{ "uniprot_canonical_ac": "P00759-1", "uniprot_ac": "P00759", "uniprot_id": "KLK2_RAT", "mass": { "chemical_mass": 28248.0, "monoisotopic_mass": 28248.0 }, "refseq": { "ac": "NP_036809", "name": "tonin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" }, "gene_names": [ { "name": "Klk1c2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P00759", "id": "P00759" }, { "name": "Klk2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P00759", "id": "P00759" }, { "name": "KLK2; Klna1; rGK-2; Ton", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "id": "NP_036809" }, { "name": "Klk-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00759", "id": "P00759" }, { "name": "Klk1c2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "id": "NP_036809" }, { "name": "Ton", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00759", "id": "P00759" } ], "protein_names": [ { "name": "Tonin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P00759" }, { "name": "3.4.21.35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "Esterase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "Glandular kallikrein-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "RSKG-5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "S2 kallikrein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "rGK-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00759" }, { "name": "tonin precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "id": "NP_036809" }, { "name": "tonin; S2 kallikrein; RSKG-5; esterase 1; glandular kallikrein-2; kallikrein a1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "id": "NP_036809" } ], "function": [ { "annotation": "KLK2 rat gene was expressed at high levels in the submandibular glands of transgenic mice.", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" }, { "database": "PubMed", "id": "17366701", "url": "https://glygen.org/publication/PubMed/17366701" } ] }, { "annotation": "The environment of tonin abundance may increase N-domain ACE activity liberated by a secretase able to cleave somatic ACE.", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" }, { "database": "PubMed", "id": "26216430", "url": "https://glygen.org/publication/PubMed/26216430" } ] }, { "annotation": "This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759#function" } ] }, { "annotation": "Tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system.", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" }, { "database": "PubMed", "id": "20180641", "url": "https://glygen.org/publication/PubMed/20180641" } ] } ], "disease": [ { "disease_id": "DOID:0050700", "recommended_name": { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle." }, "synonyms": [ { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "Cardiomyopathies", "description": "" } ], "evidence": [ { "id": "0050700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:783", "recommended_name": { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease." }, "synonyms": [ { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal failure", "description": "" }, { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end-stage kidney disease", "description": "" } ], "evidence": [ { "id": "783", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:783" } ] }, { "disease_id": "DOID:784", "recommended_name": { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic kidney disease", "description": "A kidney failure that is characterized by the gradual loss of kidney function." }, "synonyms": [ { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "CKD", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "CRF", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic kidney failure", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic renal disease", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic renal failure syndrome", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "renal failure - chronic", "description": "" } ], "evidence": [ { "id": "784", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:784" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "common_name": "Rat" } ], "gene": [ { "name": "Klk2", "url": "https://www.uniprot.org/uniprot/P00759", "locus": {} } ], "crossref": [ { "id": "ENSRNOG00000029237", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000029237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSRNOG00000032857", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032857", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "24841", "url": "https://www.ncbi.nlm.nih.gov/gene/24841", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:24841", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24841", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGGRECL", "url": "https://omabrowser.org/oma/group/IGGRECL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4629979at2759", "url": "http://www.orthodb.org/?query=4629979at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1TON", "url": "https://www.rcsb.org/structure/1TON", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00089", "url": "http://pfam.xfam.org/family/PF00089", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P00759", "url": "http://purl.obolibrary.org/obo/PR_P00759", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "3888", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3888", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JX00", "url": "https://www.uniprot.org/uniprot/A0A0G2JX00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JX00-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JX00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P00759-1", "url": "https://www.uniprot.org/uniprot/P00759-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLQILSLVLSVGRIDAAPPGQSRIVGGYKCEKNSQPWQVAVINEYLCGGVLIDPSWVITAAHCYSNNYQVLLGRNNLFKDEPFAQRRLVRQSFRHPDYIPLIVTNDTEQPVHDHSNDLMLLHLSEPADITGGVKVIDLPTKEPKVGSTCLASGWGSTNPSEMVVSHDLQCVNIHLLSNEKCIETYKDNVTDVMLCAGEMEGGKDTCAGDSGGPLICDGVLQGITSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259, "header": "sp|P00759-1|KLK2_RAT Isoform 1 of Tonin OS=Rattus norvegicus OX=10116 GN=Klk2 PE=1 SV=1 CANONICAL=P00759-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JX00-1", "url": "", "sequence": { "sequence": "EWTGILSLSLSLSLSLSLSLSLSLAYAAPPGQSRIVGGYKCEKNSQPWQVAVINEYLCGGVLIDPSWVITAAHCYSNNYQVLLGRNNLFKDEPFAQRRLVRQSFRHPDYIPLIVTNDTEQPVHDHSNDLMLLHLSEPADITGGVKVIDLPTKEPKVGSTCLASGWGSTNPSEMVVSHDLQCVNIHLLSNEKCIETYKDNVTDVMLCAGEMEGGKDTCAGDSGGPLICDGVLQGITSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 269, "header": "tr|A0A0G2JX00-1|KLK2_RAT Computationally mapped isoform of Tonin OS=Rattus norvegicus OX=10116 GN=Klk2 PE=1 SV=2 CANONICAL=P00759-1" }, "locus": { "chromosome": "1", "start_pos": 94494728, "end_pos": 94492378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000081095.2", "url": "https://www.ensembl.org/id/ENSRNOT00000081095.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070080.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070080.2" } ] } }, { "isoform_ac": "P00759-1", "url": "", "sequence": { "sequence": "MWLQILSLVLSVGRIDAAPPGQSRIVGGYKCEKNSQPWQVAVINEYLCGGVLIDPSWVITAAHCYSNNYQVLLGRNNLFKDEPFAQRRLVRQSFRHPDYIPLIVTNDTEQPVHDHSNDLMLLHLSEPADITGGVKVIDLPTKEPKVGSTCLASGWGSTNPSEMVVSHDLQCVNIHLLSNEKCIETYKDNVTDVMLCAGEMEGGKDTCAGDSGGPLICDGVLQGITSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259, "header": "sp|P00759-1|KLK2_RAT Isoform 1 of Tonin OS=Rattus norvegicus OX=10116 GN=Klk2 PE=1 SV=1 CANONICAL=P00759-1" }, "locus": { "chromosome": "1", "start_pos": 94496445, "end_pos": 94492378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107012", "url": "https://www.ensembl.org/id/ENSRNOT00000107012" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081904", "url": "https://www.ensembl.org/id/ENSRNOP00000081904" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 106, "start_aa": "Asn", "end_pos": 106, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn106", "evidence": [ { "id": "P00759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00759#ptm_processing" }, { "id": "3038148", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3038148" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 189, "start_aa": "Asn", "end_pos": 189, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn189", "evidence": [ { "id": "P00759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00759#ptm_processing" }, { "id": "3038148", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3038148" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Protein products of the rat kallikrein gene family. Substrate specificities of kallikrein rK2 (tonin) and kallikrein rK9.", "journal": "J. Biol. Chem.", "date": "1992", "authors": "Moreau T, Brillard-Bourdet M, Bouhnik J, Gauthier F", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "1315752", "url": "https://glygen.org/publication/PubMed/1315752" } ] }, { "title": "The transcriptional regulatory strategy of the rat tissue kallikrein gene family.", "journal": "Genes and function", "date": "1997", "authors": "Kroon E, MacDonald RJ, Hammer RE", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" } ], "reference": [ { "type": "PubMed", "id": "17366701", "url": "https://glygen.org/publication/PubMed/17366701" } ] }, { "title": "Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain.", "journal": "Biological chemistry", "date": "2010", "authors": "Cardoso CC, Alenina N, Ferreira AJ, Qadri F, Lima MP, Gross V, Todiras M, Pesquero JB, Pesquero JL, Bader M", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" } ], "reference": [ { "type": "PubMed", "id": "20180641", "url": "https://glygen.org/publication/PubMed/20180641" } ] }, { "title": "Observation of tissue prokallikrein activation by some serine proteases, arginine esterases in rat submandibular gland.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1990", "authors": "Kamada M, Furuhata N, Yamaguchi T, Ikekita M, Kizuki K, Moriya H", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "2302205", "url": "https://glygen.org/publication/PubMed/2302205" } ] }, { "title": "Characterization of genes encoding rat tonin and a kallikrein-like serine protease.", "journal": "Biochemistry", "date": "1989", "authors": "Shai SY, Woodley-Miller C, Chao J, Chao L", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "2550051", "url": "https://glygen.org/publication/PubMed/2550051" } ] }, { "title": "Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin.", "journal": "Journal of the renin-angiotensin-aldosterone system : JRAAS", "date": "2015", "authors": "Ribeiro AA, Palomino Z, Lima MP, Souza LE, Ferreira DS, Pesquero JB, Irigoyen MC, Pesquero JL, Casarini DE", "evidence": [ { "database": "RefSeq", "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809" } ], "reference": [ { "type": "PubMed", "id": "26216430", "url": "https://glygen.org/publication/PubMed/26216430" } ] }, { "title": "Organization and expression of the rat kallikrein gene family.", "journal": "J. Biol. Chem.", "date": "1989", "authors": "Pritchett D.B., Roberts J.L., MacDonald R.J., Brady J.M., Wines D.R.", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "2708383", "url": "https://glygen.org/publication/PubMed/2708383" } ] }, { "title": "Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8-A resolution.", "journal": "J. Mol. Biol.", "date": "1987", "authors": "Fujinaga M, James MN", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "2821276", "url": "https://glygen.org/publication/PubMed/2821276" } ] }, { "title": "Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin.", "journal": "Biochemistry", "date": "1985", "authors": "Ashley PL, MacDonald RJ", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "2998455", "url": "https://glygen.org/publication/PubMed/2998455" } ] }, { "title": "The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis.", "journal": "Biochemistry and cell biology = Biochimie et biologie cellulaire", "date": "1987", "authors": "Lazure C, Leduc R, Seidah NG, Thibault G, Genest J, Chretien M", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759#ptm_processing" }, { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "3038148", "url": "https://glygen.org/publication/PubMed/3038148" } ] }, { "title": "Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases.", "journal": "Nature", "date": "1984", "authors": "Chretien M., Lazure C., Seidah N.G., Genest J., Leduc R., Thibault G.", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "reference": [ { "type": "PubMed", "id": "6320014", "url": "https://glygen.org/publication/PubMed/6320014" } ] } ], "pathway": [ { "id": "rno:24841", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:24841", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAN9-1", "protein_name": "Kallikrein 1-related peptidase C3", "gene_name": "Klk1c3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "IWTEILSLSLSLSLSLSLSLSLSLPFPTSSGHVLALPNCVPQHYIHNPYLFQPYPHPRLLLTDAAPPGQSRVVGGFKCEKNSQPWQVAVINEDLCGGVLIDPSWVITAAHCYSDNYHVLLGQNNLSEDVQHRLVSQSFRHPDYKPFLMRNHTRKPKDYSNDLMLLHLSEPADITDGVKVIDLPTKEPKVGSTCLVSGWGSTNPSETWLGSCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCRGDSGGPLICDGVLQGITSWGSVPCGEPNKPGIYTKLIKFTSWIKEVMKKNP", "length": 299 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "G3V8H1-1", "protein_name": "Kallikrein a3", "gene_name": "Klk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLDLSLGQIDAAPPGQSRVIGGYKCEKNSQPWQVALYSFSKYLCGGVLIDPSWVITAAHCSSNNYQVWLGRNNLLEDEPFAQHRLVSQSFPHPDYKPFLMRNHTRKPGDDHSNDLMLLHLSQPADITDGVKVIDLPTEEPKVGSTCLASGWGSTKPLIWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCTGDSGGPLLCDGVLQGITSWGSVPCAKTNMPAIYTKLIKFTSWIKEVMKENP", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P00755-1", "protein_name": "Kallikrein 1-related peptidase b1", "gene_name": "Klk1b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYRYKEYICGGVLLDANWVLTAAHCYYEKNNVWLGKNNLYQDEPSAQHRLVSKSFLHPCYNMSLHRNRIQNPQDDYSYDLMLLRLSKPADITDVVKPIALPTEEPKLGSTCLASGWGSIIPVKFQYAKDLQCVNLKLLPNEDCDKAYVQKVTDVMLCAGVKGGGKDTCKGDSGGPLICDGVLQGLTSWGYNPCGEPKKPGVYTKLIKFTSWIKDTLAQNP", "length": 261 }, "evidence": [ { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00756-1", "protein_name": "Kallikrein 1-related peptidase b3", "gene_name": "Klk1b3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYRYTQYLCGGVLLDPNWVLTAAHCYDDNYKVWLGKNNLFKDEPSAQHRFVSKAIPHPGFNMSLMRKHIRFLEYDYSNDLMLLRLSKPADITDTVKPITLPTEEPKLGSTCLASGWGSITPTKFQFTDDLYCVNLKLLPNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSWGHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00757-1", "protein_name": "Kallikrein 1-related peptidase-like b4", "gene_name": "Klk1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQCGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGILQGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP", "length": 256 }, "evidence": [ { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00758-1", "protein_name": "Kallikrein-1", "gene_name": "Ngfg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGRNDAAPPVQSRVVGGYNCEMNSQPWQVAVYYFGEYLCGGVLIDPSWVITAAHCATDNYQVWLGRNNLYEDEPFAQHRLVSQSFPHPGFNQDLIWNHTRQPGDDYSNDLMLLHLSQPADITDGVKVIDLPIEEPKVGSTCLASGWGSITPDGLELSDDLQCVNIDLLSNEKCVEAHKEEVTDLMLCAGEMDGGKDTCKGDSGGPLICNGVLQGITSWGFNPCGEPKKPGIYTKLIKFTPWIKEVMKENP", "length": 261 }, "evidence": [ { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P04071-1", "protein_name": "Kallikrein 1-related peptidase b16", "gene_name": "Klk1b16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWQVAVYYHKEHICGGVLLDRNWVLTAAHCYVDECEVWLGKNQLFQEEPSAQNRLVSKSFPHPGFNMTLLTFEKLPPGADFSNDLMLLRLSKPADITDVVKPIDLPTKEPKLDSTCLVSGWGSITPTKWQKPDDLQCMFTKLLPNENCAKAYLLKVTDVMLCTIEMGEDKGPCVGDSGGPLICDGVLQGTVSIGPDPCGIPGVSAIYTNLVKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06870-1", "protein_name": "Kallikrein-1", "gene_name": "KLK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS", "length": 262 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P07628-1", "protein_name": "Kallikrein 1-related peptidase b8", "gene_name": "Klk1b8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYDNKEHICGGVLLERNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLTLKEIPPGADFSNDLMLLRLSKPADITDAVKPITLPTKESKLGSTCLASGWGSITPTKWQKPDDLQCVFLKLLPIKNCIENHNVKVTDVMLCAGEMSGGKNICKGDSGGPLICDSVLQGITSTGPIPCGKPGVPAMYTNLIKFNSWIKDTMTKNS", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P07647-1", "protein_name": "Submandibular glandular kallikrein-9", "gene_name": "Klk9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGQIDAAPPGQSRVVGGYNCETNSQPWQVAVIGTTFCGGVLIDPSWVITAAHCYSKNYRVLLGRNNLVKDEPFAQRRLVSQSFQHPDYIPVFMRNHTRQRAYDHNNDLMLLHLSKPADITGGVKVIDLPTEEPKVGSICLASGWGMTNPSEMKLSHDLQCVNIHLLSNEKCIETYKNIETDVTLCAGEMDGGKDTCTGDSGGPLICDGVLQGLTSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P15945-1", "protein_name": "Kallikrein 1-related peptidase b5", "gene_name": "Klk1b5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIFGGFNCEKNSQPWQVAVYRFTKYQCGGVLLNANWVLTAAHCHNDKYQVWLGKNNFFEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVIYEPADDLQCVNFKLLPNEDCVKAHIEKVTDVMLCAGDMDGGKDTCMGDSGGPLICDGVLHGITSWGPSPCGKPNVPGIYTKLIKFNSWIKDTIAKNA", "length": 261 }, "evidence": [ { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15946-1", "protein_name": "Kallikrein 1-related peptidase b11", "gene_name": "Klk1b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWHVAVYRYNKYICGGVLLDRNWVLTAAHCHVSQYNVWLGKTKLFQREPSAQHRMVSKSFPHPDYNMSLLIIHNPEPEDDESNDLMLLRLSEPADITDAVKPIALPTEEPKLGSTCLVSGWGSITPTKFQTPDDLQCVSIKLLPNEVCVKNHNQKVTDVMLCAGEMGGGKDTCKGDSGGPLICDGVLHGITAWGPIPCGKPNTPGVYTKLIKFTNWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15947-1", "protein_name": "Kallikrein-1", "gene_name": "Klk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWQVAVYRFTKYQCGGILLNANWVLTAAHCHNDKYQVWLGKNNFLEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVKYEYPDELQCVNLKLLPNEDCAKAHIEKVTDDMLCAGDMDGGKDTCAGDSGGPLICDGVLQGITSWGPSPCGKPNVPGIYTRVLNFNTWIRETMAEND", "length": 261 }, "evidence": [ { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15948-1", "protein_name": "Kallikrein 1-related peptidase b22", "gene_name": "Klk1b22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYYLDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFNMSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQLIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP", "length": 259 }, "evidence": [ { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15949-1", "protein_name": "Kallikrein 1-related peptidase b9", "gene_name": "Klk1b9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVHSRIVGGFKCEKNSQPWHVAVYRYNEYICGGVLLDANWVLTAAHCYYEENKVSLGKNNLYEEEPSAQHRLVSKSFLHPGYNRSLHRNHIRHPEYDYSNDLMLLRLSKPADITDVVKPIALPTEEPKLGSTCLASGWGSTTPFKFQNAKDLQCVNLKLLPNEDCGKAHIEKVTDVMLCAGETDGGKDTCKGDSGGPLICDGVLQGITSWGFTPCGEPKKPGVYTKLIKFTSWIKDTMAKNL", "length": 261 }, "evidence": [ { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P36368-1", "protein_name": "Epidermal growth factor-binding protein type B", "gene_name": "Egfbp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPLQSRVVGGFNCKKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTIPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSKCLASGWGSITPTRWQKPDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCRDDSGGPLICDGILQGTTSYGPVPCGKPGVPAIYTNLIKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P36369-1", "protein_name": "Kallikrein 1-related peptidase b26", "gene_name": "Klk1b26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFPALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTTPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSTCLASGWGSITPTRWQKSDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILQGTTSNGPEPCGKPGVPAIYTNLIKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P36373-1", "protein_name": "Glandular kallikrein-7, submandibular/renal", "gene_name": "Klk7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLDLSLGQIDAAPPGQSRVIGGYKCEKNSQPWQVALYSFTKYLCGGVLIDPSWVITAAHCSSNNYQVWLGRNNLLEDEPFAQHRLVSQSFPHPDYKPFLMRNHTRKPGDDHSNDLMLLHLSQPADITDGVKVIDLPTEEPKVGSTCLASGWGSTKPLIWEFPDDLQCVNIHLLSNEKCIKAYKEKVTDLMLCAGELEGGKDTCTGDSGGPLLCDGVLQGITSWGSVPCAKTNMPAIYTKLIKFTSWIKEVMKENP", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P36374-1", "protein_name": "Prostatic glandular kallikrein-6", "gene_name": "Klk6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLLILFLILSLGWNDAAPPGQSRIIGGFNCEKNSQPWQVAVYHFNEPQCGGVLIHPSWVITAAHCYSVNYQVWLGRNNLLEDEPFAQHRLVSQSFPHPGFNLDIIKNHTRKPGNDYSNDLMLLHLKTPADITDGVKVIDLPTEEPKVGSTCLTSGWGSITPLKWEFPDDLQCVNIHLLSNEKCIKAYNDEVTDVMLCAGEMDGGKDICKGDSGGPLICDGVLQGITSWGSMPCGEPNKPSVYTKLIKFTSWMKKVMKENP", "length": 261 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P36375-1", "protein_name": "Glandular kallikrein-10", "gene_name": "Klk10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPGQSRIVGGYKCEKNSQPWQVAIINEYLCGGVLIDPSWVITAAHCYSNYYHVLLGRNNLFEDEPFAQYRFVNQSFPHPDYKPFLMRNHTRQRGDDYSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWGSTKPLNWELPDDLQCVNIHLLSNEKCIEAYEQKVTDLMLCAGEMDGRKDTCKGDSGGPLICDGVLQGITSWGNVPCAEPYNPGVYTKLIKFTSWIKEVMKENP", "length": 259 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P36376-1", "protein_name": "Glandular kallikrein-12, submandibular/renal", "gene_name": "Klk12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLQILFLVLSVGRIDAAPPGQSRVVGGYKCEKNSQPWQVAVINRYLCGGVLIDPSWVITAAHCYSHNYHVLLGRNNLFKDEPFAQYRVVNQSFPHPDYNPFFMKNHTLFPGDDHSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWSSTKPLEWEFPDDLQCVNINILSNEKCIKAHTQMVTDVMLCAGELEGGKDTCNGDSGGPLLCDGVLQGITSWSSVPCGETNRPAIYTKLIKFTSWIKEVMKENS", "length": 259 }, "evidence": [ { "id": "45241729", "url": "http://www.informatics.jax.org/homology/45241729", "database": "MGI" }, { "id": "45241728", "url": "http://www.informatics.jax.org/homology/45241728", "database": "MGI" }, { "id": "45241721", "url": "http://www.informatics.jax.org/homology/45241721", "database": "MGI" }, { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" }, { "id": "45241723", "url": "http://www.informatics.jax.org/homology/45241723", "database": "MGI" }, { "id": "45241722", "url": "http://www.informatics.jax.org/homology/45241722", "database": "MGI" }, { "id": "45241725", "url": "http://www.informatics.jax.org/homology/45241725", "database": "MGI" }, { "id": "45241724", "url": "http://www.informatics.jax.org/homology/45241724", "database": "MGI" }, { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" }, { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" }, { "id": "45241718", "url": "http://www.informatics.jax.org/homology/45241718", "database": "MGI" }, { "id": "45241719", "url": "http://www.informatics.jax.org/homology/45241719", "database": "MGI" }, { "id": "45241732", "url": "http://www.informatics.jax.org/homology/45241732", "database": "MGI" }, { "id": "45241730", "url": "http://www.informatics.jax.org/homology/45241730", "database": "MGI" }, { "id": "45241731", "url": "http://www.informatics.jax.org/homology/45241731", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61754-1", "protein_name": "Kallikrein 1-related peptidase b24", "gene_name": "Klk1b24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNATSQYNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP", "length": 263 }, "evidence": [ { "id": "45241726", "url": "http://www.informatics.jax.org/homology/45241726", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61759-1", "protein_name": "Kallikrein 1-related peptidase b21", "gene_name": "Klk1b21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGEIDAAPPVQSRIVGGFNCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQHESSAQHRLVSKSFPHPDYNMSLMNDHTPHPEDDYSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQIPNDLQCGFIKPLPNENCAKAYIHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGVLQGITSWGSIPCAKPNAPAIYTKLIKFTSWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45241727", "url": "http://www.informatics.jax.org/homology/45241727", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JM71-1", "protein_name": "Kallikrein 1-related peptidase b27", "gene_name": "Klk1b27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVQSRIIGGFKCKKNSQPWHVAVLRSNKYICGGVLLDPNWVLTAAHCYGNDTSQHNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDHIPHPEDKSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKYQIPNDLQCVFIKLLPNENCAKAYVHKVTDVMLCVGETGGGKGTCKGDSGGPLICDGVLHGITSWGSIPCAKPNAPGVFTKLIKFTSWIKDTMAKNP", "length": 263 }, "evidence": [ { "id": "45241720", "url": "http://www.informatics.jax.org/homology/45241720", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "pmid": "" }, { "name": "regulation of systemic arterial blood pressure", "id": "GO:0003073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003073", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": "https://www.uniprot.org/uniprot/P00759" } ], "pmid": "" }, { "name": "zymogen activation", "id": "GO:0031638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031638", "evidence": [ { "database": "UniProtKB", "id": "P00759", "url": 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