{ "uniprot_canonical_ac": "O88483-1", "uniprot_ac": "O88483", "uniprot_id": "PDP1_RAT", "mass": { "chemical_mass": 61207.0, "monoisotopic_mass": 61207.0 }, "refseq": { "ac": "NP_001258037", "name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" }, "gene_names": [ { "name": "Pdp1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O88483", "id": "O88483" }, { "name": "Pdp1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237969", "id": "XP_006237969" }, { "name": "Ppm2c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237969", "id": "XP_006237969" }, { "name": "Ppm2c", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O88483", "id": "O88483" } ], "protein_names": [ { "name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O88483" }, { "name": "3.1.3.43", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88483" }, { "name": "PDP 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88483" }, { "name": "PDPC 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88483" }, { "name": "Protein phosphatase 2C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88483" }, { "name": "Pyruvate dehydrogenase phosphatase catalytic subunit 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O88483" }, { "name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037", "id": "NP_001258037" }, { "name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245", "id": "NP_062245" }, { "name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; PDP 1; PDPC 1; pyruvate dehydrogenase phosphatase isoenzyme 1; protein phosphatase 2C, magnesium dependent, catalytic subunit; pyruvate dehyrogenase phosphatase catalytic subunit 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037", "id": "NP_001258037" }, { "name": "pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237969", "id": "XP_006237969" } ], "function": [ { "annotation": "Asp445 might be involved in the control of interactions between PDP1c and the protein substrate pyruvate dehydrogenase", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "15210124", "url": "https://glygen.org/publication/PubMed/15210124" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] }, { "annotation": "Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483#function" } ] }, { "annotation": "Divergent alterations of PDP1 mRNA expression were found in different brain regions following traumatic brain injury.", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "22884618", "url": "https://glygen.org/publication/PubMed/22884618" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] }, { "annotation": "MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "35148687", "url": "https://glygen.org/publication/PubMed/35148687" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] }, { "annotation": "Results report the crystal structure of the rat pyruvate dehydrogenase phosphatase 1 catalytic subunit at 1.8 A resolution.", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "17532339", "url": "https://glygen.org/publication/PubMed/17532339" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] }, { "annotation": "Results suggest that decreased PDP activity in oxidative skeletal muscles may play a role in the impairment of carbohydrate metabolism in obese rats, which is reversible with endurance training.", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "18716035", "url": "https://glygen.org/publication/PubMed/18716035" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] }, { "annotation": "Role of PP2C and AMPK in the derangements of cardiac lipid metabolism in obesity", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "PubMed", "id": "15367397", "url": "https://glygen.org/publication/PubMed/15367397" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ] } ], "disease": [ { "disease_id": "DOID:3649", "recommended_name": { "id": "DOID:3649", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3649", "name": "pyruvate decarboxylase deficiency", "description": "A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex." }, "synonyms": [ { "id": "DOID:3649", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3649", "name": "deficiency of pyruvic dehydrogenase", "description": "" }, { "id": "DOID:3649", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3649", "name": "pyruvate dehydrogenase complex deficiency disease", "description": "" }, { "id": "DOID:3649", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3649", "name": "pyruvate dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0012120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012120", "name": "pyruvate dehydrogenase phosphatase deficiency", "description": "Pyruvate dehydrogenase phosphatase deficiency is a very rare subtype of pyruvate dehydrogenase deficiency (PDHD) characterized by lactic acidemia in the neonatal period." }, { "id": "MONDO:0012120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012120", "name": "PDH phosphatase deficiency", "description": "" }, { "id": "MONDO:0012120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012120", "name": "pyruvate dehydrogenase phosphatase deficiency", "description": "" }, { "id": "MONDO:0012120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012120", "name": "PDHPD", "description": "" }, { "id": "MONDO:0012120", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012120", "name": "lactic acidemia with pyruvate dehydrogenase phosphatase deficiency", "description": "" }, { "id": "MONDO:0013580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013580", "name": "pyruvate dehydrogenase E1-beta deficiency", "description": "Pyruvate dehydrogenase E1-beta deficiency is an extremely rare form of pyruvate dehydrogenase deficiency (PDHD) characterized by severe lactic acidosis, developmental delay and hypotonia." }, { "id": "MONDO:0013580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013580", "name": "PDHBD", "description": "" }, { "id": "MONDO:0013580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013580", "name": "pyruvate dehydrogenase E1-beta deficiency", "description": "" }, { "id": "MONDO:0013580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013580", "name": "pyruvate dehydrogenase complex E1 component subunit beta deficiency", "description": "" }, { "id": "MONDO:0013580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013580", "name": "pyruvate dehydrogenase E1-BETA deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase E1-alpha deficiency", "description": "Pyruvate dehydrogenase E1-alpha deficiency is the most frequent form of pyruvate dehydrogenase deficiency (PDHD) characterized by variable lactic acidosis, impaired psychomotor development, hypotonia and neurological dysfunction." }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate decarboxylase deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "PDHAD", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase E1-alpha deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase complex E1 component subunit alpha deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase e1-alpha deficiency, X-linked dominant", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "PDH deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "ataxia with lactic acidosis 1", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "ataxia, intermittent, with abnormal pyruvate metabolism", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "ataxia, intermittent, with pyruvate dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "ataxia, intermittent, with pyruvate dehydrogenase, or decarboxylase, deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "lactic acidemia, thiamine-responsive", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase Complex deficiency", "description": "" }, { "id": "MONDO:0010717", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010717", "name": "pyruvate dehydrogenase E1-ALPHA deficiency", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "pyruvate dehydrogenase E2 deficiency", "description": "Pyruvate dehydrogenase E2 deficiency is a very rare form of pyruvate dehydrogenase deficiency (PDHD) characterized by variable lactic acidosis and neurological dysfunction, mainly appearing during childhood." }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex deficiency", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex deficiency", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "pyruvate dehydrogenase E2 deficiency", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "pyruvate dehydrogenase complex component E2 deficiency", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "PDHDD", "description": "" }, { "id": "MONDO:0009502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009502", "name": "lactic acidemia due to defect of E2 lipoyl transacetylase of the pyruvate dehydrogenase Complex", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "pyruvate dehydrogenase E3-binding protein deficiency", "description": "Pyruvate dehydrogenase E3-binding protein deficiency is a rare mild form of pyruvate dehydrogenase deficiency (PDHD) characterized by variable lactic acidosis and neurological dysfunction." }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "2-oxoglutarate complex deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "Glycine cleavage system L protein deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "branched chain alpha-ketoacid dehydrogenase complex deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "diaphorase deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "dihydrolipoyl dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "lacticacidemia due to PDX1 deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "lipoamide dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "pyruvate dehydrogenase E3-binding protein deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "pyruvate dehydrogenase complex component E3 deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "pyruvate dehydrogenase protein X component deficiency", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "PDHXD", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "lactic acidemia due to defect in lipoyl-containing component 10 of the pyruvate dehydrogenase Complex", "description": "" }, { "id": "MONDO:0009503", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009503", "name": "pyruvate dehydrogenase E3-binding PROTEIN deficiency", "description": "" }, { "id": "MIM:608782", "resource": "MIM", "url": "https://www.omim.org/entry/608782", "name": "Pyruvate dehydrogenase phosphatase deficiency", "description": "Pyruvate dehydrogenase phosphatase deficiency" }, { "id": "MIM:614111", "resource": "MIM", "url": "https://www.omim.org/entry/614111", "name": "Pyruvate dehydrogenase E1-beta deficiency", "description": "Pyruvate dehydrogenase E1-beta deficiency" }, { "id": "MIM:312170", "resource": "MIM", "url": "https://www.omim.org/entry/312170", "name": "Pyruvate dehydrogenase E1-alpha deficiency", "description": "Pyruvate dehydrogenase E1-alpha deficiency" }, { "id": "MIM:245348", "resource": "MIM", "url": "https://www.omim.org/entry/245348", "name": "Pyruvate dehydrogenase E2 deficiency", "description": "Pyruvate dehydrogenase E2 deficiency" }, { "id": "MIM:245349", "resource": "MIM", "url": "https://www.omim.org/entry/245349", "name": "Pyruvate dehydrogenase E3-binding protein deficiency", "description": "Pyruvate dehydrogenase E3-binding protein deficiency" } ], "evidence": [ { "id": "3649", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3649" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pdp1", "url": "https://www.uniprot.org/uniprot/O88483", "locus": { "chromosome": "5", "start_pos": 25446272, "end_pos": 25455217, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000016180", "url": "https://www.ensembl.org/id/ENSRNOG00000016180" } ] } } ], "crossref": [ { "id": "ENSRNOG00000016180", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016180", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.3.43", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.43&UniProtAcc=O88483", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00143", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "54705", "url": "https://www.ncbi.nlm.nih.gov/gene/54705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "O88483", "url": "https://www.ebi.ac.uk/intact/interactors/id:O88483*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:54705", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:54705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CDRRMCV", "url": "https://omabrowser.org/oma/group/CDRRMCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1131727at2759", "url": "http://www.orthodb.org/?query=1131727at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13832", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13832", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13832:SF627", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13832:SF627", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2PNQ", "url": "https://www.rcsb.org/structure/2PNQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00481", "url": "http://pfam.xfam.org/family/PF00481", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O88483", "url": "http://purl.obolibrary.org/obo/PR_O88483", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-204174", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-204174", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "620393", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620393", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "12669", "url": "https://www.rhea-db.org/rhea/12669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JWE0", "url": "https://www.uniprot.org/uniprot/A0A0G2JWE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JWE0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JWE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2QC17", "url": "https://www.uniprot.org/uniprot/A0A0G2QC17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2QC17-1", "url": "https://www.uniprot.org/uniprot/A0A0G2QC17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1L1J4", "url": "https://www.uniprot.org/uniprot/A1L1J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A1L1J4-1", "url": "https://www.uniprot.org/uniprot/A1L1J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O88483-1", "url": "https://www.uniprot.org/uniprot/O88483-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNRLPANAPIEDRRSATTCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNGLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELQRLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 538, "header": "sp|O88483-1|PDP1_RAT Isoform 1 of [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdp1 PE=1 SV=1 CANONICAL=O88483-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JWE0-1", "url": "", "sequence": { "sequence": "MSISALLSMGRCCCRCCCPRGLWMLSAPCCDDRRMCVCPGPRRIGIPVRTSSLPLFSDAMPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 597, "header": "tr|A0A0G2JWE0-1|PDP1_RAT Computationally mapped isoform of [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdp1 PE=1 SV=1 CANONICAL=O88483-1" }, "locus": { "chromosome": "5", "start_pos": 25454395, "end_pos": 25449118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090579.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090579.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069844.2", "url": "https://www.ensembl.org/id/ENSRNOP00000069844.2" } ] } }, { "isoform_ac": "A0A0G2QC17-1", "url": "", "sequence": { "sequence": "MCVCPGPRRIGIPVRTSSLPLFSDAMPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 563, "header": "tr|A0A0G2QC17-1|A0A0G2QC17_RAT Computationally mapped isoform of Pyruvate dehydrogenase phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=Pdp1 PE=3 SV=1 CANONICAL=O88483-1" }, "locus": { "chromosome": "5", "start_pos": 25454293, "end_pos": 25449118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000067823.4", "url": "https://www.ensembl.org/id/ENSRNOT00000067823.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062054.3", "url": "https://www.ensembl.org/id/ENSRNOP00000062054.3" } ] } }, { "isoform_ac": "A1L1J4-1", "url": "", "sequence": { "sequence": "MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 538, "header": "tr|A1L1J4-1|PDP1_RAT Computationally mapped isoform of [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdp1 PE=1 SV=1 CANONICAL=O88483-1" }, "locus": { "chromosome": "5", "start_pos": 25450731, "end_pos": 25449118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090376.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090376.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070525.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070525.2" } ] } }, { "isoform_ac": "O88483-1", "url": "", "sequence": { "sequence": "MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNRLPANAPIEDRRSATTCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNGLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELQRLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 538, "header": "sp|O88483-1|PDP1_RAT Isoform 1 of [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pdp1 PE=1 SV=1 CANONICAL=O88483-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesis.", "journal": "Biochimica et biophysica acta", "date": "2004", "authors": "Karpova T, Danchuk S, Huang B, Popov KM", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ], "reference": [ { "type": "PubMed", "id": "15210124", "url": "https://glygen.org/publication/PubMed/15210124" } ] }, { "title": "Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2005", "authors": "Wang MY, Unger RH", "evidence": [ { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" }, { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" } ], "reference": [ { "type": "PubMed", "id": "15367397", "url": "https://glygen.org/publication/PubMed/15367397" } ] }, { "title": "Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications.", "journal": "J. Mol. Biol.", "date": "2007", "authors": "Vassylyev DG, Symersky J", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" }, { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" } ], "reference": [ { "type": "PubMed", "id": "17532339", "url": "https://glygen.org/publication/PubMed/17532339" } ] }, { "title": "Skeletal muscle type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression: effects of obesity and endurance training.", "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "date": "2008", "authors": "Leblanc PJ, Mulligan M, Antolic A, Macpherson L, Inglis JG, Martin D, Roy BD, Peters SJ", "evidence": [ { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" }, { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" } ], "reference": [ { "type": "PubMed", "id": "18716035", "url": "https://glygen.org/publication/PubMed/18716035" } ] }, { "title": "Pyruvate dehydrogenase phosphatase1 mRNA expression is divergently and dynamically regulated between rat cerebral cortex, hippocampus and thalamus after traumatic brain injury: a potential biomarker of TBI-induced hyper- and hypo-glycaemia and neuronal vulnerability.", "journal": "Neuroscience letters", "date": "2012", "authors": "Xing G, Ren M, O'Neill JT, Sharma P, Verma A, Watson WD", "evidence": [ { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" }, { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" } ], "reference": [ { "type": "PubMed", "id": "22884618", "url": "https://glygen.org/publication/PubMed/22884618" } ] }, { "title": "MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1.", "journal": "The journal of physiological sciences : JPS", "date": "2022", "authors": "Feng X, Lu J, Wu Y, Xu H", "evidence": [ { "database": "RefSeq", "id": "NP_001258037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258037" }, { "database": "RefSeq", "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245" } ], "reference": [ { "type": "PubMed", "id": "35148687", "url": "https://glygen.org/publication/PubMed/35148687" } ] }, { "title": "Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Huang B, Gudi R, Wu P, Harris RA, Hamilton J, Popov KM", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "reference": [ { "type": "PubMed", "id": "9651365", "url": "https://glygen.org/publication/PubMed/9651365" } ] } ], "pathway": [ { "id": "rno:54705", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:54705", "resource": "KEGG Pathway" }, { "id": "R-RNO-204174", "name": "Regulation of pyruvate dehydrogenase (PDH) complex", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-204174", "resource": "Reactome", "description": "Regulation of pyruvate dehydrogenase (PDH) complex" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3UV70-1", "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "Pdp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ", "length": 538 }, "evidence": [ { "id": "45234126", "url": "http://www.informatics.jax.org/homology/45234126", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0J1-1", "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "PDP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE", "length": 537 }, "evidence": [ { "id": "45234126", "url": "http://www.informatics.jax.org/homology/45234126", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "[pyruvate dehydrogenase (lipoamide)] phosphatase activity", "id": "GO:0004741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004741", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "id": "GO:0019909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019909", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "peptidyl-threonine dephosphorylation", "id": "GO:0035970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035970", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "protein dephosphorylation", "id": "GO:0006470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006470", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "positive regulation of pyruvate dehydrogenase activity", "id": "GO:1904184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904184", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "O88483", "url": "https://www.uniprot.org/uniprot/O88483" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12669", "name": "", "equation": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88483-1", "O88484-1", "Q9P0J1-1", "Q9P2J9-1", "Q3UV70-1", "P25646-1", "Q12511-1" ], "evidence": [ { "id": "12669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12669" } ] }, { "id": "R-RNO-204169", "name": "PDP dephosphorylates p-lipo-PDH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P6R2-1", "P26284-1", "D4A5G8-1", "O88483-1", "O88484-1", "P49432-1", "P08461-1", "Q06437-1" ], "evidence": [ { "id": "R-RNO-204169", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-204169" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D4A5G8", "gene_name": "Pdha1l1", "activity": [ { "ec_number": "1.2.4.1", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2.", "evidence": [ { "id": "D4A5G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5G8" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "D4A5G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A5G8" } ] } ] }, { "uniprot_ac": "O88483", "gene_name": "Pdp1", "activity": [ { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "O88483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88483" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "O88483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88483" } ] } ] }, { "uniprot_ac": "O88484", "gene_name": "Pdp2", "activity": [ { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "O88484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88484" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "O88484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88484" } ] } ] }, { "uniprot_ac": "P08461", "gene_name": "Dlat", "activity": [ { "ec_number": "2.3.1.12", "activity": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P08461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08461" } ] }, { "ec_number": "2.3.1.12", "activity": "", "evidence": [ { "id": "P08461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08461" } ] } ] }, { "uniprot_ac": "P25646", "gene_name": "PTC6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] } ] }, { "uniprot_ac": "P26284", "gene_name": "Pdha1", "activity": [ { "ec_number": "1.2.4.1", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2.", "evidence": [ { "id": "P26284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26284" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P26284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26284" } ] } ] }, { "uniprot_ac": "P49432", "gene_name": "Pdhb", "activity": [ { "ec_number": "1.2.4.1", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2.", "evidence": [ { "id": "P49432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49432" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P49432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49432" } ] } ] }, { "uniprot_ac": "Q06437", "gene_name": "Pdha2", "activity": [ { "ec_number": "1.2.4.1", "activity": "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2.", "evidence": [ { "id": "Q06437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06437" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "Q06437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06437" } ] } ] }, { "uniprot_ac": "Q12511", "gene_name": "PTC5", "activity": [ { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "Q12511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12511" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "Q12511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12511" } ] } ] }, { "uniprot_ac": "Q3UV70", "gene_name": "Pdp1", "activity": [ { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "Q3UV70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UV70" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "Q3UV70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UV70" } ] } ] }, { "uniprot_ac": "Q6P6R2", "gene_name": "Dld", "activity": [ { "ec_number": "1.8.1.4", "activity": "(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH.", "evidence": [ { "id": "Q6P6R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6R2" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "Q6P6R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6R2" } ] } ] }, { "uniprot_ac": "Q9P0J1", "gene_name": "PDP1", "activity": [ { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "Q9P0J1", "database": "UniProtKB", "url": 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"field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", 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