{ "uniprot_canonical_ac": "O97179-1", "uniprot_ac": "O97179", "uniprot_id": "ESM6_DROME", "mass": { "chemical_mass": 8059.0, "monoisotopic_mass": 8059.0 }, "refseq": { "ac": "NP_524512", "name": "enhancer of split m6, bearded family member", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512" }, "gene_names": [ { "name": "E(spl)m6-BFM", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O97179", "id": "O97179" }, { "name": "CG8354; DmelCG8354; Dmel\\CG8354; E(spl)-m6; E(spl)m6; E(spl)M6; HLHm6; m6; M6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512", "id": "NP_524512" }, { "name": "CG8354", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O97179", "id": "O97179" }, { "name": "E(spl)m6-BFM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512", "id": "NP_524512" }, { "name": "m6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O97179", "id": "O97179" } ], "protein_names": [ { "name": "Enhancer of split m6 protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O97179" }, { "name": "CG8354-PA; E(spl)m6-BFM-PA; enhancer of split m6; enhancer of split region transcript m6; E(spl) region transcript m6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512", "id": "NP_524512" }, { "name": "E(spl)m6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O97179" }, { "name": "enhancer of split m6, bearded family member", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512", "id": "NP_524512" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "E(spl)m6-BFM", "url": "https://www.uniprot.org/uniprot/O97179", "locus": { "chromosome": "3R", "start_pos": 26034047, "end_pos": 26032911, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0002632", "url": "https://www.ensembl.org/id/FBgn0002632" } ] } } ], "crossref": [ { "id": "FBgn0002632", "url": "https://bgee.org/?page=gene&gene_id=FBgn0002632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0002632", "url": "https://flybase.org/reports/FBgn0002632", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "43159", "url": "https://www.ncbi.nlm.nih.gov/gene/43159", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "dme:Dmel_CG8354", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8354", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQHYESL", "url": "https://omabrowser.org/oma/group/CQHYESL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3520669at2759", "url": "http://www.orthodb.org/?query=3520669at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PR_O97179", "url": "http://purl.obolibrary.org/obo/PR_O97179", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_524512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524512", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O97179-1", "url": "https://www.uniprot.org/uniprot/O97179-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKVKNLLAKMLQRFGKNSSQADSQRYDSLEEIAQNQANERMLRATQVGLEEHLVICLETEAGSFYWHSQ", "length": 70, "header": "sp|O97179-1|ESM6_DROME Isoform 1 of Enhancer of split m6 protein OS=Drosophila melanogaster OX=7227 GN=E(spl)m6-BFM PE=2 SV=2 CANONICAL=O97179-1" }, "isoforms": [ { "isoform_ac": "O97179-1", "url": "", "sequence": { "sequence": "MSKVKNLLAKMLQRFGKNSSQADSQRYDSLEEIAQNQANERMLRATQVGLEEHLVICLETEAGSFYWHSQ", "length": 70, "header": "sp|O97179-1|ESM6_DROME Isoform 1 of Enhancer of split m6 protein OS=Drosophila melanogaster OX=7227 GN=E(spl)m6-BFM PE=2 SV=2 CANONICAL=O97179-1" }, "locus": { "chromosome": "3R", "start_pos": 26033193, "end_pos": 26032984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0084959", "url": "https://www.ensembl.org/id/FBtr0084959" }, { "database": "Ensembl Peptide", "id": "FBpp0084333", "url": "https://www.ensembl.org/id/FBpp0084333" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes.", "journal": "Mech. Dev.", "date": "1999", "authors": "Wurmbach E, Wech I, Preiss A", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "reference": [ { "type": "PubMed", "id": "10072784", "url": "https://glygen.org/publication/PubMed/10072784" } ] }, { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila.", "journal": "Mol. Biol. Evol.", "date": "2005", "authors": "Macdonald SJ, Long AD", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "reference": [ { "type": "PubMed", "id": "15537803", "url": "https://glygen.org/publication/PubMed/15537803" } ] } ], "pathway": [ { "id": "dme:Dmel_CG8354", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8354", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell fate specification", "id": "GO:0001708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001708", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "O97179", "url": "https://www.uniprot.org/uniprot/O97179" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }