{ "uniprot_canonical_ac": "O95155-1", "uniprot_ac": "O95155", "uniprot_id": "UBE4B_HUMAN", "mass": { "chemical_mass": 146185.0, "monoisotopic_mass": 146185.0 }, "refseq": {}, "gene_names": [ { "name": "UBE4B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95155", "id": "O95155" }, { "name": "HDNB1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95155", "id": "O95155" }, { "name": "KIAA0684", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95155", "id": "O95155" }, { "name": "UFD2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95155", "id": "O95155" } ], "protein_names": [ { "name": "Ubiquitin conjugation factor E4 B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95155" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95155" }, { "name": "Homozygously deleted in neuroblastoma 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95155" }, { "name": "RING-type E3 ubiquitin transferase E4 B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95155" }, { "name": "Ubiquitin fusion degradation protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95155" } ], "function": [ { "annotation": "Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820).", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155#function" }, { "database": "UniProtKB", "id": "P54860", "url": "https://www.uniprot.org/uniprot/P54860#function" }, { "database": "UniProtKB", "id": "Q9ES00", "url": "https://www.uniprot.org/uniprot/Q9ES00#function" }, { "database": "PubMed", "id": "17369820", "url": "https://glygen.org/publication/PubMed/17369820" }, { "database": "UniProtKB", "id": "K7ERA7", "url": "https://www.uniprot.org/uniprot/K7ERA7#function" }, { "database": "UniProtKB", "id": "RU369083", "url": "https://www.uniprot.org/uniprot/RU369083#function" }, { "database": "UniProtKB", "id": "K7EP75", "url": "https://www.uniprot.org/uniprot/K7EP75#function" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs755420565", "database": "dbSNP", "url": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any 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"url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", 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"MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95155" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" } ], "common_name": "Human" } ], "gene": [ { "name": "UBE4B", "url": "https://www.uniprot.org/uniprot/O95155", "locus": { "chromosome": "1", "start_pos": 10181239, "end_pos": 10032832, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000130939", "url": "https://www.ensembl.org/id/ENSG00000130939" } ] } } ], "crossref": [ { "id": "ENSG00000130939", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O95155", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95155", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "2.3.2.27", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27&UniProtAcc=O95155", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "2.3.2.B12", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.B12&UniProtAcc=O95155", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd16658", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16658", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "UBE4B", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=UBE4B", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "12500", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12500", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "B1AQ61", "url": "https://www.ebi.ac.uk/intact/interactors/id:B1AQ61*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O95155", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95155*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10277", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "613565", "url": "http://www.omim.org/entry/613565", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95155", "url": "https://www.nextprot.org/entry/NX_O95155", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "O95155", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95155", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "INKNAGR", "url": "https://omabrowser.org/oma/group/INKNAGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1554at2759", "url": "http://www.orthodb.org/?query=1554at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13931", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13931", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13931:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13931:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2KRE", "url": "https://www.rcsb.org/structure/2KRE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3L1X", "url": "https://www.rcsb.org/structure/3L1X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3L1Z", "url": "https://www.rcsb.org/structure/3L1Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5O75", "url": "https://www.rcsb.org/structure/5O75", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF04564", "url": "http://pfam.xfam.org/family/PF04564", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10408", "url": "http://pfam.xfam.org/family/PF10408", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95155", "url": "https://pharos.nih.gov/targets/O95155", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95155", "url": "http://purl.obolibrary.org/obo/PR_O95155", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_005263479", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005263479", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B1AQ61", "url": "https://www.uniprot.org/uniprot/B1AQ61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AQ61-1", "url": "https://www.uniprot.org/uniprot/B1AQ61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EP75", "url": "https://www.uniprot.org/uniprot/K7EP75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EP75-1", "url": "https://www.uniprot.org/uniprot/K7EP75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERA7", "url": "https://www.uniprot.org/uniprot/K7ERA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERA7-1", "url": "https://www.uniprot.org/uniprot/K7ERA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95155-1", "url": "https://www.uniprot.org/uniprot/O95155-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95155-2", "url": "https://www.uniprot.org/uniprot/O95155-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95155-3", "url": "https://www.uniprot.org/uniprot/O95155-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95155-4", "url": "https://www.uniprot.org/uniprot/O95155-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH", "length": 1302, "header": "sp|O95155-1|UBE4B_HUMAN Isoform 1 of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "isoforms": [ { "isoform_ac": "B1AQ61-1", "url": "", "sequence": { "sequence": "MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGLGIISDDKMIKTEFGSADFMNLVDGFKIK", "length": 100, "header": "tr|B1AQ61-1|UBE4B_HUMAN Computationally mapped isoform of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10072542, "end_pos": 10033671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000377153.5", "url": "https://www.ensembl.org/id/ENST00000377153.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000366358.1", "url": "https://www.ensembl.org/id/ENSP00000366358.1" } ] } }, { "isoform_ac": "K7EP75-1", "url": "", "sequence": { "sequence": "XTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLK", "length": 276, "header": "tr|K7EP75-1|K7EP75_HUMAN Computationally mapped isoform of Ubiquitin conjugation factor E4 OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10145039, "end_pos": 10122042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000470736.1", "url": "https://www.ensembl.org/id/ENST00000470736.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000467258.1", "url": "https://www.ensembl.org/id/ENSP00000467258.1" } ] } }, { "isoform_ac": "K7ERA7-1", "url": "", "sequence": { "sequence": "XDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRSLQCST", "length": 98, "header": "tr|K7ERA7-1|K7ERA7_HUMAN Computationally mapped isoform of Ubiquitin conjugation factor E4 OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10166263, "end_pos": 10158354, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000488228.1", "url": "https://www.ensembl.org/id/ENST00000488228.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000468178.1", "url": "https://www.ensembl.org/id/ENSP00000468178.1" } ] } }, { "isoform_ac": "O95155-1", "url": "", "sequence": { "sequence": "MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH", "length": 1302, "header": "sp|O95155-1|UBE4B_HUMAN Isoform 1 of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10179953, "end_pos": 10033671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000343090.11", "url": "https://www.ensembl.org/id/ENST00000343090.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000343001.6", "url": "https://www.ensembl.org/id/ENSP00000343001.6" } ] } }, { "isoform_ac": "O95155-2", "url": "", "sequence": { "sequence": "MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH", "length": 1173, "header": "sp|O95155-2|UBE4B_HUMAN Isoform 2 of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10179953, "end_pos": 10033671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000253251.12", "url": "https://www.ensembl.org/id/ENST00000253251.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000253251.8", "url": "https://www.ensembl.org/id/ENSP00000253251.8" } ] } }, { "isoform_ac": "O95155-3", "url": "", "sequence": { "sequence": "MSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRGKWTHPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH", "length": 1061, "header": "sp|O95155-3|UBE4B_HUMAN Isoform 3 of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": {} }, { "isoform_ac": "O95155-4", "url": "", "sequence": { "sequence": "MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSMYDNPFSFLFLALSGDSSDEEDEEEDDDDGDGDDEGGGGGDDFSCVQFGSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH", "length": 1353, "header": "sp|O95155-4|UBE4B_HUMAN Isoform 4 of Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 CANONICAL=O95155-1" }, "locus": { "chromosome": "1", "start_pos": 10179953, "end_pos": 10033671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000672724.1", "url": "https://www.ensembl.org/id/ENST00000672724.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000500453.1", "url": "https://www.ensembl.org/id/ENSP00000500453.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 22, "start_aa": "Thr", "end_pos": 22, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "O95155", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95155" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35008409", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35008409" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 30, "start_aa": "Thr", "end_pos": 30, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr30", "evidence": [ { "id": "O95155", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95155" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35008409", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35008409" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" } ] } ], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser101" }, { "start_pos": 103, "end_pos": 103, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser103" }, { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser105" }, { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser124" }, { "start_pos": 1265, "end_pos": 1265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1265" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser224" }, { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr22" }, { "start_pos": 238, "end_pos": 238, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser238" }, { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser23" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr26" }, { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser31" }, { "start_pos": 383, "end_pos": 383, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "site_lbl": "Ser383" }, { "start_pos": 392, "end_pos": 392, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser392" }, { "start_pos": 798, "end_pos": 798, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser798" }, { "start_pos": 803, "end_pos": 803, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "phospho.ELM", "id": "O95155", "url": "http://phospho.elm.eu.org/byAccession/O95155.html" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" }, { "database": "PubMed", "id": "18220336", "url": 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homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.", "journal": "Biochem. J.", "date": "2002", "authors": "Mahoney JA, Odin JA, White SM, Shaffer D, Koff A, Casciola-Rosen L, Rosen A", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" } ], "reference": [ { "type": "PubMed", "id": "11802788", "url": "https://glygen.org/publication/PubMed/11802788" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.", "journal": "Nature biotechnology", "date": "2006", "authors": "Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "UniProtKB", "id": "B1AQ61", "url": "https://www.uniprot.org/uniprot/B1AQ61" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "UniProtKB", "id": "K7EP75", "url": "https://www.uniprot.org/uniprot/K7EP75" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.", "journal": "Nat. Cell Biol.", "date": "2007", "authors": "Kim J., Krause S., Lochmueller H., Cassata G., Hoppe T., Janiesch P.C., Barikbin R., Mouysset J.", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" } ], "reference": [ { "type": "PubMed", "id": "17369820", "url": "https://glygen.org/publication/PubMed/17369820" } ] }, { "title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.", "journal": "J. Proteome Res.", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Molecular cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "UniProtKB", "id": "B1AQ61", "url": "https://www.uniprot.org/uniprot/B1AQ61" }, { "database": "UniProtKB", "id": "K7EP75", "url": "https://www.uniprot.org/uniprot/K7EP75" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.", "journal": "PLoS ONE", "date": "2011", "authors": "Mammen AL, Mahoney JA, St Germain A, Badders N, Taylor JP, Rosen A, Spinette S", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" } ], "reference": [ { "type": "PubMed", "id": "22174917", "url": "https://glygen.org/publication/PubMed/22174917" } ] }, { "title": "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.", "journal": "Mol. 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Proteomics", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "B1AQ61", "url": "https://www.uniprot.org/uniprot/B1AQ61" }, { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O95155", "url": "https://www.uniprot.org/uniprot/O95155" }, { "database": "iPTMnet", "id": "O95155", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95155" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": 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MY, Chou TY", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95155", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95155" } ], "reference": [ { "type": "PubMed", "id": "35008409", "url": "https://glygen.org/publication/PubMed/35008409" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95155", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95155" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", 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