{ "uniprot_canonical_ac": "O88665-1", "uniprot_ac": "O88665", "uniprot_id": "BRD7_MOUSE", "mass": { "chemical_mass": 74000.0, "monoisotopic_mass": 74000.0 }, "refseq": { "ac": "NP_036177", "name": "bromodomain-containing protein 7 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177" }, "gene_names": [ { "name": "Brd7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O88665", "id": "O88665" }, { "name": "BP75; CELTIX1; Ptpn13ip", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "id": "NP_036177" }, { "name": "Bp75", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O88665", "id": "O88665" }, { "name": "Brd7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "id": "NP_036177" } ], "protein_names": [ { "name": "Bromodomain-containing protein 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O88665" }, { "name": "75 kDa bromodomain protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88665" }, { "name": "bromodomain-containing protein 7 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "id": "NP_036177" }, { "name": "protein tyrosine phosphatase, non-receptor type 13 interacting protein; bromodomain-containing protein 7; 75 kDa bromodomain protein; bromodomain protein 75 kDa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "id": "NP_036177" } ], "function": [ { "annotation": "Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665#function" }, { "database": "PubMed", "id": "12941796", "url": "https://glygen.org/publication/PubMed/12941796" }, { "database": "PubMed", "id": "19909775", "url": "https://glygen.org/publication/PubMed/19909775" }, { "database": "PubMed", "id": "18809673", "url": "https://glygen.org/publication/PubMed/18809673" } ] }, { "annotation": "BRD7 improves glucose homeostasis independent of IRS proteins. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_036177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177" }, { "database": "PubMed", "id": "37578842", "url": "https://glygen.org/publication/PubMed/37578842" } ] } ], "disease": [ { "disease_id": "DOID:0080199", "recommended_name": { "id": "DOID:0080199", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080199", "name": "colorectal carcinoma", "description": "A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa." }, "synonyms": [], "evidence": [ { "id": "0080199", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080199" } ] }, { "disease_id": "DOID:1574", "recommended_name": { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol use disorder", "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences." }, "synonyms": [ { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "Ethanol abuse", "description": "" }, { "id": "DOID:1574", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1574", "name": "alcohol abuse", "description": "" } ], "evidence": [ { "id": "1574", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1574" } ] }, { "disease_id": "DOID:2152", "recommended_name": { "id": "DOID:2152", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2152", "name": "ovary epithelial cancer", "description": "An ovarian cancer that is derives_from ovarian surface epithelium." }, "synonyms": [ { "id": "DOID:2152", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2152", "name": "Ovarian Surface epithelial-Stromal tumor", "description": "" } ], "evidence": [ { "id": "2152", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2152" } ] }, { "disease_id": "DOID:3068", "recommended_name": { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes." }, "synonyms": [ { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "glioblastoma multiforme", "description": "" }, { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "GBM", "description": "" }, { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "adult glioblastoma multiforme", "description": "" }, { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "grade IV adult Astrocytic tumor", "description": "" }, { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "primary glioblastoma multiforme", "description": "" }, { "id": "DOID:3068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3068", "name": "spongioblastoma multiforme", "description": "" } ], "evidence": [ { "id": "3068", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ] }, { "disease_id": "DOID:3069", "recommended_name": { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "malignant astrocytoma", "description": "A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord." }, "synonyms": [ { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "Astrocytic tumor", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of Cerebrum", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astrocytoma of brain", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "astroglioma", "description": "" }, { "id": "DOID:3069", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3069", "name": "cerebral astrocytoma", "description": "" } ], "evidence": [ { "id": "3069", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3069" } ] }, { "disease_id": "DOID:3070", "recommended_name": { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "high grade glioma", "description": "A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine." }, "synonyms": [ { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "malignant glioma", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "Neuroglial tumor", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "glial cell tumor", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "glioma, malignant", "description": "" }, { "id": "DOID:3070", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3070", "name": "malignant Neuroglial tumor", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "GLM1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioblastoma, somatic", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma susceptibility 1, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma, susceptibility to, somatic", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "astrocytoma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "ependymoma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioblastoma multiforme", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "glioma of brain, familial", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "oligodendroglioma", "description": "" }, { "id": "MONDO:0024498", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024498", "name": "subependymoma", "description": "" }, { "id": "MIM:137800", "resource": "MIM", "url": "https://www.omim.org/entry/137800", "name": "Glioma 1", "description": "Glioma 1" } ], "evidence": [ { "id": "3070", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3070" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ { "id": "3908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:9119", "recommended_name": { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukemia", "description": "A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells." }, "synonyms": [ { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "AML - acute Myeloid Leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "Leukemia, Myelocytic, acute", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myelogenous leukemia", "description": "" }, { "id": "DOID:9119", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9119", "name": "acute myeloid leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. 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"acute Nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute granulocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myelogenous leukemias", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute myeloid leukemia, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute nonlymphocytic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukaemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "hematopoeitic - acute Myleogenous leukemia (AML)", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, reduced survival in, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, myelocytic, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "myeloid leukemia, acute, M4/M4Eo subtype, somatic", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukaemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "acute non lymphoblastic leukemia", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myelogenous", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid", "description": "" }, { "id": "MONDO:0018874", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018874", "name": "leukemia, acute myeloid, susceptibility to", "description": "" }, { "id": "MIM:601626", "resource": "MIM", "url": "https://www.omim.org/entry/601626", "name": "Leukemia, acute myelogenous", "description": "Leukemia, acute myelogenous" } ], "evidence": [ { "id": "9119", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9119" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Brd7", "url": "https://www.uniprot.org/uniprot/O88665", "locus": { "chromosome": "8", "start_pos": 89057667, "end_pos": 89088822, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031660", "url": "https://www.ensembl.org/id/ENSMUSG00000031660" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031660", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031660", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3822348", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3822348", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "26992", "url": "https://www.ncbi.nlm.nih.gov/gene/26992", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O88665", "url": "https://www.ebi.ac.uk/intact/interactors/id:O88665*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:26992", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26992", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1349766", "url": "http://www.informatics.jax.org/marker/MGI:1349766", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "HQGHRER", "url": "https://omabrowser.org/oma/group/HQGHRER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1221506at2759", "url": "http://www.orthodb.org/?query=1221506at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22881", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22881", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22881:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22881:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "http://pfam.xfam.org/family/PF00439", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12024", "url": "http://pfam.xfam.org/family/PF12024", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O88665", "url": "http://purl.obolibrary.org/obo/PR_O88665", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804758", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_036177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O88665-1", "url": "https://www.uniprot.org/uniprot/O88665-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVDRDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQREREDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTGRLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIVGNSFVDLTGECEEPKETSTAECGPDAS", "length": 651, "header": "sp|O88665-1|BRD7_MOUSE Isoform 1 of Bromodomain-containing protein 7 OS=Mus musculus OX=10090 GN=Brd7 PE=1 SV=1 CANONICAL=O88665-1" }, "isoforms": [ { "isoform_ac": "O88665-1", "url": "", "sequence": { "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVDRDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQREREDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTGRLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIVGNSFVDLTGECEEPKETSTAECGPDAS", "length": 651, "header": "sp|O88665-1|BRD7_MOUSE Isoform 1 of Bromodomain-containing protein 7 OS=Mus musculus OX=10090 GN=Brd7 PE=1 SV=1 CANONICAL=O88665-1" }, "locus": { "chromosome": "8", "start_pos": 89088582, "end_pos": 89059119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000034085", "url": "https://www.ensembl.org/id/ENSMUST00000034085" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000034085", "url": "https://www.ensembl.org/id/ENSMUSP00000034085" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O88665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O88665" } ], "site_lbl": "Ser279" }, { "start_pos": 289, "end_pos": 289, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "site_lbl": "Ser289" }, { "start_pos": 380, "end_pos": 380, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "site_lbl": "Ser380" }, { "start_pos": 475, "end_pos": 475, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O88665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O88665" } ], "site_lbl": "Ser475" }, { "start_pos": 482, "end_pos": 482, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O88665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O88665" } ], "site_lbl": "Ser482" }, { "start_pos": 483, "end_pos": 483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "O88665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O88665" } ], "site_lbl": "Ser483" }, { "start_pos": 621, "end_pos": 621, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "site_lbl": "Ser621" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification and molecular characterization of BP75, a novel bromodomain-containing protein.", "journal": "FEBS Lett.", "date": "1999", "authors": "Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "reference": [ { "type": "PubMed", "id": "10526152", "url": "https://glygen.org/publication/PubMed/10526152" } ] }, { "title": "BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta.", "journal": "Cancer Res.", "date": "2003", "authors": "Kim S, Lee J, Park J, Chung J", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "reference": [ { "type": "PubMed", "id": "12941796", "url": "https://glygen.org/publication/PubMed/12941796" } ] }, { "title": "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.", "journal": "J. Biol. Chem.", "date": "2008", "authors": "Yates J.R. III, Dong M.Q., Aslanian A., Emerson B.M., Kaeser M.D.", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "reference": [ { "type": "PubMed", "id": "18809673", "url": "https://glygen.org/publication/PubMed/18809673" } ] }, { "title": "TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.", "journal": "Biochim. Biophys. Acta", "date": "2009", "authors": "Miyajima N., Watanabe M., Kikuchi M., Hatakeyama S., Imamura M., Okumura F., Tanaka J., Tsukiyama T.", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "reference": [ { "type": "PubMed", "id": "19909775", "url": "https://glygen.org/publication/PubMed/19909775" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" }, { "database": "iPTMnet", "id": "O88665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O88665" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "date": "2013", "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "reference": [ { "type": "PubMed", "id": "23806337", "url": "https://glygen.org/publication/PubMed/23806337" } ] }, { "title": "BRD7 improves glucose homeostasis independent of IRS proteins.", "journal": "The Journal of endocrinology", "date": "2023-09-01", "authors": "Kim Yoo, Lee Junsik M, Han Youngah, Tao Rongya, White Morris F, Liu Renyan, Park Sang Won", "evidence": [ { "database": "RefSeq", "id": "NP_036177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036177" } ], "reference": [ { "type": "PubMed", "id": "37578842", "url": "https://glygen.org/publication/PubMed/37578842" } ] } ], "pathway": [ { "id": "mmu:26992", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26992", "resource": "KEGG Pathway" }, { "id": "R-MMU-6804758", "name": "Regulation of TP53 Activity through Acetylation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804758", "resource": "Reactome", "description": "Regulation of TP53 Activity through Acetylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTM7-1", "protein_name": "Bromodomain containing 7", "gene_name": "Brd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRVENEADKDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDRADACQGGEDSGCWQREREDSGDAETQAFKSPTKDNKKKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANCQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMPSPEDEGQTRALDVAKEAEQVAHIEPAGRLESSGQDRLTALQAVTNFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIMGHSLVDLTEECEDPKETSTAESGPAAS", "length": 652 }, "evidence": [ { "id": "45232518", "url": "http://www.informatics.jax.org/homology/45232518", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NPI1-1", "protein_name": "Bromodomain-containing protein 7", "gene_name": "BRD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS", "length": 651 }, "evidence": [ { "id": "45232518", "url": "http://www.informatics.jax.org/homology/45232518", "database": "MGI" }, { "id": "O88665", "url": "https://omabrowser.org/oma/group/O88665/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "regulation of nucleotide-excision repair", "id": "GO:2000819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000819", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "positive regulation of cell differentiation", "id": "GO:0045597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045597", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "regulation of mitotic metaphase/anaphase transition", "id": "GO:0030071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030071", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "negative regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000134", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair", "id": "GO:2000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000781", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "positive regulation of T cell differentiation", "id": "GO:0045582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045582", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000045", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "positive regulation of myoblast differentiation", "id": "GO:0045663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045663", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "regulation of G0 to G1 transition", "id": "GO:0070316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070316", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "O88665", "url": "https://www.uniprot.org/uniprot/O88665" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": 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