP_001185605" }, { "name": "Cype; CYPIIB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605", "id": "NP_001185605" } ], "protein_names": [ { "name": "Cytochrome P450 2B2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P04167" }, { "name": "1.14.14.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04167" }, { "name": "CYPIIB2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04167" }, { "name": "Cytochrome P450 PB4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04167" }, { "name": "Cytochrome P450E", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04167" }, { "name": "cytochrome P450 2B2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605", "id": "NP_001185605" }, { "name": "cytochrome P450 2B2; cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P-450e-M; cytochrome P-450b type e; cytochrome P450E; cytochrome P450 PB4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605", "id": "NP_001185605" } ], "function": [ { "annotation": "Analysis of the spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2 and comparison with fluorometric assay", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" }, { "database": "PubMed", "id": "22905390", "url": "https://glygen.org/publication/PubMed/22905390" } ] }, { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GGX5", "url": "https://www.uniprot.org/uniprot/A0A8I6GGX5#function" }, { "database": "UniProtKB", "id": "RU368046", "url": "https://www.uniprot.org/uniprot/RU368046#function" }, { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167#function" } ] }, { "annotation": "LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1.", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" }, { "database": "PubMed", "id": "22612225", "url": "https://glygen.org/publication/PubMed/22612225" } ] }, { "annotation": "Stimulation of hepatic heme oxygenase-1 expression by ascorbic acid deficiency caused the decrease in CYP content in liver", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" }, { "database": "PubMed", "id": "25036135", "url": "https://glygen.org/publication/PubMed/25036135" } ] } ], "disease": [ { "disease_id": "DOID:399", "recommended_name": { "id": "DOID:399", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes." }, "synonyms": [], "evidence": [ { "id": "399", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:399" } ] }, { "disease_id": "DOID:526", "recommended_name": { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands." }, "synonyms": [ { "id": "DOID:526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:526", "name": "HIV infection", "description": "" } ], "evidence": [ { "id": "526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:526" } ] }, { "disease_id": "DOID:9119", "recommended_name": { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, "synonyms": [ { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "AML - acute Myeloid Leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "Leukemia, Myelocytic, acute", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections." }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "AML - acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "ANLL", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute Nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemias", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, reduced survival in, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, myelocytic, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute, M4/M4Eo subtype, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myelogenous", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to", "description": "" }, { "id": "MIM:601626", "resource": "MIM", "url": "https://www.omim.org/entry/601626", "name": "Leukemia, acute myelogenous", "description": "Leukemia, acute myelogenous" } ], "evidence": [ { "id": "9119", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cyp2b2", "url": "https://www.uniprot.org/uniprot/P04167", "locus": { "chromosome": "1", "start_pos": 81608566, "end_pos": 81594555, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000062471", "url": "https://www.ensembl.org/id/ENSRNOG00000062471" } ] } } ], "crossref": [ { "id": "cd20672", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20672", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "361523", "url": "https://www.ncbi.nlm.nih.gov/gene/361523", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:361523", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361523", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RIFINIW", "url": "https://omabrowser.org/oma/group/RIFINIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2900138at2759", "url": "http://www.orthodb.org/?query=2900138at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "http://pfam.xfam.org/family/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P04167", "url": "http://purl.obolibrary.org/obo/PR_P04167", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "2467", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2467", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "17149", "url": "https://www.rhea-db.org/rhea/17149", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6GGX5", "url": "https://www.uniprot.org/uniprot/A0A8I6GGX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GGX5-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GGX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P04167-1", "url": "https://www.uniprot.org/uniprot/P04167-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P04167-2", "url": "https://www.uniprot.org/uniprot/P04167-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGTETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTLKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKIPPTYQICFSAR", "length": 491, "header": "sp|P04167-1|CP2B2_RAT Isoform 1 of Cytochrome P450 2B2 OS=Rattus norvegicus OX=10116 GN=Cyp2b2 PE=1 SV=2 CANONICAL=P04167-1" }, "isoforms": [ { "isoform_ac": "A0A8I6GGX5-1", "url": "", "sequence": { "sequence": "MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQFREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVFFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKVSPAWMREEKSNHHTEFHHENLMISLLSLFFAGTETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTLKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKIPPTYQICFSAR", "length": 499, "header": "tr|A0A8I6GGX5-1|A0A8I6GGX5_RAT Computationally mapped isoform of Cytochrome P450 OS=Rattus norvegicus OX=10116 GN=Cyp2b2 PE=1 SV=1 CANONICAL=P04167-1" }, "locus": { "chromosome": "1", "start_pos": 81608178, "end_pos": 81594572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102544.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102544.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088265.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088265.1" } ] } }, { "isoform_ac": "P04167-1", "url": "", "sequence": { "sequence": "MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGTETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTLKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKIPPTYQICFSAR", "length": 491, "header": "sp|P04167-1|CP2B2_RAT Isoform 1 of Cytochrome P450 2B2 OS=Rattus norvegicus OX=10116 GN=Cyp2b2 PE=1 SV=2 CANONICAL=P04167-1" }, "locus": {} }, { "isoform_ac": "P04167-2", "url": "", "sequence": { "sequence": "MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKVSPAWMREEKSNHHTEFHHENLMISLLSLFFAGTETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTLKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKIPPTYQICFSAR", "length": 499, "header": "sp|P04167-2|CP2B2_RAT Isoform 2 of Cytochrome P450 2B2 OS=Rattus norvegicus OX=10116 GN=Cyp2b2 PE=1 SV=2 CANONICAL=P04167-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" }, { "database": "phospho.ELM", "id": "P04167", "url": "http://phospho.elm.eu.org/byAccession/P04167.html" }, { "database": "iPTMnet", "id": "P04167", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04167" }, { "database": "PubMed", "id": "2583091", "url": "https://glygen.org/publication/PubMed/2583091" } ], "site_lbl": "Ser128" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.", "journal": "The Biochemical journal", "date": "2012", "authors": "Sun H, Lee CM, Tripathi S, Kim KB, Morgan ET", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" } ], "reference": [ { "type": "PubMed", "id": "22612225", "url": "https://glygen.org/publication/PubMed/22612225" } ] }, { "title": "A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay.", "journal": "Indian journal of biochemistry & biophysics", "date": "2002", "authors": "Rastogi S, Khanna SK, Das M", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" } ], "reference": [ { "type": "PubMed", "id": "22905390", "url": "https://glygen.org/publication/PubMed/22905390" } ] }, { "title": "Alternative splicing of mRNA encoding rat liver cytochrome P450e (P450IIB2).", "journal": "Gene", "date": "1990", "authors": "Lacroix D, Desrochers M, Lambert M, Anderson A", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "2323573", "url": "https://glygen.org/publication/PubMed/2323573" } ] }, { "title": "Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.", "journal": "Bioscience, biotechnology, and biochemistry", "date": "2014", "authors": "Kobayashi M, Hoshinaga Y, Miura N, Tokuda Y, Shigeoka S, Murai A, Horio F", "evidence": [ { "database": "RefSeq", "id": "NP_001185605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185605" } ], "reference": [ { "type": "PubMed", "id": "25036135", "url": "https://glygen.org/publication/PubMed/25036135" } ] }, { "title": "Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2.", "journal": "Arch. Biochem. Biophys.", "date": "1989", "authors": "Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "2539047", "url": "https://glygen.org/publication/PubMed/2539047" } ] }, { "title": "Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450.", "journal": "EMBO J.", "date": "1989", "authors": "Pyerin W, Taniguchi H", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" }, { "database": "iPTMnet", "id": "P04167", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04167" } ], "reference": [ { "type": "PubMed", "id": "2583091", "url": "https://glygen.org/publication/PubMed/2583091" } ] }, { "title": "A mutant rat strain deficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes.", "journal": "J. Biochem.", "date": "1988", "authors": "Hashimoto T., Kawabata S., Matsumoto T., Nishizawa M., Morohashi K., Omura T., Handa S.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "2839467", "url": "https://glygen.org/publication/PubMed/2839467" } ] }, { "title": "Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver.", "journal": "Biochem. Pharmacol.", "date": "1988", "authors": "Wolf C.R., Oesch F., Amelizad Z., Narbonne J.F., Robertson L.W.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "3041969", "url": "https://glygen.org/publication/PubMed/3041969" } ] }, { "title": "Gene conversion in a cytochrome P-450 gene family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1986", "authors": "Adesnik M., Atchison M.L.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "3458196", "url": "https://glygen.org/publication/PubMed/3458196" } ] }, { "title": "The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies.", "journal": "J. Biol. Chem.", "date": "1985", "authors": "Kreibich G., Waxman D.J., Frey A.B.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "3877725", "url": "https://glygen.org/publication/PubMed/3877725" } ] }, { "title": "Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1983", "authors": "Muramatsu M., Fujii-Kuriyama Y., Sogawa K., Mizukami Y., Suwa Y.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "6306654", "url": "https://glygen.org/publication/PubMed/6306654" } ] }, { "title": "Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1984", "authors": "Anderson A., Affolter M.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "6322758", "url": "https://glygen.org/publication/PubMed/6322758" } ] }, { "title": "Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.", "journal": "J. Biol. Chem.", "date": "1983", "authors": "Kumar A., Adesnik M., Raphael C.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "6688421", "url": "https://glygen.org/publication/PubMed/6688421" } ] }, { "title": "Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.", "journal": "Gene", "date": "1983", "authors": "Ashworth A., Phillips I.R., Shephard E.A., Rabin B.R.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "reference": [ { "type": "PubMed", "id": "6689485", "url": "https://glygen.org/publication/PubMed/6689485" } ] } ], "pathway": [ { "id": "rno:361523", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:361523", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P12791-1", "protein_name": "Cytochrome P450 2B10", "gene_name": "Cyp2b10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLKSLIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANVICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFELFSGFLKYFPGAHRQISKNLQELLDYIGHSVERHKATLDPSVPRDFIDIYLLRMEKEKSNQNAEFHHQNLMMSVLSLFFVGTETSSTTLHYGFLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYSDAVIHEIQRFSDLIPIGVPHRVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDQFLDANGALKKSEAFLPFSTGQIFDQKSVGKRICLGESIARSELFLFFTSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR", "length": 500 }, "evidence": [ { "id": "45231007", "url": "http://www.informatics.jax.org/homology/45231007", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P20813-1", "protein_name": "Cytochrome P450 2B6", "gene_name": "CYP2B6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR", "length": 491 }, "evidence": [ { "id": "45231007", "url": "http://www.informatics.jax.org/homology/45231007", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "aromatase activity", "id": "GO:0070330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "arachidonic acid epoxygenase activity", "id": "GO:0008392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "steroid hydroxylase activity", "id": "GO:0008395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008395", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "response to calcium ion", "id": "GO:0051592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051592", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "response to metal ion", "id": "GO:0010038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010038", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" }, { "name": "nicotine metabolic process", "id": "GO:0018933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018933", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylation is accompanied by a decrease in enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "P04167", "url": "https://www.uniprot.org/uniprot/P04167" }, { "database": "PubMed", "id": "2583091", "url": "https://glygen.org/publication/PubMed/2583091" } ] } ], "interactions": [], "reactions": [ { "id": "17149", "name": "", "equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11711-1", "P05182-1", "A0A8I6A0P6-1", "P10633-1", "P51538-1", "P00176-1", "P05178-1", "P10610-1", "P13107-1", "P20812-1", "P33272-1", "P51870-1", "P00185-1", "Q64581-1", "P05179-1", "P51871-1", "P04167-1", "P04800-1", "P05183-1", "P10634-1", "P11510-1", "P12938-1", "P12939-1", "P15129-1", "P15149-1", "P20814-1", "P33273-1", "P51590-1", "Q64583-1", "Q64680-1", "P04799-1", "Q64678-1", "P08683-1", "P24464-1", "D4A820-1", "A0A0G2K5K4-1", "F1LT33-1", "G3V9D2-1", "Q9QXF7-1", "A0A8I5ZZ08-1", "P05181-1", "A0A087X1C5-1", "P08684-1", "P20853-1", "P04798-1", "P05177-1", "P33261-1", "Q86W10-1", "Q16678-1", "P98187-1", "P10632-1", "P11712-1", "P24462-1", "Q9HB55-1", "P13584-1", "Q16696-1", "Q9HCS2-1", "P33260-1", "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "P24903-1", "P20815-1", "Q6V0L0-1", "P20852-1", "O09158-1", "O55071-1", "Q64459-1", "Q64481-1", "O54749-1", "P11714-1", "P15392-1", "Q8CIM7-1", "P24456-1", "P56654-1", "P56655-1", "P56656-1", "P12791-1", "P56593-1", "O54750-1", "Q91WL5-1", "Q91X77-1", "Q64458-1", "P00186-1", "P00184-1", "Q05421-1", "Q6XVG2-1", "Q9D816-1", "P12790-1", "P24457-1", "Q9JMA7-1", "Q64462-1", "Q64464-1", "Q64429-1", "D3YYZ0-1", "D3Z2W7-1", "Q9WV19-1", "Q9DBX6-1", "B2RXZ2-1", "E9Q593-1", "A2A974-1", "A6H6J2-1", "Q9EQW4-1", "B2RXA7-1" ], "evidence": [ { "id": "17149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17149" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A087X1C5", "gene_name": "CYP2D7", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "A0A087X1C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A087X1C5" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A0A087X1C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A087X1C5" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A0A087X1C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A087X1C5" } ] } ] }, { "uniprot_ac": "A0A0G2K5K4", "gene_name": "Cyp3a62", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "A0A0G2K5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K5K4" } ] } ] }, { "uniprot_ac": "A0A8I5ZZ08", "gene_name": "LOC103691092", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A0A8I5ZZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZ08" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A0A8I5ZZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZ08" } ] } ] }, { "uniprot_ac": "A0A8I6A0P6", "gene_name": "Cyp3a73", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "A0A8I6A0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0P6" } ] } ] }, { "uniprot_ac": "A2A974", "gene_name": "Cyp4a12b", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] } ] }, { "uniprot_ac": "A6H6J2", "gene_name": "Cyp2b13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] } ] }, { "uniprot_ac": "B2RXA7", "gene_name": "Cyp26c1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] } ] }, { "uniprot_ac": "B2RXZ2", "gene_name": "Cyp2a22", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] } ] }, { "uniprot_ac": "D3YYZ0", "gene_name": "Cyp3a57", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3YYZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYZ0" } ] } ] }, { "uniprot_ac": "D3Z2W7", "gene_name": "Cyp3a59", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3Z2W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z2W7" } ] } ] }, { "uniprot_ac": "D4A820", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] } ] }, { "uniprot_ac": "E9Q593", "gene_name": "Cyp2b23", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] } ] }, { "uniprot_ac": "F1LT33", "gene_name": "Cyp2b14", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] } ] }, { "uniprot_ac": "G3V9D2", "gene_name": "Cyp2b21", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] } ] }, { "uniprot_ac": "O09158", "gene_name": "Cyp3a25", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] } ] }, { "uniprot_ac": "O54749", "gene_name": "Cyp2j5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] } ] }, { "uniprot_ac": "O54750", "gene_name": "Cyp2j6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] } ] }, { "uniprot_ac": "O55071", "gene_name": "Cyp2b19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] } ] }, { "uniprot_ac": "P00176", "gene_name": "Cyp2b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] } ] }, { "uniprot_ac": "P00184", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] } ] }, { "uniprot_ac": "P00185", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] } ] }, { "uniprot_ac": "P00186", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] } ] }, { "uniprot_ac": "P04167", "gene_name": "Cyp2b2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] } ] }, { "uniprot_ac": "P04798", "gene_name": "CYP1A1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] } ] }, { "uniprot_ac": "P04799", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] } ] }, { "uniprot_ac": "P04800", "gene_name": "Cyp3a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] } ] }, { "uniprot_ac": "P05177", "gene_name": "CYP1A2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] } ] }, { "uniprot_ac": "P05178", "gene_name": "Cyp2c6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] } ] }, { "uniprot_ac": "P05179", "gene_name": "Cyp2c7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] } ] }, { "uniprot_ac": "P05181", "gene_name": "CYP2E1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] } ] }, { "uniprot_ac": "P05182", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] } ] }, { "uniprot_ac": "P05183", "gene_name": "Cyp3a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] } ] }, { "uniprot_ac": "P08683", "gene_name": "Cyp2c11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] } ] }, { "uniprot_ac": "P08684", "gene_name": "CYP3A4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10610", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P10633", "gene_name": "Cyp2d1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] } ] }, { "uniprot_ac": "P10634", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] } ] }, { "uniprot_ac": "P11510", "gene_name": "Cyp2c12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] } ] }, { "uniprot_ac": "P11711", "gene_name": "Cyp2a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] } ] }, { "uniprot_ac": "P11712", "gene_name": "CYP2C9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] } ] }, { "uniprot_ac": "P11714", "gene_name": "Cyp2d9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] } ] }, { "uniprot_ac": "P12790", "gene_name": "Cyp2b9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] } ] }, { "uniprot_ac": "P12791", "gene_name": "Cyp2b10", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] } ] }, { "uniprot_ac": "P12938", "gene_name": "Cyp2d3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] } ] }, { "uniprot_ac": "P12939", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] } ] }, { "uniprot_ac": "P13107", "gene_name": "Cyp2b3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] } ] }, { "uniprot_ac": "P13584", "gene_name": "CYP4B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] } ] }, { "uniprot_ac": "P15129", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] } ] }, { "uniprot_ac": "P15149", "gene_name": "Cyp2a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] } ] }, { "uniprot_ac": "P15392", "gene_name": "Cyp2a4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] } ] }, { "uniprot_ac": "P20812", "gene_name": "Cyp2a3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] } ] }, { "uniprot_ac": "P20814", "gene_name": "Cyp2c13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P20852", "gene_name": "Cyp2a5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] } ] }, { "uniprot_ac": "P20853", "gene_name": "CYP2A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] } ] }, { "uniprot_ac": "P24456", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] } ] }, { "uniprot_ac": "P24457", "gene_name": "Cyp2d11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] } ] }, { "uniprot_ac": "P24462", "gene_name": "CYP3A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] } ] }, { "uniprot_ac": "P24464", "gene_name": "Cyp4a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] } ] }, { "uniprot_ac": "P24903", "gene_name": "CYP2F1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "P33261", "gene_name": "CYP2C19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.75", "activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] } ] }, { "uniprot_ac": "P33272", "gene_name": "Cyp2b12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] } ] }, { "uniprot_ac": "P33273", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] } ] }, { "uniprot_ac": "P51538", "gene_name": "Cyp3a9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] } ] }, { "uniprot_ac": "P51590", "gene_name": "Cyp2j3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] } ] }, { "uniprot_ac": "P51870", "gene_name": "Cyp4f5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] } ] }, { "uniprot_ac": "P51871", "gene_name": "Cyp4f6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] } ] }, { "uniprot_ac": "P56593", "gene_name": "Cyp2a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] } ] }, { "uniprot_ac": "P56654", "gene_name": "Cyp2c37", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] } ] }, { "uniprot_ac": "P56655", "gene_name": "Cyp2c38", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] } ] }, { "uniprot_ac": "P56656", "gene_name": "Cyp2c39", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] } ] }, { "uniprot_ac": "P78329", "gene_name": "CYP4F2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] } ] }, { "uniprot_ac": "P98187", "gene_name": "CYP4F8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] } ] }, { "uniprot_ac": "Q02928", "gene_name": "CYP4A11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] } ] }, { "uniprot_ac": "Q05421", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] } ] }, { "uniprot_ac": "Q08477", "gene_name": "CYP4F3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] } ] }, { "uniprot_ac": "Q16678", "gene_name": "CYP1B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] } ] }, { "uniprot_ac": "Q16696", "gene_name": "CYP2A13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] } ] }, { "uniprot_ac": "Q64429", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] } ] }, { "uniprot_ac": "Q64458", "gene_name": "Cyp2c29", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] } ] }, { "uniprot_ac": "Q64459", "gene_name": "Cyp3a11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] } ] }, { "uniprot_ac": "Q64462", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] } ] }, { "uniprot_ac": "Q64464", "gene_name": "Cyp3a13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] } ] }, { "uniprot_ac": "Q64481", "gene_name": "Cyp3a16", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] } ] }, { "uniprot_ac": "Q64581", "gene_name": "Cyp3a18", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] } ] }, { "uniprot_ac": "Q64583", "gene_name": "Cyp2b15", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] } ] }, { "uniprot_ac": "Q64678", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] } ] }, { "uniprot_ac": "Q64680", "gene_name": "Cyp2d4", "activity": [ { "ec_number": 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